Molecularly imprinted drug delivery systems

2005 ◽  
Author(s):  
D CUNLIFFE ◽  
A KIRBY ◽  
C ALEXANDER
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Molecularly Imprinted

scholarly journals Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2085 ◽  
Author(s):  
Andreea Elena Bodoki ◽  
Bogdan-Cezar Iacob ◽  
Ede Bodoki
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Drug Delivery Systems ◽  
Value Added ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Severe Toxicity ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cancer Management

Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics’ release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.

Molecularly imprinted polymers as drug delivery systems for the sustained release of glycyrrhizic acid

2010 ◽  
Vol 62 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Giuseppe Cirillo ◽  
Ortensia Ilaria Parisi ◽  
Manuela Curcio ◽  
Francesco Puoci ◽  
Francesca Iemma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Molecularly Imprinted Polymers ◽  
Drug Delivery Systems ◽  
Glycyrrhizic Acid ◽  
Delivery Systems ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Ocular Therapy

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3649
Author(s):  
Andreea E. Bodoki ◽  
Bogdan-C. Iacob ◽  
Elena Dinte ◽  
Oliviu Vostinaru ◽  
Ovidiu Samoila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymer ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Avant Garde ◽  
Internal Structures ◽  
Molecular Imprinting Technology ◽  
Ocular Therapy

Although the human eye is an easily accessible sensory organ, it remains a challenge for drug administration due to the presence of several anatomical and physiological barriers which limit the access of drugs to its internal structures. Molecular imprinting technology may be considered the avant-garde approach in advanced drug delivery applications and, in particular, in ocular therapy. In fact, molecularly imprinted polymers hold the promise to compensate for the current shortcomings of the available arsenal of drug delivery systems intended for ocular therapy. The present manuscript aims to review the recent advances, the current challenges and most importantly to raise awareness on the underexplored potential and future perspectives of molecularly imprinted polymer-based drug delivery systems intended for the treatment of eye diseases.

scholarly journals Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 831
Author(s):  
Nasim Sanadgol ◽  
Judith Wackerlig
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Molecularly Imprinted Polymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Loading Capacity ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

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