scholarly journals Rapid and Local Self-Healing Ability of Polyurethane Nanocomposites Using Photothermal Polydopamine-Coated Graphene Oxide Triggered by Near-Infrared Laser

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1274
Author(s):  
Yu-Mi Ha ◽  
Young Nam Kim ◽  
Yong Chae Jung
Keyword(s):  
Graphene Oxide ◽  
Near Infrared ◽  
Resonance Effect ◽  
The Self ◽  
Ex Situ ◽  
Photothermal Effect ◽  
Self Healing ◽  
Local Surface Plasmon Resonance ◽  
X Ray ◽  
Nir Laser

In this study, we report the self-healing ability of polyurethane (PU) nanocomposites based on the photothermal effect of polydopamine-coated graphene oxide (PDA–rGO). Polydopamine (PDA) was coated on the graphene oxide (GO) surface, while simultaneously reducing GO by the oxidation of dopamine hydrochloride in an alkaline aqueous solution. The PDA–rGO was characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, Raman spectroscopy, thermogravimetric analysis, and scanning electron microscopy–energy-dispersive X-ray analysis. PDA–rGO/PU nanocomposites with nanofiller contents of 0.1, 0.5 and 1 wt% were prepared by ex situ mixing method. The photothermal effect of the PDA–rGO in the PU matrix was investigated at 0.1 W/cm2 using an 808 nm near-infrared (NIR) laser. The photothermal properties of the PDA–rGO/PU nanocomposites were superior to those of the GO/PU nanocomposites, owing to an increase in the local surface plasmon resonance effect by coating with PDA. Subsequently, the self-healing efficiency was confirmed by recovering the tensile stress of the damaged nanocomposites using the thermal energy generated by the NIR laser.

Stimuli-responsive graphene oxide and methotrexate-loaded magnetic nanoparticles for breast cancer-targeted therapy

Nanomedicine ◽  
2021 ◽  
Vol 16 (24) ◽  
pp. 2155-2174
Author(s):  
Mitra Dolatkhah ◽  
Nastaran Hashemzadeh ◽  
Jaleh Barar ◽  
Khosro Adibkia ◽  
Ayuob Aghanejad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Near Infrared ◽  
Folate Receptor ◽  
Superparamagnetic Iron Oxide ◽  
Photothermal Effect ◽  
Breast Cancer Cell Lines ◽  
Stimuli Responsive ◽  
High Cytotoxicity ◽  
Nir Laser

Aim: Nanocomposites of graphene oxide (GO) loaded with PEGylated superparamagnetic iron oxide nanoparticles and grafted with methotrexate and stimuli-responsive linkers (GO-SPION-MTX) were developed for photothermal and chemotherapy of breast cancer. Methods: PEGylated SPIONs were synthesized and conjugated with chemotherapeutic targeting agent MTX, which were then loaded on GO to prepare GO-SPION-MTX nanocomposites. To evaluate the photothermal effect of the nanocomposites, they were examined in breast cancer cell lines with low doses of near-infrared (NIR) laser radiation with/without acetazolamide. Results: The GO-SPION-MTX nanocomposites were found to be internalized by the folate-receptor-positive cancer cells and induce high cytotoxicity on exposure to NIR laser rays. Conclusion: Our findings suggest that the GO-SPION-MTX nanocomposite can potentially be used as a multimodal nanomedicine/theranostic against breast cancer.

scholarly journals Photothermal-assisted antibacterial application of GO-Ag against clinical isolated MDR E. coli

2019 ◽  
Author(s):  
Yuqing Chen ◽  
Wei Wu ◽  
Zeqiao Xu ◽  
Cheng Jiang ◽  
Shuang Han ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Near Infrared ◽  
Antibacterial Effect ◽  
Luria Bertani ◽  
Fluorescent Imaging ◽  
Photothermal Effect ◽  
Antibacterial Efficiency ◽  
E Coli ◽  
Morphology Characterization

Abstract Background: Treatment of multidrug-resistant (MDR) bacterial infection is a great challenge in public health. Herein, we provide a solution to this problem with the use of graphene oxide-silver (GO-Ag) nanocomposites as anti-bacterial agent. Methods: Following established protocols, silver nanoparticles were grown on graphene oxide sheets. Then, a series of in-vitro studies were conducted to validate the antibacterial efficiency of the GO-Ag nanocomposites against clinical MDR Escherichia coli (E. coli) strains. Firstly, minimum inhibitory concentrations (MICs) of different antimicrobials were tested against MDR E. Coli strains. Then, bacteria viability assessments were conducted with different nanomaterials in Luria-Bertani (LB) broth. Afterwards, photothermal irradiation was conducted on MDR E. coli with lower GO-Ag concentration. At last, fluorescent imaging and morphology characterization using scanning electron microscope (SEM) were done to find the possible cause of antibacterial effect. Results: GO-Ag nanocomposites showed the highest antibacterial efficiency among tested antimicrobials. Synergetic antibacterial effect was observed in GO-Ag nanocomposites treated group. The remained bacteria viabilities were 4.4% and 4.1% respectively for different bacteria strains with GO-Ag concentration at 14.0 µg mL-1. In addition, GO-Ag nanocomposites have strong absorption in the near-infrared field and can convert the electromagnetic energy to heat. With the use of this photothermal effect, effective sterilization could be achieved using GO-Ag nanocomposites concentration as low as 7.0 µg mL-1. Fluorescent imaging and morphology characterization were used to analyze bacteria living status, which uncovered that bacteria integrity was disrupted after GO-Ag nanocomposites treatment. Conclusions: GO-Ag nanocomposites are proved to be efficient antibacterial agent against multi-drug resistant E. coli. Their strong antibacterial effect arises from inherent antibacterial property and photothermal effect that provides aid for bacteria killing.

scholarly journals Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1286 ◽  
Author(s):  
Lee ◽  
Jung ◽  
Jo ◽  
Yang ◽  
Koh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Photothermal Effect ◽  
Great Promise ◽  
Targeted Cancer Therapy ◽  
Potential Applications ◽  
Photothermal Property ◽  
Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

Scanning transmission X-ray microscopy probe forin situmechanism study of graphene-oxide-based resistive random access memory

2013 ◽  
Vol 21 (1) ◽  
pp. 170-176 ◽  
Author(s):  
Hyun Woo Nho ◽  
Jong Yun Kim ◽  
Jian Wang ◽  
Hyun-Joon Shin ◽  
Sung-Yool Choi ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Random Access ◽  
Random Access Memory ◽  
Resistive Random Access Memory ◽  
Ex Situ ◽  
Access Memory ◽  
Bipolar Resistive Switching ◽  
X Ray ◽  
Scanning Transmission

Here, anin situprobe for scanning transmission X-ray microscopy (STXM) has been developed and applied to the study of the bipolar resistive switching (BRS) mechanism in an Al/graphene oxide (GO)/Al resistive random access memory (RRAM) device. To performin situSTXM studies at the CK- and OK-edges, both the RRAM junctions and theI0junction were fabricated on a single Si3N4membrane to obtain local XANES spectra at these absorption edges with more delicateI0normalization. Using this probe combined with the synchrotron-based STXM technique, it was possible to observe unique chemical changes involved in the BRS process of the Al/GO/Al RRAM device. Reversible oxidation and reduction of GO induced by the externally applied bias voltages were observed at the OK-edge XANES feature located at 538.2 eV, which strongly supported the oxygen ion drift model that was recently proposed fromex situtransmission electron microscope studies.

scholarly journals Indocyanine Green and Methyl-β-Cyclodextrin Complex for Enhanced Photothermal Cancer Therapy

Biomedicines ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 476 ◽  
Author(s):  
Gayoung Jo ◽  
Bo Young Lee ◽  
Eun Jeong Kim ◽  
Min Ho Park ◽  
Hoon Hyun
Keyword(s):  
Cancer Therapy ◽  
Indocyanine Green ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Body Weight Loss ◽  
Photothermal Effect ◽  
Cyclodextrin Complex ◽  
Photothermal Treatment ◽  
Potential Strategy ◽  
Nir Laser

A feasible and biocompatible supramolecular complex self-assembled from indocyanine green (ICG) and methyl-β-cyclodextrin (Mβ-CD) was developed for targeted cancer imaging, which enhanced fluorescence-guided photothermal cancer therapy. This study confirmed that the formation of an inclusion complex of the heterocyclic ICG moiety and Mβ-CD inner cavity could result in improved tumor targetability compared with free ICG. The ICG-CD complex could be used as a bifunctional phototherapeutic agent for targeted cancer phototherapy due to the high tumor targetability of the Mβ-CD moiety and effective photothermal performance of the near-infrared (NIR) ICG moiety. Upon NIR laser irradiation, the photothermal effect exerted by the ICG-CD complex significantly enhanced the temperature at the tumor site by 56.2 °C within 5 min. Targeting HT-29 tumors using the ICG-CD complex resulted in an apparent reduction in tumor volumes over the 9 days after photothermal treatment. Moreover, no tumor recurrence or body weight loss were observed after administering a single dose of ICG-CD complex with NIR laser irradiation. Therefore, the administration of the biocompatible ICG-CD complex in combination with NIR laser treatment can be safely explored as a potential strategy for future clinical applications.

Synthesis of Cu2(OH)PO4 superstructures with NIR-laser enhanced photocatalytic activity

2020 ◽  
Vol 13 (03) ◽  
pp. 2050015 ◽  
Author(s):  
Lu Cheng ◽  
Nuo Yu ◽  
Yan Zhang ◽  
Zhun Shi ◽  
Haifeng Wang ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Visible Light ◽  
Near Infrared ◽  
Visible Region ◽  
Photogenerated Electron ◽  
Photothermal Effect ◽  
Hydrothermal Route ◽  
Electron Hole ◽  
Light Group ◽  
Nir Laser

The development of photocatalysts with wide UV-Vis-near-infrared (NIR) photoabsorption has received tremendous interest for utilizing sunlight efficiently. In this work, Cu2(OH)PO4 superstructures are prepared by a simple hydrothermal route, and they have strong bandgap absorption in UV-Visible region and a distinctive plasmon resonance absorption in NIR region. Under the synergetic illumination of visible light and 980[Formula: see text]nm laser (3.0[Formula: see text]W[Formula: see text]cm[Formula: see text]), Cu2(OH)PO4 superstructures can degrade 89.2% MB with the elevated temperature ([Formula: see text]51∘C) of solution, which is higher than that from visible light group (50.0%), laser group (16.4%), and visible-light/exterior-heating group (62.5%, same temperature at [Formula: see text]51.0∘C). These facts reveal that Cu2(OH)PO4 superstructures exhibit NIR-laser enhanced photocatalytic activity, which not only comes from the photothermal effect-induced temperature elevation, but also mainly results from the increased production of photogenerated electron-hole pairs by NIR-laser. Therefore, Cu2(OH)PO4 superstructures can act as efficient photocatalyst with NIR-laser enhanced photocatalytic activity.

scholarly journals Hyperthermia Induced by Near-Infrared Laser-Irradiated CsWO3 Nanoparticles Disintegrates Preformed Lysozyme Amyloid Fibrils

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 442
Author(s):  
Po-Sheng Hu ◽  
Natalia Tomasovicova ◽  
Hsiu-Jen Chou ◽  
Meng-Chang Li ◽  
Marek Vojtko ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Near Infrared ◽  
Amyloid Fibrils ◽  
Research Study ◽  
Photothermal Effect ◽  
Force Microscopy ◽  
Atomic Force ◽  
Dendritic Structures ◽  
Nir Laser ◽  
Scanning Electron

This research study attempts to prove the concept of the applicability of hyperthermia to treating the lysozyme amyloid fibrils (LAFs)’s self-assembled fibrillary aggregates by a feedback-modulated temperature controller ranging from 26 °C to 80 °C, and separately, by near-infrared (NIR) laser-irradiated cesium tungstate (CsWO3) nanoparticle (NPs). The dependence of the final morphology of the amyloidal assembly on external heating and the photothermal effect of the NPs on treating the fibrillary assembly were investigated and analyzed. Experimentally, atomic force microscopy (AFM), optical stereoscopy, and scanning electron microscopy (SEM) were used primarily to ensure mutual interaction between LAFs and NPs, optically elucidate the surface contour and final fibrillary assembly upon the influence of thermal treatment, and further reveal fine-details of the optical samples. Finally, conclusive remarks are drawn that the fibrillary structures doped with the NPs exhibit an increasing degree of unique orthogonality. As the temperature rises, utter deformation of the dendritic structures of fibrillary assemblies at 70 °C was found, and NIR laser-irradiated CsWO3 NPs have been demonstrated to be useful in topically destructing pre-assembled LAFs, which may be conducive to the future development of neurodegenerative therapeutic techniques.

scholarly journals Gold Nanorod-Mediated Photothermal Modulation for Localized Ablation of Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yoochan Hong ◽  
Eugene Lee ◽  
Jihye Choi ◽  
Seung Jae Oh ◽  
Seungjoo Haam ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Laser Power ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Transduction Efficiency ◽  
Dead Cell ◽  
Photothermal Ablation ◽  
Power Densities ◽  
Nir Laser

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

scholarly journals Gold Nanostars Embedded in PDMS Films: A Photothermal Material for Antibacterial Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3252
Author(s):  
Gemma Toci ◽  
Francesca Olgiati ◽  
Piersandro Pallavicini ◽  
Yuri Antonio Diaz Fernandez ◽  
Lorenzo De Vita ◽  
...  
Keyword(s):  
Human Health ◽  
Medical Devices ◽  
Hybrid Material ◽  
Temperature Increase ◽  
Near Infrared ◽  
Laser Source ◽  
Photothermal Effect ◽  
Biocompatible Material ◽  
Gold Nanostars ◽  
Nir Laser

Bacteria infections and related biofilms growth on surfaces of medical devices are a serious threat to human health. Controlled hyperthermia caused by photothermal effects can be used to kill bacteria and counteract biofilms formation. Embedding of plasmonic nano-objects like gold nanostars (GNS), able to give an intense photothermal effect when irradiated in the NIR, can be a smart way to functionalize a transparent and biocompatible material like polydimethylsiloxane (PDMS). This process enables bacteria destruction on surfaces of PDMS-made medical surfaces, an action which, in principle, can also be exploited in subcutaneous devices. We prepared stable and reproducible thin PDMS films containing controllable quantities of GNS, enabling a temperature increase that can reach more than 40 degrees. The hyperthermia exerted by this hybrid material generates an effective thermal microbicidal effect, killing bacteria with a near infrared (NIR) laser source with irradiance values that are safe for skin.

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