scholarly journals Gold Nanorod-Mediated Photothermal Modulation for Localized Ablation of Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yoochan Hong ◽  
Eugene Lee ◽  
Jihye Choi ◽  
Seung Jae Oh ◽  
Seungjoo Haam ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Laser Power ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Transduction Efficiency ◽  
Dead Cell ◽  
Photothermal Ablation ◽  
Power Densities ◽  
Nir Laser

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

Porous Pd nanoparticles with high photothermal conversion efficiency for efficient ablation of cancer cells

Nanoscale ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 4345-4351 ◽  
Author(s):  
Jia-Wen Xiao ◽  
Shi-Xuan Fan ◽  
Feng Wang ◽  
Ling-Dong Sun ◽  
Xiao-Yu Zheng ◽  
...  
Keyword(s):  
Porous Structure ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Pd Nanoparticles ◽  
Photothermal Effect ◽  
High Efficacy ◽  
Photothermal Ablation ◽  
Nir Absorption ◽  
Very High

Pd NPs with a porous structure exhibit enhanced near infrared (NIR) absorption and enhanced photothermal effect compared to Pd nanocubes with a similar size, and show very high efficacy in photothermal ablation of HeLa cells.

scholarly journals Synthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Bing Liu ◽  
Jian Zhou ◽  
Bin Zhang ◽  
Jing Qu
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Cell Counting ◽  
Photothermal Effect ◽  
Ovarian Cancer Cells ◽  
Photothermal Treatment ◽  
Skov3 Cells ◽  
Nir Laser

Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe3O4 nanoparticles have promising applications in photothermal treatment of cancer cells.

scholarly journals Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Ha Hee Shin ◽  
Hyung Woo Choi ◽  
Jae Hyun Lim ◽  
Ji Woon Kim ◽  
Bong Geun Chung
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Solution Temperature ◽  
Photothermal Effect ◽  
Synthetic Process ◽  
Nir Laser

AbstractThe combination therapy based on multifunctional nanocomposites has been considered as a promising approach to improve cancer therapeutic efficacy. Herein, we report targeted multi-functional poly(N-isopropylacrylamide) (PNIPAM)-based nanocomposites for synergistic chemo-photothermal therapy toward breast cancer cells. To increase the transition temperature, acrylic acid (AAc) was added in synthetic process of PNIPAM, showing that the intrinsic lower critical solution temperature was changed to 42 °C . To generate the photothermal effect under near-infrared (NIR) laser irradiation (808 nm), polypyrrole (ppy) nanoparticles were uniformly decorated in PNIPAM-AAc. Folic acid (FA), as a cancer targeting ligand, was successfully conjugated on the surplus carboxyl groups in PNIPAM network. The drug release of PNIPAM-ppy-FA nanocomposites was efficiently triggered in response to the temperature change by NIR laser irradiation. We also confirmed that PNIPAM-ppy-FA was internalized to MDA-MB-231 breast cancer cells by folate-receptor-mediated endocytosis and significantly enhanced cancer therapeutic efficacy with combination treatment of chemo-photothermal effects. Therefore, our work encourages further exploration of multi-functional nanocarrier agents for synergistic therapeutic approaches to different types of cancer cells.

scholarly journals In Vitro Photothermal Destruction of Cancer Cells Using Gold Nanorods and Pulsed-Train Near-Infrared Laser

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jui-Teng Lin ◽  
Yueh-Sheng Chiang ◽  
Guang-Hong Lin ◽  
Hsinyu Lee ◽  
Hsia-Wei Liu
Keyword(s):  
Cancer Cells ◽  
Diode Laser ◽  
Near Infrared ◽  
Irradiation Time ◽  
Laser System ◽  
Gold Nanorod ◽  
Near Ir ◽  
Laser Heated ◽  
Train System

We present a novel pulsed-train near-IR diode laser system with real-time temperature monitoring of the laser-heated cancer cell mixed in gold nanorod solution. Near-IR diode laser at 808 nm matching the gold nanorod absorption peak (with an aspect ratio about 4.0) was used in this study. Both surface and volume temperatures were measured and kept above 43°C, the temperature for cancer cells destruction. The irradiation time needed in our pulsed-train system with higher laser fluence for killing the cancel cells is about 1–3 minutes, much shorter than conventional methods (5–10 minutes). Cell viabilities in gold nanorod mixed and controlled solutions are studied by green fluorescence.

scholarly journals Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13432-13442 ◽  
Author(s):  
Lun Qin ◽  
Peijian Yan ◽  
Congkun Xie ◽  
Jie Huang ◽  
Zhaohui Ren ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Therapeutic System

A localized therapeutic system, consisting of gold nanorods (Au NRs) loaded with hTERT siRNA assembled on the surface of ZnGa2O4:Cr (ZGOC) nanofibers, offers the potential for a LED-induced mild photothermal effect which enhances gene silencing effect in cancer cells.

scholarly journals Photothermal Effect of Superparamagnetic Fe3O4 Nanoparticles Irradiated by Near-Infrared Laser

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Shawei Fu ◽  
Yuchun Man ◽  
Fuquan Jia
Keyword(s):  
Cancer Treatment ◽  
Power Density ◽  
Infrared Absorption ◽  
Fe3o4 Nanoparticles ◽  
Near Infrared ◽  
Infrared Laser ◽  
Photothermal Effect ◽  
Transduction Efficiency ◽  
Large Power ◽  
Fe3o4 Nps

Fe3O4 nanoparticles (NPs) have been widely used in biomedicine due to their unique magnetism, biocompatibility, and biodegradability. Magnetic hyperthermia of Fe3O4 NPs for cancer treatment has attracted more attention. However, it could interfere with magnetic field-sensitive devices of patients, such as pacemakers. Therefore, it is necessary to find a new method for clinical therapy. In this study, the superparamagnetic Fe3O4 NPs were fabricated. Visible-near-infrared absorption spectra indicated that the Fe3O4 NPs have near-infrared absorption. The influences of Fe3O4 NP concentrations, power density, and wavelength of near-infrared laser irradiation on the photothermal performance of Fe3O4 NPs were investigated. The results revealed that high concentrations, large power density, and short irradiation wavelength could improve the photothermal performance of Fe3O4 NPs. The temperature variation and the absorption intensity simultaneously determined the photothermal transduction efficiency of Fe3O4 NPs. The application of the photothermal performance of Fe3O4 NPs would provide a new opportunity for clinic cancer treatment.

scholarly journals Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1286 ◽  
Author(s):  
Lee ◽  
Jung ◽  
Jo ◽  
Yang ◽  
Koh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Photothermal Effect ◽  
Great Promise ◽  
Targeted Cancer Therapy ◽  
Potential Applications ◽  
Photothermal Property ◽  
Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

scholarly journals Poly-amino acids coated gold nanorod and doxorubicin for synergistic photodynamic therapy and chemotherapy in ovarian cancer cells

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
JinYing Liu ◽  
Wei Ma ◽  
Wei Kou ◽  
Lina Shang ◽  
Rui Huang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Gold Nanorod ◽  
Cell Group ◽  
Ovarian Cancer Cells ◽  
Ros Generation ◽  
Burst Release

Abstract In this work, we have successfully designed and formulated a doxorubicin-loaded polypeptide-based multilayer assembled gold nanorod (DH-GNR). We have hypothesized that near-infrared (NIR) laser irradiation of DH-GNR will combine the benefits of chemotherapy and photothermal therapy. The GNR was surface functionalized with poly-glutamic acid (PGA) and poly-l-Lysine (PLL) with a final layer of hyaluronic acid (HA) that could also serve as a targeting ligand toward the overexpressed CD44 receptors in ovarian cancer cells. The zigzag ζ potential of nanoparticle is a proof of successful assembly of alternative polymers on the GNR surface. NIR irradiation exhibited a burst release of drug in pH 7.4 and pH 5.0 buffer conditions. The combination of doxorubicin (DOX)-based chemotherapy and GNR-based photothermal therapy exhibited a synergistic effect in killing the SKOV3 cancer cells. DH-GNR(+NIR) induced a 82.5% apoptosis (combined early and late apoptosis) compared with only 35.2 and 38.5% for DOX or DH-GNR(−NIR) treated cell group. Results clearly suggest that the excessive reactive oxygen species (ROS) generation in DH-GNR (+NIR) might be responsible for the cell apoptosis and cell death. The promising anticancer effect of DH-GNR will be of great potential in the treatment of ovarian cancers and worth further development for treating other malignant tumors.

Stimuli-responsive graphene oxide and methotrexate-loaded magnetic nanoparticles for breast cancer-targeted therapy

Nanomedicine ◽  
2021 ◽  
Vol 16 (24) ◽  
pp. 2155-2174
Author(s):  
Mitra Dolatkhah ◽  
Nastaran Hashemzadeh ◽  
Jaleh Barar ◽  
Khosro Adibkia ◽  
Ayuob Aghanejad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Near Infrared ◽  
Folate Receptor ◽  
Superparamagnetic Iron Oxide ◽  
Photothermal Effect ◽  
Breast Cancer Cell Lines ◽  
Stimuli Responsive ◽  
High Cytotoxicity ◽  
Nir Laser

Aim: Nanocomposites of graphene oxide (GO) loaded with PEGylated superparamagnetic iron oxide nanoparticles and grafted with methotrexate and stimuli-responsive linkers (GO-SPION-MTX) were developed for photothermal and chemotherapy of breast cancer. Methods: PEGylated SPIONs were synthesized and conjugated with chemotherapeutic targeting agent MTX, which were then loaded on GO to prepare GO-SPION-MTX nanocomposites. To evaluate the photothermal effect of the nanocomposites, they were examined in breast cancer cell lines with low doses of near-infrared (NIR) laser radiation with/without acetazolamide. Results: The GO-SPION-MTX nanocomposites were found to be internalized by the folate-receptor-positive cancer cells and induce high cytotoxicity on exposure to NIR laser rays. Conclusion: Our findings suggest that the GO-SPION-MTX nanocomposite can potentially be used as a multimodal nanomedicine/theranostic against breast cancer.

Preparation of Composite Cypate Nanoparticles and Its Application in the Treatment of Pediatric Bladder Tumors

2021 ◽  
Vol 21 (2) ◽  
pp. 868-877
Author(s):  
Ling Wang ◽  
Hong Tao ◽  
Zhigang Li ◽  
Yi Lei ◽  
Bing Bai ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Negative Impact ◽  
Particle Diameter ◽  
Photothermal Effect ◽  
Average Particle ◽  
Bladder Cancer Cells

Cypate is an organic material with tumor treatment function, which has photothermal effect. Based on the characteristics of this material, this study adopted the coupling method to obtain FB-Cypate nano-microspheres, BDI-1-FB-Cypate albumin nano-microsphere diad and CPPs-BDI-1-FB-Cypate albumin nano-microsphere triad. Cypate and FB-Cypate materials were characterized by scanning TEM, particle size analyzer, and spectrophotometer. An injection-ureter introduction device was used to perfuse pediatric bladder cancer cells into the bladder cavity of nude mice, and different Cypate-type material solutions were perfused into the bladder cavity at the same time. Then, the anti-bladdertumor performance of different materials on tumor cells was compared. The test proves that the average particle diameter of FB-Cypate material is (102.3 ±8.6) nm, which can be used for near-infrared imaging, and the temperature rise is obvious under light conditions. In the test of inhibiting bladder cancer cells in children, the use of Cypate type materials can significantly inhibit the survival of bladder tumor cells, and it has less negative impact on physiological functions after surgery.

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