scholarly journals On Complex Coacervate Core Micelles: Structure-Function Perspectives

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1953 ◽  
Author(s):  
Jose Rodrigo Magana ◽  
Christian C. M. Sproncken ◽  
Ilja K. Voets
Keyword(s):  
Structure Function ◽  
Nanoparticle Synthesis ◽  
Controlled Delivery ◽  
Research Activity ◽  
Functional Roles ◽  
Charged Species ◽  
Complex Coacervate ◽  
Oppositely Charged ◽  
Widespread Interest ◽  
Complex Coacervate Core Micelles

The co-assembly of ionic-neutral block copolymers with oppositely charged species produces nanometric colloidal complexes, known, among other names, as complex coacervates core micelles (C3Ms). C3Ms are of widespread interest in nanomedicine for controlled delivery and release, whilst research activity into other application areas, such as gelation, catalysis, nanoparticle synthesis, and sensing, is increasing. In this review, we discuss recent studies on the functional roles that C3Ms can fulfil in these and other fields, focusing on emerging structure–function relations and remaining knowledge gaps.

Thermal stability, swelling behavior and CO2 absorption properties of Nanoscale Ionic Materials (NIMs)

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 65195-65204 ◽  
Author(s):  
Kun-Yi Andrew Lin ◽  
Youngjune Park ◽  
Camille Petit ◽  
Ah-Hyung Alissa Park
Keyword(s):  
Thermal Stability ◽  
Swelling Behavior ◽  
Co2 Absorption ◽  
Absorption Properties ◽  
Charged Species ◽  
The Core ◽  
Ionic Materials ◽  
Oppositely Charged

Nanoscale Ionic Materials (NIMs) consist of a nanoscale core, a corona of charged brushes tethered on the surface of the core, and a canopy of the oppositely charged species linked to the corona.

scholarly journals Assembly, Disassembly and Reassembly of Complex Coacervate Core Micelles with Redox‐Responsive Supramolecular Cross‐Linkers

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Camilla Facciotti ◽  
Vittorio Saggiomo ◽  
Anton Bunschoten ◽  
Jan Bart Hove ◽  
Marcus T. M. Rood ◽  
...  
Keyword(s):  
Complex Coacervate ◽  
Redox Responsive ◽  
Complex Coacervate Core Micelles

scholarly journals Secondary Structural Model of Human MALAT1 Reveals Multiple Structure–Function Relationships

2019 ◽  
Vol 20 (22) ◽  
pp. 5610 ◽  
Author(s):  
Phillip J. McCown ◽  
Matthew C. Wang ◽  
Luc Jaeger ◽  
Jessica A. Brown
Keyword(s):  
Structure Function ◽  
Noncoding Rna ◽  
Structural Model ◽  
Dynamic Structure ◽  
Nucleotide Polymorphisms ◽  
Rna Structures ◽  
Rna Modifications ◽  
Functional Roles ◽  
Conserved Core

Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is an abundant nuclear-localized long noncoding RNA (lncRNA) that has significant roles in cancer. While the interacting partners and evolutionary sequence conservation of MALAT1 have been examined, much of the structure of MALAT1 is unknown. Here, we propose a hypothetical secondary structural model for 8425 nucleotides of human MALAT1 using three experimental datasets that probed RNA structures in vitro and in various human cell lines. Our model indicates that approximately half of human MALAT1 is structured, forming 194 helices, 13 pseudoknots, five structured tetraloops, nine structured internal loops, and 13 intramolecular long-range interactions that give rise to several multiway junctions. Evolutionary conservation and covariation analyses support 153 of 194 helices in 51 mammalian MALAT1 homologs and 42 of 194 helices in 53 vertebrate MALAT1 homologs, thereby identifying an evolutionarily conserved core that likely has important functional roles in mammals and vertebrates. Data mining revealed that RNA modifications, somatic cancer-associated mutations, and single-nucleotide polymorphisms may induce structural rearrangements that sequester or expose binding sites for several cancer-associated microRNAs. Our findings reveal new mechanistic leads into the roles of MALAT1 by identifying several intriguing structure–function relationships in which the dynamic structure of MALAT1 underlies its biological functions.

Stability of Complex Coacervate Core Micelles Containing Metal Coordination Polymer

2008 ◽  
Vol 112 (35) ◽  
pp. 10908-10914 ◽  
Author(s):  
Yun Yan ◽  
Arie de Keizer ◽  
Martien A. Cohen Stuart ◽  
Markus Drechsler ◽  
Nicolaas A. M. Besseling
Keyword(s):  
Coordination Polymer ◽  
Metal Coordination ◽  
Complex Coacervate ◽  
Complex Coacervate Core Micelles

Comprehensive structure–function correlation of photoactive ionic π-conjugated supermolecular assemblies: an experimental and computational study

2016 ◽  
Vol 4 (43) ◽  
pp. 10223-10239 ◽  
Author(s):  
Morteza Adinehnia ◽  
Bryan Borders ◽  
Michael Ruf ◽  
Bhaskar Chilukuri ◽  
K. W. Hipps ◽  
...  
Keyword(s):  
Structure Function ◽  
Computational Study ◽  
Function Study ◽  
Computational Structure ◽  
Function Correlation ◽  
Oppositely Charged

Experimental and computational structure–function study of an organic crystalline photoconductor composed of oppositely charged ionic porphyrins.

Tuning interionic interaction for highly selective in vivo analysis

2015 ◽  
Vol 44 (17) ◽  
pp. 5959-5968 ◽  
Author(s):  
Ping Yu ◽  
Xiulan He ◽  
Lanqun Mao
Keyword(s):  
Recent Progress ◽  
Weak Interactions ◽  
Electrostatic Attraction ◽  
Interionic Interaction ◽  
Charged Species ◽  
In Vivo Analysis ◽  
Oppositely Charged

The interionic interaction demonstrated here refers to the interaction between ions and their counterparts, which is not only composed of electrostatic attraction between oppositely charged species but also other kinds of weak interactions. This review focuses on the recent progress in the tuning of interionic interaction to improve the selectivity of biosensors for in vivo analysis.

Complex Coacervate Core Micelles with Spectroscopic Labels for Diffusometric Probing of Biopolymer Networks

Langmuir ◽  
2015 ◽  
Vol 31 (46) ◽  
pp. 12635-12643 ◽  
Author(s):  
Nadia Bourouina ◽  
Daan W. de Kort ◽  
Freek J. M. Hoeben ◽  
Henk M. Janssen ◽  
Henk Van As ◽  
...  
Keyword(s):  
Complex Coacervate ◽  
Complex Coacervate Core Micelles
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