scholarly journals Naringenin Regulates Doxorubicin-Induced Liver Dysfunction: Impact on Oxidative Stress and Inflammation

Plants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 550 ◽  
Author(s):  
Adil Farooq Wali ◽  
Summya Rashid ◽  
Shahzada Mudasir Rashid ◽  
Mushtaq Ahmad Ansari ◽  
Mohammad Rashid Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Liver Damage ◽  
Enzyme System ◽  
Potential Effect ◽  
Antioxidant Enzyme System ◽  
Prophylactic Dose ◽  
Research Findings ◽  
Biochemical Estimation ◽  
Inflammatory Molecules

Doxorubicin (Dox) is an operational and largely used anticancer drug, used to treat an array of malignancies. Nonetheless, its beneficial use is constrained due to its renal and hepatotoxicity dose dependently. Numerous research findings favor the use of antioxidants may impact Dox-induced liver injury/damage. In the current study, Wistar rats were given naringenin (50 and 100 mg/kg b.wt.) orally for 20 days as prophylactic dose, against the hepatotoxicity induced by single intraperitoneal injection of Dox (20 mg/kg b.wt.). Potency of naringenin against the liver damage caused by Dox was assessed by measuring malonyl aldehyde (MDA) as a by-product of lipid peroxidation, biochemical estimation of antioxidant enzyme system, reactive oxygen species (ROS) level, and inflammatory mediators. Naringenin-attenuated ROS production, ROS-induced lipid peroxidation, and replenished reduced antioxidant armory, namely, catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione (GSH). Naringenin similarly diminished expression of Cox-2 and levels of NF-κB and other inflammatory molecules induced by the Dox treatment. Histology added further evidence to the defensive effects of naringenin on Dox-induced liver damage. The outcomes of the current study reveal that oxidative stress and inflammation are meticulously linked with Dox-triggered damage, and naringenin illustrates the potential effect on Dox-induced hepatotoxicity probably through diminishing the oxidative stress and inflammation.

scholarly journals AGE-RELATED CHANGES OF RELIABILITY OF ANTIOXIDANT ENZYME DEFENSE ARE ASSOCIATED WITH ADAPTIVE BEHAVIOR OF PRIMATES

2012 ◽  
Vol 10 (2) ◽  
pp. 20-27
Author(s):  
Nadezda Dmitrievna Goncharova ◽  
Viktor Yuryevich Marenin ◽  
Arsen Arsenovich Vengerin ◽  
Alla Vyacheslavovna Shmaliy
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Enzyme ◽  
Adaptive Behavior ◽  
Rhesus Monkeys ◽  
Enzyme System ◽  
Antioxidant Enzyme System ◽  
Age Related ◽  
Female Rhesus ◽  
Age Related Changes

We have investigated age-related changes in the activity of antioxidant enzyme system and intensity of lipid peroxidation in erythrocytes of young and old female rhesus monkeys with depression-like and standard behavior. Revealed significant disturbances in the activities of GR and GSH-Px in monkeys with depression-like behavior are accompanied more pronounced age-related decrease in reliability of antioxidant enzyme defense and development of oxidative stress.

Effect of diallyldisulphide on an antioxidant enzyme system in Candida species

2010 ◽  
Vol 56 (10) ◽  
pp. 816-821 ◽  
Author(s):  
Snowber Yousuf ◽  
Aijaz Ahmad ◽  
Amber Khan ◽  
Nikhat Manzoor ◽  
Luqman Ahmad Khan
Keyword(s):  
Oxidative Stress ◽  
Candida Species ◽  
Allium Sativum ◽  
Enzyme System ◽  
Antioxidant Systems ◽  
Glutathione S Transferase ◽  
Antioxidant Enzyme System ◽  
Antioxidant Metabolites ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Sublethal Concentrations

This study was carried out to show the effect of diallyldisulphide (DADS), an important organosulphur compound found in garlic ( Allium sativum ), on antioxidant systems in Candida species. Changes in antioxidant metabolites and antioxidant activity in the presence of DADS were found in Candida albicans and Candida tropicalis . Candida cells were treated with sublethal concentrations of DADS. DADS caused a decrease in the activity of all antioxidant enzymes except catalase, resulting in oxidative stress and damaged cells. The amount of oxidative stress generated by DADS was found to be a function of its concentration. A significant decrease in superoxide dismutase, glutathione-S-transferase, and glutathione peroxidase activities but an increase in catalase activity were observed. Increased levels of lipid peroxidation and decreased levels of glutathione were observed in treated cells. Activity of glucose-6-phosphate dehydrogenase decreased significantly following DADS treatment and could be correlated with a decrease in glutathione concentration in both Candida species. These results indicate that diallyl disulphide acts as a pro-oxidant to Candida species and hence may act as a potent antifungal in the management of candidiasis.

scholarly journals Impact of Murraya koenigii (L.) Sprengel (Rutaceae) extracts on lifespan and oxidative stress markers in Drosophila melanogaster Meigen, 1830 (Diptera)

2020 ◽  
Vol 7 (15) ◽  
pp. 59-67
Author(s):  
Dinesh Kumar ◽  
Sunita Sunita ◽  
Veer Bhan
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Free Radicals ◽  
Antioxidant Enzyme ◽  
Enzyme System ◽  
Antioxidant Properties ◽  
Fruit Fly ◽  
Standard Diet ◽  
Murraya Koenigii ◽  
Antioxidant Enzyme System

The free radicals (ROS and RNS) damage to proteins, DNA, lipids of the cell. These free radicals creates the imbalance in physiological functions and acts as a prevalent cause of various diseases such as cancer, diabetes, cardiovascular diseases, aging, oxidative stress and metabolic syndrome by dysfunction of antioxidant enzyme system of cell. Using the fruit fly Drosophila melanogaster Meigen, 1830 (Diptera) as a model we examined the antioxidant properties of Murraya koenigii (L.) Sprengel (Rutaceae) on the life history parameters. We demonstrate a novel physiological interaction between free radicals, oxidative stress and antioxidant enzyme system by using extracts of M. koenigii in standard diet of the fly. This study describes how this interaction impacts a very early cellular defect associated with ageing and ageing associate diseases. We also describe progressive deficits in flies expressing the superoxide dismutase gene, catalase and lipid peroxidation. Collectively, our work demonstrates that Drosophila can be used to study the cellular, physiological and behavioral basis of human ageing related diseases.

Toxicity of glyoxals – role of oxidative stress, metabolic detoxification and thiamine deficiency

2003 ◽  
Vol 31 (6) ◽  
pp. 1390-1393 ◽  
Author(s):  
N. Shangari ◽  
W.R. Bruce ◽  
R. Poon ◽  
P.J. O'Brien
Keyword(s):  
Oxidative Stress ◽  
Thiamine Deficiency ◽  
Clinical Evidence ◽  
Enzyme System ◽  
Aberrant Crypt Foci ◽  
Antioxidant Enzyme System ◽  
Pathological Conditions ◽  
Metabolic Detoxification ◽  
Oxidation By Hydrogen Peroxide

Glyoxals are reactive α-oxoaldehydes that are formed endogenously from sugars, the levels of which are increased in various pathological conditions associated with hyperglycaemia and thiamine deficiency. However, the molecular cytotoxic mechanisms of glyoxal are not known. Results presented here and in the other studies cited provide a glimpse into the cytotoxicity mechanisms involved and their pathological implications. We found that glyoxal (10 μM) markedly increased the susceptibility of hepatocyte glutathione (GSH) to oxidation by hydrogen peroxide (H2O2) and markedly increased cytotoxicity by compromising the cellular antioxidant enzyme system. At higher concentrations, glyoxal was cytotoxic towards hepatocytes, which can be attributed to GSH depletion, oxidative stress and mitochondrial toxicity. Aminoguanidine or penicillamine protected the hepatocytes. Glyoxal cytotoxicity was prevented by increasing glyoxal metabolism with thiamine or NAD(P)H generators, and was increased in GSH- or thiamine-deficient hepatocytes. It was also found that feeding rats reduced thiamine levels in a diet high in simple sugars increased the number of aberrant crypt foci/colon in the absence of clinical evidence of beriberi. This was associated with decreased plasma thiamine and low erythrocyte transketolase activity. Western diets, which are frequently poor in thiamine and high in sugars, could result in increased levels of endogenous glyoxals, which in turn may lead to a predisposition to AGE (advanced glycation end-product)-related pathologies and neoplastic conditions.

scholarly journals Effects ofBauhinia forficataTea on Oxidative Stress and Liver Damage in Diabetic Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Andréia Caroline Fernandes Salgueiro ◽  
Vanderlei Folmer ◽  
Marianne Pires da Silva ◽  
Andreas Sebastian Loureiro Mendez ◽  
Ana Paula Pegoraro Zemolin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Body Weight ◽  
Liver Damage ◽  
Weight Ratio ◽  
Protein Carbonyl ◽  
Diabetic Mice ◽  
Body Weight Ratio ◽  
Glucose Levels ◽  
Nonprotein Thiols

This study was designed to evaluate the effects ofBauhinia forficataLink subsp.pruinosa(BF) tea on oxidative stress and liver damage in streptozotocin (STZ)-induced diabetic mice. Diabetic male mice have remained 30 days without any treatment. BF treatment started on day 31 and continued for 21 days as a drinking-water substitute. We evaluated (1) BF chemical composition; (2) glucose levels; (3) liver/body weight ratio and liver transaminases; (4) reactive oxygen species (ROS), lipid peroxidation, and protein carbonylation in liver; (5) superoxide dismutase (SOD) and catalase (CAT) activities in liver; (6)δ-aminolevulinate dehydratase (δ-ALA-D) and nonprotein thiols (NPSH) in liver; (7) Nrf2, NQO-1, and HSP70 levels in liver and pancreas. Phytochemical analyses identified four phenols compounds. Diabetic mice present high levels of NQO-1 in pancreas, increased levels of ROS and lipid peroxidation in liver, and decrease in CAT activity. BF treatment normalized all these parameters. BF did not normalize hyperglycemia, liver/body weight ratio, aspartate aminotransferase, protein carbonyl, NPSH levels, andδ-ALA-D activity. The raised oxidative stress seems to be a potential mechanism involved in liver damage in hyperglycemic conditions. Our results indicated that BF protective effect could be attributed to its antioxidant capacity, more than a hypoglycemic potential.

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