scholarly journals AGE-RELATED CHANGES OF RELIABILITY OF ANTIOXIDANT ENZYME DEFENSE ARE ASSOCIATED WITH ADAPTIVE BEHAVIOR OF PRIMATES

2012 ◽  
Vol 10 (2) ◽  
pp. 20-27
Author(s):  
Nadezda Dmitrievna Goncharova ◽  
Viktor Yuryevich Marenin ◽  
Arsen Arsenovich Vengerin ◽  
Alla Vyacheslavovna Shmaliy
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Enzyme ◽  
Adaptive Behavior ◽  
Rhesus Monkeys ◽  
Enzyme System ◽  
Antioxidant Enzyme System ◽  
Age Related ◽  
Female Rhesus ◽  
Age Related Changes

We have investigated age-related changes in the activity of antioxidant enzyme system and intensity of lipid peroxidation in erythrocytes of young and old female rhesus monkeys with depression-like and standard behavior. Revealed significant disturbances in the activities of GR and GSH-Px in monkeys with depression-like behavior are accompanied more pronounced age-related decrease in reliability of antioxidant enzyme defense and development of oxidative stress.

scholarly journals Naringenin Regulates Doxorubicin-Induced Liver Dysfunction: Impact on Oxidative Stress and Inflammation

Plants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 550 ◽  
Author(s):  
Adil Farooq Wali ◽  
Summya Rashid ◽  
Shahzada Mudasir Rashid ◽  
Mushtaq Ahmad Ansari ◽  
Mohammad Rashid Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Liver Damage ◽  
Enzyme System ◽  
Potential Effect ◽  
Antioxidant Enzyme System ◽  
Prophylactic Dose ◽  
Research Findings ◽  
Biochemical Estimation ◽  
Inflammatory Molecules

Doxorubicin (Dox) is an operational and largely used anticancer drug, used to treat an array of malignancies. Nonetheless, its beneficial use is constrained due to its renal and hepatotoxicity dose dependently. Numerous research findings favor the use of antioxidants may impact Dox-induced liver injury/damage. In the current study, Wistar rats were given naringenin (50 and 100 mg/kg b.wt.) orally for 20 days as prophylactic dose, against the hepatotoxicity induced by single intraperitoneal injection of Dox (20 mg/kg b.wt.). Potency of naringenin against the liver damage caused by Dox was assessed by measuring malonyl aldehyde (MDA) as a by-product of lipid peroxidation, biochemical estimation of antioxidant enzyme system, reactive oxygen species (ROS) level, and inflammatory mediators. Naringenin-attenuated ROS production, ROS-induced lipid peroxidation, and replenished reduced antioxidant armory, namely, catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione (GSH). Naringenin similarly diminished expression of Cox-2 and levels of NF-κB and other inflammatory molecules induced by the Dox treatment. Histology added further evidence to the defensive effects of naringenin on Dox-induced liver damage. The outcomes of the current study reveal that oxidative stress and inflammation are meticulously linked with Dox-triggered damage, and naringenin illustrates the potential effect on Dox-induced hepatotoxicity probably through diminishing the oxidative stress and inflammation.

scholarly journals Impact of Murraya koenigii (L.) Sprengel (Rutaceae) extracts on lifespan and oxidative stress markers in Drosophila melanogaster Meigen, 1830 (Diptera)

2020 ◽  
Vol 7 (15) ◽  
pp. 59-67
Author(s):  
Dinesh Kumar ◽  
Sunita Sunita ◽  
Veer Bhan
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Free Radicals ◽  
Antioxidant Enzyme ◽  
Enzyme System ◽  
Antioxidant Properties ◽  
Fruit Fly ◽  
Standard Diet ◽  
Murraya Koenigii ◽  
Antioxidant Enzyme System

The free radicals (ROS and RNS) damage to proteins, DNA, lipids of the cell. These free radicals creates the imbalance in physiological functions and acts as a prevalent cause of various diseases such as cancer, diabetes, cardiovascular diseases, aging, oxidative stress and metabolic syndrome by dysfunction of antioxidant enzyme system of cell. Using the fruit fly Drosophila melanogaster Meigen, 1830 (Diptera) as a model we examined the antioxidant properties of Murraya koenigii (L.) Sprengel (Rutaceae) on the life history parameters. We demonstrate a novel physiological interaction between free radicals, oxidative stress and antioxidant enzyme system by using extracts of M. koenigii in standard diet of the fly. This study describes how this interaction impacts a very early cellular defect associated with ageing and ageing associate diseases. We also describe progressive deficits in flies expressing the superoxide dismutase gene, catalase and lipid peroxidation. Collectively, our work demonstrates that Drosophila can be used to study the cellular, physiological and behavioral basis of human ageing related diseases.

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