A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations

2019 ◽  
Vol 10 (22) ◽  
pp. 2840-2853 ◽  
Author(s):  
Arman Moini Jazani ◽  
Newsha Arezi ◽  
Chaitra Shetty ◽  
Sung Hwa Hong ◽  
Haowen Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Acid Reduction

Dual acid/reduction-degradable block copolymer nanoassemblies both at core/corona interfaces and in micellar cores leading to synergistic and accelerated drug release for robust tumor-targeting intracellular drug delivery.

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

2015 ◽  
Vol 51 (4) ◽  
pp. 776-779 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
Xiaoxiao Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Manganese Oxide ◽  
Drug Carriers ◽  
New Class ◽  
Oxide Nanostructures ◽  
Redox Responsive ◽  
Intracellular Glutathione ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for efficient intracellular GSH-triggered drug release.

scholarly journals pH-triggered drug release from biodegradable microwells for oral drug delivery

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
Line Hagner Nielsen ◽  
Johan Nagstrup ◽  
Sarah Gordon ◽  
Stephan Sylvest Keller ◽  
Jesper Østergaard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Triggered Drug Release

An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment

2020 ◽  
Vol 8 (8) ◽  
pp. 2202-2211 ◽  
Author(s):  
Li Zhang ◽  
Shiyu Zhang ◽  
Huajian Chen ◽  
Yu Liang ◽  
Bingxia Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hybrid System ◽  
Tumor Treatment ◽  
Triggered Drug Release ◽  
Ultrasound Assisted ◽  
Doxorubicin Delivery

Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.

scholarly journals Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1007
Author(s):  
Mohamadreza Amin ◽  
Wenqiu Huang ◽  
Ann L. B. Seynhaeve ◽  
Timo L. M. ten Hagen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Level ◽  
Advanced Technology ◽  
Temperature Sensitive ◽  
Triggered Release ◽  
Adjuvant Effect ◽  
Triggered Drug Release ◽  
High Level ◽  
External Stimuli

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.

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