scholarly journals Iron Absorption in Iron-Deficient Women, Who Received 65 mg Fe with an Indonesian Breakfast, Is Much Better from NaFe(III)EDTA than from Fe(II)SO4, with an Acceptable Increase of Plasma NTBI. A Randomized Clinical Trial

2018 ◽  
Vol 11 (3) ◽  
pp. 85 ◽  
Author(s):  
Eka Ginanjar ◽  
Lilik Indrawati ◽  
Iswari Setianingsih ◽  
Djumhana Atmakusumah ◽  
Alida Harahap ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Absorption ◽  
Normal Values ◽  
Test Dose ◽  
Food Fortification ◽  
Double Blind ◽  
Blood Tests ◽  
Oral Test ◽  
Iron Deficient ◽  
Fe Complexes

Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases. Studies in iron-replete and iron-deficient subjects, receiving a single oral test dose of Fe(II)SO4 or NaFe(III)EDTA with water, revealed that FeSO4 was well absorbed when compared with NaFeEDTA, while only the Fe(II) compound showed a remarkable increase of NTBI. As NaFeEDTA is successfully used for food fortification, a double-blind randomized cross-over trial was conducted in 11 healthy women with uncomplicated iron deficiency. All subjects received a placebo, 6.5 mg FeSO4, 65 mg FeSO4, 6.5 mg NaFeEDTA, and 65 mg NaFeEDTA with a traditional Indonesian breakfast in one-week intervals. Blood tests were carried out every 60 min for five hours. NTBI detection was performed using the fluorescein-labeled apotransferrin method. Plasma iron values were highly increased after 65 mg NaFeEDTA, twice as high as after FeSO4. A similar pattern was seen for NTBI. After 6.5 mg of NaFeEDTA and FeSO4, NTBI was hardly detectable. NaFeEDTA was highly effective for the treatment of iron deficiency if given with a meal, inhibiting the formation of nonabsorbable Fe-complexes, while NTBI did not exceed the range of normal values for iron-replete subjects.

scholarly journals Consumption of a Double-Fortified Salt Affects Perceptual, Attentional, and Mnemonic Functioning in Women in a Randomized Controlled Trial in India

2017 ◽  
Vol 147 (12) ◽  
pp. 2297-2308 ◽  
Author(s):  
Michael J Wenger ◽  
Laura E Murray-Kolb ◽  
Julie EH Nevins ◽  
Sudha Venkatramanan ◽  
Gregory A Reinhart ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Status ◽  
Controlled Trial ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Control Group ◽  
Attention And Memory ◽  
Double Blind ◽  
Iron Deficient ◽  
Mnemonic Function

Abstract Background: Iron deficiency and iron deficiency anemia have been shown to have negative effects on aspects of perception, attention, and memory. Objective: The purpose of this investigation was to assess the extent to which increases in dietary iron consumption are related to improvements in behavioral measures of perceptual, attentional, and mnemonic function. Methods: Women were selected from a randomized, double-blind, controlled food-fortification trial involving ad libitum consumption of either a double-fortified salt (DFS) containing 47 mg potassium iodate/kg and 3.3 mg microencapsulated ferrous fumarate/g (1.1 mg elemental Fe/g) or a control iodized salt. Participants' blood iron status (primary outcomes) and cognitive functioning (secondary outcomes) were assessed at baseline and after 10 mo at endline. The study was performed on a tea plantation in the Darjeeling district of India. Participants (n = 126; 66% iron deficient and 49% anemic at baseline) were otherwise healthy women of reproductive age, 18–55 y. Results: Significant improvements were documented for iron status and for perceptual, attentional, and mnemonic function in the DFS group (percentage of variance accounted for: 16.5%) compared with the control group. In addition, the amount of change in perceptual and cognitive performance was significantly (P < 0.05) related to the amount of change in blood iron markers (mean percentage of variance accounted for: 16.0%) and baseline concentrations of blood iron markers (mean percentage of variance accounted for: 25.0%). Overall, there was evidence that the strongest effects of change in iron status were obtained for perceptual and low-level attentional function. Conclusion: DFS produced measurable and significant improvements in the perceptual, attentional, and mnemonic performance of Indian female tea pickers of reproductive age. This trial was registered at clinicaltrials.gov as NCT01032005.

Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches

2020 ◽  
Vol 99 ◽  
pp. 58-75 ◽  
Author(s):  
Kumar Shubham ◽  
T. Anukiruthika ◽  
Sayantani Dutta ◽  
A.V. Kashyap ◽  
Jeyan A. Moses ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Absorption ◽  
Deficiency Anemia ◽  
Food Fortification ◽  
Comprehensive Review

Zinc, cadmium, and iron interactions during intestinal absorption in iron-deficient mice

1978 ◽  
Vol 56 (3) ◽  
pp. 384-389 ◽  
Author(s):  
D. L. Hamilton ◽  
J. E. C. Bellamy ◽  
J. D. Valberg ◽  
L. S. Valberg
Keyword(s):  
Zinc Chloride ◽  
Binding Sites ◽  
Iron Absorption ◽  
High Capacity ◽  
Test Dose ◽  
The Body ◽  
Zinc Uptake ◽  
Iron Deficient ◽  
Zinc Cadmium ◽  
Iron And Zinc

Zinc absorption from a test dose of (65Zn) zinc chloride was increased in mice with a high capacity to absorb iron induced by a low-iron diet. When radiolabelled zinc chloride in concentrations varying from 0.025 to 0.30 mM was perfused through open-ended duodenal loops of mice fed this diet, the proportion of zinc taken up from the lumen and transferred to the body was greater from lower than from higher doses. The addition of iron to the perfusate inhibited zinc uptake and transfer, and zinc had a similar effect on iron absorption. Cadmium, a potent inhibitor of iron uptake in mice fed a low-iron diet, impaired zinc uptake under these dietary conditions. These results suggest that in dietary-induced iron deficiency there are analogous mucosal binding sites for the uptake of iron and zinc. There also appear to be mutually exclusive binding sites for the absorption of these metals: radiolabeled iron absorption from an intragastric test dose was enhanced in mice with a high capacity to absorb iron produced by bleeding, whereas the absorption of zinc was not increased.

A Preliminary Study of Iron Absorption by Whole Body Counting and Correlation with DFO Excretion

1975 ◽  
Vol 14 (01) ◽  
pp. 74-80
Author(s):  
M. M. Gupta ◽  
R. Manchanda ◽  
L. Bhattacharyya ◽  
M. Bhargva ◽  
S. Kumar ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Iron Absorption ◽  
Whole Body ◽  
Healthy Controls ◽  
Deficiency Anaemia ◽  
Iron Deficient ◽  
Body Counting ◽  
Preliminary Study ◽  
Whole Body Counting

SummaryA preliminary study of iron absorption by whole body counting was carried on a group of 16 women. The cases included 8 patients suffering from iron deficiency anaemia and various infections as well as 8 healthy controls. High iron absorption is associated with iron dificiency, these changes being more marked in iron deficient controls than in those with infection or malignancy. In iron deficient controls results of whole body counting correlate very well with other haematological investigations.

Effects of hypoxia on iron absorption and mobilization in the rat

1964 ◽  
Vol 207 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Georg W. Strohmeyer ◽  
Stephen A. Miller ◽  
Robert W. Scarlata ◽  
Edward W. Moore ◽  
Mortimer S. Greenberg ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Iron Absorption ◽  
Test Dose ◽  
Oral Iron ◽  
Base Line ◽  
Tissue Storage ◽  
Iron Load ◽  
Tissue Iron ◽  
Iron Deficient

Rats exposed to an atmosphere of 10% oxygen increase their absorption of a test dose of iron after 6 8 hr. Release of tissue storage iron begins within 2 hr of the start of hypoxia and continues for at least 8 hr. An oral iron load does not prevent the release of tissue iron in response to hypoxia. Iron-loaded rats also release iron from storage depots and increase their minimal absorption in response to hypoxia. Iron-deficient rats apparently have a diminished tissue release and also increase absorption above their elevated base-line levels. Xanthine loading had no effect on the release of tissue iron or changes in absorption with hypoxia, and there was no evidence that changes in xanthine oxidase activity in the liver or bowel were directly associated with tissue release or absorption of iron.

scholarly journals Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1087
Author(s):  
Aida Zečkanović ◽  
Marko Kavčič ◽  
Tomaž Prelog ◽  
Alenka Šmid ◽  
Janez Jazbec
Keyword(s):  
Iron Deficiency ◽  
Iron Supplementation ◽  
Ferric Iron ◽  
Hematological Parameters ◽  
Food Supplement ◽  
Healthy Children ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Randomized Clinical Study ◽  
Iron Deficient

A major problem of oral iron supplementation efficacy in children is its tolerability and compliance. We aimed to determine the safety and efficacy of a novel food supplement >Your< Iron Syrup in the replenishment of iron stores and improvement of hematological parameters in iron-deficient children aged nine months to six years. We randomized 94 healthy children with iron deficiency in a ratio of 3:1 to either receive >Your< Iron Syrup or placebo. A 12-week supplementation with >Your< Iron Syrup resulted in a significant increase in ferritin and hemoglobin levels as compared to placebo (p = 0.04 and p = 0.02). Adverse events were reported with similar frequencies across both study arms. >Your< Iron Syrup represents an effective, well-tolerated, and safe option for the management of nutritional iron deficiency in children.

Iron Deficiency Anemia: Adverse Effects on Infant Psychomotor Development

PEDIATRICS ◽  
1989 ◽  
Vol 84 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Tomas Walter ◽  
Isidora De Andraca ◽  
Patricia Chadud ◽  
Carmen G. Perales
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Oral Iron ◽  
Iron Therapy ◽  
Psychomotor Development ◽  
Deficiency Anemia ◽  
Placebo Control ◽  
Double Blind ◽  
Iron Deficient

In a double-blind, placebo-control prospective cohort study of 196 infants from birth to 15 months of age, assessment was made at 12 months of age of the relationship between iron status and psychomotor development, the effect of a short-term (10-day) trial of oral iron vs placebo, and the effect of long-term (3 months) oral iron therapy. Development was assessed with the mental and psychomotor indices and the infant behavior record of the Bayley Scales of Infant Development in 39 anemic, 30 control, and 127 nonanemic iron-deficient children. Anemic infants had significantly lower Mental and Psychomotor Developmental Index scores than control infants or nonanemic iron-deficient infants (one-way analysis of variance, P &lt; .0001). Control infants and nonanemic iron-deficient infants performed comparably. No difference was noted between the effect of oral administration of iron or placebo after 10 days or after 3 months of iron therapy. Among anemic infants a hemoglobin concentration &lt; 10.5 g/dL and duration of anemia of &gt; 3 months were correlated with significantly lower motor and mental scores (P &lt; .05). Anemic infants failed specifically in language capabilities and body balance-coordination skills when compared with controls. These results, in a design in which intervening variables were closely controlled, suggest that when iron deficiency progrsses to anemia, but not before, adverse influences in the performance of developmental tests appear and persist for at least 3 months despite correction of anemia with iron therapy. If these impairments prove to be long standing, prevention of iron deficiency anemia in early infancy becomes the only way to avoid them.

Pharmacokinetics of pulmonary manganese absorption: evidence for increased susceptibility to manganese loading in iron-deficient rats

2005 ◽  
Vol 288 (5) ◽  
pp. L887-L893 ◽  
Author(s):  
Elizabeth Heilig ◽  
Ramon Molina ◽  
Thomas Donaghey ◽  
Joseph D. Brain ◽  
Marianne Wessling-Resnick
Keyword(s):  
Iron Deficiency ◽  
Iron Absorption ◽  
Iron Status ◽  
Mrna Levels ◽  
Blood Clearance ◽  
Divalent Metal Transporter 1 ◽  
Divalent Metal Transporter ◽  
Pulmonary Uptake ◽  
Iron Deficient ◽  
Metal Absorption

High levels of airborne manganese can be neurotoxic, yet little is known about absorption of this metal via the lungs. Intestinal manganese uptake is upregulated by iron deficiency and is thought to be mediated by divalent metal transporter 1 (DMT1), an iron-regulated factor known to play a role in dietary iron absorption. To better characterize metal absorption from the lungs to the blood and test whether iron deficiency may modify this process, the pharmacokinetics of pulmonary manganese and iron absorption by control and iron-deficient rats were compared. Levels of DMT1 expression in the lungs were determined to explore potential changes induced by iron deficiency that might alter metal absorption. The pharmacokinetic curves for intratracheally instilled54Mn and59Fe were significantly different, suggesting that pulmonary uptake of the two metals involves different mechanisms. Intratracheally instilled iron-deficient rats had significantly higher blood54Mn levels, whereas blood59Fe levels were significantly reduced compared with controls. The same trend was observed when radioisotopes were delivered by intravenous injection, indicating that iron-deficient rats have altered blood clearance of manganese. In situ analysis revealed the presence of DMT1 transcripts in airway epithelium; however, mRNA levels did not change in iron deficiency. Although lung DMT1 levels and metal absorption did not appear to be influenced by iron deficiency, the differences in blood clearance of instilled manganese identified by this study support the idea that iron status can influence the potential toxicity of this metal.

scholarly journals Studies in Iron Metabolism. IV. Iron Absorption in Experimental Iron Deficiency

Blood ◽  
1962 ◽  
Vol 20 (5) ◽  
pp. 532-546 ◽  
Author(s):  
R. M. BANNERMAN ◽  
J. R. P. O’BRIEN ◽  
L. J. WITTS
Keyword(s):  
Iron Deficiency ◽  
Iron Absorption ◽  
Scintillation Counter ◽  
Sudden Change ◽  
Progressive Increase ◽  
Whole Body ◽  
Deficient Diet ◽  
Simple Diffusion ◽  
Iron Deficient ◽  
Body Counting

Abstract 1) Whole body counting by means of a large phosphor well scintillation counter has been used to measure the absorption of Fe59-tagged inorganic iron, and shown to compare favourably with other methods. 2) There is a delay in the fecal elimination of the unabsorbed portion of the dose of Fe59 by iron-deficient rats on iron-deficient diet. The cause of this delay is unknown but it may be associated with the marked cecal enlargement which exists in these animals. 3) It is confirmed that iron deficiency is associated with striking enhancement of absorption of ferrous and ferric inorganic iron. 4) When a series of doses of ferrous iron of increasing size from 5 to 1,000 µg. was given, there was a progressive increase in absorption for each increase in dose in both iron-supplemented and iron-deficient rats. The relationship between amount of iron given and amount absorbed suggests that two processes may be involved: 1) simple diffusion, and 2) a carrier mechanism. 5) The effect on iron absorption of a sudden change in iron intake has been investigated. Switch from a low to high iron diet reduces absorption, and from a high to a low iron diet increases absorption, too rapidily for hemoglobin level or body iron stores alone to be the most important governing factors and this finding emphasizes the importance of local changes in the intestine.

scholarly journals Ferritin iron absorption in man

Blood ◽  
1975 ◽  
Vol 45 (5) ◽  
pp. 689-698 ◽  
Author(s):  
M Layrisse ◽  
C Martinez-Torres ◽  
M Renzy ◽  
I Leets
Keyword(s):  
Iron Deficiency ◽  
Iron Absorption ◽  
Geometric Mean ◽  
Normal Subjects ◽  
Iron Deficient ◽  
Ferritin Iron ◽  
The Difference ◽  
Vegetable Foods ◽  
Iron Pool ◽  
Absorption Level

The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects with moderate iron deficiency and 5.7 percent in subjects with marked iron deficiency. The administration of this iron compound with vegetals in a meal showed distinctly lower absorption values than the absorption from either maize, wheat, or soybean. Ferritin iron absorption was also different from that of ferric chloride when they were administered together as a drink or mixed with maize or liver. The iron absorption from ferritin was markedly increased when it was administered with either meat or liver, but it did not reach the absorption level of these foods. It is still to be elucidated whether the difference in iron absorption between ferritin and vegetable foods administered together reflect that this iron is incompletely miscible with a nonheme iron pool or that it really forms a third iron pool.

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