scholarly journals Development of Visceral and Subcutaneous-Abdominal Adipose Tissue in Breastfed Infants during First Year of Lactation

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3294
Author(s):  
Zoya Gridneva ◽  
Alethea Rea ◽  
Ching Tat Lai ◽  
Wan Jun Tie ◽  
Sambavi Kugananthan ◽  
...  
Keyword(s):  
Milk Intake ◽  
First Year ◽  
Abdominal Adiposity ◽  
Bioactive Components ◽  
Breastfed Infants ◽  
Total Carbohydrates ◽  
Subcutaneous Abdominal Adipose Tissue ◽  
Daily Intakes ◽  
Subcutaneous Adiposity ◽  
Maternal Adiposity

This study aimed to investigate relationships between infant abdominal visceral and subcutaneous adiposity and human milk (HM) components and maternal body composition (BC) during first year of lactation. Subcutaneous-abdominal depth (SAD), subcutaneous-abdominal fat area (SFA), visceral depth (VD) and preperitoneal fat area of 20 breastfed infants were assessed at 2, 5, 9 and 12 months using ultrasound. Maternal BC was determined with bioimpedance spectroscopy. HM macronutrients and bioactive components concentrations and infant 24-h milk intake were measured and calculated daily intakes (CDI) determined. Maternal adiposity associated with infant SFA (negatively at 2, 5, 12, positively at 9 months, all overall p < 0.05). 24-h milk intake positively associated with infant SAD (p = 0.007) and VD (p = 0.013). CDI of total protein (p = 0.013), total carbohydrates (p = 0.004) and lactose (p = 0.013) positively associated with SFA. Lactoferrin concentration associated with infant VD (negatively at 2, 12, positively at 5, 9 months, overall p = 0.003). CDI of HM components and maternal adiposity have differential effects on development of infant visceral and subcutaneous abdominal adiposity. Maintaining healthy maternal BC and continuing breastfeeding to 12 months and beyond may facilitate favourable BC development reducing risk of obesity.

scholarly journals Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1472 ◽  
Author(s):  
Zoya Gridneva ◽  
Alethea Rea ◽  
Wan Jun Tie ◽  
Ching Tat Lai ◽  
Sambavi Kugananthan ◽  
...  
Keyword(s):  
Body Composition ◽  
Human Milk ◽  
Bioelectrical Impedance ◽  
Term Infant ◽  
Fat Free Mass ◽  
Mixed Effects Models ◽  
First Year ◽  
Term Infants ◽  
Total Carbohydrates ◽  
Daily Intakes

Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads (n = 20) was determined at 2, 5, 9, and/or 12 months postpartum using ultrasound skinfolds (infants) and bioelectrical impedance spectroscopy (infants/mothers). Breastfeeding frequency, 24-h milk intake and total carbohydrates (TCH) and lactose were measured to calculate HM oligosaccharides (HMO) concentration and CDI of carbohydrates. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Higher TCH concentrations were associated with greater infant length, weight, fat-free mass (FFM), and FFM index (FFMI), and decreased fat mass (FM), FM index (FMI), %FM and FM/FFM ratio. Higher HMO concentrations were associated with greater infant FFM and FFMI, and decreased FMI, %FM, and FM/FFM ratio. Higher TCH CDI were associated with greater FM, FMI, %FM, and FM/FFM ratio, and decreased infant FFMI. Higher lactose CDI were associated with greater FM, FMI, %FM, and FM/FFM, ratio and decreased FFMI. Concentrations and intakes of HM carbohydrates differentially influence development of infant BC in the first 12 months postpartum, and may potentially influence risk of later obesity via modulation of BC.

scholarly journals Human Milk Lactose, Insulin, and Glucose Relative to Infant Body Composition during Exclusive Breastfeeding

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3724
Author(s):  
Ali S. Cheema ◽  
Lisa F. Stinson ◽  
Alethea Rea ◽  
Ching Tat Lai ◽  
Matthew S. Payne ◽  
...  
Keyword(s):  
Body Composition ◽  
Human Milk ◽  
Lean Body Mass ◽  
Body Mass ◽  
Milk Intake ◽  
Maternal Characteristics ◽  
Z Scores ◽  
Daily Intakes ◽  
Infant Birth ◽  
Maternal Adiposity

Human milk (HM) components may influence infant growth and development. This study aimed to investigate relationships between infant body composition (BC) and HM lactose, insulin, and glucose (concentrations and calculated daily intakes (CDI)) as well as 24-h milk intake and maternal BC at 3 months postpartum. HM samples were collected at 2 months postpartum. Infant and maternal BC was assessed with bioimpedance spectroscopy. Statistical analysis used linear regression accounting for infant birth weight. 24-h milk intake and CDI of lactose were positively associated with infant anthropometry, lean body mass and adiposity. Higher maternal BC measures were associated with lower infant anthropometry, z-scores, lean body mass, and adiposity. Maternal characteristics including BC and age were associated with concentrations and CDI of HM components, and 24-h milk intake. In conclusion, 24-h intake of HM and lactose as well as maternal adiposity are related to development of infant BC.

scholarly journals Dynamic Associations of Milk Components With the Infant Gut Microbiome and Fecal Metabolites in a Mother–Infant Model by Microbiome, NMR Metabolomic, and Time-Series Clustering Analyses

2022 ◽  
Vol 8 ◽  
Author(s):  
Yosuke Komatsu ◽  
Daiki Kumakura ◽  
Namiko Seto ◽  
Hirohisa Izumi ◽  
Yasuhiro Takeda ◽  
...  
Keyword(s):  
Breast Milk ◽  
Gut Microbiome ◽  
Lactation Period ◽  
Bioactive Components ◽  
Fecal Microbiome ◽  
Breastfed Infants ◽  
H Nmr ◽  
Milk Components ◽  
Infant Gut Microbiome ◽  
Infant Feces

Background: The gut microbiome and fecal metabolites of breastfed infants changes during lactation, and are influenced by breast milk components. This study aimed to investigate dynamic associations of milk components with the infant gut microbiome and fecal metabolites throughout the lactation period in a mother–infant model.Methods: One month after delivery, breast milk and subsequent infant feces were collected in a pair for 5 months from a mother and an exclusively breastfed infant. Composition of the fecal microbiome was determined with 16S rRNA sequencing. Low-molecular-weight metabolites, including human milk oligosaccharides (HMOs), and antibacterial proteins were measured in feces and milk using 1H NMR metabolomics and enzyme-linked immunosorbent assays. The association of milk bioactive components with the infant gut microbiome and fecal metabolites was determined with Python clustering and correlation analyses.Results: The HMOs in milk did not fluctuate throughout the lactation period. However, they began to disappear in infant feces at the beginning of month 4. Notably, at this time-point, a bifidobacterium species switching (from B. breve to B. longum subsp. infantis) occurred, accompanied by fluctuations in several metabolites including acetate and butyrate in infant feces.Conclusions: Milk bioactive components, such as HMOs, might play different roles in the exclusively breastfed infants depending on the lactation period.

scholarly journals Excessive Weight Gain Followed by Catch-Down in Exclusively Breastfed Infants: An Exploratory Study

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1290 ◽  
Author(s):  
Melanie Larsson ◽  
Mads Lind ◽  
Anni Larnkjær ◽  
Anette Due ◽  
Irina Blom ◽  
...  
Keyword(s):  
Weight Gain ◽  
Fat Mass ◽  
High Serum ◽  
Normal Weight ◽  
Milk Intake ◽  
Leptin Resistance ◽  
Serum Leptin ◽  
Excessive Weight Gain ◽  
Breastfed Infants ◽  
Excessive Weight

Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group). Anthropometry, body composition, milk and blood samples, and milk intake were measured. Mean body-mass-index-for-age z-scores (BAZ) increased 1.93 from birth to 5 mo in the HW-group (n = 13) while the NW-group (n = 17) was unchanged (−0.01). The HW-group had 70% more fat mass at 5 mo, and then showed marked catch-down in BAZ from 5 to 18 mo (−0.84). Milk intake at 5–6 mo did not differ between the groups. In the HW-group milk-leptin was lower at 5 mo and serum-leptin was considerably higher at 5 and 9 mo compared to the NW-group. Serum-leptin at 5 mo was positively associated with weight-for-age z-score (WAZ) and fat mass and negatively with WAZ change from 5 to 9 mo. In conclusion, breastfed infants with EWG had catch-down growth when other foods were introduced. Low milk-leptin in the HW-group may have stimulated appetite and milk intake when weight gain was high. High serum-leptin in the HW-group suggests early leptin resistance, which could impact cerebral regulation of energy intake. Larger studies are needed to confirm these results.

scholarly journals Iron Stores of Breastfed Infants during the First Year of Life

Nutrients ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2023-2034 ◽  
Author(s):  
Ekhard Ziegler ◽  
Steven Nelson ◽  
Janice Jeter
Keyword(s):  
First Year ◽  
Iron Stores ◽  
Breastfed Infants ◽  
First Year Of Life

Iron intake and iron status in breastfed infants during the first year of life

2010 ◽  
Vol 29 (6) ◽  
pp. 773-778 ◽  
Author(s):  
Katharina Dube ◽  
Jana Schwartz ◽  
Manfred J. Mueller ◽  
Hermann Kalhoff ◽  
Mathilde Kersting
Keyword(s):  
Iron Status ◽  
First Year ◽  
Iron Intake ◽  
Breastfed Infants ◽  
First Year Of Life

scholarly journals Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1125 ◽  
Author(s):  
Zoya Gridneva ◽  
Sambavi Kugananthan ◽  
Alethea Rea ◽  
Ching Lai ◽  
Leigh Ward ◽  
...  
Keyword(s):  
Body Composition ◽  
Human Milk ◽  
Term Infant ◽  
Fat Free Mass ◽  
First Year ◽  
Feeding Frequency ◽  
Critical Window ◽  
Whole Milk ◽  
Daily Intakes ◽  
First Year Of Life

Human milk (HM) adipokines may influence infant feeding patterns, appetite regulation, and body composition (BC). The associations between concentrations/calculated daily intakes (CDI) of HM adipokines in the first 12 months postpartum and maternal/term infant BC, and infant breastfeeding parameters were investigated. BC of breastfeeding dyads (n = 20) was measured at 2, 5, 9, and/or 12 months postpartum with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers). 24-h milk intake and feeding frequency were measured along with whole milk adiponectin and skim and whole milk leptin (SML and WML) and CDI were calculated. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Adipokine concentrations did not associate with infant BC. Higher CDI of adiponectin were associated with lower infant fat-free mass (FFM; p = 0.005) and FFM index (FFMI; p = 0.009) and higher fat mass (FM; p < 0.001), FM index (FMI; p < 0.001), and %FM (p < 0.001). Higher CDI of SML were associated with higher infant FM (p < 0.001), FMI (p < 0.001), and %FM (p = 0.002). At 12 months, higher CDI of WML were associated with larger increases in infant adiposity (2–12 month: FM, p = 0.0006; %FM, p = 0.0004); higher CDI of SML were associated with a larger decrease in FFMI (5–12 months: p = 0.0004). Intakes of HM adipokines differentially influence development of infant BC in the first year of life, which is a critical window of infant programming and may potentially influence risk of later disease via modulation of BC.

scholarly journals 103 THE RELATIONSHIP BETWEEN NURSING PATTERN &, BREAST MILK INTAKE IN THE FIRST YEAR OF LIFE

1986 ◽  
Vol 20 (10) ◽  
pp. 1051-1051
Author(s):  
S M Imong ◽  
D A Jackson ◽  
M W Woolridge ◽  
R F Drewett ◽  
K Amatayakul
Keyword(s):  
Breast Milk ◽  
Milk Intake ◽  
First Year ◽  
First Year Of Life ◽  
The Relationship

Human Milk Intake of Thai Breastfed Infants During the First 6 Months Using the Dose-to-Mother Deuterium Dilution Method

2020 ◽  
Vol 41 (3) ◽  
pp. 343-354
Author(s):  
Wanabhorn Tongchom ◽  
Tippawan Pongcharoen ◽  
Kunchit Judprasong ◽  
Emorn Udomkesmalee ◽  
Wantanee Kriengsinyos ◽  
...  
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Deuterium Oxide ◽  
Milk Intake ◽  
Dilution Method ◽  
Distributed Data ◽  
Middle Income ◽  
Breastfed Infants ◽  
Post Hoc ◽  
Normally Distributed

Background: Data on infant human milk intakes in low- and middle-income countries are limited, although the deuterium oxide dose-to-mother method (DTM) is an accurate tool for its estimation. Objective: We assessed human milk intakes of Thai infants during the first 6 months comparing exclusive breastfeeding (EBF), predominant breastfeeding (PBF), and partial breastfeeding (PartBF). Methods: One hundred and ten healthy Thai lactating mother–infant pairs were followed from birth. Human milk intakes were determined at 6 weeks, 3 months, and 6 months using the DTM method. Daily energy and protein intakes were assessed using 3-day nonconsecutive 24-hour recalls. Sociodemographic characteristics were collected using a questionnaire. To compare breastfeeding practices, one-way analysis of variance with Tukey post hoc test assessed normally distributed data, while the Kruskal-Wallis test with Mann-Whitney U test was used for not normally distributed data. Results: No difference existed in human milk intakes during the first 6 months between EBF (743-776 g/d) and PBF (748-862 g/d). Human milk intakes of PartBF infants were significantly lower compared to other infants. Human milk intake was sufficient to meet infant energy and protein requirements during the first 3 months for EBF and PBF groups. Infant formula largely replaced human milk during the first 3 months; other solid foods were also introduced among the PartBF infants. Conclusions: Human milk intakes were comparable between EBF and PBF infants during the first 6 months and provided adequate energy and protein to meet requirements. Infant formula largely replaced breast milk among PartBF infants, although other foods were also given early. This study was registered at clinicaltrials.gov as NCT04020640.

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