scholarly journals Dietary Protein Intake and Transition between Frailty States in Octogenarians Living in New Zealand

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2843
Author(s):  
Ruth Teh ◽  
Nuno Mendonça ◽  
Marama Muru-Lanning ◽  
Sue MacDonell ◽  
Louise Robinson ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Lower Risk ◽  
Dietary Protein Intake ◽  
Frailty Status ◽  
Co Morbidity ◽  
Second Year ◽  
The Relationship ◽  
Frailty Criteria

Adequate nutritional status may influence progression to frailty. The purpose of this study is to determine the prevalence of frailty and examine the relationship between dietary protein intake and the transition between frailty states and mortality in advanced age. We used data from a longitudinal cohort study of Māori (80–90 years) and non-Māori (85 years). Dietary assessments (24-h multiple pass dietary recalls) were completed at the second year of follow-up (wave 2 and forms the baseline in this study). Frailty was defined using the Fried Frailty criteria. Multi-state modelling examined the association of protein intake and transitions between frailty states and death over four years. Over three quarters of participants were pre-frail or frail at baseline (62% and 16%, respectively). Those who were frail had a higher co-morbidity (p < 0.05), where frailty state changed, 44% showed a worsening of frailty status (robust → pre-frail or pre-frail → frail). Those with higher protein intake (g/kg body weight/day) were less likely to transition from robust to pre-frail [Hazard Ratio (95% Confidence Interval): 0.28 (0.08–0.91)] but also from pre-frail to robust [0.24 (0.06–0.93)]. Increased protein intake was associated with lower risk of transitioning from pre-frailty to death [0.19 (0.04–0.80)], and this association was moderated by energy intake [0.22 (0.03–1.71)]. Higher protein intake in this sample of octogenarians was associated with both better and worse outcomes.

scholarly journals The relationship between dietary protein intake and blood pressure: results from the PREMIER study

2008 ◽  
Vol 22 (11) ◽  
pp. 745-754 ◽  
Author(s):  
Y F Wang ◽  
WS Yancy Jr ◽  
D Yu ◽  
C Champagne ◽  
L J Appel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
The Relationship

scholarly journals P1455PRIORITIZATION BY MEDICAL DIRECTORS OF NUTRITIONAL PROTEIN VERSUS DIETARY PHOSPHORUS CONTROL IN HEMODIALYSIS PATIENTS: ASSOCIATION WITH MORTALITY IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS)

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Suguru Yamamoto ◽  
Brian Bieber ◽  
Hirotaka Komaba ◽  
Hiroki Kitabayashi ◽  
Takanobu Nomura ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Serum Albumin ◽  
Dietary Protein ◽  
Protein Intake ◽  
Case Mix ◽  
Dietary Protein Intake ◽  
All Cause Mortality ◽  
Exposure Variable ◽  
Medical Directors

Abstract Background and Aims Patients undergoing dialysis for end-stage kidney disease (ESKD) have poorer nutritional status than the general population, and worse nutritional status is associated with poor clinical outcomes. Hyperphosphatemia is common in dialysis patients owing to abnormal mineral and bone metabolism. Nephrologists manage hyperphosphatemia by prescribing phosphate binders and/or recommending restriction of dietary protein intake; the latter may, however, adversely affect nutritional status. In this analysis, we address the hypothesis that, even in the presence of hyperphosphatemia, liberalizing dietary protein leads to better patient outcomes. Method The analysis includes 11,628 hemodialysis (HD) patients in 12 countries in DOPPS phase 4 (2009-2011), from 254 facilities where the medical director completed a survey reporting facility practices. Demographic data, comorbid conditions, laboratory values, and medications were abstracted from patient records. Mortality was assessed during study follow-up. The primary exposure variable was response to the following question: “For patients with serum albumin 3.0 g/dL and phosphate 6.0 mg/dL, do you typically recommend to (A) increase or (B) not change or decrease dietary protein intake?” The primary outcome was all-cause mortality, analyzed by Cox regression, stratified by country, accounting for facility clustering using robust sandwich covariance estimators, and adjusted for case-mix and laboratory values. Linear regression was used to model the associations between the exposure variable and intermediate nutritional markers including serum albumin, creatinine, and phosphorus. We used multiple imputation to replace missing values for model covariates. Results Median follow-up was 1.4 years. In the case scenario, 91% of medical directors in North America recommended to increase protein intake compared to 58% in Europe (range=36-83% across 7 countries) and 56% in Japan (Figure). Advice to increase dietary protein intake was associated with 0.33 mg/dL higher serum creatinine levels (95% CI: 0.08-0.57) after adjustment for case mix, while clinically meaningful associations were not observed for serum albumin and phosphorus. Advice to increase dietary protein intake was weakly associated with lower mortality [HR (95% CI): 0.89 (0.77-1.03)]. The association with survival was stronger in patients with age 70+ years [HR (95% CI): 0.81(0.68-0.96), P=0.08 for interaction] and for those without diabetes [HR (95% CI): 0.81(0.66-0.98), P=0.20 for interaction] Conclusion In this large international cohort study, the medical director’s stated preference to recommend an increase in dietary protein intake for HD patients with low albumin and high phosphorus levels was most common in North America and was associated with higher patient serum creatinine levels and potentially lower all-cause mortality. Additional research into the possible benefits of protein intake liberalization for HD patients, even in the presence of hyperphosphatemia, is warranted. This abstract was directly supported by Kyowa Kirin Co.,Ltd..

scholarly journals Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2190 ◽  
Author(s):  
Allman ◽  
Diaz Fuentes ◽  
Williams ◽  
Turner ◽  
Andres ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Early Pregnancy ◽  
Dietary Protein ◽  
Protein Intake ◽  
Late Pregnancy ◽  
Oral Glucose ◽  
Metabolic Clearance ◽  
Dietary Protein Intake ◽  
Food Record ◽  
The Relationship

The purpose of this study was to determine the associations between amount and type of dietary protein intake and insulin sensitivity in late pregnancy, in normal weight and overweight women (29.8 ± 0.2 weeks gestation, n = 173). A 100-gram oral glucose tolerance test (OGTT) was administered following an overnight fast to estimate the metabolic clearance rate of glucose (MCR, mg · kg-1 · min-1) using four different equations accounting for the availability of blood samples. Total (TP), animal (AP), and plant (PP) protein intakes were assessed using a 3-day food record. Two linear models with MCR as the response variable were fitted to the data to estimate the relationship of protein intake to insulin sensitivity either unadjusted or adjusted for early pregnancy body mass index (BMI) because of the potential of BMI to influence this relationship. There was a positive association between TP (β = 1.37, p = 0.002) and PP (β = 4.44, p < 0.001) intake in the last trimester of pregnancy and insulin sensitivity that weakened when accounting for early pregnancy BMI. However, there was no relationship between AP intake and insulin sensitivity (β = 0.95, p = 0.08). Therefore, early pregnancy BMI may be a better predictor of insulin sensitivity than dietary protein intake in late pregnancy.

The relationship between muscle strength and dietary protein intake and bone health

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S211
Author(s):  
C.S. McDonald ◽  
G.C. Chan ◽  
N.P. Kennedy ◽  
Z. Toth ◽  
J.B. Walsh ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Bone Health ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
The Relationship

scholarly journals Serum Amino Acids Patterns and 4-Year Sarcopenia Risk in Community-Dwelling Chinese Older Adults

Gerontology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Suey S.Y. Yeung ◽  
Zoe L.Y. Zhu ◽  
Timothy Kwok ◽  
Jean Woo
Keyword(s):  
Older Adults ◽  
Dietary Protein ◽  
Protein Intake ◽  
Principal Component ◽  
Community Dwelling ◽  
Dietary Protein Intake ◽  
Chinese Older Adults ◽  
Serum Amino Acids ◽  
Composite Scores

<b><i>Introduction:</i></b> Dietary protein intake and serum amino acids (AAs) are factors controlling the rate of muscle protein synthesis and catabolism. This study examined the association between serum AAs patterns and incident sarcopenia in community-dwelling older adults. <b><i>Methods:</i></b> Chinese older adults in Hong Kong aged ≥65 years attended a health check at baseline and 4-year follow-up. At baseline, fasting blood was collected to measure 17 serum AAs. Serum AAs patterns were identified using principal component analysis. Dietary protein intake was assessed using a validated food frequency questionnaire. A composite score was computed by summing the principal component score and sex-standardized protein intake. Six composite scores representing each AAs pattern were available for each participant. Sarcopenia was defined using the updated version of the Asian Working Group for Sarcopenia. Crude and adjusted multiple logistic regressions were performed to examine the associations between each of the 6 composite scores and sarcopenia over 4 years. Results are presented as odds ratio (OR) and 95% confidence interval (CI). To address multiple testing, a Bonferroni correction was applied using a corrected significance level of <i>p</i> &#x3c; 0.008 (α 0.05/6 patterns). <b><i>Results:</i></b> Data of 2,610 participants (mean age 71.6 years, 45.4% men) were available. In men, serum AAs patterns characterized by high branched-chain AAs (BCAAs) (OR 0.77, 95% CI 0.69–0.87, <i>p</i> &#x3c; 0.001) and tyrosine, tryptophan, and phenylalanine (OR 0.79, 95% CI 0.71–0.89, <i>p</i> &#x3c; 0.001) were significantly associated with a lower risk of sarcopenia over 4-year follow-up. After adjusting for confounders, the associations were no longer significant. In women, serum AAs patterns characterized by glutamine, glutamic acid, and methionine (OR 1.28, 95% CI 1.11–1.47, <i>p</i> = 0.001) and arginine, taurine, and serine (OR 1.20, 95% CI 1.06–1.35, <i>p</i> = 0.003) were associated with a higher risk of sarcopenia. After adjusting for confounders, serum AAs pattern characterized by high BCAAs (adjusted OR 1.52, 95% CI 1.25–1.86, <i>p</i> &#x3c; 0.001) and arginine, taurine, and serine (adjusted OR 1.30, 95% CI 1.09–1.56, <i>p</i> = 0.004) were significantly associated with a higher risk of sarcopenia. No association between other AAs patterns with incident sarcopenia was found. <b><i>Conclusions:</i></b> In community-dwelling Chinese older adults, serum AAs patterns characterized by high BCAAs and nonessential AAs (arginine, taurine, and serine) were associated with a higher risk of sarcopenia in women. Findings may allow identifying new targets for interventions.

scholarly journals Impact of dietary protein intake and obesity on lean mass in middle-aged individuals after a 12-year follow-up: the Korean Genome and Epidemiology Study (KoGES)

2019 ◽  
Vol 122 (03) ◽  
pp. 322-330 ◽  
Author(s):  
Eunjin So ◽  
Seul Ki Choi ◽  
Hyojee Joung
Keyword(s):  
Lean Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Normal Weight ◽  
Obese Group ◽  
Dietary Protein Intake ◽  
Epidemiology Study ◽  
Obesity Status ◽  
The Impact

AbstractThe present study investigated the association between protein intake and lean mass according to obesity status over a 12-year period. Data on 4412 participants aged 40–69 years were obtained from the Korean Genome and Epidemiology Study. The usual dietary protein intake of these participants was assessed at baseline using a semi-quantitative FFQ. Body composition was measured using bioelectrical impedance analysis at baseline and after a 12-year follow-up. Linear mixed-effects models were used to examine the associations between lean mass after a 12-year follow-up and protein intake at baseline. After adjusting for covariates and lean mass at baseline, comparisons between the highest and lowest tertiles revealed that dietary protein intake was positively associated with lean mass in both men (β = 0·79, P = 0·001) and women (β = 0·28, P = 0·082) after the 12-year period; however, those differences were attenuated after additional adjustment for fat mass at baseline and were stronger in the normal-weight group (men, β = 0·85, P = 0·002; women, β = 0·97, P &lt; 0·001) but were not detected in the obese group. In the obese group, age (men, β = 4·08, P &lt; 0·001; women, β = 2·61, P &lt; 0·001) and regular physical activity (men, β = 0·88, P = 0·054; women, β = 0·76, P &lt; 0·001) were significantly associated with lean mass after 12 years of follow-up. The results of the present study showed that protein intake may contribute to the prevention of ageing-related lean mass loss; however, the impact of this intake may vary depending on obesity status. Therefore, the maintenance of a healthy body weight during ageing through enhanced protein intake is likely to confer health benefits.

scholarly journals Dietary protein intake is associated with better physical function and muscle strength among elderly women

2016 ◽  
Vol 115 (7) ◽  
pp. 1281-1291 ◽  
Author(s):  
Masoud Isanejad ◽  
Jaakko Mursu ◽  
Joonas Sirola ◽  
Heikki Kröger ◽  
Toni Rikkonen ◽  
...  
Keyword(s):  
Physical Function ◽  
Dietary Protein ◽  
Protein Intake ◽  
Elderly Women ◽  
Fracture Prevention ◽  
Dietary Protein Intake ◽  
Food Record ◽  
Cross Sectional ◽  
European Working

AbstractDietary protein intake might be beneficial to physical function (PF) in the elderly. We examined the cross-sectional and prospective associations of protein intake of g/kg body weight (BW), fat mass (FM) and lean mass (LM) with PF in 554 women aged 65·3–71·6 years belonging to the Osteoporosis Risk Factor and Prevention Fracture Prevention Study. Participants filled a questionnaire on lifestyle factors and 3-d food record in 2002. Body composition was measured by dual-energy X-ray absorptiometry, and PF measures were performed at baseline and at 3-year follow-up. Sarcopaenia was defined using European Working Group on Sarcopenia in Older People criteria. At the baseline, women with higher protein intake (≥1·2 g/kg BW) had better performance in hand-grip strength/body mass (GS/BM) (P=0·001), knee extension/BM (P=0·003), one-leg stance (P=0·047), chair rise (P=0·043), squat (P=0·019), squat to the ground (P=0·001), faster walking speed for 10 m (P=0·005) and higher short physical performance battery score (P=0·004) compared with those with moderate and lower intakes (0·81–1·19 and ≤0·8 g/kg BW, respectively). In follow-up results, higher protein intake was associated with less decline in GS/BM, one-leg stance and tandem walk for 6 m over 3 years. Overall, results were no longer significant after controlling for FM. Associations were detected between protein intake and PF in non-sarcopaenic women but not in sarcopaenic women, except for change of GS (P=0·037). Further, FM but not LM was negatively associated with PF measures (P<0·050). This study suggests that higher protein intake and lower FM might be positively associated with PF in elderly women.

scholarly journals Habitual dietary protein intake affects body iron status in Japanese female college rhythmic gymnasts: a follow-up study

SpringerPlus ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Yuki Kokubo ◽  
Kumiko Kisara ◽  
Yuri Yokoyama ◽  
Yoshiko Ohira-Akiyama ◽  
Yuki Tada ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Iron Status ◽  
Dietary Protein Intake ◽  
Female College ◽  
Body Iron ◽  
Follow Up Study ◽  
Japanese Female ◽  
Rhythmic Gymnasts
Sign in / Sign up

Export Citation Format

Share Document