scholarly journals Serum Amino Acids Patterns and 4-Year Sarcopenia Risk in Community-Dwelling Chinese Older Adults

Gerontology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Suey S.Y. Yeung ◽  
Zoe L.Y. Zhu ◽  
Timothy Kwok ◽  
Jean Woo
Keyword(s):  
Older Adults ◽  
Dietary Protein ◽  
Protein Intake ◽  
Principal Component ◽  
Community Dwelling ◽  
Dietary Protein Intake ◽  
Chinese Older Adults ◽  
Serum Amino Acids ◽  
Composite Scores

<b><i>Introduction:</i></b> Dietary protein intake and serum amino acids (AAs) are factors controlling the rate of muscle protein synthesis and catabolism. This study examined the association between serum AAs patterns and incident sarcopenia in community-dwelling older adults. <b><i>Methods:</i></b> Chinese older adults in Hong Kong aged ≥65 years attended a health check at baseline and 4-year follow-up. At baseline, fasting blood was collected to measure 17 serum AAs. Serum AAs patterns were identified using principal component analysis. Dietary protein intake was assessed using a validated food frequency questionnaire. A composite score was computed by summing the principal component score and sex-standardized protein intake. Six composite scores representing each AAs pattern were available for each participant. Sarcopenia was defined using the updated version of the Asian Working Group for Sarcopenia. Crude and adjusted multiple logistic regressions were performed to examine the associations between each of the 6 composite scores and sarcopenia over 4 years. Results are presented as odds ratio (OR) and 95% confidence interval (CI). To address multiple testing, a Bonferroni correction was applied using a corrected significance level of <i>p</i> &#x3c; 0.008 (α 0.05/6 patterns). <b><i>Results:</i></b> Data of 2,610 participants (mean age 71.6 years, 45.4% men) were available. In men, serum AAs patterns characterized by high branched-chain AAs (BCAAs) (OR 0.77, 95% CI 0.69–0.87, <i>p</i> &#x3c; 0.001) and tyrosine, tryptophan, and phenylalanine (OR 0.79, 95% CI 0.71–0.89, <i>p</i> &#x3c; 0.001) were significantly associated with a lower risk of sarcopenia over 4-year follow-up. After adjusting for confounders, the associations were no longer significant. In women, serum AAs patterns characterized by glutamine, glutamic acid, and methionine (OR 1.28, 95% CI 1.11–1.47, <i>p</i> = 0.001) and arginine, taurine, and serine (OR 1.20, 95% CI 1.06–1.35, <i>p</i> = 0.003) were associated with a higher risk of sarcopenia. After adjusting for confounders, serum AAs pattern characterized by high BCAAs (adjusted OR 1.52, 95% CI 1.25–1.86, <i>p</i> &#x3c; 0.001) and arginine, taurine, and serine (adjusted OR 1.30, 95% CI 1.09–1.56, <i>p</i> = 0.004) were significantly associated with a higher risk of sarcopenia. No association between other AAs patterns with incident sarcopenia was found. <b><i>Conclusions:</i></b> In community-dwelling Chinese older adults, serum AAs patterns characterized by high BCAAs and nonessential AAs (arginine, taurine, and serine) were associated with a higher risk of sarcopenia in women. Findings may allow identifying new targets for interventions.

scholarly journals DIETARY PROTEIN INTAKE PATTERN AND SOURCES AND THEIR ASSOCIATIONS WITH MUSCLE AND PHYSICAL FUNCTION MEASURES IN OLDER CHINESE ADULTS WITH SARCOPENIA IN HONG KONG

2018 ◽  
pp. 1-7
Author(s):  
L.-Y. Zhu ◽  
R. Chan ◽  
L. Li ◽  
T. Kwok ◽  
J. Woo
Keyword(s):  
Older Adults ◽  
Body Weight ◽  
Hong Kong ◽  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Community Dwelling ◽  
Muscle Performance ◽  
Dietary Protein Intake ◽  
Chinese Older Adults

Background: Protein intake is a major risk factor of sarcopenia. To combat sarcopenia, strategies focused on providing sufficient high quality dietary protein are required. Objectives: We aimed to identify the pattern of dietary protein intake and its association with muscle and physical functions among community-dwelling sarcopenic Chinese older adults in Hong Kong. Design: Baseline data of a randomized controlled trial in sarcopenia were analyzed. Setting: Participants who were ambulant and could travel to the assessment centre at a regional hospital in Hong Kong were recruited in nearby community elderly centers, nursing homes and other institutional settings. Participants: A total of 113 Chinese older adults aged 65 or above who had sarcopenia defined using The Asia Working Group Criteria for Sarcopenia were recruited. Measurements: Dietary data and muscle function tests were measured. Results: Although the energy intake (mean + standard deviation: 1491.7±338.6 kcal/d in female, 1738.1±392.9 kcal/d in male) was lower than the recommended daily energy requirement, protein intake averaged 1.6±0.5 g/kg body weight/day, which was high compared to the current Recommended Daily Allowance (RDA, 0.8 g/kg body weight/day for older people). Animal and plant sources contributed to 62% and 38% respectively of the total protein intake. Dietary protein intake was not evenly distributed throughout the day. Physical Activity Scale for the Elderly (PASE) score was more predictive of muscle mass and functions compared to protein intake and sources. Conclusions: Our findings showed that PASE was more predictive of muscle mass and functions compared to protein intake and sources, and there was a minimal association between protein intake and muscle performance measures in our community-dwelling sacropenic older adults. The protein replete state of our study population may explain these findings. The observations that an uneven distribution of protein intake throughout a day may suggest the need to increase protein intake at breakfast among Chinese sarcopenic older adults.

scholarly journals Digitally Supported Dietary Protein Counseling Changes Dietary Protein Intake, Sources, and Distribution in Community-Dwelling Older Adults

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 502
Author(s):  
Jantine van den Helder ◽  
Sjors Verlaan ◽  
Michael Tieland ◽  
Jorinde Scholten ◽  
Sumit Mehra ◽  
...  
Keyword(s):  
Older Adults ◽  
Dietary Protein ◽  
Dairy Products ◽  
Protein Intake ◽  
Community Dwelling ◽  
Animal Protein ◽  
Dietary Protein Intake ◽  
Protein Sources ◽  
Dietary Counselling ◽  
Community Dwelling Older Adults

Digitally supported dietary counselling may be helpful in increasing the protein intake in combined exercise and nutritional interventions in community-dwelling older adults. To study the effect of this approach, 212 older adults (72.2 ± 6.3 years) were randomised in three groups: control, exercise, or exercise plus dietary counselling. The dietary counselling during the 6-month intervention was a blended approach of face-to-face contacts and videoconferencing, and it was discontinued for a 6-month follow-up. Dietary protein intake, sources, product groups, resulting amino acid intake, and intake per eating occasion were assessed by a 3-day dietary record. The dietary counselling group was able to increase the protein intake by 32% at 6 months, and the intake remained 16% increased at 12 months. Protein intake mainly consisted of animal protein sources: dairy products, followed by fish and meat. This resulted in significantly more intake of essential amino acids, including leucine. The protein intake was distributed evenly over the day, resulting in more meals that reached the protein and leucine targets. Digitally supported dietary counselling was effective in increasing protein intake both per meal and per day in a lifestyle intervention in community-dwelling older adults. This was predominantly achieved by consuming more animal protein sources, particularly dairy products, and especially during breakfast and lunch.

Dietary protein intake is associated with lean body mass in community-dwelling older adults

2013 ◽  
Vol 33 (8) ◽  
pp. 608-612 ◽  
Author(s):  
Olof G. Geirsdottir ◽  
Atli Arnarson ◽  
Alfons Ramel ◽  
Palmi V. Jonsson ◽  
Inga Thorsdottir
Keyword(s):  
Older Adults ◽  
Lean Body Mass ◽  
Body Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Community Dwelling ◽  
Dietary Protein Intake ◽  
Community Dwelling Older Adults

scholarly journals Association between Very Low Dietary Protein Intake and Subsequent Falls in Community-Dwelling Older Adults in the United States

2020 ◽  
Vol 4 (2) ◽  
pp. 1-12
Author(s):  
Marika Haritos Paul ◽  
◽  
Mary Beth Arensberg ◽  
Judy R. Simon ◽  
Satya S. Jonnalagadda ◽  
...  
Keyword(s):  
United States ◽  
Older Adults ◽  
Dietary Protein ◽  
Protein Intake ◽  
The United States ◽  
Community Dwelling ◽  
Dietary Protein Intake ◽  
Community Dwelling Older Adults

Animal protein intake is inversely associated with mortality in older adults: the InCHIANTI study

2021 ◽  
Author(s):  
Tomás Meroño ◽  
Raúl Zamora-Ros ◽  
Nicole Hidalgo-Liberona ◽  
Montserrat Rabassa ◽  
Stefania Bandinelli ◽  
...  
Keyword(s):  
Older Adults ◽  
Total Energy ◽  
Cardiovascular Mortality ◽  
Protein Intake ◽  
Cox Regression ◽  
Clinical Information ◽  
Community Dwelling ◽  
Animal Protein ◽  
Plant Protein

Abstract Background In general, plant protein intake was inversely associated with mortality in studies in middle-aged adults. Our aim was to evaluate the long-term associations of animal and plant protein intake with mortality in older adults. Methods A prospective cohort study including 1,139 community-dwelling older adults (mean age 75 years, 56% women) living in Tuscany, Italy, followed for 20 years (InCHIANTI study) was analyzed. Dietary intake by food frequency questionnaires and clinical information were assessed five times during the follow-up. Protein intakes were expressed as percentages of total energy. Time-dependent Cox regression models adjusted for confounders were used to assess the association between plant and animal protein intake, and mortality. Results During the 20-years of follow up (mean: 12y), 811 deaths occurred (292 of cardiovascular- and 151 of cancer-related causes). Animal protein intake was inversely associated with all-cause (HR per 1% of total energy from protein increase, 95%CI: 0.96, 0.93-0.99) and cardiovascular mortality (HR per 1% of total energy from protein increase, 95%CI: 0.93, 0.87-0.98). Plant protein intake showed no association with any of the mortality outcomes, but an interaction with baseline hypertension was found for all-cause and cardiovascular mortality (p&lt;0.05). Conclusions Animal protein was inversely associated with all-cause and cardiovascular mortality in older adults. Further studies are needed to provide recommendations on dietary protein intake for older adults.

scholarly journals P1455PRIORITIZATION BY MEDICAL DIRECTORS OF NUTRITIONAL PROTEIN VERSUS DIETARY PHOSPHORUS CONTROL IN HEMODIALYSIS PATIENTS: ASSOCIATION WITH MORTALITY IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS)

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Suguru Yamamoto ◽  
Brian Bieber ◽  
Hirotaka Komaba ◽  
Hiroki Kitabayashi ◽  
Takanobu Nomura ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Serum Albumin ◽  
Dietary Protein ◽  
Protein Intake ◽  
Case Mix ◽  
Dietary Protein Intake ◽  
All Cause Mortality ◽  
Exposure Variable ◽  
Medical Directors

Abstract Background and Aims Patients undergoing dialysis for end-stage kidney disease (ESKD) have poorer nutritional status than the general population, and worse nutritional status is associated with poor clinical outcomes. Hyperphosphatemia is common in dialysis patients owing to abnormal mineral and bone metabolism. Nephrologists manage hyperphosphatemia by prescribing phosphate binders and/or recommending restriction of dietary protein intake; the latter may, however, adversely affect nutritional status. In this analysis, we address the hypothesis that, even in the presence of hyperphosphatemia, liberalizing dietary protein leads to better patient outcomes. Method The analysis includes 11,628 hemodialysis (HD) patients in 12 countries in DOPPS phase 4 (2009-2011), from 254 facilities where the medical director completed a survey reporting facility practices. Demographic data, comorbid conditions, laboratory values, and medications were abstracted from patient records. Mortality was assessed during study follow-up. The primary exposure variable was response to the following question: “For patients with serum albumin 3.0 g/dL and phosphate 6.0 mg/dL, do you typically recommend to (A) increase or (B) not change or decrease dietary protein intake?” The primary outcome was all-cause mortality, analyzed by Cox regression, stratified by country, accounting for facility clustering using robust sandwich covariance estimators, and adjusted for case-mix and laboratory values. Linear regression was used to model the associations between the exposure variable and intermediate nutritional markers including serum albumin, creatinine, and phosphorus. We used multiple imputation to replace missing values for model covariates. Results Median follow-up was 1.4 years. In the case scenario, 91% of medical directors in North America recommended to increase protein intake compared to 58% in Europe (range=36-83% across 7 countries) and 56% in Japan (Figure). Advice to increase dietary protein intake was associated with 0.33 mg/dL higher serum creatinine levels (95% CI: 0.08-0.57) after adjustment for case mix, while clinically meaningful associations were not observed for serum albumin and phosphorus. Advice to increase dietary protein intake was weakly associated with lower mortality [HR (95% CI): 0.89 (0.77-1.03)]. The association with survival was stronger in patients with age 70+ years [HR (95% CI): 0.81(0.68-0.96), P=0.08 for interaction] and for those without diabetes [HR (95% CI): 0.81(0.66-0.98), P=0.20 for interaction] Conclusion In this large international cohort study, the medical director’s stated preference to recommend an increase in dietary protein intake for HD patients with low albumin and high phosphorus levels was most common in North America and was associated with higher patient serum creatinine levels and potentially lower all-cause mortality. Additional research into the possible benefits of protein intake liberalization for HD patients, even in the presence of hyperphosphatemia, is warranted. This abstract was directly supported by Kyowa Kirin Co.,Ltd..

scholarly journals Dietary Protein Intake Is Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort

2015 ◽  
Vol 71 (3) ◽  
pp. 356-361 ◽  
Author(s):  
Robert R. McLean ◽  
Kelsey M. Mangano ◽  
Marian T. Hannan ◽  
Douglas P. Kiel ◽  
Shivani Sahni
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
Offspring Cohort
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