scholarly journals Obesity Status Affects the Relationship Between Protein Intake and Insulin Sensitivity in Late Pregnancy

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2190 ◽  
Author(s):  
Allman ◽  
Diaz Fuentes ◽  
Williams ◽  
Turner ◽  
Andres ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Early Pregnancy ◽  
Dietary Protein ◽  
Protein Intake ◽  
Late Pregnancy ◽  
Oral Glucose ◽  
Metabolic Clearance ◽  
Dietary Protein Intake ◽  
Food Record ◽  
The Relationship

The purpose of this study was to determine the associations between amount and type of dietary protein intake and insulin sensitivity in late pregnancy, in normal weight and overweight women (29.8 ± 0.2 weeks gestation, n = 173). A 100-gram oral glucose tolerance test (OGTT) was administered following an overnight fast to estimate the metabolic clearance rate of glucose (MCR, mg · kg-1 · min-1) using four different equations accounting for the availability of blood samples. Total (TP), animal (AP), and plant (PP) protein intakes were assessed using a 3-day food record. Two linear models with MCR as the response variable were fitted to the data to estimate the relationship of protein intake to insulin sensitivity either unadjusted or adjusted for early pregnancy body mass index (BMI) because of the potential of BMI to influence this relationship. There was a positive association between TP (β = 1.37, p = 0.002) and PP (β = 4.44, p < 0.001) intake in the last trimester of pregnancy and insulin sensitivity that weakened when accounting for early pregnancy BMI. However, there was no relationship between AP intake and insulin sensitivity (β = 0.95, p = 0.08). Therefore, early pregnancy BMI may be a better predictor of insulin sensitivity than dietary protein intake in late pregnancy.

scholarly journals Dietary Protein Intake during Pregnancy Is Not Associated with Offspring Insulin Sensitivity during the First Two Years of Life

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1338
Author(s):  
Brittany R. Allman ◽  
D. Keith Williams ◽  
Elisabet Børsheim ◽  
Aline Andres
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Dietary Protein ◽  
Protein Intake ◽  
Late Pregnancy ◽  
Model Assessment ◽  
Dietary Protein Intake ◽  
Fat Percentage ◽  
Homeostatic Model Assessment ◽  
The Relationship

Literature describing a relationship between dietary protein intake during pregnancy and offspring insulin resistance are equivocal perhaps because of the lapse between maternal and offspring measurements (~9–40 years). Thus, we evaluated protein intake in healthy women [n = 182, mean ± SD; body mass index (BMI): 26.2 ± 4.2 kg/m2] in early pregnancy (8.4 ± 1.6 weeks, EP), late pregnancy (30.1 ± 0.4 weeks, LP), and averaged throughout pregnancy, and determined the relationship between protein intake and offspring homeostatic model assessment of insulin resistance (HOMA2-IR) at 12 (12mo) and 24 (24mo) months. EP protein (g·kg−1·day−1) did not associate with HOMA2-IR at 12mo (β = 0.153, p = 0.429) or 24mo (β = −0.349, p = 0.098). LP protein did not associate with HOMA2-IR at 12mo (β = 0.023, p = 0.916) or 24mo (β = −0.442, p = 0.085). Finally, average protein did not associate with HOMA2-IR at 12mo (β = 0.711, p = 0.05) or 24mo (β = −0.445, p = 0.294). Results remained unchanged after adjusting for plant protein intake quartiles during pregnancy, maternal BMI, and offspring sex and body fat percentage. Additionally, these relationships did not change after quartile analysis of average protein intake, even after considering offspring fasting time and HOMA2-IR outliers, and maternal under-reporters of energy intake. Protein intake during pregnancy is not associated with indirect measurements of insulin sensitivity in offspring during the first two years of life.

scholarly journals Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO)

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2207 ◽  
Author(s):  
Mitchell ◽  
Milan ◽  
Mitchell ◽  
Gillies ◽  
D’Souza ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Dietary Protein ◽  
Protein Intake ◽  
High Protein ◽  
Oral Glucose ◽  
Dietary Protein Intake ◽  
Cvd Risk ◽  
Post Intervention ◽  
The Impact

Higher dietary protein intake is increasingly recommended for the elderly; however, high protein diets have also been linked to increased cardiovascular disease (CVD) risk. Trimethylamine-N-oxide (TMAO) is a bacterial metabolite derived from choline and carnitine abundant from animal protein-rich foods. TMAO may be a novel biomarker for heightened CVD risk. The purpose of this study was to assess the impact of a high protein diet on TMAO. Healthy men (74.2 ± 3.6 years, n = 29) were randomised to consume the recommended dietary allowance of protein (RDA: 0.8 g protein/kg bodyweight/day) or twice the RDA (2RDA) as part of a supplied diet for 10 weeks. Fasting blood samples were collected pre- and post-intervention for measurement of TMAO, blood lipids, glucose tolerance, insulin sensitivity, and inflammatory biomarkers. An oral glucose tolerance test was also performed. In comparison with RDA, the 2RDA diet increased circulatory TMAO (p = 0.002) but unexpectedly decreased renal excretion of TMAO (p = 0.003). LDL cholesterol was increased in 2RDA compared to RDA (p = 0.049), but no differences in other biomarkers of CVD risk and insulin sensitivity were evident between groups. In conclusion, circulatory TMAO is responsive to changes in dietary protein intake in older healthy males.

scholarly journals No Association Between Maternal Dietary Protein Intake and Offspring Insulin Sensitivity Measures in the First Two Years of Life

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 932-932
Author(s):  
Brittany Allman ◽  
Eva Fuentes ◽  
D Keith Williams ◽  
Donald Turner ◽  
Elisabet Børsheim ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Dietary Protein ◽  
Protein Intake ◽  
Agricultural Research ◽  
United States Department ◽  
Model Assessment ◽  
Dietary Protein Intake ◽  
Food Record ◽  
Service Project ◽  
Relationship Of

Abstract Objectives Findings of an association between maternal dietary protein intake (1.1–1.7 g·kg−1·day−1) close to requirements for pregnant women throughout gestation (1.22–1.52 g·kg−1·day−1) and offspring insulin sensitivity are mixed, perhaps as a result of the small spread in protein intake and the large gap between measurements (∼9–40 years). Therefore, our objective was to evaluate the association between a wider spread of dietary protein intake during pregnancy and measurements of insulin sensitivity in the offspring in early life. Methods Healthy women (n = 182, mean ± SD; BMI: 26.2 ± 4.2 kg/m2) were recruited early in pregnancy (&lt;10 weeks). Dietary protein intake was assessed using a 3-day food record in early (∼10 weeks, EP) and late (∼30 weeks, LP) pregnancy. Offspring blood was sampled at 12 and 24 months, and the updated homeostatic model assessment of insulin resistance (HOMA2-IR) was computed using fasting glucose and insulin. Body composition was measured using nuclear magnetic resonance. Two linear models were fitted to the data to estimate: 1) the unadjusted relationship of maternal protein intake to offspring HOMA2-IR and 2) the relationship of maternal protein intake to offspring HOMA2-IR adjusted for maternal plant protein intake and BMI, and offspring sex and body fat percentage. Values are mean ± SD. Results Habitual protein intake (average of early and late pregnancy measurements range: 0.5–1.9 g·kg−1·day−1) decreased throughout pregnancy (EP: 1.09 ± 0.36; vs. LP: 0.97 ± 0.28 g·kg−1·day−1, P = 0.0003). Offspring HOMA2-IR did not change from 12 (0.8 ± 0.8) to 24 (0.8 ± 0.9) months. Simple regression analysis: EP dietary protein intake did not associate with HOMA2-IR at 12 (β = 0.153, P = 0.429) and 24 (β = −0.349, P = 0.098) months. Similarly, LP dietary protein intake did not associate with offspring HOMA2-IR at 12 (β = 0.023, P = 0.916) and 24 (β = −0.442, P = 0.085) months. Results remained unchanged after multiple regression analyses were conducted. Conclusions Maternal dietary protein intake (amount or type) during pregnancy is not associated with indirect measurements of insulin sensitivity in offspring during the first two years of life. Funding Sources United States Department of Agriculture Agricultural Research Service Project 6026-51,000-012-06S, and NIH/NIDDK R01 DK107516.

scholarly journals Higher maternal dietary protein intake in late pregnancy is associated with a lower infant ponderal index at birth

2006 ◽  
Vol 61 (4) ◽  
pp. 498-508 ◽  
Author(s):  
K Andreasyan ◽  
A-L Ponsonby ◽  
T Dwyer ◽  
R Morley ◽  
M Riley ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Late Pregnancy ◽  
Ponderal Index ◽  
Dietary Protein Intake

scholarly journals The relationship between dietary protein intake and blood pressure: results from the PREMIER study

2008 ◽  
Vol 22 (11) ◽  
pp. 745-754 ◽  
Author(s):  
Y F Wang ◽  
WS Yancy Jr ◽  
D Yu ◽  
C Champagne ◽  
L J Appel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
The Relationship

The relationship between muscle strength and dietary protein intake and bone health

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S211
Author(s):  
C.S. McDonald ◽  
G.C. Chan ◽  
N.P. Kennedy ◽  
Z. Toth ◽  
J.B. Walsh ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Bone Health ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
The Relationship

scholarly journals Effects of protein intake on blood pressure, insulin sensitivity and blood lipids in children: a systematic review

2015 ◽  
Vol 113 (3) ◽  
pp. 383-402 ◽  
Author(s):  
Trudy Voortman ◽  
Anna Vitezova ◽  
Wichor M. Bramer ◽  
Charlotte L. Ars ◽  
Paula K. Bautista ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Dietary Protein ◽  
Protein Intake ◽  
Blood Lipids ◽  
Healthy Children ◽  
Inverse Association ◽  
Dietary Protein Intake ◽  
Cross Sectional ◽  
Beneficial Effects

High protein intake in early childhood is associated with obesity, suggesting possible adverse effects on other cardiometabolic outcomes. However, studies in adults have suggested beneficial effects of protein intake on blood pressure (BP) and lipid profile. Whether dietary protein intake is associated with cardiovascular and metabolic health in children is unclear. Therefore, we aimed to systematically review the evidence on the associations of protein intake with BP, insulin sensitivity and blood lipids in children. We searched the databases Medline, Embase, Cochrane Central and PubMed for interventional and observational studies in healthy children up to the age of 18 years, in which associations of total, animal and/or vegetable protein intake with one or more of the following outcomes were reported: BP; measures of insulin sensitivity; cholesterol levels; or TAG levels. In the search, we identified 6636 abstracts, of which fifty-six studies met all selection criteria. In general, the quality of the included studies was low. Most studies were cross-sectional, and many did not control for potential confounders. No overall associations were observed between protein intake and insulin sensitivity or blood lipids. A few studies suggested an inverse association between dietary protein intake and BP, but evidence was inconclusive. Only four studies examined the effects of vegetable or animal protein intake, but with inconsistent results. In conclusion, the literature, to date provides insufficient evidence for effects of protein intake on BP, insulin sensitivity or blood lipids in children. Future studies could be improved by adequately adjusting for key confounders such as energy intake and obesity.

scholarly journals Early Detection of Insulin Sensitivity and β-Cell Function with Simple Tests Indicates Future Derangements in Late Pregnancy

2008 ◽  
Vol 93 (3) ◽  
pp. 876-880 ◽  
Author(s):  
A. Lapolla ◽  
M. G. Dalfrà ◽  
G. Mello ◽  
E. Parretti ◽  
R. Cioni ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Early Pregnancy ◽  
Cell Function ◽  
Late Pregnancy ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Β Cell ◽  
Β Cell Function

Abstract Objective: Insulin sensitivity and secretion during early and late pregnancy were assessed in women with normal glucose tolerance and gestational diabetes mellitus (GDM). Research Design and Methods: The oral glucose tolerance test (OGTT) was performed in 903 women at 16–20th gestational week, of whom 37 had GDM (GDM1 group), and 859 repeated the OGTT at wk 26–30. At the second test, 55 had GDM (GDM2 group); the others remained normotolerant (ND group). Insulin sensitivity from OGTT (as quantitative insulin sensitivity check index and OGTT insulin sensitivity) and β-cell function (as the ratio of the areas under the insulin and glucose concentration curves, adjusted for insulin sensitivity) were assessed in both tests. Results: In early pregnancy the quantitative insulin sensitivity check index was not different in the three groups, whereas OGTT insulin sensitivity was lowest in GDM2, intermediate in GDM1, and highest in ND. In late pregnancy both indices were reduced in GDM compared with ND and lower than in early pregnancy. In early pregnancy GDM1, but not GDM2, had lower β-cell function than ND. During the late visit, GDM2 also showed impaired β-cell function compared with ND; furthermore, the adaptation to the increase to insulin resistance from early to late pregnancy was defective in GDM2. Conclusions: In early pregnancy insulin sensitivity, as assessed from the OGTT but not from fasting measurements, is impaired in women who developed GDM. β-Cell function impairment is evident only when GDM is manifest and is characterized by inappropriate adaptation to the pregnancy induced increase in insulin resistance.

scholarly journals Dietary Protein Intake and Transition between Frailty States in Octogenarians Living in New Zealand

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2843
Author(s):  
Ruth Teh ◽  
Nuno Mendonça ◽  
Marama Muru-Lanning ◽  
Sue MacDonell ◽  
Louise Robinson ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Lower Risk ◽  
Dietary Protein Intake ◽  
Frailty Status ◽  
Co Morbidity ◽  
Second Year ◽  
The Relationship ◽  
Frailty Criteria

Adequate nutritional status may influence progression to frailty. The purpose of this study is to determine the prevalence of frailty and examine the relationship between dietary protein intake and the transition between frailty states and mortality in advanced age. We used data from a longitudinal cohort study of Māori (80–90 years) and non-Māori (85 years). Dietary assessments (24-h multiple pass dietary recalls) were completed at the second year of follow-up (wave 2 and forms the baseline in this study). Frailty was defined using the Fried Frailty criteria. Multi-state modelling examined the association of protein intake and transitions between frailty states and death over four years. Over three quarters of participants were pre-frail or frail at baseline (62% and 16%, respectively). Those who were frail had a higher co-morbidity (p < 0.05), where frailty state changed, 44% showed a worsening of frailty status (robust → pre-frail or pre-frail → frail). Those with higher protein intake (g/kg body weight/day) were less likely to transition from robust to pre-frail [Hazard Ratio (95% Confidence Interval): 0.28 (0.08–0.91)] but also from pre-frail to robust [0.24 (0.06–0.93)]. Increased protein intake was associated with lower risk of transitioning from pre-frailty to death [0.19 (0.04–0.80)], and this association was moderated by energy intake [0.22 (0.03–1.71)]. Higher protein intake in this sample of octogenarians was associated with both better and worse outcomes.

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