scholarly journals Cardiovascular Diseases of Developmental Origins: Preventive Aspects of Gut Microbiota-Targeted Therapy

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2290
Author(s):  
Chien-Ning Hsu ◽  
Chih-Yao Hou ◽  
Wei-Hsuan Hsu ◽  
You-Lin Tain
Keyword(s):  
Targeted Therapy ◽  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Early Life ◽  
Animal Studies ◽  
Renin Angiotensin System ◽  
Later Life ◽  
Short Chain Fatty Acids ◽  
Treatment Modalities ◽  
Developmental Origins

Cardiovascular diseases (CVDs) can originate from early life. Accumulating evidence suggests that gut microbiota in early life is linked to CVDs in later life. Gut microbiota-targeted therapy has gained significant importance in recent decades for its health-promoting role in the prevention (rather than just treatment) of CVDs. Thus far, available gut microbiota-based treatment modalities used as reprogramming interventions include probiotics, prebiotics, and postbiotics. The purpose of this review is, first, to highlight current studies that link dysbiotic gut microbiota to the developmental origins of CVD. This is followed by a summary of the connections between the gut microbiota and CVD behind cardiovascular programming, such as short chain fatty acids (SCFAs) and their receptors, trimethylamine-N-oxide (TMAO), uremic toxins, and aryl hydrocarbon receptor (AhR), and the renin-angiotensin system (RAS). This review also presents an overview of how gut microbiota-targeted reprogramming interventions can prevent the developmental origins of CVD from animal studies. Overall, this review reveals that recent advances in gut microbiota-targeted therapy might provide the answers to reduce the global burden of CVDs. Still, additional studies will be needed to put research findings into practice.

scholarly journals Levels of Predominant Intestinal Microorganisms in 1 Month-Old Full-Term Babies and Weight Gain During the First Year of Life

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2412
Author(s):  
Sonia González ◽  
Marta Selma-Royo ◽  
Silvia Arboleya ◽  
Cecilia Martínez-Costa ◽  
Gonzalo Solís ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gut Microbiota ◽  
Early Life ◽  
Later Life ◽  
Full Term ◽  
First Year ◽  
Term Infants ◽  
Term Newborns ◽  
Infant Weight Gain ◽  
First Year Of Life

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.

scholarly journals Short chain fatty acids and methylamines produced by gut microbiota as mediators and markers in the circulatory system

2020 ◽  
Vol 245 (2) ◽  
pp. 166-175 ◽  
Author(s):  
Maksymilian Onyszkiewicz ◽  
Kinga Jaworska ◽  
Marcin Ufnal
Keyword(s):  
Fatty Acids ◽  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Therapeutic Targets ◽  
Circulatory System ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Bacterial Strains ◽  
Ample Evidence ◽  
Chain Fatty Acids

Ample evidence suggests that gut microbiota-derived products affect the circulatory system functions. For instance, short chain fatty acids, that are the products of dietary fiber bacterial fermentation, have been found to dilate blood vessels and lower blood pressure. Trimethylamine, a gut bacteria metabolite of carnitine and choline, has recently emerged as a potentially toxic molecule for the circulatory system. To enter the bloodstream, microbiota products cross the gut–blood barrier, a multilayer system of the intestinal wall. Notably, experimental and clinical studies show that cardiovascular diseases may compromise function of the gut–blood barrier and increase gut-to-blood penetration of microbiota-derived molecules. Hence, the bacteria products and the gut–blood barrier may be potential diagnostic and therapeutic targets in cardiovascular diseases. In this paper, we review research on the cardiovascular effects of microbiota-produced short chain fatty acids and methylamines. Impact statement Despite a progress in the diagnosis and treatment of cardiovascular diseases, there are still significant gaps in understanding complex mechanisms underlying cardiovascular pathology. Increasing evidence suggests that gut microbiota products such as short chain fatty acids or methylamines may affect the circulatory system in health and disease. Hence, the microbiota-derived molecules are potential diagnostic and therapeutic targets in cardiovascular diseases. Therapeutic options may include administration of selected bacterial strains (probiotics) producing desired metabolites or administration of direct gut microbiota products.

Food contaminants and programming of type 2 diabetes: recent findings from animal studies

2016 ◽  
Vol 7 (5) ◽  
pp. 505-512 ◽  
Author(s):  
S. Firmin ◽  
N. Bahi-Jaber ◽  
L. Abdennebi-Najar
Keyword(s):  
Type 2 Diabetes ◽  
Early Life ◽  
Animal Studies ◽  
Cell Mass ◽  
Later Life ◽  
Adult Health ◽  
Food Contaminants ◽  
Insulin Synthesis ◽  
Increased Risk

It is now accepted that the way our health evolves with aging is intimately linked to the quality of our early life. The present review highlights the emerging data of Developmental Origins of Health and Disease field on developmental disruption by toxicants and their subsequent effect on type 2 diabetes. We report adverse neonatal effects of several food contaminants during pregnancy and lactation, among them bisphenol A, chlorpyrifos, perfluorinated chemicals on pancreas integrity and functionality in later life. The described alterations, in conjunction with disruption of β cell mass in early life, can lead to dysregulation of glucose metabolism, insulin synthesis, which facilitates the development of insulin resistance and progression of diabetes in the adult. Despite limited and often inconclusive epidemiologic and experimental data, more recent data clearly show that infants appear to be at increased risk of type 2 diabetes in later life. This may be a result of continued exposure to chemical food contaminants during the critical window of pancreas development. In societies already burdened with increased incidence of non-communicable chronic diseases, there is a clear need for information regarding the potential harmful effects of chemical food contaminants on adult health diseases.

scholarly journals Circadian disruption and divergent microbiota acquisition under extended photoperiod regimens in chicken

2018 ◽  
Author(s):  
Anne-Sophie Charlotte Hieke ◽  
Shawna Marie Hubert ◽  
Giridhar Athrey
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Clock Genes ◽  
Later Life ◽  
Fecal Microbiota ◽  
Circadian Disruption ◽  
Management Tool ◽  
Light Regimes ◽  
Cecal Microbiota ◽  
Microbiota Structure

The gut microbiota is crucial for metabolic homeostasis, immunity, growth and overall health, and it recognized that early-life microbiota acquisition is a pivotal event for later life health. Recent studies show that gut microbiota diversity and functional activity are synchronized with the host circadian rhythms in healthy individuals, and circadian disruption elicits dysbiosis in mammalian models. However, no studies have determined the associations between circadian disruption in early life, microbiota colonization, and the consequences for microbiota structure in birds. Chickens, as a major source of protein around the world, are one of the most important agricultural species, and their gut and metabolic health are significant concerns. The poultry industry routinely employs extended photoperiods (>18 hours’ light) as a management tool, and their impacts on the chicken circadian, its role in gut microbiota acquisition in early life, and consequences for later life microbiota structure remain unknown. In this study, the objectives were to a) characterize chicken circadian activity under two different light regimes (12/12 hours’ Light/Dark and 23/1 hours Light/Dark), b) characterize gut microbiota acquisition and composition in the first four weeks of life, c) determine if gut microbiota oscillate in synchrony with the host circadian, and d) to determine if fecal microbiota is representative of cecal microbiota. Expression of clock genes (clock, bmal1, and per2) were assayed, and fecal and cecal microbiota was characterized using 16s rRNA amplicon analyses from birds raised under two photoperiod treatments. Chickens raised under 12/12 LD photoperiods exhibited rhythmic clock gene activity, which was absent in birds raised under the extended (23/1 LD) photoperiod. This study is also the first to report differential microbiota acquisition under different photoperiod regimes. Gut microbiota members showed a similar oscillating pattern as the host, but this association was not as strong as found in mammals. Finally, the fecal microbiota was found to be not representative of cecal microbiota membership and structure. This is one of the first studies to demonstrate the use of photoperiods to modulate microbiota acquisition, and show its potential utility as a tool to promote the colonization of beneficial microorganisms.

scholarly journals Circadian disruption and divergent microbiota acquisition under extended photoperiod regimens in chicken

2018 ◽  
Author(s):  
Anne-Sophie Charlotte Hieke ◽  
Shawna Marie Hubert ◽  
Giridhar Athrey
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Clock Genes ◽  
Later Life ◽  
Fecal Microbiota ◽  
Circadian Disruption ◽  
Management Tool ◽  
Light Regimes ◽  
Cecal Microbiota ◽  
Microbiota Structure

The gut microbiota is crucial for metabolic homeostasis, immunity, growth and overall health, and it recognized that early-life microbiota acquisition is a pivotal event for later life health. Recent studies show that gut microbiota diversity and functional activity are synchronized with the host circadian rhythms in healthy individuals, and circadian disruption elicits dysbiosis in mammalian models. However, no studies have determined the associations between circadian disruption in early life, microbiota colonization, and the consequences for microbiota structure in birds. Chickens, as a major source of protein around the world, are one of the most important agricultural species, and their gut and metabolic health are significant concerns. The poultry industry routinely employs extended photoperiods (>18 hours’ light) as a management tool, and their impacts on the chicken circadian, its role in gut microbiota acquisition in early life, and consequences for later life microbiota structure remain unknown. In this study, the objectives were to a) characterize chicken circadian activity under two different light regimes (12/12 hours’ Light/Dark and 23/1 hours Light/Dark), b) characterize gut microbiota acquisition and composition in the first four weeks of life, c) determine if gut microbiota oscillate in synchrony with the host circadian, and d) to determine if fecal microbiota is representative of cecal microbiota. Expression of clock genes (clock, bmal1, and per2) were assayed, and fecal and cecal microbiota was characterized using 16s rRNA amplicon analyses from birds raised under two photoperiod treatments. Chickens raised under 12/12 LD photoperiods exhibited rhythmic clock gene activity, which was absent in birds raised under the extended (23/1 LD) photoperiod. This study is also the first to report differential microbiota acquisition under different photoperiod regimes. Gut microbiota members showed a similar oscillating pattern as the host, but this association was not as strong as found in mammals. Finally, the fecal microbiota was found to be not representative of cecal microbiota membership and structure. This is one of the first studies to demonstrate the use of photoperiods to modulate microbiota acquisition, and show its potential utility as a tool to promote the colonization of beneficial microorganisms.

scholarly journals Nutritional modulation of the epigenome and its implication for future health

2019 ◽  
Vol 78 (3) ◽  
pp. 305-312 ◽  
Author(s):  
Mark A. Burton ◽  
Karen A. Lillycrop
Keyword(s):  
Gene Expression ◽  
Early Life ◽  
Animal Studies ◽  
Disease Risk ◽  
Regulation Of Gene Expression ◽  
Later Life ◽  
Future Health ◽  
Level Of Activity ◽  
Epigenetic Processes

Non-communicable diseases (NCD) such as type-2 diabetes and CVD are now highly prevalent in both developed and developing countries. Evidence from both human and animal studies shows that early-life nutrition is an important determinant of NCD risk in later life. The mechanism by which the early-life environment influences future disease risk has been suggested to include the altered epigenetic regulation of gene expression. Epigenetic processes regulate the accessibility of genes to the cellular proteins that control gene transcription, determining where and when a gene is switched on and its level of activity. Epigenetic processes not only play a central role in regulating gene expression but also allow an organism to adapt to the environment. In this review, we will focus on how both maternal and paternal nutrition can alter the epigenome and the evidence that these changes are causally involved in determining future disease risk.

scholarly journals Implication of Gut Microbiota in Cardiovascular Diseases

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Wenyi Zhou ◽  
Yiyu Cheng ◽  
Ping Zhu ◽  
M. I. Nasser ◽  
Xueyan Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cardiovascular Diseases ◽  
Programmed Cell Death ◽  
Gut Microbiota ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Secondary Bile Acid ◽  
Cardiac Disorders ◽  
The Relationship

Emerging evidence has identified the association between gut microbiota and various diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has been described in detail in CVDs, such as hypertension, atherosclerosis, myocardial infarction, heart failure, and arrhythmia. In contrast, the importance of fermentation metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and secondary bile acid (BA), has also been implicated in CVD development, prevention, treatment, and prognosis. The potential mechanisms are conventionally thought to involve immune regulation, host energy metabolism, and oxidative stress. However, numerous types of programmed cell death, including apoptosis, autophagy, pyroptosis, ferroptosis, and clockophagy, also serve as a key link in microbiome-host cross talk. In this review, we introduced and summarized the results from recent studies dealing with the relationship between gut microbiota and cardiac disorders, highlighting the role of programmed cell death. We hope to shed light on microbiota-targeted therapeutic strategies in CVD management.

scholarly journals Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 247
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain
Keyword(s):  
Cardiovascular Disease ◽  
Hydrogen Sulfide ◽  
Animal Studies ◽  
Current Knowledge ◽  
Renin Angiotensin System ◽  
Nutrient Sensing ◽  
Supporting Evidence ◽  
Developmental Origins ◽  
Nitric Oxide Deficiency ◽  
Underlying Mechanisms

The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H2S), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early H2S-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on H2S implicated in cardiovascular programming. This will be followed by supporting evidence for the links between H2S signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin–angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how H2S-based reprogramming interventions, such as precursors of H2S and H2S donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in H2S-based interventions might provide the answers to bring down the global burden of CVD.

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