scholarly journals Levels of Predominant Intestinal Microorganisms in 1 Month-Old Full-Term Babies and Weight Gain During the First Year of Life

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2412
Author(s):  
Sonia González ◽  
Marta Selma-Royo ◽  
Silvia Arboleya ◽  
Cecilia Martínez-Costa ◽  
Gonzalo Solís ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gut Microbiota ◽  
Early Life ◽  
Later Life ◽  
Full Term ◽  
First Year ◽  
Term Infants ◽  
Term Newborns ◽  
Infant Weight Gain ◽  
First Year Of Life

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.

scholarly journals Neonatal gut and respiratory microbiota: coordinated development through time and space

2018 ◽  
Author(s):  
Alex Grier ◽  
Andrew McDavid ◽  
Bokai Wang ◽  
Xing Qiu ◽  
James Java ◽  
...  
Keyword(s):  
Infant Health ◽  
Term Infant ◽  
Full Term ◽  
First Year ◽  
Body Site ◽  
Clinical Practices ◽  
Dynamic Interactions ◽  
Term Infants ◽  
First Year Of Life ◽  
Respiratory Microbiota

ABSTRACTBackground: Postnatal development of the microbiota in early life influences immunity, metabolism, neurodevelopment and long-term infant health. Microbiome development occurs at multiple body sites, each with distinct community compositions and functions. Associations between microbiota at multiple sites represent an unexplored influence on the infant microbiome. Here, we examined co-occurrence patterns of gut and respiratory microbiota in pre- and full-term infants over the first year of life, a period critical to neonatal development and risk of respiratory diseases.Results: Gut and respiratory microbiota collected as longitudinal rectal, throat and nasal samples from 38 pre-term and 44 full-term infants were first clustered into community state types (CSTs) on the basis of their composition. Multiple methods were used to relate the occurrence of CSTs to several measures of infant maturity, including gestational age (GA) at birth, week of life (WOL), and post menstrual age (PMA: equal to GA plus WOL). Manifestation of CSTs followed one of three patterns with respect to infant maturity. First, chronological: independent of infant maturity (GA) at birth, and strongly associated with post-natal age (WOL). Second, idiosyncratic: primarily dependent on maturity (GA) at birth, with persistent differences in CST occurrence between pre- and full-term infants through the first year of life. Third, convergent: CSTs appear earlier in infants with greater maturity (GA) at birth, but after a sufficient post-natal interval their occurrence in pre-term infants reaches parity with full-term infants. The composition of CSTs was highly dissimilar between different body sites, but the CST of any one body site was highly predictive of the CSTs at other body sites. There were significant associations between the abundance of individual taxa at each body site and the CSTs of the other body sites, which persisted after stringent control for the non-linear effects of infant maturity. Significant canonical correlations exist between the microbiota composition at each pair of body sites, with the strongest correlations between more proximal locations.Conclusion: Cross-body site associations of developing infant microbiota suggest the importance of research and clinical practices that focus on dynamic interactions between multiple microbial communities to elucidate and promote systemic microbiota development.

Motor trajectories of preterm and full‐term infants in the first year of life

2019 ◽  
Vol 61 (10) ◽  
pp. 967-977 ◽  
Author(s):  
Nadia Cristina Valentini ◽  
Keila Ruttnig Guidony Pereira ◽  
Eloá Maria dos Santos Chiquetti ◽  
Cibelle Kayenne Martins Roberto Formiga ◽  
Maria Beatriz Martins Linhares
Keyword(s):  
Full Term ◽  
First Year ◽  
Term Infants ◽  
First Year Of Life

scholarly journals Humoral markers of endothelial dysfunction in children of the first year of life born with intrauterine growth retardation syndrome

2020 ◽  
Vol 64 (6) ◽  
pp. 57-61
Author(s):  
S. Yu. Zakharova ◽  
L. G. Levina
Keyword(s):  
Functional State ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Main Group ◽  
Full Term ◽  
First Year ◽  
Endothelin 1 ◽  
Intrauterine Growth ◽  
Term Newborns ◽  
First Year Of Life

The article presents data on the functional state of endothelium in children of the first year of life, born with different variants of intrauterine growth retardation syndrome. The main group consisted of 60 full-term newborns with hypotrophic and hypoplastic variants of intrauterine growth retardation syndrome. The comparison group included 20 full-term newborns with normal anthropometric indicators. The examination was conducted on 7–10 days of life and at the age of 1 year of life. Newborns of the main group had deviations in health status: perinatal damage to the central nervous system, anemia, irregular colonization of the intestinal microflora, hyperbilirubinemia. Violations of the functional state of the endothelium was manifested by a change in the ratio of vasoconstrictors and vasodilators, in particular, a reduced content of endothelin-1 and nitric oxide in the blood and an increased content of renin and vascular endothelial growth factor. During the first year of life, all children were diagnosed with physical underdevelopment. Violation of the functional state of the endothelium was manifested by an increase in the level of endothelin-1, which is a vasoconstrictor. The results obtained allow to suggest that the identified changes contribute to the disruption of blood circulation and gas exchange in the organs and systems that ensure the growth and development of children.

scholarly journals Microbiota development in early life mediates association between mode of delivery and vaccine responses

2021 ◽  
Author(s):  
Emma M. de Koff ◽  
Debbie van Baarle ◽  
Marlies A. van Houten ◽  
Marta Reyman ◽  
Guy A.M. Berbers ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Mode Of Delivery ◽  
Microbial Community Composition ◽  
First Year ◽  
Vaccine Responses ◽  
Childhood Vaccines ◽  
First Year Of Life ◽  
Immune Maturation ◽  
Conjugate Vaccination

The gut microbiota in early life, when critical immune maturation takes place, may influence the immunogenicity of childhood vaccinations. We assessed the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific immunoglobulin G (IgG) responses against pneumococcal and meningococcal conjugate vaccination at ages 12 and 18 months, respectively, in a prospective birth cohort of 120 infants. Birth by natural delivery was associated with higher IgG responses against both vaccines, which for the anti-pneumococcal IgG response could be explained by a gut microbial community composition with high abundances of Bifidobacterium and Escherichia coli in the first weeks of life. High E. coli abundance in the same period was also associated with higher anti-meningococcal IgG responses. Our results suggest that associations between mode of delivery and antibody responses to routine childhood vaccines are mediated by gut microbiota development.

scholarly journals Effect of massage stimulation on weight gain in full term infants

2011 ◽  
Vol 51 (4) ◽  
pp. 202
Author(s):  
Nyoman Nursari Dewi ◽  
Soetjiningsih Soetjiningsih ◽  
Endy Paryanto Prawirohartono
Keyword(s):  
Weight Gain ◽  
Full Term ◽  
The Body ◽  
Control Group ◽  
Infant Massage ◽  
Term Infants ◽  
Massage Group ◽  
Quasi Experimental ◽  
Infant Weight Gain ◽  
And Control

Background Massage is a tactile/kinesthetic stimulation with biochemical and physiological effects on the body. Newborn infant massage stimulation given by mothers may promote maternal-infant bonding and attachment, enhance infant weight gain and stimulate the production of breast milk. There have been few studies on the effect of massage stimulation on weight gain in full term infants, and this topic remains controversial.Objective To examine the effect of massage stimulation on weight gain in full term infants.Methods This quasi-experimental study was held in Sanglah Hospital and Bunda Setia Maternity Clinic. Massage stimulation was performed by mothers once daily for a four week period. Massage stimulation was given to 30 full term infants and their weight gain was compared to 31 control infants who did not receive massages.Results There were no differences in subject characteristics between the massage and control groups. Median weight gain in the massage group was 1230 grams, while that in the control group was 830 grams (P=0.028).Conclusion Weight gain in full term infants in the massage group was significantly greater than that in the control group after 4 weeks.

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