scholarly journals Intermittent Fasting Ameliorated High-Fat Diet-Induced Memory Impairment in Rats via Reducing Oxidative Stress and Glial Fibrillary Acidic Protein Expression in Brain

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 10
Author(s):  
Suzan M. Hazzaa ◽  
Mabrouk A. Abd Eldaim ◽  
Amira A. Fouda ◽  
Asmaa Shams El Dein Mohamed ◽  
Mohamed Mohamed Soliman ◽  
...  
Keyword(s):  
Body Weight ◽  
Glial Fibrillary Acidic Protein ◽  
Brain Tissue ◽  
High Fat Diet ◽  
Serum Lipids ◽  
Memory Performance ◽  
Granular Cell ◽  
Intermittent Fasting ◽  
High Fat ◽  
Cell Layers

Intermittent fasting (IF) plays an important role in the protection against metabolic syndrome-induced memory defects. This study aimed to assess the protective effects of both prophylactic and curative IF against high-fat diet (HFD)-induced memory defects in rats. The control group received a normal diet; the second group received a HFD; the third group was fed a HFD for 12 weeks and subjected to IF during the last four weeks (curative IF); the fourth group was fed a HFD and subjected to IF simultaneously (prophylactic IF). A high-fat diet significantly increased body weight, serum lipids levels, malondialdehyde (MDA) concentration, glial fibrillary acidic protein (GFAP) and H score in brain tissue and altered memory performance. In addition, it significantly decreased reduced glutathione (GSH) concentration in brain tissue and viability and thickness of pyramidal and hippocampus granular cell layers. However, both types of IF significantly decreased body weight, serum lipids, GFAP protein expression and H score and MDA concentration in brain tissue, and improved memory performance, while it significantly increased GSH concentration in brain tissue, viability, and thickness of pyramidal and granular cell layers of the hippocampus. This study indicated that IF ameliorated HFD-induced memory disturbance and brain tissue damage and the prophylactic IF was more potent than curative IF.

scholarly journals Green Coffee Extract Modifies Body Weight, Serum Lipids and TNF-α in High-Fat Diet-Induced Obese Rats

2019 ◽  
Author(s):  
Fajar Fitri ◽  
Zelly Dia Rofinda ◽  
Mohamad Reza ◽  
Cimi Ilmiawati
Keyword(s):  
Body Weight ◽  
Effective Dose ◽  
High Fat Diet ◽  
Serum Lipids ◽  
Potential Candidate ◽  
Green Coffee ◽  
High Fat ◽  
Tnf Α ◽  
Obese Rats ◽  
Α Level

Abstract Objective: Currently there are many efforts to find functional nutrients for obesity management and green coffee extract is a potential candidate. This study aimed to examine the effect of green coffee extract on body weight, serum lipids and TNF-α level in obese rats. Results: Administration of green coffee extract to high-fat diet-induced male Wistar rats (Rattus norvegicus) reduced body weight, serum total cholesterol, and triglyceride at the dose of 2, 4, and 8 mg/kgBW/day; lowered LDL-cholesterol and TNF-α at the dose of 4 mg/kgBW/day (p<0.05), in a dose–dependent manner. The effective dose to decrease serum TNF-α level was 4 mg/kgBW/day, while the effective dose to improve the lipid profile was 2 mg/kgBW/day. These results supported the potential use of green coffee extract as a functional nutrient in the management of obesity.

scholarly journals Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Cimi Ilmiawati ◽  
Fajar Fitri ◽  
Zelly Dia Rofinda ◽  
Mohamad Reza
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Serum Lipids ◽  
Green Coffee ◽  
High Fat ◽  
Tnf Α ◽  
Obese Rats

scholarly journals Green Coffee Extract Modifies Body Weight, Serum Lipids and TNF-α in High-Fat Diet-Induced Obese Rats

2020 ◽  
Author(s):  
Cimi Ilmiawati ◽  
Fajar Fitri ◽  
Zelly Dia Rofinda ◽  
Mohamad Reza
Keyword(s):  
Body Weight ◽  
Effective Dose ◽  
High Fat Diet ◽  
Serum Lipids ◽  
Total Serum ◽  
Green Coffee ◽  
High Fat ◽  
Tnf Α ◽  
Obese Rats ◽  
Α Level

Abstract Objective: Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of the green coffee extract on body weight, serum lipids, and TNF-α level in obese rats. Results: Administration of green coffee extract to high-fat diet-induced male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered LDL-cholesterol at the treatment of 20 mg/kg BW/day (p<0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results supported the potential use of green coffee extract as a functional nutrient in the management of obesity

Effect of Garlic on Serum Lipids Profiles and Leptin in Rats Fed High Fat Diet

2006 ◽  
Vol 11 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Soon-Ah Kang ◽  
Ho-Jung Shin ◽  
Ki-Hyo Jang ◽  
Sung-Eun Choi ◽  
Kyung-Ah Yoon ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Serum Lipids ◽  
High Fat

scholarly journals Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 464 ◽  
Author(s):  
Bright Asare-Bediako ◽  
Sunil Noothi ◽  
Sergio Li Calzi ◽  
Baskaran Athmanathan ◽  
Cristiano Vieira ◽  
...  
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Fundus Photography ◽  
Vascular Density ◽  
Sensitivity Index ◽  
High Fat ◽  
Permeability Studies ◽  
Induced Changes ◽  
Acellular Capillaries

We sought to delineate the retinal features associated with the high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either a high-fat (60% fat; HFD) or low-fat (10% fat; LFD) diet for up to 12 months. The effect of HFD on body weight and insulin resistance were measured. The retina was assessed by electroretinogram (ERG), fundus photography, permeability studies, and trypsin digests for enumeration of acellular capillaries. The HFD cohort experienced hypercholesterolemia when compared to the LFD cohort, but not hyperglycemia. HFD mice developed a higher body weight (60.33 g vs. 30.17g, p < 0.0001) as well as a reduced insulin sensitivity index (9.418 vs. 62.01, p = 0.0002) compared to LFD controls. At 6 months, retinal functional testing demonstrated a reduction in a-wave and b-wave amplitudes. At 12 months, mice on HFD showed evidence of increased retinal nerve infarcts and vascular leakage, reduced vascular density, but no increase in number of acellular capillaries compared to LFD mice. In conclusion, the HFD mouse is a useful model for examining the effect of prediabetes and hypercholesterolemia on the retina. The HFD-induced changes appear to occur slower than those observed in type 2 diabetes (T2D) models but are consistent with other retinopathy models, showing neural damage prior to vascular changes.

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