scholarly journals Iron Supplementation Influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency—A Literature-Based Review

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1993 ◽  
Author(s):  
Ioana Gabriela Rusu ◽  
Ramona Suharoschi ◽  
Dan Cristian Vodnar ◽  
Carmen Rodica Pop ◽  
Sonia Ancuța Socaci ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Gut Microbiota ◽  
Human Body ◽  
Iron Concentration ◽  
The Body ◽  
Oxidation Reduction ◽  
Global Issue ◽  
And Control ◽  
And Storage ◽  
Electron Transfer Mediation

Iron deficiency in the human body is a global issue with an impact on more than two billion individuals worldwide. The most important functions ensured by adequate amounts of iron in the body are related to transport and storage of oxygen, electron transfer, mediation of oxidation-reduction reactions, synthesis of hormones, the replication of DNA, cell cycle restoration and control, fixation of nitrogen, and antioxidant effects. In the case of iron deficiency, even marginal insufficiencies may impair the proper functionality of the human body. On the other hand, an excess in iron concentration has a major impact on the gut microbiota composition. There are several non-genetic causes that lead to iron deficiencies, and thus, several approaches in their treatment. The most common methods are related to food fortifications and supplements. In this review, following a summary of iron metabolism and its health implications, we analyzed the scientific literature for the influence of iron fortification and supplementation on the gut microbiome and the effect of probiotics, prebiotics, and/or synbiotics in iron absorption and availability for the organism.

No Difference Between Iron Supplementation Only and Iron Supplementation with Synbiotic Fermented Milk on Iron Status, Growth, and Gut Microbiota Profile in Elementary School Children with Iron Deficiency

2020 ◽  
Vol 16 (2) ◽  
pp. 220-227 ◽  
Author(s):  
Siti Helmyati ◽  
Endang Sutriswati Rahayu ◽  
Bernadette Josephine Istiti Kandarina ◽  
Mohammad Juffrie
Keyword(s):  
Iron Deficiency ◽  
Gut Microbiota ◽  
School Children ◽  
Elementary School Children ◽  
Iron Supplementation ◽  
Iron Status ◽  
Body Height ◽  
Fermented Milk ◽  
The Body ◽  
Iron Deficient

Background: Iron deficiency may inhibit the height increase and weight gain of children. On the other hand, the supplementation of iron causes gut microbiota imbalance which leads to inflammation and diarrhea. The addition of synbiotic fermented milk is expected to have beneficial effects on iron supplementation. This study aimed to determine the effects of iron supplementation only and its administration with synbiotic fermented milk on iron status, body height and weight, and gut microbiota profile of iron deficient elementary school children. Methods: This research was an experimental study with pre and post test conducted on 59 irondeficient children. Subjects were given iron supplementation in syrups (IS group) or given iron supplementation in syrup with fermented milk (containing synbiotic Lactobacillus plantarum Dad 13 and fructo-oligosaccharide) (ISFM group) for 3 months. The body weight and height, hemoglobin and serum ferritin levels, and total number of Lactobacilli, Enterobacteria, Bifidobacteria, and Escherichia coli were measured at the beginning and the end of the study. Results: The body height in the ISFM group increased significantly than that in IS group after the intervention (1.67 vs. 2.42, p<0.05). The hemoglobin and serum ferritin levels in IS and ISFM groups were improved significantly (p<0.05) although the difference between the two groups was not significant (p>0.05). The results showed no significant difference of gut microbiota profile between the IS and ISFM groups (p>0.05). Conclusion: There is no difference on the iron status, height, weight, and gut microbiota profile of iron-deficient primary school children received iron supplementation only or iron supplementation with synbiotic fermented milk.

Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability

2007 ◽  
Vol 232 (8) ◽  
pp. 1014-1020 ◽  
Author(s):  
Jerome l. Sullivan
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Atherosclerotic Plaque ◽  
Animal Studies ◽  
Iron Concentration ◽  
Normal Subjects ◽  
Lesion Size ◽  
The Body ◽  
Deficiency Anemia ◽  
Iron Depletion

Hepcidin has emerged as the key hormone in the regulation of iron balance and recycling. Elevated levels increase iron in macrophages and inhibit gastrointestinal iron uptake. The physiology of hepcidin suggests an additional mechanism by which iron depletion could protect against atherosclerotic lesion progression. Without hepcidin, macrophages retain less iron. Very low hepcidin levels occur in iron deficiency anemia and also in homozygous hemochromatosis. There is defective retention of iron in macrophages in hemochromatosis and also evidently no increase in atherosclerosis in this disorder. In normal subjects with intact hepcidin responses, atherosclerotic plaque has been reported to have roughly an order of magnitude higher iron concentration than that in healthy arterial wall. Hepcidin may promote plaque destabilization by preventing iron mobilization from macrophages within atherosclerotic lesions; the absence of this mobilization may result in increased cellular iron loads, lipid peroxidation, and progression to foam cells. Marked downregulation of hepcidin (e.g., by induction of iron deficiency anemia) could accelerate iron loss from intralesional macrophages. It is proposed that the minimally proatherogenic level of hepcidin is near the low levels associated with iron deficiency anemia or homozygous hemochromatosis. Induced iron deficiency anemia intensely mobilizes macrophage iron throughout the body to support erythropoiesis. Macrophage iron in the interior of atherosclerotic plaques is not exempt from this process. Decreases in both intralesional iron and lesion size by systemic iron reduction have been shown in animal studies. It remains to be confirmed in humans that a period of systemic iron depletion can decrease lesion size and increase lesion stability as demonstrated in animal studies. The proposed effects of hepcidin and iron in plaque progression offer an explanation of the paradox of no increase in atherosclerosis in patients with hemochromatosis despite a key role of iron in atherogenesis in normal subjects.

scholarly journals A Framework for the Collection, Retention and Use of Human Body Parts

2021 ◽  
Author(s):  
◽  
Cordelia Mary Thomas
Keyword(s):  
Decision Making ◽  
Cultural Values ◽  
Human Body ◽  
Rapid Development ◽  
Legal Framework ◽  
The Body ◽  
Body Parts ◽  
Property Interest ◽  
Bioethical Issues ◽  
And Control

<p>Organ transplantation and biotechnological research depend on the availability of body parts, which necessitates the willing involvement of the public. The rapid development of biotechnology has led to a search for an adequate decision-making framework for the acquisition, retention and utilisation of body parts. It has also lead to disquiet about the commercialisation of research with the source being the only participant who is unable to benefit financially. In developing such a framework it is necessary to conceptualise the nature of the interest that individuals have in their bodies. The principle of autonomy may form a basis for structuring decision-making and weighing conflicting principles. As a society we value autonomy in the sense that a competent adult may make decisions about his or her own health care. The concept is that of an individual separated from others by a wall of rights. This may be of assistance as a basis for formulating competing rights, but this must then be mediated with reference to other principles. In this context this thesis applies the concepts of property interests to the human body. The purpose of this research is to consider selected bioethical issues in an attempt to formulate a principled approach to issues of consent and control over the body and its component parts. It argues that a living person should have a property interest in excised body parts during life. There should also be a property interest in the cadaver that arises at the point of death, which can be passed to the deceased's personal representative, who would be required to deal with the cadaver in accord with the previous instructions of the deceased. However, it does not argue that there are property interests in entire living persons. It does not suggest that property alone is adequate to resolve the issues, but that it should operate alongside existing concepts such as autonomy, informed consent and privacy. It proposes draft legislation to illustrate the operation of the suggested medico-legal framework. It recognises that any framework should be respectful of Maori cultural values, in light of the special position of Maori as tangata whenua, as expressed in the Treaty of Waitangi. It argues that the framework allows Maori the freedom to choose collective or individualistic decision-making, in recognition of the diversity of values within the Maori population. In addition, it considers areas where public policy might determine that the free disposition of this property interest should be restricted to protect vulnerable persons, such as incompetent persons and living organ donors.</p>

scholarly journals Electrochemically Activated Water Catholyte for the Activation of Hydrogen Ions and ATP for Sport’s Shape and Recovery

2020 ◽  
pp. 112-119
Author(s):  
Ignat Ignatov ◽  
Nezabravka Gencheva ◽  
Todor Marinov ◽  
Iliana Yaneva ◽  
Mariana Angelcheva ◽  
...  
Keyword(s):  
Human Body ◽  
Physical Exertion ◽  
Medical Doctor ◽  
The Body ◽  
Physical Workload ◽  
Negative Effects ◽  
Oxidation Reduction ◽  
Football Team ◽  
Football Match ◽  
Cardio Vascular

The biological processes of a human body occur in liquid medium. The human body contains around 55-60% of water in young people. At birth the percentage is around 75%, and in elderly people it is - 50-55% (by weight). The state of water in the body of athletes is an indicator for their status during physical exertion and recovery. Dehydration is a natural process developing during the period of training and football match, which influences the functioning of the locomotor, nervous, respiratory and cardio-vascular systems. The research of Ivaylo Yakimov for the period 2014-2019 from Bulgarian football players confirmed the importance of the requirement for the footballers to start physical workload optimally hydrated, in order to slow down and decrease the influence of the negative effects from the inevitable dehydration during a football match. Yakimov is а medical doctor in the football team Ludogorets. One of the co-authors considers the possibility for hydration and recovery to be done using water with hydrogen index pH over 8.5, and a negative oxidation reduction potential (ORP). The results show that footballers, who drink Catholyte water have better heart indicators compared to the ones they would have if they drink table water. Analyses are conducted of processes in ATP and mitochondria in the cell for faster achieving of maximum sports performance and recovery.

scholarly journals Farm Stage, Bird Age, and Body Site Dominantly Affect the Quantity, Taxonomic Composition, and Dynamics of Respiratory and Gut Microbiota of Commercial Layer Chickens

2019 ◽  
Vol 85 (9) ◽  
Author(s):  
John M. Ngunjiri ◽  
Kara J. M. Taylor ◽  
Michael C. Abundo ◽  
Hyesun Jang ◽  
Mohamed Elaish ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Gut Microbiota ◽  
Taxonomic Composition ◽  
The Body ◽  
Production Performance ◽  
Body Site ◽  
Upper Respiratory Tract ◽  
Commercial Chicken ◽  
And Control ◽  
Respiratory Microbiota

ABSTRACTThe digestive and respiratory tracts of chickens are colonized by bacteria that are believed to play important roles in the overall health and performance of the birds. Most of the current research on the commensal bacteria (microbiota) of chickens has focused on broilers and gut microbiota, and less attention has been given to layers and respiratory microbiota. This research bias has left significant gaps in our knowledge of the layer microbiome. This study was conducted to define the core microbiota colonizing the upper respiratory tract (URT) and lower intestinal tract (LIT) in commercial layers under field conditions. One hundred eighty-one chickens were sampled from a flock of >80,000 birds at nine times to collect samples for 16S rRNA gene-based bacterial metabarcoding. Generally, the body site and age/farm stage had very dominant effects on the quantity, taxonomic composition, and dynamics of core bacteria. Remarkably, ileal and URT microbiota were compositionally more related to each other than to that from the cecum. Unique taxa dominated in each body site yet some taxa overlapped between URT and LIT sites, demonstrating a common core. The overlapping bacteria also contained various levels of several genera with well-recognized avian pathogens. Our findings suggest that significant interaction exists between gut and respiratory microbiota, including potential pathogens, in all stages of the farm sequence. The baseline data generated in this study can be useful for the development of effective microbiome-based interventions to enhance production performance and to prevent and control disease in commercial chicken layers.IMPORTANCEThe poultry industry is faced with numerous challenges associated with infectious diseases and suboptimal performance of flocks. As microbiome research continues to grow, it is becoming clear that poultry health and production performance are partly influenced by nonpathogenic symbionts that occupy different habitats within the bird. This study has defined the baseline composition and overlaps between respiratory and gut bacteria in healthy, optimally performing chicken layers across all stages of the commercial farm sequence. Consequently, the study has set the groundwork for the development of interventions that seek to enhance production performance and to prevent and control infectious diseases through the modulation of gut and respiratory bacteria.

scholarly journals Evidence for Multiple, Distinct Representations of the Human Body

2005 ◽  
Vol 17 (4) ◽  
pp. 543-553 ◽  
Author(s):  
John Schwoebel ◽  
H. Branch Coslett
Keyword(s):  
Human Body ◽  
Semantic Information ◽  
Single Case ◽  
Body Representation ◽  
The Body ◽  
Body Representations ◽  
Impaired Performance ◽  
On Line ◽  
Components Analysis ◽  
And Control

Previous data from single-case and small group studies have suggested distinctions among structural, conceptual, and online sensorimotor representations of the human body. We developed a battery of tasks to further examine the prevalence and anatomic substrates of these body representations. The battery was administered to 70 stroke patients. Fifty-one percent of the patients were impaired relative to controls on at least one body representation measure. Further, principal components analysis of the patient data as well as direct comparisons of patient and control performance suggested a triple dissociation between measures of the 3 putative body representations. Consistent with previous distinctions between the “what” and “how” pathways, lesions of the left temporal lobe were most consistently associated with impaired performance on tasks assessing knowledge of the shape or lexical-semantic information about the body, whereas lesions of the dorsolateral frontal and parietal regions resulted in impaired performance on tasks requiring on-line coding of body posture.

scholarly journals A Framework for the Collection, Retention and Use of Human Body Parts

2021 ◽  
Author(s):  
◽  
Cordelia Mary Thomas
Keyword(s):  
Decision Making ◽  
Cultural Values ◽  
Human Body ◽  
Rapid Development ◽  
Legal Framework ◽  
The Body ◽  
Body Parts ◽  
Property Interest ◽  
Bioethical Issues ◽  
And Control

<p>Organ transplantation and biotechnological research depend on the availability of body parts, which necessitates the willing involvement of the public. The rapid development of biotechnology has led to a search for an adequate decision-making framework for the acquisition, retention and utilisation of body parts. It has also lead to disquiet about the commercialisation of research with the source being the only participant who is unable to benefit financially. In developing such a framework it is necessary to conceptualise the nature of the interest that individuals have in their bodies. The principle of autonomy may form a basis for structuring decision-making and weighing conflicting principles. As a society we value autonomy in the sense that a competent adult may make decisions about his or her own health care. The concept is that of an individual separated from others by a wall of rights. This may be of assistance as a basis for formulating competing rights, but this must then be mediated with reference to other principles. In this context this thesis applies the concepts of property interests to the human body. The purpose of this research is to consider selected bioethical issues in an attempt to formulate a principled approach to issues of consent and control over the body and its component parts. It argues that a living person should have a property interest in excised body parts during life. There should also be a property interest in the cadaver that arises at the point of death, which can be passed to the deceased's personal representative, who would be required to deal with the cadaver in accord with the previous instructions of the deceased. However, it does not argue that there are property interests in entire living persons. It does not suggest that property alone is adequate to resolve the issues, but that it should operate alongside existing concepts such as autonomy, informed consent and privacy. It proposes draft legislation to illustrate the operation of the suggested medico-legal framework. It recognises that any framework should be respectful of Maori cultural values, in light of the special position of Maori as tangata whenua, as expressed in the Treaty of Waitangi. It argues that the framework allows Maori the freedom to choose collective or individualistic decision-making, in recognition of the diversity of values within the Maori population. In addition, it considers areas where public policy might determine that the free disposition of this property interest should be restricted to protect vulnerable persons, such as incompetent persons and living organ donors.</p>

scholarly journals Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Chang Yi Shi ◽  
Chen Huan Yu ◽  
Wen Ying Yu ◽  
Hua Zhong Ying
Keyword(s):  
Gut Microbiota ◽  
Human Body ◽  
Respiratory Diseases ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
The Body ◽  
Lymphoid Cells ◽  
Next Generation Sequencing Technology ◽  
Chronic Respiratory Diseases ◽  
Therapeutic Modalities

The microbiota colonized in the human body has a symbiotic relationship with human body and forms a different microecosystem, which affects human immunity, metabolism, endocrine, and other physiological processes. The imbalance of microbiota is usually linked to the aberrant immune responses and inflammation, which eventually promotes the occurrence and development of respiratory diseases. Patients with chronic respiratory diseases, including asthma, COPD, bronchiectasis, and idiopathic pulmonary fibrosis, often have alteration of the composition and function of intestinal and lung microbiota. Gut microbiota affects respiratory immunity and barrier function through the lung-gut microbiota, resulting in altered prognosis of chronic respiratory diseases. In turn, lung dysbiosis promotes aggravation of lung diseases and causes intestinal dysfunction through persistent activation of lymphoid cells in the body. Recent advances in next-generation sequencing technology have disclosed the pivotal roles of lung-gut microbiota in the pathogenesis of chronic respiratory diseases. This review focuses on the association between the gut-lung dysbiosis and respiratory diseases pathogenesis. In addition, potential therapeutic modalities, such as probiotics and fecal microbiota transplantation, are also evaluated for the prevention of chronic respiratory diseases.

Equilibration of Tracer Radioiron with Body Iron

1980 ◽  
Vol 58 (1) ◽  
pp. 93-100 ◽  
Author(s):  
R. W. Charlton ◽  
L. P. Fatti ◽  
S. R. Lynch ◽  
J. D. Torrance ◽  
T. H. Bothwell
Keyword(s):  
Iron Deficiency ◽  
Mathematical Models ◽  
Iron Deficiency Anaemia ◽  
The Body ◽  
Iron Loss ◽  
Ferritin Concentration ◽  
Deficiency Anaemia ◽  
Body Iron ◽  
Initial Plasma ◽  
And Storage

1. The degree to which a tracer quantity of 55Fe bound to transferrin and introduced into the plasma 36 months previously had equilibrated with the body iron was studied in a subject who was phlebotomized repeatedly until iron-deficiency anaemia developed. 2. Analysis of the results with two mathematical models showed that equilibration with haemoglobin iron and storage iron was complete. 3. Estimates of the quantity of iron initially stored in the body by three different methods yielded values of 37·3, 33·1 and 34·8 mmol. 4. Since the previously determined mean initial plasma ferritin concentration was 185 μg/l (462 pmol/l), there was 0·179–0·197 mmol of stored iron per 1 μg of plasma ferritin/l. 5. The study suggests that the assumption on which currently accepted values for daily body iron loss were calculated is valid.

scholarly journals SALIVA IRON AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA AND IRON DEFICIENCY ANEMIA

2012 ◽  
Vol 4 (1) ◽  
pp. e2012051 ◽  
Author(s):  
Duran Canatan ◽  
Sevgi Kosaci Akdeniz
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Iron Concentration ◽  
Thalassemia Major ◽  
The Body ◽  
Deficiency Anemia ◽  
Control Group ◽  
Healthy Children ◽  
Positive Correlation

Most of the  techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at different systemic diseases shows the quantity of the element at the body. The aim of this study was to compare the levels of iron and ferritin in saliva and serum in patients  with thalassemia and iron deficiency anemia. For this purpose, 35 healthy children as control group and 71 thalassemia major, 10 thalassemia intermedia and 15 thalassemia trait patients were involved. Their saliva  and serum iron and ferritin levels were measured.  There was no statistically difference between age and gender in all groups and control group (p>0.05).  In all groups saliva iron levels are higher than serum iron levels(p<0.05). Furthermore there was a positive correlation betwen serum and saliva  iron levels in thalassemia major, intermedia and trait groups ( p=0.000, r=0.972, r=0.720, r=0.955) and also there was a positive correlation between serum and saliva iron levels in control and iron deficiency group (p= 0.000, r= 0.885, r= 0.368).  In conclusion,  Saliva iron and ferritin levels increase  as well as serum in patients with thalassemia and decrease in patients with iron deficiency anemia. Saliva can be used for diagnosis routinely  to shows the iron overload  and deficiency of the body and its easy applicability and also a non-invasive procedure is important advantage.

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