Equilibration of Tracer Radioiron with Body Iron

1980 ◽  
Vol 58 (1) ◽  
pp. 93-100 ◽  
Author(s):  
R. W. Charlton ◽  
L. P. Fatti ◽  
S. R. Lynch ◽  
J. D. Torrance ◽  
T. H. Bothwell
Keyword(s):  
Iron Deficiency ◽  
Mathematical Models ◽  
Iron Deficiency Anaemia ◽  
The Body ◽  
Iron Loss ◽  
Ferritin Concentration ◽  
Deficiency Anaemia ◽  
Body Iron ◽  
Initial Plasma ◽  
And Storage

1. The degree to which a tracer quantity of 55Fe bound to transferrin and introduced into the plasma 36 months previously had equilibrated with the body iron was studied in a subject who was phlebotomized repeatedly until iron-deficiency anaemia developed. 2. Analysis of the results with two mathematical models showed that equilibration with haemoglobin iron and storage iron was complete. 3. Estimates of the quantity of iron initially stored in the body by three different methods yielded values of 37·3, 33·1 and 34·8 mmol. 4. Since the previously determined mean initial plasma ferritin concentration was 185 μg/l (462 pmol/l), there was 0·179–0·197 mmol of stored iron per 1 μg of plasma ferritin/l. 5. The study suggests that the assumption on which currently accepted values for daily body iron loss were calculated is valid.

scholarly journals Nutrition Knowledge is Associated With the Consumption of Iron Rich Foods: A Survey Among Pregnant Women From a Rural District in Northern Ghana

2021 ◽  
Vol 14 ◽  
pp. 117863882110394
Author(s):  
Nhyira Yaw Adjei-Banuah ◽  
Victor Abugah Aduah ◽  
Shamsu-Deen Ziblim ◽  
Martin Amogre Ayanore ◽  
Anthony Amalba ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anaemia ◽  
Nutrition Knowledge ◽  
The Body ◽  
Rural District ◽  
Leafy Vegetables ◽  
Health Concern ◽  
Deficiency Anaemia ◽  
Increased Risk

Introduction: Iron deficiency anaemia is an international public health concern and pregnant women are at an increased risk. We investigated the consumption of iron rich foods and associated factors among pregnant women in a rural district from Ghana. Methods: Following a cross-sectional design, dietary intake of iron rich foods was obtained from 252 pregnant women using a 24-hour recall food check list. Nutrition knowledge, attitudes and socio-demographic characteristics were also assessed. Findings: Participants had a mean (SD) knowledge score of 54.66 (22.74)%. About 73% of the participants had heard about iron-deficiency anaemia. Only 16.3% of the participants knew foods that help the body to absorb and use iron while 9.1% knew beverages that decrease iron absorption. About 71% of the participants ate fish and/or seafood while 67.1% of them ate green leafy vegetables. Only 4.4% of the participants ate organ meat, and 29% took flesh meat. Only 22.4% of the study participants usually drank coffee or tea while 78.2% ate vitamin C-rich foods. With regards to attitudes, 88.5% of the participants perceived anaemia to be a serious disease. Nutrition knowledge was significantly associated with the consumption of iron rich foods (β = .02; 95% CI = 0.01-0.02). Conclusion: Nutrition knowledge may be an important determinant of the consumption of iron rich foods among pregnant women making it necessary for healthcare providers to continue to provide nutrition education to pregnant women during routine antenatal care.

scholarly journals Evaluating iron deficiency anaemia in the third trimester of pregnancy with haematological parameters and serum ferritin concentration

2019 ◽  
Vol 8 (9) ◽  
pp. 3744
Author(s):  
Niranjani Selva Muthukumaran ◽  
Radha B. P. Thangappah ◽  
Amrin Azad ◽  
Kesari Sravaniy
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Ferritin Level ◽  
Haematological Parameters ◽  
Third Trimester ◽  
Ferritin Concentration ◽  
Deficiency Anaemia ◽  
The Third ◽  
The Mean

Background: Iron deficiency is the commonest cause of anaemia and at least half of anaemia cases will have causes other than iron deficiency. The objective of this study was to determine the prevalence of iron deficiency anaemia among antenatal mothers based on haematological parameters and serum ferritin levels.Methods: This was a hospital based cross sectional study, conducted at Meenakshi Medical College and Research Institute, Kancheepuram from January 2017 to June 2018. Two hundred antenatal mothers who were diagnosed with anaemia in the third trimester of pregnancy were evaluated by haematological parameters and serum ferritin assay.Results: 38% of women had mild anaemia, 50% had moderate anaemia and 12% had severe anaemia. On peripheral smear, 60% had microcytic hypochromic anaemia indicating iron deficiency, and 12% had megaloblastic anaemia. In 41% of cases, the mean corpuscular volume was <82fL indicative of iron deficiency. Among the 120 women diagnosed with iron deficiency anaemia on smear, the mean ferritin level was 16.62±73.42 (less than 30µg/l). There was a statistically significant low levels of serum ferritin levels in those diagnosed with iron deficiency anaemia (P < 0.05). The serum ferritin level was >160µg/lit in 19% of cases.Conclusions: Based on the haematological parameters and serum ferritin estimation, in 60% of cases, anaemia was due to iron deficiency. Before initiating treatment, it is important to differentiate various types of anaemia, so that appropriate treatment can be given.

scholarly journals A REVIEW ON COMPARITIVE STUDY ON SAFETY AND EFFECTIVENESS OF IV FERRIC CARBOXY MALTOSE VERSUS IRON SUCROSE IN PATIENTS WITH IRON DEFICIENCY ANAEMIA OF CKD

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
LAYANA V. S ◽  
RANI MANJU ◽  
MATHEW GEORGE ◽  
LINCY JOSEPH
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Iron Sucrose ◽  
Deficiency Anemia ◽  
Deficiency Anaemia ◽  
Body Iron ◽  
Iron Stores

Deficiency of iron is one of the most common nutritional disorders in the society. Iron deficiency anemia is described as decreased production in red blood cells (RBCs) due to low body iron stores.Anemia commonly occurs in people with chronic kidney disease and it might begin to develop in the early stages and tends to worsen as disease progresses. Iron supplementation is mandatory in the majority of patients with renal disease, particularly in those receiving ESA therapy. Treatment with intravenous iron in some clinical situations could present some advantages over oral iron, such as faster and higher increases of hemoglobin (Hb) levels and body iron stores. Some modern formulations of intravenous iron have emerged as a safe and effective alternative for iron deficiency anaemia management. E.g.: iron sucrose. Ferric carboxy maltose is a parenteral iron dextran-free product and the first of the new agents approved for rapid and high-dose replenishment of depleted iron stores. Keywords:  Iron deficiency anaemia, chronic kidney disease, hemoglobin, iron sucrose, ferric carboxy maltose

scholarly journals Hypoferritinaemia in anaemic patients attending a tertiary hospital in Maiduguri, Nigeria

2016 ◽  
Vol 10 ◽  
Author(s):  
Amos Dangana ◽  
Idris Abdullahi Nasir ◽  
Jessy Thomas Medugu ◽  
Peter Musa Omale ◽  
Bibiana Nonye Egenti
Keyword(s):  
Iron Deficiency ◽  
Clinical Diagnosis ◽  
Serum Ferritin ◽  
Iron Deficiency Anaemia ◽  
Enzyme Linked Immunosorbent Assay ◽  
World Population ◽  
Statistical Association ◽  
Ferritin Concentration ◽  
Deficiency Anaemia ◽  
Serum Ferritin Concentration

It has been reported that over one-quarter of the world population is anaemic and half of these were due to iron deficiency anaemia (IDA). Since serum ferritin is widely used to assess iron load, this study sought to determine the serum ferritin concentrations of anaemic patients attending the University of Maiduguri Teaching Hospital (UMTH), Nigeria. This study was prospective study carried out from March to September 2015. Blood samples of Ninety-one (91) anaemic patients were analysed for their individual packed cell volume (PCV) and serum ferritin concentrations using microhematocrit centrifuge and Enzyme linked immunosorbent assay (using Bio-Quant TM) respectively. Findings from these analyses were correlated in respect to their age, gender and prior clinical diagnosis. Out of 91 patients, 59 (64.8%) had normal and 28 (30.8%) had high ferritin concentration, however, 4 (4.4%) had hypoferritinamia. The overall mean± SD of PCV (L/L) was 0.21± 0.46. There was statistical association between serum ferritin concentration and gender of adults but not with gender of children (≤ 12 years) (P =.013 and P =.555 respectively). There was no significant statistical association between serum ferritin concentration with age of subjects (P = 0.250) and prior clinical diagnosis of subjects (P =.125) Serum ferritin has been proven to be a logical measure of iron deficiency anaemia; however hypoferritinaemia may also be affected by inflammation especially in subjects with chronic diseases. In order to gain better insight into iron metabolic activities, it is recommended to conduct serum transferrin total iron binding capacity assays in these patients.

scholarly journals Factors associated with iron deficiency anaemia among pregnant teenagers in Ashanti Region, Ghana: A hospital-based prospective cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250246
Author(s):  
Reginald Adjetey Annan ◽  
Linda Afriyie Gyimah ◽  
Charles Apprey ◽  
Anthony Kwaku Edusei ◽  
Odeafo Asamoah-Boakye ◽  
...  
Keyword(s):  
Cohort Study ◽  
Iron Deficiency ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Associated Factors ◽  
Iron Deficiency Anaemia ◽  
Serum Levels ◽  
Deficiency Anaemia ◽  
Body Iron ◽  
Iron Stores

Background Iron Deficiency Anaemia (IDA) is reportedly high in pregnant adults and the causes well studied. However, among pregnant teenagers, the levels and associated factors of IDA are not fully understood. Methods In a prospective cohort study among Ghanaian pregnant teenagers, aged 13–19 years, IDA prevalence and associated factors were investigated. Sociodemographic data, household hunger scale (HHS), lived poverty index (LPI), FAO’s women’s dietary diversity score (WDDS) and interventions received during antenatal care (ANC) were obtained from 416 pregnant teenagers in Ashanti Region, Ghana. Micronutrient intakes using a repeated 24-hour dietary recall, and mid-upper arm circumference (MUAC) were determined and blood samples analysed for haemoglobin (Hb), serum levels of ferritin, prealbumin, vitamin A, total antioxidant capacity (TAC), C-reactive protein (CRP), and zinc protoporphyrin (ZPP). Results Anaemia (Hb cutoff <11.0 g/dL) was 57.1%; deficient systemic supply of iron stores (31.4%), depleted body stores of iron (4.4%), inadequate dietary iron intake (94.5%), and inadequate multiple micronutrient intakes (49.5%), were all notable among study participants. Between-subject effects using Generalized Linear Modelling indicated malaria tablet given at ANC (p = 0.035), MUAC (p = 0.043), ZPP (p<0.001), ZPP/Hb ratio (p<0.001) and depleted body iron stores (DBIS) (p<0.001) to significantly affect Hb levels. Pregnant teenagers with a high ZPP/Hb ratio (OR = 9.7, p<0.001, 95%CI = 6.0–15.8) had increased odds of being anaemic compared to those with normal ZPP/Hb ratio. Participants who were wasted (OR = 1.2, p = 0.543, 95%CI = 0.6–2.3), and those with depleted iron stores (OR = 3.0, p = 0.167, 95%CI = 0.6–14.6) had increased odds of being anaemic. Participants who experienced hunger were close to 3 times more likely (OR = 2.9, p = 0.040, 95%CI = 1.1–7.8) for depleted iron stores, compared to those who did not experience hunger. Also, participants with inadequate multiple micronutrients intakes (OR = 2.6, p = 0.102, 95%CI = 0.8–8.4), and those with low serum levels of ferritin (OR = 3.3, p = 0.291, 95%CI = 0.4–29.2) had increased odds of depleted body iron stores. Conclusions IDA is common among pregnant teenagers and the related factors include malaria tablets given at ANC, maternal hunger, maternal MUAC, a deficient systemic supply of iron, depleted body iron stores, ZPP, and ZPP/Hb ratio. Appropriate interventions are urgently needed to address the causes of IDA among pregnant teenagers.

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