scholarly journals Does ENaC Work as Sodium Taste Receptor in Humans?

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1195 ◽  
Author(s):  
Albertino Bigiani

Taste reception is fundamental for the proper selection of food and beverages. Among the several chemicals recognized by the human taste system, sodium ions (Na+) are of particular relevance. Na+ represents the main extracellular cation and is a key factor in many physiological processes. Na+ elicits a specific sensation, called salty taste, and low-medium concentrations of table salt (NaCl, the common sodium-containing chemical we use to season foods) are perceived as pleasant and appetitive. How we detect this cation in foodstuffs is scarcely understood. In animal models, such as the mouse and the rat, the epithelial sodium channel (ENaC) has been proposed as a key protein for recognizing Na+ and for mediating preference responses to low-medium salt concentrations. Here, I will review our current understanding regarding the possible involvement of ENaC in the detection of food Na+ by the human taste system.

Geophysics ◽  
2016 ◽  
Vol 81 (4) ◽  
pp. V271-V282 ◽  
Author(s):  
Jorge H. Faccipieri ◽  
Tiago A. Coimbra ◽  
Leiv-J. Gelius ◽  
Martin Tygel

It is well known that the quality of stacking results (e.g., noise reduction, event enhancement, and continuity) can be greatly influenced not only by the traveltime operator chosen but also by the apertures used. We have considered two so-called diffraction-stack traveltimes, together with the corresponding apertures, designed to enhance reflections and diffractions, respectively. The first one is the common-reflection-surface (CRS) diffraction traveltime that is obtained from the general CRS traveltime upon the condition that the target reflector reduced to a point, which we refer to as the diffraction CRS (DCRS) traveltime. The second one is the double-square-root (DSR) traveltime, well established in time migration. We have observed that the DCRS and DSR traveltimes depend on fewer parameters (two in 2D and five in 3D) than the full CRS traveltime (three in 2D and eight in 3D). For the DCRS and DSR traveltimes, we have proposed specific apertures based on the projected Fresnel zone, which are able to produce high-quality stacked sections using less parameters to be estimated. The key factor in that approach lies in the choice of traveltime operators together with careful selection of stacking apertures. In particular, suitable choices of operators and apertures lead to stacking volumes in which reflections are enhanced (and the diffractions are attenuated) or the corresponding ones in which diffractions are enhanced (and reflections are attenuated). Synthetic and field data confirm the proposed approach has good potential for image-quality improvement.


2018 ◽  
Vol 26 (2) ◽  
pp. 275-296
Author(s):  
Athary Ibraheam Alshuaibi Athary Ibraheam Alshuaibi

Choosing a capital for any country or nation is a key factor in its organizational and economical composition. It also gives an impression about its social status and political vision. Most of the motives in choosing a capital for any country are usually unannounced. Researchers have to study that and link it to previous and next events to fully understand the reasons for choosing the capital of any nation. There were many states which ruled and led the Islamic nation world-wide or region-wide. Each of these states had a new capital usually made by them and different from the states before them. This process requires searching and studying from researchers for the motives of choosing the capital of any state. It also needs to be analyzed to discover the common reasons in choosing a capital in these states. For these reasons this study came to discuss the motives and to identify the common factors in choosing the capitals for the Islamic states. As a result, the researcher chose four capitals as a selected sample for the main Islamic caliphates and countries. These capitals are: Kufa, Damascus, Baghdad, and Cairo. The researcher divided the paper into four major parts, and tried through that to study the advantages of these capitals in different areas. These areas are : geography, strategy, military, politics, and economy. The researcher ended the paper with a conclusion which discussed the main results. Overall, the results show that the geographic factor is the most important reason in choosing a capital. Self-sufficiency in economic and food supply was also essential in choosing a capital so the capital does not require any help or support in general. The rulers did not ignore to choose a capital which is a center for their supporters or at least close to them. So, it is clear that choosing the Islamic capitals was done with a lot of efforts and planning. There were some basic features in choosing the capital which gave these states: political strength, and provided military, and economic importance to these states which allowed the capital to stay strong and thriving for long periods. key words: Islamic history - Islamic capitals - Islamic civilization.


Metahumaniora ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 354
Author(s):  
Ferli Hasanah

ABSTRAKGramatika pada setiap bahasa memiliki kekhasannya masing-masing.Mahasiswa Program Studi Sastra Perancis tahun pertama sebagai pembelajar pemulasering mengalami kesulitan dalam memahami gramatika bahasa. Kesulitan mereka tidakterlepas dari perbedaan-perbedaan mendasar pada struktur bahasa Indonesia sebagaibahasa ibu mereka dan bahasa Perancis yang tengah dipelajari. Penelitian ini dilaksanakandengan tujuan untuk mengetahui hambatan yang dimiliki mahasiswa pembelajar pemuladi Program Studi Sastra Perancis Universitas Padjadjaran dalam memahami gramatikabahasa Perancis. Metode yang digunakan dalam penelitian ini adalah metode simak dancatat. Hasil analisis ini menunjukkan bahwa kesalahan-kesalahan yang umum dilakukanpembelajar pemula ada pada penggunaan accent, konjugasi verba, partikel défini maupunindéfini, accord penanda feminin atau jamak, serta pemilihan preposisi.Kata kunci: gramatika, bahasa Perancis, konjugasiABST RACTThe grammar in every language has its own particularities. French literaturestudents in the first year as a beginner learners often have problem in understandingFrench grammar which is frequently considered difficult. Their struggle is inseparablefrom the fundamental differences between Indonesian structure as their mother tongueand the French language which being studied. This research aims to know the obstaclesof the students of beginner learners in the French Literature of Padjadjaran university inunderstanding the basic French grammar. The method used in this research is referringand taking notes method. The results of the analysis shows that the common mistakes oflearners are in the use of accents, verb conjugations, particles défini or indéfini, markeraccord feminine or plural, and the selection of prepositions.Keywords: grammar, French, conjugation


2020 ◽  
Vol 3 (152) ◽  
pp. 92-99
Author(s):  
S. M. Geiko ◽  
◽  
O. D. Lauta

The article provides a philosophical analysis of the tropological theory of the history of H. White. The researcher claims that history is a specific kind of literature, and the historical works is the connection of a certain set of research and narrative operations. The first type of operation answers the question of why the event happened this way and not the other. The second operation is the social description, the narrative of events, the intellectual act of organizing the actual material. According to H. White, this is where the set of ideas and preferences of the researcher begin to work, mainly of a literary and historical nature. Explanations are the main mechanism that becomes the common thread of the narrative. The are implemented through using plot (romantic, satire, comic and tragic) and trope systems – the main stylistic forms of text organization (metaphor, metonymy, synecdoche, irony). The latter decisively influenced for result of the work historians. Historiographical style follows the tropological model, the selection of which is determined by the historian’s individual language practice. When the choice is made, the imagination is ready to create a narrative. Therefore, the historical understanding, according to H. White, can only be tropological. H. White proposes a new methodology for historical research. During the discourse, adequate speech is created to analyze historical phenomena, which the philosopher defines as prefigurative tropological movement. This is how history is revealed through the art of anthropology. Thus, H. White’s tropical history theory offers modern science f meaningful and metatheoretically significant. The structure of concepts on which the classification of historiographical styles can be based and the predictive function of philosophy regarding historical knowledge can be refined.


2020 ◽  
Vol 62 ◽  
pp. 32-38
Author(s):  
E. A. Dolmatov ◽  
R. B. Borzayev ◽  
A. N. Shaipov

The results of the study of the duration of the juvenile period of indigenous Chechen willow leaf pear genotypes (Pyrus salicifolia Pall.) are given in connection with the acceleration of the breeding process and the use of selected forms in pear breeding for high precocity. The studies were carried out in 2016-2019 at OOO “Orchards of Chechnya” in accordance with the Agreement on creative cooperation with the Russian Research Institute of Fruit Crop Breeding. The work was carried out in accordance with generally accepted programs and methods. The objects of the study were one-year and two-year-old pear seedlings obtained from sowing seeds of selected dwarf and low-growing local Chechen forms of willow pear (P. salicifolia Pall.), laying fruit buds on annual growths and seedlings of Caucasian pear (P. caucasica Fed.), 20 500 pcs. of each specie. The aim of the research was to study the potential of precocity of willow pear seedlings and to reveal of selected forms with the greatest degree of this trait. Stratified seeds were sown in the sowing department of the OOO “Orchards of Chechnya” production nursery in April, 2017. The seedlings were grown according to the common technology in dryland conditions on the plot with chestnut soil. The first fl owering of plants was noted in the spring, 2019. As a result of the research, for the first time on a large number of the experimental material it was found that in the off spring of the indigenous Chechen willow leaf pear genotypes, the selection of a little more than 2% of seedlings with a very short juvenile period (2 years) was possible. They are of great interest in accelerating the breeding process and in the selection of new pear varieties with high precocity. 20 willow leaf pear genotypes were selected for the further use in breeding for high precocity and as sources of the trait of short juvenile period.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Elena Cagnoli Fiecconi

Abstract I argue that a study of the Nicomachean Ethics and of the Parva Naturalia shows that Aristotle had a notion of attention. This notion captures the common aspects of apparently different phenomena like perceiving something vividly, being distracted by a loud sound or by a musical piece, focusing on a geometrical problem. For Aristotle, these phenomena involve a specific selectivity that is the outcome of the competition between different cognitive stimuli. This selectivity is attention. I argue that Aristotle studied the common aspects of the physiological processes at the basis of attention and its connection with pleasure. His notion can explain perceptual attention and intellectual attention as voluntary or involuntary phenomena. In addition, it sheds light on how attention and enjoyment can enhance our cognitive activities.


Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1737
Author(s):  
Milan Banić ◽  
Dušan Stamenković ◽  
Aleksandar Miltenović ◽  
Dragan Jovanović ◽  
Milan Tica

The selection of a rubber compound has a determining influence on the final characteristics of rubber-metal springs. Therefore, the correct selection of a rubber compound is a key factor for development of rubber-metal vibration isolation springs with required characteristics. The procedure for the selection of the rubber compound for vibration isolation of rubber-metal springs has been proposed, so that the rubber-metal elements have the necessary characteristics, especially in terms of deflection. The procedure is based on numerical simulation of spring deflection with Bergström-Boyce constitutive model in virtual experiment, with a goal to determine which parameters of the constitutive model will lead to spring required deflection. The procedure was verified by case study defined to select rubber compound for a rubber–metal spring used in railway engineering.


2016 ◽  
Vol 27 (7) ◽  
pp. 1771-1780 ◽  
Author(s):  
Jaime Villacís ◽  
Cristina Armas ◽  
Susana Hang ◽  
Fernando Casanoves

Author(s):  
Irfan Ullah ◽  
Sridhar Kota

Abstract Use of mathematical optimization methods for synthesis of path-generating mechanisms has had only limited success due to the very complex nature of the commonly used Structural Error objective function. The complexity arises, in part, because the objective function represents not only the error in the shape of the coupler curve, but also the error in location, orientation and size of the curve. Furthermore, the common introduction of timing (or crank angle), done generally to facilitate selection of corresponding points on the curve for calculating structural error, has little practical value and unnecessarily limits possible solutions. This paper proposes a new objective function, based on Fourier Descriptors, which allows search for coupler curve of the desired shape without reference to location, orientation, or size. The proposed objective function compares overall shape properties of curves rather than making point-by-point comparison and therefore does not requires prescription of timing. Experimental evidence is provided to show that it is much easier to search the space of the proposed objective function compared to the structural error function.


2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Oleksandr Malykhin ◽  
Nataliia Oleksandrivna Aristova ◽  
Liudmyla Kalinina ◽  
Tetyana Opaliuk

The present paper addresses the issue of determining the best international practices for developing soft skills among students of different specialties through carrying out a theoretical review. Basing on literature on present-day theory the authors make an attempt to explain soft skills dichotomies, summarize existing approaches to classifying soft skills, consolidate and document best international practices for soft skills development among potential employees of different specialties including bachelor students, master students, doctoral and postdoctoral students. The data obtained in the theoretical analysis reveal that the possible ambiguities in the interpretation of the concept of “soft skills” are caused, on the one hand, by the dichotomic perception of their nature by present-day researchers and educators and, on the other hand, by the absence of the common language which makes it difficult to provide a more unified definition most satisfactory to all concerned. The authors are convinced that soft skills have a cross-cutting nature and regard them as personal and interpersonal meta-qualities and meta-abilities that are vital to any potential employee who is going to make positive contributions not only to his/her professional development but to the development of a company he/she is going to work for. The results of the conducted theoretical review clearly indicate that the absence of the unified understanding of the concept of “soft skills” is reflected in the existence of different approaches to classifying soft skills, let alone, the selection of didactic tools for developing soft skills among potential employees.


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