scholarly journals Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2999 ◽  
Author(s):  
Victoria Arija ◽  
Carmen Hernández-Martínez ◽  
Mónica Tous ◽  
Josefa Canals ◽  
Mónica Guxens ◽  
...  
Keyword(s):  
Working Memory ◽  
Serum Ferritin ◽  
Iron Status ◽  
Population Based ◽  
Maternal Serum ◽  
Iron Intake ◽  
Good State ◽  
Trail Making ◽  
Neuropsychological Outcomes ◽  
Maternal Iron

Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.

Hematological Status of Male Runners in Relation to the Extent of Physical Training

1992 ◽  
Vol 2 (4) ◽  
pp. 366-375 ◽  
Author(s):  
John D. Robertson ◽  
Ronald J. Maughan ◽  
Ann C. Milne ◽  
Ronald J.L. Davidson
Keyword(s):  
Serum Ferritin ◽  
Iron Status ◽  
Normal Population ◽  
Venous Blood ◽  
Biological Significance ◽  
Iron Intake ◽  
Dietary Analysis ◽  
Control Subjects ◽  
Blood Biochemical ◽  
Biochemical Indices

Blood biochemical indices of iron status were measured in venous blood from 20 runners and 6 control subjects. All subjects were.male, ages 20 to 40 years, and stable with regard to body weight and degree of physical activity. Dietary analysis was undertaken using a 7-day weighed food intake. There was no evidence of iron deficiency: hemoglobin concentrations and serum femtin levels were within the normal population range for all individuals. However, serum ferritin was negatively correlated with the amount of training. Daily iron intake appeared to be adequate; iron intake was correlated with protein intake but not related to training or energy intake. Serum ferritin, an indicator of iron status, was significantly correlated with vitamin C intake but not iron intake. Serum transferrin concentration was higher in the group of athletes undertaking a high weekly training load compared with the control subjects, suggesting an alteration in iron metabolism although there was no evidence of increased erythropoiesis. The biological significance of this is unclear.

scholarly journals Molecular Fingerprints of Iron Parameters among a Population-Based Sample

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1800 ◽  
Author(s):  
Anne Kaul ◽  
Annette Masuch ◽  
Kathrin Budde ◽  
Gabi Kastenmüller ◽  
Anna Artati ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Iron Metabolism ◽  
Iron Status ◽  
Population Based ◽  
Plasma Metabolites ◽  
Resonance Spectroscopy ◽  
Large Set ◽  
Lipoprotein Subfractions ◽  
Molecular Fingerprints ◽  
Apparently Healthy

Iron deficiency is the most frequent deficiency disease and parameters of iron metabolism appear to be linked to major metabolic and cardiovascular diseases. We screened a large set of small molecules in plasma for associations with iron status among apparently healthy subjects to elucidate subclinical profiles which may provide a link between iron status and onset of diseases. Based on mass spectrometry and nuclear magnetic resonance spectroscopy we determined 613 plasma metabolites and lipoprotein subfractions among 820 apparently healthy individuals. Associations between ferritin, transferrin, haemoglobin and myoglobin and metabolite levels were tested by sex-specific linear regression analyses controlling for common confounders. Far more significant associations in women (82 out of 102) compared to men became obvious. The majority of the metabolites associated with serum ferritin and haemoglobin in women comprising fatty acid species, branched-chain amino acid catabolites and catabolites of heme. The latter was also obvious among men. Positive associations between serum transferrin and VLDL and IDL particle measures seen in women were observed in men with respect to serum ferritin. We observed a sexual-dimorphic fingerprint of surrogates of iron metabolism which may provide a link for the associations between those parameters and major metabolic and cardiovascular disease.

scholarly journals Transferrin-gene expression in the rat mammary gland. Independence of maternal iron status

1990 ◽  
Vol 267 (3) ◽  
pp. 815-819 ◽  
Author(s):  
M R Grigor ◽  
F J McDonald ◽  
N Latta ◽  
C L Richardson ◽  
W P Tate
Keyword(s):  
Iron Status ◽  
Maternal Serum ◽  
Mammary Tissue ◽  
Serum Transferrin ◽  
Total Rna ◽  
Mrna Concentration ◽  
Transferrin Gene ◽  
Rat Mammary Gland ◽  
Dietary Treatments ◽  
Maternal Iron

Transferrin mRNA concentrations were measured in total RNA isolated from liver and mammary tissue of lactating rats at different stages of lactation. The mammary transferrin mRNA concentration varied in a biphasic manner, increasing up to parturition and then decreasing to undetectable levels at days 5 and 10 of lactation before increasing again markedly in late lactation. The values obtained at day 20 of lactation were double those found in livers of lactating rats. The concentrations of total RNA and mRNA for alpha-casein and alpha-lactalbumin did not change between days 5 and 20 of lactation. Transferrin concentrations were measured in milk from rats fed on an iron-free, a control and an iron-supplemented diet. Although there was a 5-fold difference in the transferrin concentration of samples taken between day 5 and day 20 of lactation, the dietary treatments did not result in significant changes. Maternal serum transferrin concentrations were, however, elevated, and pup haemoglobin concentrations were suppressed for the rats receiving the iron-free diet, indicating an alteration of the iron status of these rats.

scholarly journals Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 810
Author(s):  
Limin Yang ◽  
Miori Sato ◽  
Mayako Saito-Abe ◽  
Makoto Irahara ◽  
Minaho Nishizato ◽  
...  
Keyword(s):  
Early Childhood ◽  
Propensity Score ◽  
Birth Cohort ◽  
Iron Status ◽  
Logistic Models ◽  
Allergic Diseases ◽  
Estimating Equation ◽  
Dietary Iron ◽  
Iron Intake ◽  
Maternal Iron

Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron intake during pregnancy) with allergy development in offspring during early childhood. We analyzed information on children age 0–3 years from the Japan Environment and Children’s Study (JECS). We used logistic models and generalized estimating equation models to evaluate the effect of maternal hemoglobin and hematocrit levels and dietary iron intake on allergies in children. Models were also fitted with propensity score-matched datasets. Data were collected for a total of 91,247 mother–child pairs. The prevalence (95% confidence interval) of low hemoglobin and hematocrit was 14.0% (13.7–14.2%) and 12.5% (12.3–12.8%), respectively. After adjusting confounders, low hemoglobin and hematocrit during pregnancy were not associated with childhood allergic outcomes. Findings from models with propensity score-matched datasets also indicated that children born to mothers with low hemoglobin or hematocrit levels during pregnancy did not have a higher risk of developing allergic conditions at 3 years old. We found no meaningful associations between low energy adjusted maternal dietary iron intake and allergies in children. In conclusion, using birth cohort data, we found no evidence supporting an association of low maternal hemoglobin, hematocrit and low dietary iron intake with allergy symptoms during early childhood. Further studies with more suitable proxy markers for blood iron status are needed.

scholarly journals The association between red and processed meat consumption and iron intakes and status among British adults

2003 ◽  
Vol 6 (4) ◽  
pp. 341-350 ◽  
Author(s):  
Sigrid Gibson ◽  
Margaret Ashwell
Keyword(s):  
Serum Ferritin ◽  
Iron Status ◽  
Cross Sectional Study ◽  
Processed Meat ◽  
Iron Intake ◽  
Cross Sectional ◽  
Iron Supplements ◽  
Haem Iron ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

AbstractObjective:To examine the association between consumption of red and processed meat (RPM) and iron intakes and status in adults.Design:Further analysis of the Dietary and Nutritional Survey of British Adults, a cross-sectional study of 2197 adults aged 16–64 years carried out in 1986/7.Subjects and methods:Adults (836 men and 838 women) with serum ferritin measurements, who were not taking iron supplements, were classified into four groups according to RPM consumption (from 7-day weighed records). Iron absorbed was estimated from equations based on haem and non-haem iron and the influence of iron stores.Results:Women who ate least meat (<90gday-1) had three times the risk of a low iron intake (below the Lower Reference Nutrient Intake) compared with high consumers of RPM (>140gday-1). Men who ate no RPM also had a higher risk of low iron intake. Using an estimate of minimal values for iron losses, there was a twofold difference in the potential risk of negative iron balance between women non-RPM consumers and high RPM consumers. Status measurements indicated that, among women, anaemia was least prevalent (6%) among high consumers compared with 12–14% among average RPM consumers. Inverse trends were also observed for serum ferritin in both sexes.Conclusions:Low consumption of RPM has implications for iron intakes and iron status in men and women, since the risk of negative iron balance and its consequences are increased. Dietary messages must consider these implications and provide appropriate advice.

Serum ferritin compared with other indices of iron status in children and teenagers undergoing maintenance hemodialysis.

1979 ◽  
Vol 25 (5) ◽  
pp. 741-744 ◽  
Author(s):  
D Ellis
Keyword(s):  
Serum Ferritin ◽  
Reticulocyte Count ◽  
Iron Status ◽  
Diagnostic Testing ◽  
Intravenous Iron ◽  
Visual Assessment ◽  
Maintenance Hemodialysis ◽  
Iron Intake ◽  
Iron Supplements ◽  
Patients Âgés

Abstract To determine how best to assess iron status, I studied 12 young renal patients (ages 5.5 to 20 years) undergoing regular hemodialysis treatments. Iron balance was estimated by monitoring iron loss ascribable to blood loss during dialysis and diagnostic testing, and iron intake in the form of oral and intravenous iron supplements and blood transfusions. Traditional methods of evaluating iron status--measurement of hemoglobin, erythrocyte indices, reticulocyte count, iron, and transferrin--were compared with measurement of serum ferritin. The serum ferritin measurements provided superior information. In three cases this method was superior to visual assessment of bone marrow stained for iron.

scholarly journals Plasma Hepcidin Increases with Prolonged Running in Male, but Not Female, Collegiate Distance Runners with Low Iron Stores

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1777-1777
Author(s):  
David Barney ◽  
James Ippolito ◽  
Claire Berryman ◽  
Stephen Hennigar
Keyword(s):  
Serum Ferritin ◽  
Iron Status ◽  
Total Iron ◽  
Negative Regulator ◽  
Dietary Iron ◽  
Iron Intake ◽  
Distance Runners ◽  
Vo2 Max ◽  
Iron Stores ◽  
Males And Females

Abstract Objectives Hepcidin is a negative regulator of extracellular iron availability and dietary iron absorption. Previous studies have shown that hepcidin increases with prolonged endurance exercise, but not in those with low iron stores (serum ferritin &lt;30 ng/mL). The objective of this study was to determine the plasma hepcidin response to exercise, compared to rest, in highly trained male and female collegiate distance runners. Methods In a cross-over design, healthy male (n = 14; age 20.2 ± 1.4 y; BMI 20.4 ± 1.6 kg/m2; VO2 max 69.8 ± 5.6 mL/kg/min) and female (n = 14; age 20.1 ± 1.4 y, P = 0.79; BMI 18.1 ± 1.6 kg/m2, P &lt; 0.001; VO2 max 62.5 ± 4.2 mL/kg/min, P &lt; 0.001) collegiate distance runners performed a bout of running (males: 109.8 ± 8.7 min, 15.0 ± 1.3 miles; females: 87.7 ± 10.4 min, P &lt; 0.0001, 11.3 ± 1.5 miles, P &lt; 0.0001) or no activity (rest) separated by 2 weeks. Indicators of iron status and plasma hepcidin were determined at baseline and three hours after exercise or rest. Dietary iron and total iron intake (dietary iron + iron from supplements) were determined by Food Frequency Questionnaires. Results Serum ferritin (males: 24.0 ± 15.9 ng/mL, females: 19.4 ± 9.5 ng/mL, P = 0.39) and plasma hepcidin (males: 22.3 ± 20.6 ng/mL, females: 24.6 ± 19.6 ng/mL, P = 0.77) did not differ between males and females at baseline. Baseline hemoglobin (males: 14.5 ± 0.8 g/dL, females: 13.4 ± 1.0 g/dL, P &lt; 0.01) and hematocrit (males: 45.3 ± 2.2%, females: 42.1 ± 2.6%, P &lt; 0.01) were greater in males compared to females. Dietary iron intake (males: 18.6 ± 6.3 mg/d, females: 17.1 ± 6.4 mg/d, P = 0.55) and total iron intake (males: 48.7 ± 32.9 mg/d, females: 64.6 ± 32.3 mg/d, P = 0.22) did not differ between males and females. Plasma hepcidin increased with exercise compared to rest in males (change from rest: 30.3 ± 42.0 ng/mL, P = 0.02) but not in females (change from rest: 0.8 ± 32.0 ng/mL, P = 0.93). Change in plasma hepcidin with exercise was correlated with sex (R = 0.380, P = 0.05) and BMI (R = 0.383, P = 0.04), but not baseline ferritin, run time, run distance, hemoglobin, hematocrit, dietary iron, or total iron intake (P &gt; 0.05 for all). Conclusions The post-exercise hepcidin response occurs in male, but not female, collegiate distance runners with low iron stores. These findings indicate that declines in iron status in female distance runners are independent of exercise-induced hepcidin. Funding Sources Intramural funds to S.R.H.

scholarly journals Maternal Anemia and its Correlation with Iron status of Newborn

2014 ◽  
Vol 4 (1) ◽  
pp. 27-32
Author(s):  
P Akhter ◽  
MA Momen ◽  
N Rahman ◽  
S Rahman ◽  
R Karim ◽  
...  
Keyword(s):  
Iron Status ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Placental Weight ◽  
Capital City ◽  
Medical Complications ◽  
Cross Sectional ◽  
Paired Samples ◽  
One Year ◽  
Maternal Iron

Aim: To investigate the correlation of maternal blood Hb level and iron stores with neonatal iron status. Methods: A cross sectional analytic study on was conducted on fifty hospitalized pregnant women and their neonates over one year in a teaching hospital in the capital city of Bangladesh. Paired samples (50) of maternal venous and neonatal Women who had no medical complications and had undergone caesarian section were included. Maternal serum and cord hemoglobin concentrations with ferritin values were measured immediately after delivery. Placental weight, birth weight and APGAR scores were recorded. Result: The study involved 50 participants, randomly selected, of whom 10 had normal iron status and others had mild to severe anemia. Our study found no significant correlation of maternal Hb and cord Hb levels. But maternal serum ferritin showed positive correlation with cord ferritin (r=0.94; P<0.001) and with placental weight (r=0.40; p<0.001). Conclusion: Maternal iron deficiency anaemia was strongly associated with lower iron status of newborn DOI: http://dx.doi.org/10.3329/birdem.v4i1.18550 Birdem Med J 2014; 4(1): 27-32

scholarly journals Pre-Clinical Insights into the Iron and Breast Cancer Hypothesis

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1652
Author(s):  
Henry J. Thompson ◽  
Elizabeth S. Neil ◽  
John N. McGinley
Keyword(s):  
Breast Cancer ◽  
Iron Status ◽  
Classical Model ◽  
Positive Association ◽  
Mammary Carcinogenesis ◽  
Inhibitory Effect ◽  
Population Based ◽  
Convincing Evidence ◽  
Iron Intake ◽  
Excess Iron

Population studies, systematic reviews, and meta-analyses have revealed no relationship between iron status and breast cancer, a weak positive association, or a small protective effect of low iron status. However, in those studies, the authors concluded that further investigation was merited. The set of experiments reported here used preclinical models to assess the likely value of further investigation. The effects of iron status on the initiation and promotion stage of mammary carcinogenesis are reported. Using the classical model of cancer initiation in the mammary gland, 7,12 dimethyl-benz[α]anthracene-induced carcinogenesis was unaffected by iron status. Similarly, excess iron intake showed no effect on the promotion stage of 1-methyl-1-nitrosurea-induced mammary carcinogenesis, though iron deficiency exerted a specific inhibitory effect on the carcinogenic process. Though iron-mediated cellular oxidation is frequently cited as a potential mechanism for effects on breast cancer, no evidence of increased oxidative damage to DNA attributable to excess iron intake was found. The reported preclinical data fail to provide convincing evidence that the further evaluation of the iron–breast cancer risk hypotheses is warranted and underscore the value of redefining the referent group in population-based studies of iron–cancer hypotheses in other tissues.

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