scholarly journals Transferrin-gene expression in the rat mammary gland. Independence of maternal iron status

1990 ◽  
Vol 267 (3) ◽  
pp. 815-819 ◽  
Author(s):  
M R Grigor ◽  
F J McDonald ◽  
N Latta ◽  
C L Richardson ◽  
W P Tate
Keyword(s):  
Iron Status ◽  
Maternal Serum ◽  
Mammary Tissue ◽  
Serum Transferrin ◽  
Total Rna ◽  
Mrna Concentration ◽  
Transferrin Gene ◽  
Rat Mammary Gland ◽  
Dietary Treatments ◽  
Maternal Iron

Transferrin mRNA concentrations were measured in total RNA isolated from liver and mammary tissue of lactating rats at different stages of lactation. The mammary transferrin mRNA concentration varied in a biphasic manner, increasing up to parturition and then decreasing to undetectable levels at days 5 and 10 of lactation before increasing again markedly in late lactation. The values obtained at day 20 of lactation were double those found in livers of lactating rats. The concentrations of total RNA and mRNA for alpha-casein and alpha-lactalbumin did not change between days 5 and 20 of lactation. Transferrin concentrations were measured in milk from rats fed on an iron-free, a control and an iron-supplemented diet. Although there was a 5-fold difference in the transferrin concentration of samples taken between day 5 and day 20 of lactation, the dietary treatments did not result in significant changes. Maternal serum transferrin concentrations were, however, elevated, and pup haemoglobin concentrations were suppressed for the rats receiving the iron-free diet, indicating an alteration of the iron status of these rats.

scholarly journals Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2999 ◽  
Author(s):  
Victoria Arija ◽  
Carmen Hernández-Martínez ◽  
Mónica Tous ◽  
Josefa Canals ◽  
Mónica Guxens ◽  
...  
Keyword(s):  
Working Memory ◽  
Serum Ferritin ◽  
Iron Status ◽  
Population Based ◽  
Maternal Serum ◽  
Iron Intake ◽  
Good State ◽  
Trail Making ◽  
Neuropsychological Outcomes ◽  
Maternal Iron

Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.

scholarly journals Maternal Anemia and its Correlation with Iron status of Newborn

2014 ◽  
Vol 4 (1) ◽  
pp. 27-32
Author(s):  
P Akhter ◽  
MA Momen ◽  
N Rahman ◽  
S Rahman ◽  
R Karim ◽  
...  
Keyword(s):  
Iron Status ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Placental Weight ◽  
Capital City ◽  
Medical Complications ◽  
Cross Sectional ◽  
Paired Samples ◽  
One Year ◽  
Maternal Iron

Aim: To investigate the correlation of maternal blood Hb level and iron stores with neonatal iron status. Methods: A cross sectional analytic study on was conducted on fifty hospitalized pregnant women and their neonates over one year in a teaching hospital in the capital city of Bangladesh. Paired samples (50) of maternal venous and neonatal Women who had no medical complications and had undergone caesarian section were included. Maternal serum and cord hemoglobin concentrations with ferritin values were measured immediately after delivery. Placental weight, birth weight and APGAR scores were recorded. Result: The study involved 50 participants, randomly selected, of whom 10 had normal iron status and others had mild to severe anemia. Our study found no significant correlation of maternal Hb and cord Hb levels. But maternal serum ferritin showed positive correlation with cord ferritin (r=0.94; P<0.001) and with placental weight (r=0.40; p<0.001). Conclusion: Maternal iron deficiency anaemia was strongly associated with lower iron status of newborn DOI: http://dx.doi.org/10.3329/birdem.v4i1.18550 Birdem Med J 2014; 4(1): 27-32

scholarly journals Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2221
Author(s):  
Hugo G. Quezada-Pinedo ◽  
Florian Cassel ◽  
Liesbeth Duijts ◽  
Martina U. Muckenthaler ◽  
Max Gassmann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Child Health ◽  
Methodological Quality ◽  
Iron Status ◽  
Meta Analysis ◽  
Child Health Outcomes ◽  
Maternal Iron ◽  
In Pregnancy

In pregnancy, iron deficiency and iron overload increase the risk for adverse pregnancy outcomes, but the effects of maternal iron status on long-term child health are poorly understood. The aim of the study was to systematically review and analyze the literature on maternal iron status in pregnancy and long-term outcomes in the offspring after birth. We report a systematic review on maternal iron status during pregnancy in relation to child health outcomes after birth, from database inception until 21 January 2021, with methodological quality rating (Newcastle-Ottawa tool) and random-effect meta-analysis. (PROSPERO, CRD42020162202). The search identified 8139 studies, of which 44 were included, describing 12,7849 mother–child pairs. Heterogeneity amongst the studies was strong. Methodological quality was predominantly moderate to high. Iron status was measured usually late in pregnancy. The majority of studies compared categories based on maternal ferritin, however, definitions of iron deficiency differed across studies. The follow-up period was predominantly limited to infancy. Fifteen studies reported outcomes on child iron status or hemoglobin, 20 on neurodevelopmental outcomes, and the remainder on a variety of other outcomes. In half of the studies, low maternal iron status or iron deficiency was associated with adverse outcomes in children. Meta-analyses showed an association of maternal ferritin with child soluble transferrin receptor concentrations, though child ferritin, transferrin saturation, or hemoglobin values showed no consistent association. Studies on maternal iron status above normal, or iron excess, suggest deleterious effects on infant growth, cognition, and childhood Type 1 diabetes. Maternal iron status in pregnancy was not consistently associated with child iron status after birth. The very heterogeneous set of studies suggests detrimental effects of iron deficiency, and possibly also of overload, on other outcomes including child neurodevelopment. Studies are needed to determine clinically meaningful definitions of iron deficiency and overload in pregnancy.

The influence of high-altitude living on body iron

Blood ◽  
2005 ◽  
Vol 106 (4) ◽  
pp. 1441-1446 ◽  
Author(s):  
James D. Cook ◽  
Erick Boy ◽  
Carol Flowers ◽  
Maria del Carmen Daroca
Keyword(s):  
Standard Error ◽  
Transferrin Receptor ◽  
Quantitative Assessment ◽  
Iron Status ◽  
Dietary Iron ◽  
Body Iron ◽  
Iron Stores ◽  
Iron Deficient ◽  
Iron Based ◽  
Maternal Iron

Abstract The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 ± 4.31 mg/kg (mean ± 1 SD) and 1.72 ± 4.53 mg/kg in children. No consistent effect of altitude on body iron was detected in children but body iron stores of 2.77 ± 0.70 mg/kg (mean ± 2 standard error [SE]) in women living above 3000 m was reduced by one-third compared with women living at lower altitudes (P &lt; .001). One half of the children younger than 2 years were iron deficient, but iron stores then increased linearly to approach values in their mothers by 4 years of age. When body iron in mothers was compared with that of their children, a striking correlation was observed over the entire spectrum of maternal iron status (r = 0.61, P &lt; .001). This finding could provide the strongest evidence to date of the importance of dietary iron as a determinant of iron status in vulnerable segments of a population. (Blood. 2005;106:1441-1446)

scholarly journals Rat mammary-gland fatty acid synthase. A simple purification procedure and stoicheiometry of CoA ester binding

1982 ◽  
Vol 203 (1) ◽  
pp. 45-50 ◽  
Author(s):  
P M Ahmad ◽  
D S Feltman ◽  
F Ahmad
Keyword(s):  
Mammary Gland ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Specific Activity ◽  
Simple Procedure ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Performic Acid ◽  
Mammary Tissue ◽  
Rat Mammary Gland

A simple procedure was devised which allows purification of rat lactating-mammary-gland fatty acid synthase to a high degree of purity, with recoveries of activity exceeding 50%. Over 50 mg of enzyme was isolated from 60 g of mammary tissue. The specific activity of the purified enzyme was about 2.5 mumol of NADPH oxidized/min per mg of protein at 37 degrees. The enzyme appeared homogeneous by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis and by immunodiffusion analysis. Each mol (Mr 480 000) of the enzyme bound 3 mol of acetyl and 3-4 mol of malonyl groups when the binding experiments were performed at 0 degrees for 30 s. The presence of NADPH did not influence the binding stoicheiometry for these acyl-CoA derivatives. Approx. 2 mol of taurine was found per mol of the performic acid-oxidized enzyme, suggesting that there were 2 mol of 4′-phosphopantetheine in the native enzyme. Rat mammary-gland fatty acid synthase required free CoA for activity.

scholarly journals Neonatal and maternal iron status, but not serum folate, is related to placental expression of the proton coupled folate transporter (PCFT)

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Chang Cao ◽  
Thomas Bemis ◽  
Melissa Young ◽  
Thomas McNanley ◽  
Elizabeth Cooper ◽  
...  
Keyword(s):  
Iron Status ◽  
Serum Folate ◽  
Maternal Iron

scholarly journals How much Antenatal Supplemental Iron is Required to Preserve Maternal Iron Status? The MINIMat Intervention trial in Bangladesh

2015 ◽  
Vol 5 (5) ◽  
pp. 1167-1168
Author(s):  
Shirin Ziaei ◽  
Anisur Rahman ◽  
Shams Arifeen ◽  
Eva-Charlotte Ekström
Keyword(s):  
Iron Status ◽  
Intervention Trial ◽  
Maternal Iron
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