scholarly journals Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children’s Study (JECS)

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 810
Author(s):  
Limin Yang ◽  
Miori Sato ◽  
Mayako Saito-Abe ◽  
Makoto Irahara ◽  
Minaho Nishizato ◽  
...  
Keyword(s):  
Early Childhood ◽  
Propensity Score ◽  
Birth Cohort ◽  
Iron Status ◽  
Logistic Models ◽  
Allergic Diseases ◽  
Estimating Equation ◽  
Dietary Iron ◽  
Iron Intake ◽  
Maternal Iron

Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron intake during pregnancy) with allergy development in offspring during early childhood. We analyzed information on children age 0–3 years from the Japan Environment and Children’s Study (JECS). We used logistic models and generalized estimating equation models to evaluate the effect of maternal hemoglobin and hematocrit levels and dietary iron intake on allergies in children. Models were also fitted with propensity score-matched datasets. Data were collected for a total of 91,247 mother–child pairs. The prevalence (95% confidence interval) of low hemoglobin and hematocrit was 14.0% (13.7–14.2%) and 12.5% (12.3–12.8%), respectively. After adjusting confounders, low hemoglobin and hematocrit during pregnancy were not associated with childhood allergic outcomes. Findings from models with propensity score-matched datasets also indicated that children born to mothers with low hemoglobin or hematocrit levels during pregnancy did not have a higher risk of developing allergic conditions at 3 years old. We found no meaningful associations between low energy adjusted maternal dietary iron intake and allergies in children. In conclusion, using birth cohort data, we found no evidence supporting an association of low maternal hemoglobin, hematocrit and low dietary iron intake with allergy symptoms during early childhood. Further studies with more suitable proxy markers for blood iron status are needed.

scholarly journals Association between Iron Supplementation, Dietary Iron Intake and Risk of Moderate Preterm Birth: A Birth Cohort Study in China

2021 ◽  
Author(s):  
Yawen Shao ◽  
Baohong Mao ◽  
Jie Qiu ◽  
Yan Bai ◽  
Ru Lin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Protective Effect ◽  
Birth Cohort ◽  
Iron Supplementation ◽  
Birth Cohort Study ◽  
Dietary Iron ◽  
Iron Intake ◽  
Maternal Iron ◽  
Additive Scale

Background: To evaluate the independent and collective effects of maternal iron supplementation and dietary iron intake upon the risk of moderate preterm birth and its subtypes. Methods: In this birth cohort study, 1019 pregnant women with moderate preterm birth and 9160 women with term birth were recruited at Gansu Provincial Maternity and Child Care Hospital from 2010-2012 in China. Unconditional logistic regression models were utilized to evaluate the association between maternal iron supplementation, dietary iron intake, and the risk of moderate preterm birth and its subtypes. Results: Compared with non-users, iron supplement users exerted a protective effect upon the overall (OR=0.54, 95%CI=0.40-0.72) and spontaneous moderate preterm birth (OR=0.39, 95%CI=0.33-0.83). Compared with the 25th quartiles of dietary iron intake, either before or during pregnancy, it exerted a significantly protective effect upon those who had the highest quartiles of dietary iron intake (OR=0.87, 95%CI=0.82-0.95 for the highest quartiles of dietary iron intake before pregnancy OR=0.85, 95%CI=0.79-0.91). Positive association was observed between the additive scale and multiplicative scale for preterm birth, spontaneous preterm rather than medically indicated preterm. Conclusion: Iron supplements (60 mg/day) and high-iron intake (>25.86 mg/day before pregnancy, >30.46 mg/day during pregnancy) reduced the risk of moderate preterm birth. Positive correlation is found between the additive scale and multiplicative scale for preterm birth, spontaneous preterm birth.

Iron status and dietary iron intake of female blood donors

Transfusion ◽  
2013 ◽  
Vol 54 (3pt2) ◽  
pp. 770-774 ◽  
Author(s):  
Alison O. Booth ◽  
Karen Lim ◽  
Hugh Capper ◽  
David Irving ◽  
Jenny Fisher ◽  
...  
Keyword(s):  
Blood Donors ◽  
Iron Status ◽  
Dietary Iron ◽  
Iron Intake

The influence of high-altitude living on body iron

Blood ◽  
2005 ◽  
Vol 106 (4) ◽  
pp. 1441-1446 ◽  
Author(s):  
James D. Cook ◽  
Erick Boy ◽  
Carol Flowers ◽  
Maria del Carmen Daroca
Keyword(s):  
Standard Error ◽  
Transferrin Receptor ◽  
Quantitative Assessment ◽  
Iron Status ◽  
Dietary Iron ◽  
Body Iron ◽  
Iron Stores ◽  
Iron Deficient ◽  
Iron Based ◽  
Maternal Iron

Abstract The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 ± 4.31 mg/kg (mean ± 1 SD) and 1.72 ± 4.53 mg/kg in children. No consistent effect of altitude on body iron was detected in children but body iron stores of 2.77 ± 0.70 mg/kg (mean ± 2 standard error [SE]) in women living above 3000 m was reduced by one-third compared with women living at lower altitudes (P < .001). One half of the children younger than 2 years were iron deficient, but iron stores then increased linearly to approach values in their mothers by 4 years of age. When body iron in mothers was compared with that of their children, a striking correlation was observed over the entire spectrum of maternal iron status (r = 0.61, P < .001). This finding could provide the strongest evidence to date of the importance of dietary iron as a determinant of iron status in vulnerable segments of a population. (Blood. 2005;106:1441-1446)

scholarly journals Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

2018 ◽  
Vol 15 (10) ◽  
pp. 2156 ◽  
Author(s):  
Joanna Gajewska ◽  
Jadwiga Ambroszkiewicz ◽  
Witold Klemarczyk ◽  
Ewa Głąb-Jabłońska ◽  
Halina Weker ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Status ◽  
Hematological Parameters ◽  
Daily Intake ◽  
Normal Weight ◽  
Deficiency Anemia ◽  
Dietary Iron ◽  
Iron Intake ◽  
Obese Children ◽  
Iron Concentrations

Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression model an association between the ferroportin/hepcidin ratio and the sTfR/ferritin index in obese children (β = 0.399, p = 0.017) was found. These associations did not exist in the controls. The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia. The role of other micronutrients, besides dietary iron, may also be considered in the iron status of these children.

scholarly journals Maternal iron status during pregnancy and respiratory and atopic outcomes in the offspring: a Mendelian randomisation study

2018 ◽  
Vol 5 (1) ◽  
pp. e000275 ◽  
Author(s):  
Annabelle Bédard ◽  
Sarah J Lewis ◽  
Stephen Burgess ◽  
A John Henderson ◽  
Seif O Shaheen
Keyword(s):  
Birth Cohort ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Late Pregnancy ◽  
Forced Expiratory Volume ◽  
Risk Scores ◽  
Mendelian Randomisation ◽  
Nucleotide Polymorphisms ◽  
Common Genetic Variants ◽  
Maternal Iron

IntroductionLimited evidence from birth cohort studies suggests that lower prenatal iron status may be a risk factor for childhood respiratory and atopic outcomes, but these observational findings may be confounded. Mendelian randomisation (MR) can potentially provide unconfounded estimates of causal effects by using common genetic variants as instrumental variables. We aimed to study the relationship between prenatal iron status and respiratory and atopic outcomes in the offspring using MR.MethodsIn the Avon Longitudinal Study of Parents and Children birth cohort, we constructed four maternal genotypic risk scores by summing the total number of risk alleles (associated with lower iron status) across single nucleotide polymorphisms known to be associated with at least one of four iron biomarkers (serum iron, ferritin, transferrin and transferrin saturation). We used MR to study their associations with respiratory and atopic outcomes in children aged 7–9 years (n=6002).ResultsWhen analyses were restricted to mothers without iron supplementation during late pregnancy, negative associations were found between the maternal transferrin saturation score and childhood forced expiratory volume in 1 s and forced vital capacity (difference in age, height and gender-adjusted SD units per SD increase in genotypic score: −0.05 (−0.09, −0.01) p=0.03, and −0.04 (−0.08, 0.00) p=0.04, respectively).ConclusionUsing MR we have found weak evidence suggesting that low maternal iron status during pregnancy may cause impaired childhood lung function.

P1116 AGE-DEPENDENT RESPONSES TO DIETARY IRON INTAKE IN INDICATORS OF IRON STATUS FROM 6 TO 18 MONTHS OF AGE

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S481
Author(s):  
T. Lind ◽  
O. Hernell ◽  
B. L??nnerdal ◽  
H. Stenlund ◽  
M. Domell??f ◽  
...  
Keyword(s):  
Iron Status ◽  
Dietary Iron ◽  
Iron Intake ◽  
Age Dependent

scholarly journals Dietary iron intake, iron status, and gestational diabetes

2017 ◽  
Vol 106 (Supplement 6) ◽  
pp. 1672S-1680S ◽  
Author(s):  
Cuilin Zhang ◽  
Shristi Rawal
Keyword(s):  
Gestational Diabetes ◽  
Iron Status ◽  
Dietary Iron ◽  
Iron Intake
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