scholarly journals Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2067 ◽  
Author(s):  
Mirja Grafetstätter ◽  
Laura Pletsch-Borba ◽  
Disorn Sookthai ◽  
Nena Karavasiloglou ◽  
Theron Johnson ◽  
...  
Keyword(s):  
Cancer Research ◽  
Cancer Prevention ◽  
Population Based ◽  
Lifestyle Factors ◽  
Research Fund ◽  
Linear Regression Models ◽  
American Institute ◽  
Cross Sectional ◽  
Increased Risk ◽  
The World

A pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemostatic biomarkers in a population-based study. Cross-sectional baseline data from 2267 randomly selected participants of EPIC-Heidelberg (age range 35–65 years) was used. Fibrinogen, glycoprotein IIb/IIIa, P-selectin, thrombomodulin (TM), and thrombopoietin (TPO) were measured in baseline plasma samples. A score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention was created. Associations between the WCRF/AICR score as well as its individual components and hemostatic biomarkers were analyzed by linear regression models. Multivariable-adjusted geometric means (95% confidence intervals) of TM and TPO were higher with greater adherence to the WCRF/AICR recommendations (TM, lowest vs. highest score category: 2.90 (2.7,3.1) vs. 3.10 (2.9,3.3) ng/mL, plinear trend = 0.0001; TPO: 328 (302,356) vs. 348 (321,378) pg/mL, plinear trend = 0.0007). These associations were driven by lower alcohol and meat consumption among persons with higher WCRF/AICR scores. Our results indicate that lifestyle factors favorably affect TM and TPO, two hemostatic factors implicated in chronic disease development.

scholarly journals Adherence to the World Cancer Research Fund/American Institute for Cancer Research 2018 Recommendations for Cancer Prevention and Risk of Colorectal Cancer

2019 ◽  
Vol 28 (9) ◽  
pp. 1469-1479 ◽  
Author(s):  
Joshua Petimar ◽  
Stephanie A. Smith-Warner ◽  
Bernard Rosner ◽  
Andrew T. Chan ◽  
Edward L. Giovannucci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Research ◽  
Cancer Prevention ◽  
Research Fund ◽  
American Institute ◽  
The World

scholarly journals Associations between adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and biomarkers of inflammation, hormonal, and insulin response

2016 ◽  
Vol 140 (4) ◽  
pp. 764-776 ◽  
Author(s):  
Fred K. Tabung ◽  
Teresa T. Fung ◽  
Jorge E. Chavarro ◽  
Stephanie A. Smith-Warner ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Cancer Research ◽  
Cancer Prevention ◽  
Insulin Response ◽  
Research Fund ◽  
American Institute ◽  
The World

scholarly journals Longitudinal Associations of Adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Lifestyle Recommendations with Quality of Life and Symptoms in Colorectal Cancer Survivors up to 24 Months Post-Treatment

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 417
Author(s):  
Marlou-Floor Kenkhuis ◽  
Floortje Mols ◽  
Eline H. van Roekel ◽  
José J. L. Breedveld-Peters ◽  
Stéphanie O. Breukink ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Research ◽  
Post Treatment ◽  
Research Fund ◽  
American Institute ◽  
The World ◽  
Lifestyle Recommendations ◽  
Longitudinal Associations

Post-treatment adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations were associated with health-related quality of life (HRQoL), fatigue, and chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer (CRC) survivors. In a prospective cohort among CRC survivors (n = 459), repeated home-visits were performed at 6 weeks, 6, 12, and 24 months post-treatment. Dietary intake, body composition, sedentary behaviour, and physical activity were assessed to construct a lifestyle score based on adherence to seven 2018 WCRF/AICR recommendations. Longitudinal associations of the lifestyle score with HRQoL, fatigue, and CIPN were analysed by confounder-adjusted linear mixed models. A higher lifestyle score was associated with better physical functioning and less activity-related fatigue, but not with CIPN. Adjustment for physical activity substantially attenuated observed associations, indicating its importance in the lifestyle score with regards to HRQoL. In contrast, adjustment for body composition and alcohol inflated observed associations, indicating that both recommendations had a counteractive influence within the lifestyle score. Our findings suggest that CRC survivors benefit from an overall adherence to the WCRF/AICR lifestyle recommendations in terms of HRQoL and fatigue, but not CIPN. Specific recommendations have a varying influence on these associations, complicating the interpretation and requiring further study.

scholarly journals Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

BMC Medicine ◽  
2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Nena Karavasiloglou ◽  
Anika Hüsing ◽  
Giovanna Masala ◽  
Carla H. van Gils ◽  
Renée Turzanski Fortner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Cancer Prevention ◽  
Inverse Association ◽  
American Institute ◽  
The World ◽  
In Situ Breast Cancer ◽  
Prospective Investigation

Abstract Background Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, we investigated the association between lifestyle and BCIS risk within the European Prospective Investigation into Cancer and Nutrition cohort. Methods Lifestyle was operationalized by a score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. The recommendations utilized in these analyses were the ones pertinent to healthy body weight, physical activity, consumption of plant-based foods, energy-dense foods, red and processed meat, and sugary drinks and alcohol, as well as the recommendation on breastfeeding. Cox proportional hazards regression was used to assess the association between lifestyle score and BCIS risk. The results were presented as hazard ratios (HR) and corresponding 95% confidence intervals (CI). Results After an overall median follow-up time of 14.9 years, 1277 BCIS cases were diagnosed. Greater adherence to the WCRF/AICR cancer prevention recommendations was not associated with BCIS risk (HR = 0.98, 95% CI 0.93–1.03; per one unit of increase; multivariable model). An inverse association between the lifestyle score and BCIS risk was observed in study centers, where participants were recruited mainly via mammographic screening and attended additional screening throughout follow-up (HR = 0.85, 95% CI 0.73–0.99), but not in the remaining ones (HR = 0.99, 95% CI 0.94–1.05). Conclusions While we did not observe an overall association between lifestyle and BCIS risk, our results indicate that lifestyle is associated with BCIS risk among women recruited via screening programs and with regular screening participation. This suggests that a true inverse association between lifestyle habits and BCIS risk in the overall cohort may have been masked by a lack of information on screening attendance. The potential inverse association between lifestyle and BCIS risk in our analyses is consistent with the inverse associations between lifestyle scores and breast cancer risk reported from previous studies.

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