scholarly journals Dietary Inflammatory Index and Risk of Breast Cancer Based on Hormone Receptor Status: A Case-Control Study in Korea

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1949 ◽  
Author(s):  
Lee ◽  
Quiambao ◽  
Lee ◽  
Ro ◽  
Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Hormone Receptor Status ◽  
Korean Women ◽  
Dietary Inflammatory Index ◽  
Receptor Status ◽  
Inflammatory Index ◽  
Control Study

Breast cancer is the most common cancer in women globally, and the risk of developing breast cancer is associated with inflammation. The present study aimed to examine the association between the Dietary Inflammatory Index (DII®) and breast cancer in Korean women and investigate whether the tumor’s hormone receptor status affects this association. In this case-control study, we enrolled 364 breast cancer patients and 364 age-matched controls. DII scores were calculated from dietary intake evaluated by a 106-item food frequency questionnaire. The DII score was significantly higher in cases than in controls. After adjusting for potential confounders, the odds ratio (OR) of breast cancer was higher in the highest DII tertile (OR = 3.68, 95% confidence interval (CI): 2.34–5.80, p for trend < 0.0001) than in the lowest tertile. We found that higher DII scores were related to an increased risk of breast cancer for estrogen receptor (ER)+/progesterone receptor (PR)+ tumors regardless of menopausal status (OR = 2.59, 95% CI: 1.37–4.88 in the highest DII category, p for trend = 0.01 for premenopausal women; OR = 11.00, 95% CI: 2.93–41.30 in the highest DII category, p for trend = 0.0004 for postmenopausal women), but not for ER−/PR− status. Our results suggested that the DII scores are positively associated with breast cancer risk in Korean women and that this relationship is more robust in ER+/PR+ tumors.

Risk of subsequent breast cancer after radiotherapy according to hormone-receptor status: A nested case-control study in the Childhood Cancer Survivor Study (CCSS).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10520-10520
Author(s):  
Lindsay M. Morton ◽  
Lene Veiga ◽  
Rochelle E. Curtis ◽  
Diana Withrow ◽  
Peter Inskip ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Childhood Cancer ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Hormone Receptor Status ◽  
Receptor Status ◽  
Survivors Of Childhood Cancer ◽  
Nested Case Control ◽  
Control Study

10520 Background: Survivors of childhood cancer have a high absolute risk of subsequent breast cancer after chest-directed radiotherapy; however, it is not known if this risk differs by hormone-receptor status and radiation to the ovaries. Methods: We conducted a nested case-control study within the CCSS of 282 five-year survivors of childhood cancer with subsequent breast cancer and 1202 matched controls. Radiation dose to the location of the breast tumor (or corresponding location for controls) and mean dose to the ovaries were estimated from treatment records for each patient. Risk of radiation-related breast cancer was measured with the Excess Odds Ratio per Gray (EOR/Gy) and corresponding 95% confidence interval (CI), derived from conditional logistic regression. Results: The median age at subsequent breast cancer diagnosis was 39 years (range 21-58). Although 87% of cases and 70% of controls received radiotherapy, breast doses were higher in cases than controls (61% vs 24% breast dose > 10Gy), whereas ovarian doses were lower (7% vs 13% ovary dose > 5Gy). In the subset of cases (n = 159) with currently available estrogen receptor (ER) status (76% cases ER+, 24% cases ER-), there was a linear dose-response relation with radiation dose to the breast that was similar for ER+ (EOR/Gy = 0.51; 95%CI: 0.19-1.34) and ER- breast tumors (EOR/Gy = 0.41; 95%CI: 0.05-2.88). If the patient received an ovarian dose > 5Gy, this dose-response was significantly reduced for ER+ tumors but not for ER- tumors. Conclusions: Preliminary analyses demonstrate that radiation exposure to the breast to treat childhood cancer results in an increased risk of both ER+ and ER- breast cancers. The novel finding that only the risk of ER+ breast cancer is lowered if the ovaries are also exposed is consistent with known differences by hormone receptor status in the biological mechanisms of breast carcinogenesis.

scholarly journals Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 994
Author(s):  
Facundo Vitelli-Storelli ◽  
Raul Zamora-Ros ◽  
Antonio J. Molina ◽  
Tania Fernández-Villa ◽  
Adela Castelló ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Menopausal Status ◽  
Population Based ◽  
Hormone Receptor Status ◽  
Receptor Status ◽  
Cancer Types ◽  
Polyphenol Intake ◽  
Control Study

There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56–0.89, Ptrend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59–0.93, Ptrend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57–0.93; Ptrend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.

scholarly journals A higher Dietary Inflammatory Index score is associated with a higher risk of breast cancer among Chinese women: a case–control study

2017 ◽  
Vol 117 (10) ◽  
pp. 1358-1367 ◽  
Author(s):  
Wu-Qing Huang ◽  
Xiong-Fei Mo ◽  
Yan-Bin Ye ◽  
Nitin Shivappa ◽  
Fang-Yu Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Control Study

AbstractPrevious studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential confounders. DII scores in this study ranged from −5·87 (most anti-inflammatory score) to +5·71 (most proinflammatory score). A higher DII score was associated with a higher breast cancer risk (adjusted ORquartile 4 v. 1 2·28; 95 % CI 1·71, 3·03; adjusted ORcontinuous 1·40; 95 %CI 1·25, 1·39). In stratified analyses, positive associations also were observed except for underweight women or women with either oestrogen receptor+ or progesterone receptor+ status (but not both). Results from this study indicated that higher DII scores, corresponding to more proinflammatory diets, were positively associated with breast cancer risk among Chinese women.

scholarly journals Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study

2018 ◽  
Vol 244 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Yoko Takizawa ◽  
Masaaki Kawai ◽  
Yoichiro Kakugawa ◽  
Yoshikazu Nishino ◽  
Noriaki Ohuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Japanese Women ◽  
Hormone Receptor Status ◽  
Control Study

scholarly journals Association between the dietary inflammatory index and breast cancer in a large Italian case-control study

2016 ◽  
Vol 61 (3) ◽  
pp. 1600500 ◽  
Author(s):  
Nitin Shivappa ◽  
James R. Hébert ◽  
Valentina Rosato ◽  
Maurizio Montella ◽  
Diego Serraino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Italian Case ◽  
Control Study

scholarly journals Dietary inflammatory index and odds of breast cancer: A case–control study

2021 ◽  
Author(s):  
Shatha S. Hammad ◽  
Reema Mahmoud ◽  
Nitin Shivappa ◽  
James R. Hebert ◽  
Lina Marie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Control Study

Dietary Inflammatory Index and Odds of Breast Cancer in a Case-Control Study from Iran

2018 ◽  
Vol 70 (7) ◽  
pp. 1034-1042 ◽  
Author(s):  
Saba Jalali ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Zeinab Heidari ◽  
Azita Hekmatdoost ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Control Study

Dietary Inflammatory Index and Breast Cancer: report from a Large-Scale Case-Control Study

2021 ◽  
pp. 1-9
Author(s):  
Bahareh Sasanfar ◽  
Fatemeh Toorang ◽  
Maedeh Mozafari Nia ◽  
Amin Salehi-Abargouei ◽  
Kazem Zendehdel
Keyword(s):  
Breast Cancer ◽  
Large Scale ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Control Study
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