scholarly journals Associations of Lipophilic Micronutrients with Physical and Cognitive Fitness in Persons with Mild Cognitive Impairment

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 902 ◽  
Author(s):  
Perihan Gerger ◽  
Roopa Kalsank Pai ◽  
Tim Stuckenschneider ◽  
Julia Falkenreck ◽  
Hannah Weigert ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Physical Performance ◽  
Plasma Levels ◽  
Vegetable Intake ◽  
Full Dataset ◽  
Lack Of Information ◽  
Computerized Measures ◽  
Global Concern ◽  
The Relationship

Age-associated cognitive impairment in general and dementia in particular are a global concern. Preventive lifestyle strategies are highly used but there is a lack of information on the reciprocal relationships between nutrition biomarkers and measures of both cognitive and physical performance. To fill this gap of knowledge, the relationship between plasma levels of the robust nutrition- and antioxidant defense-related biomarkers carotenoid and tocopherols and both indicators of cognitive and physical performance was investigated in a group of persons with mild cognitive impairment participating in the NeuroExercise Study at the German Sport University in Cologne, Germany. In 56 participants with full dataset, significant correlations independently of fruit and vegetable intake were found between plasma levels of β-cryptoxanthin and Timed Up&Go test (p < 0.05), γ-tocopherol and number of daily steps (p < 0.01), as well as between four out of six measured carotenoids—lutein; zeaxanthin; β-cryptoxanthin and β-carotene—and the computerized CogState International Shopping List subtest (p < 0.01). In light of the increasing attention towards the nutritional cognitive neuroscience of carotenoids, computerized measures of cognitive performance might be further implemented in future studies investigating the effects of lifestyle interventions against cognitive and physical impairment.

scholarly journals Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Yi Xing ◽  
Jianghong Liu ◽  
Jingdong Xu ◽  
Linlin Yin ◽  
Lin Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Plasma Levels ◽  
Protein A ◽  
Significant Negative Correlation ◽  
Disease Stage ◽  
Specific Association ◽  
Plasma Leptin ◽  
The Relationship ◽  
Normal Controls

Increasing evidences suggested the association between leptin and cognitive functions. Estrogen is an important factor that regulates the production and metabolism of leptin. However, little is known about the relationship between leptin and estrogen in mild cognitive impairment (MCI). Plasma levels of leptin, total estradiol, andβ-amyloid protein (Aβ) were measured in a total of 23 female amnestic MCI (aMCI) patients and 19 female cognitively normal controls. This study showed that female aMCI patients had lower plasma levels of leptin and higher levels of estradiol compared to female normal controls. Leptin and estradiol levels were not correlated with cognitive performances or plasma Aβlevels in either aMCI patients or normal controls. There was a significant negative correlation between leptin and estrogen in female aMCI patients (r=-0.633,p=0.002) but not in female normal controls. The potential mechanisms of this disease-stage-specific association between leptin and estrogen need further investigations.

scholarly journals Lower functional hippocampal redundancy in mild cognitive impairment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stephanie Langella ◽  
◽  
Muhammad Usman Sadiq ◽  
Peter J. Mucha ◽  
Kelly S. Giovanello ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Resting State ◽  
Memory Performance ◽  
Potential Mechanism ◽  
Network Efficiency ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
The Relationship

AbstractWith an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements within a system that provide alternative functionality in case of failure. As the hippocampus is one of the earliest sites affected by AD pathology, we hypothesized that functional hippocampal redundancy is protective against cognitive decline. We compared hippocampal functional redundancy derived from resting-state functional MRI networks in cognitively normal older adults, with individuals with early and late MCI, as well as the relationship between redundancy and cognition. Posterior hippocampal redundancy was reduced between cognitively normal and MCI groups, plateauing across early and late MCI. Higher hippocampal redundancy was related to better memory performance only for cognitively normal individuals. Critically, functional hippocampal redundancy did not come at the expense of network efficiency. Our results provide support that hippocampal redundancy protects against cognitive decline in aging.

scholarly journals 76 Comparison of Physical Performance in Older Fallers with and without Mild Cognitive Impairment

2019 ◽  
Vol 48 (Supplement_4) ◽  
pp. iv18-iv27
Author(s):  
Yu Chi Heaw ◽  
Devinder Kaur Ajit Singh ◽  
Maw Pin Tan ◽  
Saravana Kumar
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Muscle Strength ◽  
Physical Performance ◽  
Handgrip Strength ◽  
Upper Body ◽  
Timed Up And Go ◽  
Body Muscle ◽  
Performance Patterns ◽  
Scratch Tests

Abstract Introduction While mild cognitive impairment (MCI) is a risk factor for falls in older adults, the effects of MCI on physical performance associated with MCI have not been adequately characterised. The aim of the study was to profile physical performance patterns associated with MCI. Methodology 53 older fallers (31 females, 22 males) from the Falls Clinic at Universiti Malaya Medical Centre, aged 60 years and above (76.5±6.6) were screened and categorised into 2 groups – with MCI and non-MCI – using a Visual Cognitive Assessment Test (VCAT) cut-off score of ≥23. Participants’ sociodemographic data were recorded. Participants performed the Senior Fitness Test that consisted of a battery of physical performance tests. Results Older fallers with MCI (n=26) had significantly (p&lt;0.05) poorer physical performance compared to the non-MCI (n=27) group in handgrip strength (16.7±4.8 vs 20.7±7.9 kg), Timed Up-and-Go (17.3±9.91 vs 9.54±2.10 s) and 2-minute walk (79.3±29.8 vs MCI 106.3±33.1 m) tests. There were no significant (p&gt;0.05) differences for the 30-second chair stand, chair sit-and-reach and back scratch tests. Conclusion Older fallers with MCI had poorer upper body muscle strength, balance and aerobic endurance compared to those with normal cognition. However, flexibility and lower body muscle strength were similar in older fallers with and without MCI. Further studies to evaluate specifically tailored interventions according to the pattern of physical impairment reported with MCI are needed.

scholarly journals Differential Methylation in APOE (Chr19; Exon Four; from 44,909,188 to 44,909,373/hg38) and Increased Apolipoprotein E Plasma Levels in Subjects with Mild Cognitive Impairment

2019 ◽  
Vol 20 (6) ◽  
pp. 1394 ◽  
Author(s):  
Oscar Mancera-Páez ◽  
Kelly Estrada-Orozco ◽  
María Mahecha ◽  
Francy Cruz ◽  
Kely Bonilla-Vargas ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Social History ◽  
Plasma Levels ◽  
Neuropsychological Testing ◽  
Logistic Regression Models ◽  
And Gender ◽  
Epigenetic Patterns ◽  
Risk Association

Background: Biomarkers are essential for identification of individuals at high risk of mild cognitive impairment (MCI) for potential prevention of dementia. We investigated DNA methylation in the APOE gene and apolipoprotein E (ApoE) plasma levels as MCI biomarkers in Colombian subjects with MCI and controls. Methods: In total, 100 participants were included (71% women; average age, 70 years; range, 43–91 years). MCI was diagnosed by neuropsychological testing, medical and social history, activities of daily living, cognitive symptoms and neuroimaging. Using multivariate logistic regression models adjusted by age and gender, we examined the risk association of MCI with plasma ApoE and APOE methylation. Results: MCI was diagnosed in 41 subjects (average age, 66.5 ± 9.6 years) and compared with 59 controls. Elevated plasma ApoE and APOE methylation of CpGs 165, 190, and 198 were risk factors for MCI (p < 0.05). Higher CpG-227 methylation correlated with lower risk for MCI (p = 0.002). Only CpG-227 was significantly correlated with plasma ApoE levels (correlation coefficient = −0.665; p = 0.008). Conclusion: Differential APOE methylation and increased plasma ApoE levels were correlated with MCI. These epigenetic patterns require confirmation in larger samples but could potentially be used as biomarkers to identify early stages of MCI.

scholarly journals Cognitive impairment of workers in a large-scale aluminium factory in China: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e027154 ◽  
Author(s):  
Huaxing Meng ◽  
Shanshan Wang ◽  
Junhong Guo ◽  
Yarong Zhao ◽  
Shuhui Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
High Education ◽  
Mild Cognitive Impairment ◽  
Education Level ◽  
Secondary Outcome ◽  
Cross Sectional ◽  
High Education Level ◽  
Significant Difference ◽  
The Relationship ◽  
Aluminium Exposure

ObjectivesTo investigate the prevalence of mild cognitive impairment and the relationship with plasma aluminium among aluminium workers.DesignThis was a cross-sectional case-control study in the SH Aluminium Factory, China.SettingThe university and affiliated hospital cooperated in the study.ParticipantsThere were 910 aluminium workers on duty, among whom 853 participated in our study. Participants, such as those with cerebral vascular disease, epilepsy, brain trauma, Parkinson’s and mental diseases, aluminium-containing drug and mental drug use, and any family history of dementia in first-degree relatives were excluded.Primary and secondary outcome measuresBlood samples were collected, and plasma aluminium was measured by inductively coupled plasma-mass spectrometry. For each case, four age-matched controls were evaluated to determine the relationship between aluminium exposure and mild cognitive impairment. Conditional logistic regression was used to explore influential factors in mild cognitive impairment.ResultsAmong 910 workers, 93.74% participated in stage 1; 53 cases were finally diagnosed. The crude prevalence of mild cognitive impairment among aluminium workers on duty was 6.21%. There was a significant difference in plasma aluminium concentration between the two groups. In the multivariate analysis, we found that a higher level of plasma aluminium was associated with a high risk of cognitive impairment when compared with a lower aluminium level (AOR=2.24, 95% CI=1.17 to 4.26), and a high education level was a protective factor (AOR=0.36, 95% CI=0.18 to 0.70). No other factor was statistically significant.ConclusionsMild cognitive impairment is no longer a disease specific to elderly people. High plasma aluminium exposure might be associated with an increased risk of cognitive impairment, but a reduced risk was observed with a high education level. The cognitive function of aluminium workers on duty must be considered seriously.

Sign in / Sign up

Export Citation Format

Share Document