scholarly journals Isolated Soy Protein Supplementation and Exercise Improve Fatigue-Related Biomarker Levels and Bone Strength in Ovariectomized Mice

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1792 ◽  
Author(s):  
Che-Li Lin ◽  
Mon-Chien Lee ◽  
Yi-Ju Hsu ◽  
Wen-Ching Huang ◽  
Chi-Chang Huang ◽  
...  

Isolated soy protein (ISP) is a well-known supplement and has been reported to improve health, exercise performance, body composition, and energy utilization. ISP exhibits multifunctional bioactivities and also contains branched-chain amino acids (BCAAs), which have been confirmed to positively affect body weight (BW) regulation and muscle protein synthesis. The combined effects of BCAA supplements and exercise in older postmenopausal women with osteoporosis, sarcopenia, and obesity have been inadequately investigated. Therefore, in this study, we evaluated the potential beneficial effects of soy protein supplementation and exercise training on postmenopausal mice. Forty mice (14 weeks old) with ovariectomy-induced osteosarcopenic obesity were divided into five groups (n = 8), namely sham ovariectomy (OVX, control), OVX, OVX with ISP supplementation (OVX+ISP), OVX with exercise training (ET, OVX+ET), and OVX with ISP and ET (OVX+ISP+ET). The mice received a vehicle or soy protein (3.8 g/kg BW) by oral gavage for four weeks, and the exercise performance (forelimb grip strength and exhaustive swimming time) was evaluated. In the biochemical profiles, we evaluated the serum glucose level and tissue damage markers, such as lactate, ammonia, glucose, blood urine nitrogen (BUN), and creatinine phosphate kinase (CPK). The body composition was determined by evaluating bone stiffness and muscle mass. All data were analyzed using one-way repeated measures analysis of variance. The physical performance of the OVX+ISP+ET group did not differ from that of the other groups. The OVX+ISP+ET group exhibited lower levels of serum lactate, ammonia, CPK, and BUN as well as economized glucose metabolism after an acute exercise challenge. The OVX+ISP+ET group also exhibited higher muscle mass and bone strength than the OVX group. Our study demonstrated that a combination of ISP supplementation and exercise reduced fatigue and improved bone function in OVX mice.

Author(s):  
Fang Li ◽  
Ying-Ting Hsueh ◽  
Yi-Ju Hsu ◽  
Mon-Chien Lee ◽  
Chun-Hao Chang ◽  
...  

Today, women are concerned with health promotion but also with improvements in body weight and shape. The purpose of this study was to investigate the effects of aerobic exercise training (AET) combined with isolated soy protein (ISP) supplementation on the body composition, anthropometric characteristics, and cardiopulmonary endurance of women. The qualified subjects were randomly assigned to AET or AET + ISP groups. Women in the AET + ISP group were given an ISP-rich supplement (40 g/day) 5 days a week for 8 weeks; those in the AET group were given the same amount of water in an identical manner. All women received 60 min of AET twice a week for 8 weeks at an intensity of 40–65% heart rate reserve (HRR) and their body composition, anthropometric characteristics, and physical fitness were measured one week before and after the 8-week AET class. A total of 16 subjects (age: 36.13 ± 5.76 years) completed the study and were included in the dataset. The results of this study show that the AET + ISP group obtained greater reductions in body weight (effect size = 0.99), body mass index (BMI, effect size = 1.04), percentage body fat (PBF, effect size = 1.18), circumferences (waist and hip, all effect sizes > 0.8), and greater gains in the percentage lean body mass (PLBM, effect size = 0.89), compared with the AET group, without significant differences in 20 m multi-stage shuttle run test (20 m MST). We conclude that there is a trend for the consumption of ISP following AET to improve the body composition and anthropometric characteristics in women, compared with those who received the same AET without ISP supplementation.


2015 ◽  
Vol 9 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Lorena da Silva Paes ◽  
Juliana Pereira Borges ◽  
Fernanda Monteiro dos Santos ◽  
Taciana Pinto de Oliveira ◽  
Jaciara Gomes Dupin ◽  
...  

Background :There is a lack of research investigating long-term effects of exercise training upon the body composition and muscle function in HIV-infected patients (PHIV). The study investigated the influence of a 2-year supervised exercise program on body composition and strength of PHIV under highly active antiretroviral therapy (HAART).Methods :A training program including aerobic, strength and flexibility exercises was performed by 27 PHIV (17 men/ 10 women; age: 48.7±7.0 years; HAART: 150.7±65.3 months) during 1 year and 18 PHIV (10 men/ 8 women; age: 50.6±5.2 years; HAART: 176.6±53.1 months) during 2 years. Body composition and knee isokinetic strength were assessed at baseline and at the end of each year of intervention.Results :Body composition remained stable along the whole experimentvsbaseline (1-year- total muscle mass: Δ men=1.1%,P=0.21; Δ women=1.4%,P=0.06; trunk fat: Δ men=-0.1%,P=0.65; Δ women=-1.5%,P=0.45;2 years- total muscle mass: Δ men=2.7%,P=0.54; Δ women=-1.9%,P=0.71; trunk fat: Δ men=4.4%,P=0.96; Δ women=10.0%,P=0.30). After 1-year, peak torque increased in men (Δ extension=4.2%,P=0.01; Δ flexion=12.2%,P=0.04) and total work reduced in women (Δ extension=-15.4%,P=0.01, Δ flexion=-17.5%,P=0.05). All strength markers remained stablevsbaseline after 2 years of intervention (P>0.05). Only men showed significant reduction in the risk of disability due to sarcopenia (P=0.05) after 1 year of intervention, which remained stable after 2 years.Conclusion :Long-term exercise training preserved strength and muscle mass in PHIV under HAART. Exercise programs should be part of HIV therapy to prevent sarcopenia of this population along the years.Trial Registration :ACTRN12610000683033; UTN U1111-1116-4416.


Metabolism ◽  
2019 ◽  
Vol 94 ◽  
pp. 18-27 ◽  
Author(s):  
Li Wei ◽  
Ya-Ting Wen ◽  
Mon-Chien Lee ◽  
Hua-Ming Ho ◽  
Chi-Chang Huang ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4547
Author(s):  
Mon-Chien Lee ◽  
Yi-Ju Hsu ◽  
Li-Hsuan Yang ◽  
Chi-Chang Huang ◽  
Chun-Sheng Ho

It is well known that supplementation with high protein after exercise can effectively promote muscle synthesis and repair, while green tea is rich in catechins that have antioxidant effects. We aimed to explore the effects of green tea combined with isolated soy protein on increase muscle mass in resistance-trained mice. A total of 32 male ICR mice (8-weeks old) were divided into four groups (n = 8/group), sedentary control group (SC), isolated soy protein with green tea group (ISPG), resistance training group (RT), isolated soy protein and green tea combine with resistance training group (ISPG + RT). All mice received control or ISPG by oral gavage for four consecutive weeks. Forelimb grip and exhaustive swimming time were used for exercise performance evaluation. In biochemical profile, we analyzed lactate, ammonia, blood urea nitrogen (BUN), and glucose and muscle damage index creatine kinase (CK) after exercise as biochemical parameters of exercise fatigue. The grip strength, muscular endurance, and exhaustive swimming time of the ISPG + RT group were significantly increased than other groups (p < 0.05), and also significantly decreased in serum lactate and ammonia levels (p < 0.05, respectively). The ISP + RT group was not only increased in quadriceps weight, (p < 0.05) but also decreased EFP (p < 0.05). We recommend using a 4-week supplementation with ISPG, combined with RT, to increase muscle mass, exercise performance, glycogen storage, and reduce fatigue biochemical parameters after exercise. The benefits of long-term supplementation or application to human supplementation can be further explored in the future.


2021 ◽  
pp. 1-27
Author(s):  
Masoome Piri Damaghi ◽  
Atieh Mirzababaei ◽  
Sajjad Moradi ◽  
Elnaz Daneshzad ◽  
Atefeh Tavakoli ◽  
...  

Abstract Background: Essential amino acids (EAAs) promote the process of regulating muscle synthesis. Thus, whey protein that contains higher amounts of EAA can have a considerable effect on modifying muscle synthesis. However, there is insufficient evidence regarding the effect of soy and whey protein supplementation on body composition. Thus, we sought to perform a meta-analysis of published Randomized Clinical Trials that examined the effect of whey protein supplementation and soy protein supplementation on body composition (lean body mass, fat mass, body mass and body fat percentage) in adults. Methods: We searched PubMed, Scopus, and Google Scholar, up to August 2020, for all relevant published articles assessing soy protein supplementation and whey protein supplementation on body composition parameters. We included all Randomized Clinical Trials that investigated the effect of whey protein supplementation and soy protein supplementation on body composition in adults. Pooled means and standard deviations (SD) were calculated using random-effects models. Subgroup analysis was applied to discern possible sources of heterogeneity. Results: After excluding non-relevant articles, 10 studies, with 596 participants, remained in this study. We found a significant increase in lean body mass after whey protein supplementation weighted mean difference (WMD: 0.91; 95% CI: 0.15, 1.67. P= 0.019). Subgroup analysis, for whey protein, indicated that there was a significant increase in lean body mass in individuals concomitant to exercise (WMD: 1.24; 95% CI: 0.47, 2.00; P= 0.001). There was a significant increase in lean body mass in individuals who received 12 or less weeks of whey protein (WMD: 1.91; 95% CI: 1.18, 2.63; P<0.0001). We observed no significant change between whey protein supplementation and body mass, fat mass, and body fat percentage. We found no significant change between soy protein supplementation and lean body mass, body mass, fat mass, and body fat percentage. Subgroup analysis for soy protein indicated there was a significant increase in lean body mass in individuals who supplemented for 12 or less weeks with soy protein (WMD: 1.48; 95% CI: 1.07, 1.89; P< 0.0001). Conclusion: Whey protein supplementation significantly improved body composition via increases in lean body mass, without influencing fat mass, body mass, and body fat percentage.


Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1429 ◽  
Author(s):  
Pedro L. Valenzuela ◽  
Fernando Mata ◽  
Javier S. Morales ◽  
Adrián Castillo-García ◽  
Alejandro Lucia

Protein supplementation might improve body composition and exercise performance. Supplements containing whey protein (WP) have received the most attention, but other protein sources such as beef protein (BP) are gaining popularity. We conducted a systematic review and meta-analysis of randomized controlled trials that compared the effects of exercise training combined with BP, WP or no protein supplementation (NP), on body composition or exercise performance. Secondary endpoints included intervention effects on total protein intake and hematological parameters. Seven studies (n = 270 participants) were included. No differences were found between BP and WP for total protein intake (standardized mean difference (SMD) = 0.04, p = 0.892), lean body mass (LBM) (SMD = −0.01, p = 0.970) or fat mass (SMD = 0.07, p = 0.760). BP significantly increased total daily protein intake (SMD = 0.68, p < 0.001), LBM (SMD = 0.34, p = 0.049) and lower-limb muscle strength (SMD = 0.40, p = 0.014) compared to NP, but no significant differences were found between both conditions for fat mass (SMD = 0.15, p = 0.256), upper-limb muscle strength (SMD = 0.16, p = 0.536) or total iron intake (SMD = 0.29, p = 0.089). In summary, BP provides similar effects to WP on protein intake and body composition and, compared to NP, might be an effective intervention to increase total daily protein intake, LBM and lower-limb muscle strength.


2019 ◽  
Vol 36 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Yunan Zhou ◽  
Matthias Hellberg ◽  
Thomas Hellmark ◽  
Peter Höglund ◽  
Naomi Clyne

Abstract Background Sarcopenia increases as renal function declines and is associated with higher morbidity and mortality. Myostatin is a negative regulator of muscle growth. Its expression in response to exercise is unclear. In this prespecified substudy of the Renal Exercise (RENEXC) trial, we investigated the effects of 12 months of exercise training on sarcopenia, muscle mass and plasma myostatin and the relationships between physical performance, muscle mass and plasma myostatin. Methods A total of 151 non-dialysis-dependent patients (average measured glomerular filtration rate 23 ± 8 mL/min/1.73 m2), irrespective of age or comorbidity, were randomly assigned to either strength or balance in combination with endurance training. Body composition was measured with dual-energy X-ray absorptiometry. Plasma myostatin was analysed using enzyme-linked immunosorbent assay kits. Results After 12 months, the prevalence of sarcopenia was unchanged, leg and whole-body lean mass increased significantly in the balance group and was unchanged in the strength group. Whole fat mass decreased significantly in both groups. There were no significant between-group differences in sarcopenia or body composition. Plasma myostatin levels increased significantly in both groups, with a significant difference in favour of the strength group. Plasma myostatin was significantly positively related to muscle mass and physical performance at baseline, but these relationships were attenuated after 12 months. Conclusions Exercise training seems to be effective in preventing sarcopenia and maintaining muscle mass in non-dialysis-dependent patients with chronic kidney disease (CKD). However, the role of plasma myostatin on muscle mass and physical performance in patients with CKD warrants further study.


2019 ◽  
Vol 15 (1) ◽  
pp. 108-116 ◽  
Author(s):  
Silvia Miteva ◽  
Iliya Yanev ◽  
Stefan Kolimechkov ◽  
Lubomir Petrov ◽  
Lubomir Mladenov ◽  
...  

Rhythmic gymnastics is a sport in which special consideration is given to diet and body appearance. The purpose of this study was to assess the nutrient intake and body composition of elite rhythmic gymnasts in comparison with guidelines for female gymnasts. Twenty-one elite rhythmic gymnasts from Bulgaria were divided into three groups: First National Team, mean age 24.2; Second National Team, mean age 17.8; and Junior National Team, mean age 12.6. Body fat and muscle mass were estimated by skinfold methods, and a food frequency questionnaire was applied to assess the nutrient intake. The gymnasts showed low per cent of body fat (13.9% for the First National Team, 17.0% for the Second National Team, and 15.6% for the Junior National Team) and high per cent muscle mass (44.0, 40.5, and 37.6%, respectively). They kept their weight close to the ideal one, as recommended by the coaches, and the following equation best corresponded to the recommended ideal weight: height (cm) − 118. The energy intake was lower than the calculated energy requirements, in addition to low intake of fat and carbohydrates. The relative protein intake was 1.7 g/kg for the First National Team, 1.7 g/kg for the Second National Team, and 1.9 g/kg for Junior National Team, and the energy contribution of proteins was higher than the recommended 15%. Rhythmic gymnasts should be encouraged to maintain their ideal weight without great variance from the health-related guidelines, and coaches should consider not only the body image, but also the norms relating to body composition in women when determining ideal weight.


2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiang Liu ◽  
Guoquan Ma

Relevant studies have shown that the use of sports equipment for exercise can regulate the body composition of patients, thereby achieving the purpose of improving the metabolism of blood lipids in the body. Based on this, this article takes patients with dyslipidemia as the research object and explores the changes in their body composition and shape using different strength sports equipment made of nanomaterials during sports rehabilitation training. In this study, 200 patients with dyslipidemia were selected as experimental subjects in the form of interviews and questionnaires. According to the type of exercise, they were divided into 56 men in the men’s running group, 56 men in the men’s spinning group, 44 women in the women’s running group, and 44 women in the women’s spinning group. 12 weeks of incremental exercise training were carried out. The results of the experiment found that after the end of the 12-week exercise training, the body composition of the subjects in each group changed significantly ( P < 0.05 ). The changes in the male and female spinning group were more obvious than those in the running group, and the weight of the male spinning group, waist circumference, and hip circumference decreased by 2.3%, 3%, and 3.5% and those of women’s spinning group decreased by 3.1%, 3.4%, and 3.9%. In addition, blood lipids in each group also changed significantly ( P < 0.05 ); there is a significant statistical difference. Through a return visit two years after the end of the experiment, it was found that most of the subjects had symptoms of discomfort, indicating that the nanomaterials have a certain negative impact on the human body.


2015 ◽  
Vol 112 (24) ◽  
pp. 7466-7471 ◽  
Author(s):  
Adrienne L. Zihlman ◽  
Debra R. Bolter

The human body has been shaped by natural selection during the past 4–5 million years. Fossils preserve bones and teeth but lack muscle, skin, fat, and organs. To understand the evolution of the human form, information about both soft and hard tissues of our ancestors is needed. Our closest living relatives of the genusPanprovide the best comparative model to those ancestors. Here, we present data on the body composition of 13 bonobos (Pan paniscus) measured during anatomical dissections and compare the data withHomo sapiens. These comparative data suggest that both females and males (i) increased body fat, (ii) decreased relative muscle mass, (iii) redistributed muscle mass to lower limbs, and (iv) decreased relative mass of skin during human evolution. Comparison of soft tissues betweenPanandHomoprovides new insights into the function and evolution of body composition.


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