scholarly journals Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1755 ◽  
Author(s):  
Giulia Sita ◽  
Patrizia Hrelia ◽  
Agnese Graziosi ◽  
Fabiana Morroni
Keyword(s):  
Median Overall Survival ◽  
Therapeutic Strategies ◽  
Cruciferous Vegetables ◽  
Cellular Mechanisms ◽  
Broccoli Sprouts ◽  
Leading Role ◽  
Incurable Disease ◽  
Health Promoting ◽  
Low Toxicity ◽  
Poor Efficacy

Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables, particularly broccoli and broccoli sprouts, has been widely investigated due to its promising health-promoting properties in disease, and low toxicity in normal tissue. Although not yet fully understood, many mechanisms of anticancer activity at each step of cancer development have been attributed to this ITC. Given the promising data available regarding SFN, this review aimed to provide an overview on the potential activities of SFN related to the cellular mechanisms involved in glioblastoma (GBM) progression. GBM is the most frequent malignant brain tumor among adults and is currently an incurable disease due mostly to its highly invasive phenotype, and the poor efficacy of the available therapies. Despite all efforts, the median overall survival of GBM patients remains approximately 1.5 years under therapy. Therefore, there is an urgent need to provide support for translating the progress in understanding the molecular background of GBM into more complex, but promising therapeutic strategies, in which SFN may find a leading role.

Natural Products for Regulating Macrophages M2 Polarization

2020 ◽  
Vol 15 (7) ◽  
pp. 559-569 ◽  
Author(s):  
Zhen Chang ◽  
Youhan Wang ◽  
Chang Liu ◽  
Wanli Smith ◽  
Lingbo Kong
Keyword(s):  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Therapeutic Strategies ◽  
Research Progress ◽  
Cellular Mechanisms ◽  
Pharmacological Activities ◽  
Current Review ◽  
M2 Polarization ◽  
Macrophages Polarization ◽  
Herbal Plants

Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.

scholarly journals Bioactive Compounds and Antioxidant Activity of Cauliflower According to Heat Treatment Method (P06-074-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Eun-Sun Hwang
Keyword(s):  
Heat Treatment ◽  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Science Research ◽  
Total Flavonoid ◽  
Total Phenolic ◽  
Cooking Methods ◽  
Cruciferous Vegetables ◽  
Total Polyphenol ◽  
Health Promoting

Abstract Objectives Cauliflower is one of the cruciferous vegetables and contains various physiologically active substances such as glucosinolates, polyphenols, and flavonoids. Unlike ordinary vegetables, cruciferous vegetables are often consumed by cooking through heat treatment. The purpose of this study was to investigate the effects of different heating procedures, in particular steaming and boiling, on glucosinolate, total polyphenol, and total flavonoid concentrations in cauliflower. In addition, antioxidant activity was compared between fresh uncooked, steamed, and boiled cauliflower, which are the main methods of preparing cauliflower before consumption. Methods Glucosinolates in uncooked, steamed, and boiled cauliflower were subjected to high-pressure liquid chromatography. Total phenolic and total flavonoid content and antioxidant activities in cauliflower extracted in both water and 80% ethanol were determined. Results Eight glucosinolate peaks were detected in cauliflower representing glucoiberin, progoitrin, glucoraphanin, sinigrin, gluconapin, glucoiberverin, glucobrassicin, and gluconasturtiin. Boiling cauliflower significantly decreased the glucosinolate, total polyphenol, and total flavonoid concentrations compared to those of uncooked or steamed cauliflower. The results clearly indicated that health-promoting compounds in cauliflower are significantly affected by different cooking methods, showing that uncooked > steamed > boiled. The amounts of total polyphenols and total flavonoids contained within uncooked cauliflower extracted by 80% ethanol were higher than those in the steamed and boiled extracts. The highest antioxidant activity was observed in uncooked cauliflower extracted in 80% ethanol compared to that of water extracts at the same concentration. Steamed and boiled cauliflower extracts showed lower antioxidant activity. Conclusions Based on these results, fresh uncooked cauliflower is optimal in terms of the content of health-promoting compounds and antioxidant activity. It may be desirable to use steaming rather than boiling to minimize the loss of glucosinolates when storing, pretreating, processing, and cooking cruciferous vegetables. Funding Sources This research was supported by the Basic Science Research Program through the National Research Foundation of Korea.

Effect of 2, 4-epibrassinolide on main health-promoting compounds in broccoli sprouts

LWT ◽  
2014 ◽  
Vol 58 (1) ◽  
pp. 287-292 ◽  
Author(s):  
Rongfang Guo ◽  
Qiumei Hou ◽  
Gaofeng Yuan ◽  
Yanting Zhao ◽  
Qiaomei Wang
Keyword(s):  
Broccoli Sprouts ◽  
Health Promoting

Current and Emerging Therapies for Ocular Rosacea

2013 ◽  
Vol 06 (02) ◽  
pp. 86
Author(s):  
Edward J Wladis ◽  
Alejandro P Adam ◽  
◽  
Keyword(s):  
Side Effects ◽  
Therapeutic Strategies ◽  
Treatment Modalities ◽  
Surgical Interventions ◽  
Oral Medications ◽  
Incurable Disease ◽  
Emerging Therapies ◽  
Improved Outcomes ◽  
Ocular Rosacea ◽  
Intense Research

Ocular rosacea is an incurable disease that affects millions of Americans annually. While multiple therapeutic strategies have been devised to address this disorder (including topical and oral medications, laser and light-based treatments, and surgical interventions), our current interventions are largely nonspecific and often ineffective. Nonetheless, ocular rosacea remains a source of intense research, and newer treatments offer tremendous promise for improved outcomes. In this review, we discuss the current and emerging treatment modalities for ocular rosacea and analyze novel basic science findings that will hopefully lead to highly targeted medications to treat this potentially blinding illness with greater specificity and fewer side effects.

scholarly journals Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler

2021 ◽  
Author(s):  
Sophie Strobel ◽  
Samantha Laber ◽  
Josep M Mercader ◽  
Hesam Dashti ◽  
Alina Ainbinder ◽  
...  
Keyword(s):  
High Throughput ◽  
Genetic Variants ◽  
Large Scale ◽  
Cell Types ◽  
Therapeutic Strategies ◽  
Cellular Mechanisms ◽  
Waist To Hip Ratio ◽  
Disease Mechanisms ◽  
Primary Obstacle ◽  
Genetics And Genomics

A primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants and genes associated with human diseases. Broadly applicable high-throughput, unbiased assays offer a path to rapidly characterize gene and variant function and thus illuminate disease mechanisms. Here, we report LipocyteProfiler, an unbiased high-throughput, high-content microscopy assay that is amenable to large-scale morphological and cellular profiling of lipid-accumulating cell types. We apply LipocyteProfiler to adipocytes and hepatocytes and demonstrate its ability to survey diverse cellular mechanisms by generating rich context-, and process-specific morphological and cellular profiles. We then use LipocyteProfiler to identify known and novel cellular programs altered by polygenic risk of metabolic disease, including insulin resistance, waist-to-hip ratio and the polygenic contribution to lipodystrophy. LipocyteProfiler paves the way for large-scale forward and reverse phenotypic profiling in lipid-storing cells, and provides a framework for the unbiased identification of causal relationships between genetic variants and cellular programs relevant to human disease.

Chemotherapy with FOLFOX IV in advanced gastric cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14112-14112
Author(s):  
M. A. Garrido. ◽  
G. Melgoza ◽  
H. Galindo ◽  
J. Madrid ◽  
C. Sanchez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Median Overall Survival ◽  
Lung Metastases ◽  
Stage Iv ◽  
Phase Iii ◽  
First Line ◽  
Phase Iii Trial ◽  
Low Toxicity ◽  
Grade 3

14112 Background: Gastric cancer is the first cause of mortality for cancer in Chile. 65% is observed in advanced form and the median survival without surgery is 5,4 months. We hypothesised that chemotherapy and specially FOLFOX IV is an active regimen and has low toxicity in patient with advanced gastric cancer. The main evaluated objectives were: response, toxicity and survival of patient with advanced gastric cancer. Methods: Patients with gastric adenocarcinoma, stage IV that accepted chemotherapy with FOLFOX IV in any time of evolution were included. The evaluation of response was obtained with CT scan every two month. The characteristics of patients, chemotherapy responses, toxicity and global survival were analysed. Results: Between November 2003 and October 2005, 20 patients were included, the median age was 51,5 years (range 28–67), 80% male. Hepatic, peritoneal and lung metastases were the principal places of dissemination. The response rate in first line was: PR 66%, SD 17%, with overall response of 83% (12 patients). In second line the response was: PR 37%, SD 63% (8 patients). The average of treatment was 5,5 months. The median of response was 5 months (2–12). The median overall survival was 12 months. 50% of patients showed toxicity; digestive grade 2 in 2 patients, neurological grade 2 in 4 patients and only 1 patient showed grade 3 toxicity. Conclusions: FOLFOX IV is an active chemotherapy regiment with low toxicity profile in advanced gastric cancer. With these results we propose a Phase III trial would be feasible to perform. No significant financial relationships to disclose.

scholarly journals Gold Nanoparticles: A New Golden Era in Oncology?

2020 ◽  
Vol 13 (8) ◽  
pp. 192 ◽  
Author(s):  
Clara Gerosa ◽  
Guido Crisponi ◽  
Valeria Marina Nurchi ◽  
Luca Saba ◽  
Rosita Cappai ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Clinical Practice ◽  
Anticancer Agents ◽  
High Selectivity ◽  
Clinical Medicine ◽  
Therapeutic Agents ◽  
Therapeutic Strategies ◽  
Therapeutic Approaches ◽  
Starting Point ◽  
Low Toxicity

In recent years, the spectrum of possible applications of gold in diagnostics and therapeutic approaches in clinical practice has changed significantly, becoming surprisingly broad. Nowadays, gold-based therapeutic agents are used in the therapy of multiple human diseases, ranging from degenerative to infectious diseases and, in particular, to cancer. At the basis of these performances of gold, there is the development of new gold-based nanoparticles, characterized by a promising risk/benefit ratio that favors their introduction in clinical trials. Gold nanoparticles appear as attractive elements in nanomedicine, a branch of modern clinical medicine, which combines high selectivity in targeting tumor cells and low toxicity. Thanks to these peculiar characteristics, gold nanoparticles appear as the starting point for the development of new gold-based therapeutic strategies in oncology. Here, the new gold-based therapeutic agents developed in recent years are described, with particular emphasis on the possible applications in clinical practice as anticancer agents, with the aim that their application will give rise to a new golden age in oncology and a breakthrough in the fight against cancer.

Cancer Preventing Properties of Cruciferous Vegetables

2009 ◽  
Vol 70 (1) ◽  
pp. 5-18 ◽  
Author(s):  
Janusz Czapski
Keyword(s):  
Mechanisms Of Action ◽  
Cruciferous Vegetables ◽  
Phenethyl Isothiocyanate ◽  
Active Compounds ◽  
Brussels Sprouts ◽  
Anticancer Properties ◽  
Health Promoting

Cancer Preventing Properties of Cruciferous VegetablesHealth-promoting phytonutrients in cruciferous vegetables have been gaining attention for their powerful effects in combating cancer. This review concerns anticancer properties of cruciferous green vegetables of "Brassica" genus such as broccoli, kale, Brussels sprouts, watercress. The role and mechanisms of action of cruciferous active compounds such as sulforaphane, indole-3-carbinol, diindolylmethane and phenethyl isothiocyanate in protection against cancer and cancer-fighting are discussed. Losses of nutrients and active compounds during cooking, microwaving, and blanching of vegetables which may be more substantial than commonly perceived are also reviewed.

scholarly journals Patent Insight into the Development of Therapeutic Strategies against Coronaviruses

2021 ◽  
Vol 1 (1) ◽  
pp. 93-100
Author(s):  
Hai-Long Zhang ◽  
Ai-Feng Zhou ◽  
Yiqian Li
Keyword(s):  
Therapeutic Strategy ◽  
Vaccine Development ◽  
Rna Viruses ◽  
Therapeutic Strategies ◽  
Peptide Drugs ◽  
Leading Role ◽  
Global Pandemic ◽  
Effective Therapeutic Strategy ◽  
Insight Into ◽  
Development And Evolution

Coronaviruses are a group of RNA viruses, which cause diseases in humans. The emergence of COVID-19, has caused a global pandemic. It is focused on developing an effective therapeutic strategy against COVID-19. To better understand the development and evolution of therapeutic strategies against coronaviruses, we conducted US granted patents analysis. The results showed vaccines played a leading role in therapies against coronaviruses. Both attenuated vaccines and recombinant genetic vaccines were very important approaches in vaccine development against coronaviruses. It is not a rapid approach to develop peptide drugs against COVID-19 or future novel coronaviruses. The study was the first one to show the development and evolution in therapeutic strategies against coronaviruses based on patent insight. The present study provides a new insight into the development of therapeutic strategies against coronaviruses.

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