scholarly journals Applications of Gelatin Methacryloyl (GelMA) Hydrogels in Microfluidic Technique-Assisted Tissue Engineering

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5305
Author(s):  
Taotao Liu ◽  
Wenxian Weng ◽  
Yuzhuo Zhang ◽  
Xiaoting Sun ◽  
Huazhe Yang
Keyword(s):  
Tissue Engineering ◽  
Microfluidic Chip ◽  
Production Line ◽  
Large Scale ◽  
Raw Materials ◽  
Microfluidic Devices ◽  
Building Blocks ◽  
Large Scale Integration ◽  
Scale Integration ◽  
Microfluidic Technique

In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed.

Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices

2003 ◽  
Vol 89 (3) ◽  
pp. 315-323 ◽  
Author(s):  
William H Grover ◽  
Alison M Skelley ◽  
Chung N Liu ◽  
Eric T Lagally ◽  
Richard A Mathies
Keyword(s):  
Large Scale ◽  
Microfluidic Devices ◽  
Large Scale Integration ◽  
Scale Integration

Automatic Synthesis of Comparator Circuit Using Genetic Algorithm and SPICE Optimizing Function

2015 ◽  
Vol 643 ◽  
pp. 131-140 ◽  
Author(s):  
Takayuki Negishi ◽  
Naoki Arai ◽  
Nobukazu Takai ◽  
Masato Kato ◽  
Hiroaki Seki ◽  
...  
Keyword(s):  
Circuit Design ◽  
Large Scale ◽  
Analog Circuit ◽  
Building Blocks ◽  
Digital Circuit ◽  
Automatic Design ◽  
Automatic Synthesis ◽  
Digital Circuit Design ◽  
Large Scale Integration ◽  
Scale Integration

This Paper Describes our Challenge of Automatic Analog Circuit Design by Focusingon a Comparator Circuit which is One of the Important Analog Building Blocks. the Geneticalgorithm Chooses the Optimal Circuit Topology and HSPICE Optimizing Function Obtains Theiroptimal Parameter Values Automatically. Automatic Design for Analog Circuit has Not Beenrealized yet, even though Automatic Design is being Used in Digital Circuit Design; the Reasonbehind this is that the Number of Parameters to Be Considered in an Analog Circuit Designis much Larger than Digital Circuit Design. Nowadays it is Extremely Difficult to Design Icsmanually due to their Large Scale Integration and Hence their Automatic Design is Demanded. Wepresent our Automatic Circuit Design Owchart Programmed with Java Language which Realizes1-Click Automatic Synthesis of the Comparator, and Shows that our Method can Obtain a Betterperformance Comparator Compared to an Initially-Set Comparator.

scholarly journals Controller for microfluidic large-scale integration

2017 ◽  
Author(s):  
Jonathan A White ◽  
Aaron M Streets
Keyword(s):  
High Throughput ◽  
Personal Computer ◽  
Large Scale ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Fluid Handling ◽  
Large Scale Integration ◽  
Scale Integration ◽  
Microfluidic Valves ◽  
Python Package

AbstractMicrofluidic devices with integrated valves provide precise, programmable fluid handling platforms for high-throughput biological or chemical assays. However, setting up the infrastructure to control such platforms often requires specific engineering expertise or expensive commercial solutions. To address these obstacles, we present a Kit for Arduino-based Transistor Array Actuation (KATARA), an open-source and low-cost Arduino-based controller that can drive 70 solenoid valves to pneumatically actuate integrated microfluidic valves. We include a python package with a GUI to control the KATARA from a personal computer. No programming experience is required.

scholarly journals Analysis of fast protein phosphorylation kinetics in single cells on a microfluidic chip

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 726-734 ◽  
Author(s):  
Matthias Blazek ◽  
Tomas Silva Santisteban ◽  
Roland Zengerle ◽  
Matthias Meier
Keyword(s):  
Protein Phosphorylation ◽  
Cell Cultures ◽  
Microfluidic Chip ◽  
Chemical Control ◽  
Large Scale ◽  
Single Cells ◽  
Fast Kinetics ◽  
Large Scale Integration ◽  
Scale Integration ◽  
Kinetics Of

In the present study, we developed a microfluidic large-scale integration (mLSI) platform for the temporal and chemical control of cell cultures to study fast kinetics of protein phosphorylation.

Plant hormones, plant growth regulators

2014 ◽  
Vol 155 (26) ◽  
pp. 1011-1018 ◽  
Author(s):  
György Végvári ◽  
Edina Vidéki
Keyword(s):  
Nervous System ◽  
Growth And Development ◽  
Large Scale ◽  
Essential Role ◽  
Higher Plants ◽  
Structure And Function ◽  
Wide Sense ◽  
Large Scale Integration ◽  
Scale Integration ◽  
And Function

Plants seem to be rather defenceless, they are unable to do motion, have no nervous system or immune system unlike animals. Besides this, plants do have hormones, though these substances are produced not in glands. In view of their complexity they lagged behind animals, however, plant organisms show large scale integration in their structure and function. In higher plants, such as in animals, the intercellular communication is fulfilled through chemical messengers. These specific compounds in plants are called phytohormones, or in a wide sense, bioregulators. Even a small quantity of these endogenous organic compounds are able to regulate the operation, growth and development of higher plants, and keep the connection between cells, tissues and synergy beween organs. Since they do not have nervous and immume systems, phytohormones play essential role in plants’ life. Orv. Hetil., 2014, 155(26), 1011–1018.

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