scholarly journals Controller for microfluidic large-scale integration

2017 ◽  
Author(s):  
Jonathan A White ◽  
Aaron M Streets
Keyword(s):  
High Throughput ◽  
Personal Computer ◽  
Large Scale ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Fluid Handling ◽  
Large Scale Integration ◽  
Scale Integration ◽  
Microfluidic Valves ◽  
Python Package

AbstractMicrofluidic devices with integrated valves provide precise, programmable fluid handling platforms for high-throughput biological or chemical assays. However, setting up the infrastructure to control such platforms often requires specific engineering expertise or expensive commercial solutions. To address these obstacles, we present a Kit for Arduino-based Transistor Array Actuation (KATARA), an open-source and low-cost Arduino-based controller that can drive 70 solenoid valves to pneumatically actuate integrated microfluidic valves. We include a python package with a GUI to control the KATARA from a personal computer. No programming experience is required.

Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices

2003 ◽  
Vol 89 (3) ◽  
pp. 315-323 ◽  
Author(s):  
William H Grover ◽  
Alison M Skelley ◽  
Chung N Liu ◽  
Eric T Lagally ◽  
Richard A Mathies
Keyword(s):  
Large Scale ◽  
Microfluidic Devices ◽  
Large Scale Integration ◽  
Scale Integration

Transient Modelling of Pneumatic Valves in Centrifugal Microfluidic Devices

2016 ◽  
Author(s):  
Michael R. Moon ◽  
Lin Lin
Keyword(s):  
Surface Tension ◽  
Point Of Care ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Novel Technologies ◽  
Fluid Handling ◽  
Pneumatic Valves ◽  
Microfluidic Valves ◽  
And Control ◽  
Micrometer Scale

Point of care medical instruments benefit from compact fluid handling systems in the microliter range. To handle fluid volumes this small, many novel technologies have been studied. Pneumatic valves offer advantages over other microfluidic valves, including robustness and low cost. These valves are used in centrifugal microfluidic devices, a very active area of research, and take advantage of pneumatic and centrifugal pressure to aliquot and control the flow of fluid. The physics of fluids at the micrometer scale are complex and modelling their behavior using CFD software is challenging. Representing adhesion, surface tension, and other multiphase interactions is critical to accurately model microfluidic behavior. Centrifugal devices must also consider Coriolis, centrifugal, and Euler effects. In this study, a pneumatic valve was designed and simulated using commercial CFD software. The device was also fabricated for verification of the simulation. The simulation demonstrated the multiphase interactions of fluid and air within the rotating device. In a transient analysis of the model, a 6 μl volume of water is held in stable equilibrium by a compressed volume of air at low RPM, while at a higher RPM, the fluid is observed to displace the compressed air as a result of Rayleigh-Taylor instability. Actual devices with comparable geometry were built and tested. The behavior of the valve predicted in the model was in agreement with experimental results produced from the actual devices. The results of the simulation captured the stabilizing effect of both pneumatic pressure and surface tension at low RPM, as well as the instability that results from increased centrifugal and Euler pressure at higher RPM.

Low-Temperature Polycrystalline Silicon Thin-Film Transist or Technologies for System-on-Glass Displays

MRS Bulletin ◽  
2002 ◽  
Vol 27 (11) ◽  
pp. 881-886 ◽  
Author(s):  
Shuichi Uchikoga
Keyword(s):  
Thin Film ◽  
Low Temperature ◽  
Polycrystalline Silicon ◽  
Large Scale ◽  
Low Cost ◽  
Silicon Thin Film ◽  
Light Emitting ◽  
Light Emitting Devices ◽  
Large Scale Integration ◽  
Scale Integration

AbstractThe elimination of conventional peripheral LSI (large-scale integration) drivers is considered essential to the development of future low-cost, energy-efficient, lightweight, and thin displays. System-on-glass (SOG) displays are a type of display with various functional circuits integrated on a glass substrate. Low-temperature polycrystalline silicon (LTPS) thin-film transistors (TFTs) make the integration of circuits possible because they can be assembled into complex, high-current driver circuits. Furthermore, LTPS TFTs are attracting attention for driving organic light-emitting devices (OLEDs). This article introduces present and future LTPS TFT technologies for SOG displays.

scholarly journals Is the Large-Scale Development of Wind-PV with Hydro-Pumped Storage Economically Feasible in Greece?

2021 ◽  
Vol 11 (5) ◽  
pp. 2368
Author(s):  
Anna Dianellou ◽  
Theofanis Christakopoulos ◽  
George Caralis ◽  
Vassiliki Kotroni ◽  
Konstantinos Lagouvardos ◽  
...  
Keyword(s):  
Power System ◽  
Large Scale ◽  
Low Cost ◽  
Potential Contribution ◽  
Gradual Development ◽  
Large Scale Integration ◽  
Pumped Storage ◽  
Steady State Simulation ◽  
Scale Integration ◽  
Pv Generation

The achievement of the long-term national energy targets in Greece for large-scale integration of wind and solar energy may be facilitated by the development of hydro-pumped storage projects. In light of the above, technical aspects related with the operation of the Greek power system and its ability to absorb renewable energy are analyzed in connection with the role of hydro-pumped storage and relative economic aspects. The aim of this work is to assess the potential contribution of hydro-pumped storage projects and estimate the capacity magnitude order to support large-scale wind and photovoltaic (PV) integration in Greece. For this purpose, scenarios for the Greek power system with focus on Wind and PV development, in conjunction with hydro-pumped storage capacity, are developed, and results for current situation and reference years 2030 and 2050 are presented. For the simulation, among others, high resolution mesoscale wind data for a typical year in the whole Greek territory are used for the steady state simulation of the Greek power system, in order to better estimate the power that could be generated from installed wind turbines, taking into consideration technical characteristics of a typical commercial wind turbine. Results indicate the need of gradual development of hydro-pumped storage in parallel with the large-scale integration of wind and PV capacity into the Greek power system. In addition, the feasibility of the examined scenarios is supported from the low cost of wind and PV generation. In the case of Greece, thanks to the complex morphology and hydraulic conditions of the country, hydro-pumped storage composes an efficient and low-cost storage solution.

scholarly journals Applications of Gelatin Methacryloyl (GelMA) Hydrogels in Microfluidic Technique-Assisted Tissue Engineering

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5305
Author(s):  
Taotao Liu ◽  
Wenxian Weng ◽  
Yuzhuo Zhang ◽  
Xiaoting Sun ◽  
Huazhe Yang
Keyword(s):  
Tissue Engineering ◽  
Microfluidic Chip ◽  
Production Line ◽  
Large Scale ◽  
Raw Materials ◽  
Microfluidic Devices ◽  
Building Blocks ◽  
Large Scale Integration ◽  
Scale Integration ◽  
Microfluidic Technique

In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed.

scholarly journals A generalizable experimental framework for automated cell growth and laboratory evolution

2018 ◽  
Author(s):  
Brandon G. Wong ◽  
Christopher P. Mancuso ◽  
Szilvia Kiriakov ◽  
Caleb J. Bashor ◽  
Ahmad S. Khalil
Keyword(s):  
High Throughput ◽  
Large Scale ◽  
Dynamic Pressure ◽  
Temperature Regimes ◽  
Cell Culture Systems ◽  
Selection Experiments ◽  
Growth Selection ◽  
Large Scale Integration ◽  
Fine Control ◽  
Scale Integration

ABSTRACTIn the post-genomics era, exploration of phenotypic adaptation is limited by our ability to experimentally control selection conditions, including multi-variable and dynamic pressure regimes. While automated cell culture systems offer real-time monitoring and fine control over liquid cultures, they are difficult to scale to high-throughput, or require cumbersome redesign to meet diverse experimental requirements. Here we describe eVOLVER, a multipurpose, scalable DIY framework that can be easily configured to conduct a wide variety of growth fitness experiments at scale and cost. We demonstrate eVOLVER’s versatility by configuring it for diverse growth and selection experiments that would be otherwise challenging for other systems. We conduct high-throughput evolution of yeast across different population density niches. We perform growth selection on a yeast knockout library under temporally varying temperature regimes. Finally, inspired by large-scale integration in electronics and microfluidics, we develop novel millifluidic multiplexing modules that enable complex fluidic routines including multiplexed media routing, cleaning, vial-to-vial transfers, and automated yeast mating. We propose eVOLVER to be a versatile design framework in which to study, characterize, and evolve biological systems.

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