Tannic acid-inspired, self-healing and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties

Author(s):  
Wen Shi ◽  
Yunfan Kong ◽  
Yajuan Su ◽  
Mitchell A. Kuss ◽  
Xiping Jiang ◽  
...  

Due to their intrinsic injectable and self-healing characteristics, dynamic hydrogels, based on dynamic covalent bonds, have gained a great attention. In this study, a novel dynamic hydrogel based on the...

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3050
Author(s):  
Yujie Chen ◽  
Runjing Zhang ◽  
Baiqin Zheng ◽  
Chao Cai ◽  
Zhen Chen ◽  
...  

Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.


2020 ◽  
Author(s):  
Alexis Wolfel ◽  
Cecilia Inés Alvarez Igarzabal ◽  
Marcelo Ricardo Romero

<p>Design of materials with novel sensitivities and smart behaviour is important for the development of smart systems with automated responsiveness. We have recently reported the synthesis of hydrogels, cross-linked by <i>N,N'</i>-diallyltartardiamide (DAT). The covalent DAT-crosslinking points have vicinal diols which can be easily cleaved with periodate, generating valuable a-oxo-aldehyde functional groups, useful for further chemical modification. Based on those findings, we envisioned that a self-healable hydrogel could be obtained by incorporation of primary amino functional groups, from <a>2-aminoethyl methacrylate </a>hydrochloride (AEMA), coexisting with DAT into the same network. The a-oxo-aldehyde groups generated after the reaction with periodate would arise in the immediate environment of amine groups to form imine cross-links. For this purpose, DAT-crosslinked hydrogels were synthesized and carefully characterized. The cleavage of DAT-crosslinks with periodate promoted changes in the mechanical and swelling properties of the materials. As expected, a self-healing behavior was observed, based on the spontaneous formation of imine covalent bonds. In addition, we surprisingly found a combination of fast vicinal diols cleavage and a low speed self-crosslinking reaction by imine formation. Consequently, it was found a time-window in which a periodate-treated polymer was obtained in a transient liquid state, which can be exploited to choose the final shape of the material, before automated gelling. The singular properties attained on these hydrogels could be useful for developing sensors, actuators, among other smart systems.</p>


2021 ◽  
Vol 11 (15) ◽  
pp. 6945
Author(s):  
Chukwuma O. Agubata ◽  
Cynthia C. Mbaoji ◽  
Ifeanyi T. Nzekwe ◽  
César Saldías ◽  
David Díaz Díaz

In this work, a biohydrogel based on alginate and dynamic covalent B-O bonds, and derived composites, has been evaluated for wound healing applications. In particular, a phenylboronic acid–alginate (PBA-Alg) complex was synthesized by coupling 3-aminophenylboronic acid onto alginate, and used to prepare varied concentrations of hydrogels and silicate-based nanocomposites in PBS. The resulting hydrogels were characterized in terms of interfacial tension, moisture uptake and loss, interaction with fresh acid-soluble collagen, self-healing ability, effects on blood clotting and wound healing. The interfacial tension between the hydrogels and biorelevant fluids was low and moisture loss of 55%–60% was evident without uptake from the environment. The components of the hydrogels and their mixtures with collagen were found to be compatible. These hydrogels showed efficient self-healing and thixotropic behavior, and the animals in the treatment groups displayed blood clotting times between 9.1 min and 10.7 min. In contrast, the composites showed much longer or shorter clotting times depending on the silicate content. A significant improvement in wound healing was observed in 3% w/v PBA-Alg formulations. Overall, the PBA-Alg hydrogels exhibit self-healing dynamic covalent interactions and may be useful in dressings for incision wounds.


2017 ◽  
Vol 8 (2) ◽  
pp. 1350-1355 ◽  
Author(s):  
Alexander S. Groombridge ◽  
Aniello Palma ◽  
Richard M. Parker ◽  
Chris Abell ◽  
Oren A. Scherman

The successful self-assembly of a stimuli-responsive aqueous supramolecular hyperbranched polymer from small molecules and the macrocyclic host cucurbit[8]uril (CB[8]) is reported. This self-healing supramolecular network can act as a soft matter barrier at liquid–liquid interfaces.


Author(s):  
Natascha Kuhl ◽  
Stefan Bode ◽  
Martin D. Hager ◽  
Ulrich S. Schubert

2021 ◽  
Vol 12 (39) ◽  
pp. 5623-5630
Author(s):  
Yi-Yang Peng ◽  
Qiuli Cheng ◽  
Wenda Wang ◽  
Meng Wu ◽  
Diana Diaz-Dussan ◽  
...  
Keyword(s):  

A bio-inspired, multi-responsive, injectable, and self-healing hydrogel was developed via the interaction of tannic acid (TA) and benzoxaborole-based linear copolymers.


2019 ◽  
Vol 37 (11) ◽  
pp. 1053-1059 ◽  
Author(s):  
Yi Sun ◽  
Yong-Yuan Ren ◽  
Qi Li ◽  
Rong-Wei Shi ◽  
Yin Hu ◽  
...  

2020 ◽  
Vol 117 (34) ◽  
pp. 20397-20403
Author(s):  
Dong Meng ◽  
Jonathan Lee Yang ◽  
Chengyi Xiao ◽  
Rui Wang ◽  
Xiaofei Xing ◽  
...  

Organic frameworks (OFs) offer a novel strategy for assembling organic semiconductors into robust networks that facilitate transport, especially the covalent organic frameworks (COFs). However, poor electrical conductivity through covalent bonds and insolubility of COFs limit their practical applications in organic electronics. It is known that the two-dimensional intralayer π∙∙∙π transfer dominates transport in organic semiconductors. However, because of extremely labile inherent features of noncovalent π∙∙∙π interaction, direct construction of robust frameworks via noncovalent π∙∙∙π interaction is a difficult task. Toward this goal, we report a robust noncovalent π∙∙∙π interaction-stacked organic framework, namely πOF, consisting of a permanent three-dimensional porous structure that is held together by pure intralayer noncovalent π∙∙∙π interactions. The elaborate porous structure, with a 1.69-nm supramaximal micropore, is composed of fully conjugated rigid aromatic tetragonal-disphenoid-shaped molecules with four identical platforms. πOF shows excellent thermostability and high recyclability and exhibits self-healing properties by which the parent porosity is recovered upon solvent annealing at room temperature. Taking advantage of the long-range π∙∙∙π interaction, we demonstrate remarkable transport properties of πOF in an organic-field-effect transistor, and the mobility displays relative superiority over the traditional COFs. These promising results position πOF in a direction toward porous and yet conductive materials for high-performance organic electronics.


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