scholarly journals At the Dawn of Applied DNA Nanotechnology

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 639 ◽  
Author(s):  
Veikko Linko
Keyword(s):  
Genetic Information ◽  
Deoxyribonucleic Acid ◽  
Dna Nanotechnology ◽  
Information Carrier ◽  
Nanoscale Assembly

Deoxyribonucleic acid (DNA) serves not only as a genetic information carrier but also as an excellent material for programmable nanoscale assembly [...]

Supramolecular DNA nanotechnology

2009 ◽  
Vol 81 (12) ◽  
pp. 2157-2181 ◽  
Author(s):  
Faisal A. Aldaye ◽  
Hanadi F. Sleiman
Keyword(s):  
Molecular Recognition ◽  
Base Pair ◽  
Deoxyribonucleic Acid ◽  
Materials Science ◽  
Dna Nanotechnology ◽  
Structure And Function ◽  
Fine Tuning ◽  
Functional Potential ◽  
And Function ◽  
Main Material

Nature uses deoxyribonucleic acid (DNA) as the main material for the storage and transmission of life’s blueprint. Today, DNA is being used as a “smart” material to help solve a number of long-standing issues facing researchers in materials science and nanotechnology. In DNA nanotechnology, DNA’s powerful base-pair molecular recognition criteria are utilized to control the final structure and function of the material being generated. A sub-area of research that our group has recently termed “supramolecular DNA nanotechnology” is emerging and is extending the limits of this molecule in nanotechnology by further fine-tuning DNA’s structural and functional potential. This review will discuss the fruition and fundamentals of supramolecular DNA nanotechnology, as well as its future as a viable science in a material world.

Peptide Nucleic Acid (PNA). a Structural DNA Mimic

1993 ◽  
Vol 330 ◽  
Author(s):  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Linear Order ◽  
Genetic Information ◽  
Peptide Nucleic Acid ◽  
Deoxyribonucleic Acid ◽  
Chemical Constituent ◽  
Structural Role ◽  
Phosphate Backbone ◽  
Central Molecule

Deoxyribonucleic acid (DNA) may be regarded as the central molecule of life since it is the carrier of genetic information; it is the chemical constituent of the genes. DNA is a biopolymer composed of deoxyribonucleoside units connected via phosphodiester bridges (Figure 1a). It is the linear order of the nucleobases (A, C, G & T) that contain the genetic information, whereas the deoxyribose phosphate backbone primarily fulfils a structural role.

Stochastic models for bacteriophage

1965 ◽  
Vol 2 (02) ◽  
pp. 225-268 ◽  
Author(s):  
J. Gani
Keyword(s):  
Stochastic Models ◽  
Genetic Information ◽  
Molecular Basis ◽  
Deoxyribonucleic Acid ◽  
Small Particles ◽  
The Past ◽  
Protein Coat ◽  
The Subject ◽  
Bacterial Viruses ◽  
Dna Strand

Viruses are small particles of RNA (Ribonucleic Acid) or DNA (DeoxyRibonucleic Acid) wrapped in a protein coat, which can be crystallized into a variety of regular geometric, often polyhedral, shapes. They are much smaller than bacteria, and are capable of passage through filters designed to, arrest these. Among the numerous viruses, bacteriophages (or bacterial viruses), called phages for short, have been the subject of much concentrated study. Over the past twenty years in particular, their structure, parasitic cycle, and most recently part of their genetic mapping, have been elucidated; the isolated DNA strand used by phages as their genetic information carrier, makes them eminently suitable in investigations on the molecular basis of life.

scholarly journals Humans as Genetic Information Carriers in the Pandemic Conditions (Criminal, Criminal Legal, and Civil Legal Aspects)

2020 ◽  
Vol 9 (4) ◽  
Author(s):  
Nataliia Pavlovska ◽  
◽  
Maryna Kulyk ◽  
Yuliia Tereshchenko ◽  
Halyna Strilets ◽  
...  
Keyword(s):  
Biological Sciences ◽  
Molecular Genetics ◽  
Biological Material ◽  
Genetic Information ◽  
Deoxyribonucleic Acid ◽  
Legal Aspects ◽  
Traditional Methods ◽  
New Methods ◽  
Expert Practice

It has been for the most part difficult and almost impossible to establish the origin of biological material from a particular person, as traditional methods of examining biological traces only with little probability can establish the relative chances of origin of such traces from a particular person and not their equivalence or identity. The development and implementation in the expert practice of new methods of research of human biological traces are aimed at increasing the level of identification capabilities. Major successes in this area have been achieved first of all due to molecular genetics. The importance of such research cannot be overestimated. Many of the notable advances we witness today in forensics and the biological sciences depend on our knowledge of the structure of deoxyribonucleic acid (DNA).

scholarly journals The Concept and Classification of Genomic (Genetic) Information

Lex Russica ◽  
2020 ◽  
pp. 50-58
Author(s):  
M. N. Maleina
Keyword(s):  
Ribonucleic Acid ◽  
Genetic Information ◽  
Biological Sample ◽  
Deoxyribonucleic Acid ◽  
Personal Data ◽  
Genomic Information ◽  
Genomic Technologies ◽  
And Storage ◽  
Living Being

The importance of genomic information has now increased due to the possibility of its practical use. Meanwhile, the understanding of the term “genomic information” is specified based on different criteria. Genomic information is proposed to be classified depending on the following criteria: 1) the origin of a biological sample, 2) the place of fixation and storage of genomic information, 3) the purpose of use, 4) the completeness of examination, 5) the relation of a person to the acquisition of his or her genomic information, 6) the scope of content. Genomic information can be presented as a generic concept referring to all biological objects, as a special concept (species) referring only to humans, and as subspecies reflecting specificity of such information in a particular area of activity. Genomic information of a living being (human, animal, plant, microorganism) is understood as data on certain fragments of deoxyribonucleic acid (sometimes ribonucleic acid) on the basis of which the living being is identified or other permitted activity is carried out.Human genomic information is defined as biometric personal data extracted from certain fragments of deoxyribonucleic acid (sometimes ribonucleic acid) of a living individual or corpse, on the basis of which it is possible to identify, determine genetic predispositions or extract patterns of the development of the human being obtained voluntarily, and, in cases provided for by the law, forced to be fixed in a biological sample and/or stored in an information map or database.It is proved that the existing laws on information or a new law dedicated to regulation of the application of genomic technologies should be amended instead of adopting a special law “On Genetic Information”. 

scholarly journals Engineering DNA nanotubes for resilience in an E. coli TXTL system

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Melissa A Klocke ◽  
Jonathan Garamella ◽  
Hari K K Subramanian ◽  
Vincent Noireaux ◽  
Elisa Franco
Keyword(s):  
Deoxyribonucleic Acid ◽  
Dna Nanotechnology ◽  
Dna Degradation ◽  
Dna Nanostructures ◽  
E Coli ◽  
Physiological Conditions ◽  
Double Stranded Dna ◽  
Dna Nanotubes ◽  
Sticky End ◽  
Dna Nanotube

Abstract Deoxyribonucleic acid (DNA) nanotechnology is a growing field with potential intracellular applications. In this work, we use an Escherichia coli cell-free transcription–translation (TXTL) system to assay the robustness of DNA nanotubes in a cytoplasmic environment. TXTL recapitulates physiological conditions as well as strong linear DNA degradation through the RecBCD complex, the major exonuclease in E. coli. We demonstrate that chemical modifications of the tiles making up DNA nanotubes extend their viability in TXTL for more than 24 h, with phosphorothioation of the sticky end backbone being the most effective. Furthermore, we show that a Chi-site double-stranded DNA, an inhibitor of the RecBCD complex, extends DNA nanotube lifetime significantly. These complementary approaches are a first step toward a systematic prototyping of DNA nanostructures in active cell-free cytoplasmic environments and expand the scope of TXTL utilization for bioengineering.

Application of DNA nanodevices for biosensing

The Analyst ◽  
2020 ◽  
Vol 145 (10) ◽  
pp. 3481-3489 ◽  
Author(s):  
Sinuo Yu ◽  
Tianshu Chen ◽  
Qianqian Zhang ◽  
Mengru Zhou ◽  
Xiaoli Zhu
Keyword(s):  
Genetic Information ◽  
Deoxyribonucleic Acid ◽  
Living Systems ◽  
Almost All

Deoxyribonucleic acid (DNA), the carrier of genetic information in living life, is an essential biomacromolecule in almost all living systems.

Stochastic models for bacteriophage

1965 ◽  
Vol 2 (2) ◽  
pp. 225-268 ◽  
Author(s):  
J. Gani
Keyword(s):  
Stochastic Models ◽  
Genetic Information ◽  
Molecular Basis ◽  
Deoxyribonucleic Acid ◽  
Small Particles ◽  
The Past ◽  
Protein Coat ◽  
The Subject ◽  
Bacterial Viruses ◽  
Dna Strand

Viruses are small particles of RNA (Ribonucleic Acid) or DNA (DeoxyRibonucleic Acid) wrapped in a protein coat, which can be crystallized into a variety of regular geometric, often polyhedral, shapes. They are much smaller than bacteria, and are capable of passage through filters designed to, arrest these. Among the numerous viruses, bacteriophages (or bacterial viruses), called phages for short, have been the subject of much concentrated study. Over the past twenty years in particular, their structure, parasitic cycle, and most recently part of their genetic mapping, have been elucidated; the isolated DNA strand used by phages as their genetic information carrier, makes them eminently suitable in investigations on the molecular basis of life.

scholarly journals Understanding biochemistry: structure and function of nucleic acids

2019 ◽  
Vol 63 (4) ◽  
pp. 433-456 ◽  
Author(s):  
Steve Minchin ◽  
Julia Lodge
Keyword(s):  
Nucleic Acids ◽  
Genetic Information ◽  
Deoxyribonucleic Acid ◽  
Double Helix ◽  
Protein Translation ◽  
Structure And Function ◽  
Dna Molecule ◽  
Living Things ◽  
Dna Double Helix ◽  
And Function

Abstract Nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), carry genetic information which is read in cells to make the RNA and proteins by which living things function. The well-known structure of the DNA double helix allows this information to be copied and passed on to the next generation. In this article we summarise the structure and function of nucleic acids. The article includes a historical perspective and summarises some of the early work which led to our understanding of this important molecule and how it functions; many of these pioneering scientists were awarded Nobel Prizes for their work. We explain the structure of the DNA molecule, how it is packaged into chromosomes and how it is replicated prior to cell division. We look at how the concept of the gene has developed since the term was first coined and how DNA is copied into RNA (transcription) and translated into protein (translation).

New Rules Address Use of Genetic Information

2009 ◽  
Vol 42 (19) ◽  
pp. 11
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  
Genetic Information
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