scholarly journals Hf(OTf)4 as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Solvent-Free Conditions

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 388 ◽  
Author(s):  
Shuai-Bo Han ◽  
Jing-Ying Wei ◽  
Xiao-Chong Peng ◽  
Rong Liu ◽  
Shan-Shan Gong ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
1H Nmr ◽  
Mannich Reaction ◽  
Reaction Rate ◽  
Mannich Bases ◽  
Solvent Free ◽  
Solvent Free Conditions

Hf(OTf)4 was identified as a highly potent catalyst (0.1–0.5 mol%) for three-component Mannich reaction under solvent-free conditions. Hf(OTf)4-catalyzed Mannich reaction exhibited excellent regioselectivity and diastereoselectivity when alkyl ketones were employed as substrates. 1H NMR tracing of the H/D exchange reaction of ketones in MeOH-d4 indicated that Hf(OTf)4 could significantly promote the keto-enol tautomerization, thereby contributing to the acceleration of reaction rate.

Reaction on a solid surface — A simple, economical, and efficient Mannich reaction of azacrown ethers over graphite

2008 ◽  
Vol 86 (5) ◽  
pp. 426-434 ◽  
Author(s):  
Hashem Sharghi ◽  
Reza Khalifeh
Keyword(s):  
Phenolic Compounds ◽  
Solid Surface ◽  
Mannich Reaction ◽  
Graphite Powder ◽  
Solvent Free ◽  
Azacrown Ether ◽  
Azacrown Ethers ◽  
Lariat Ether ◽  
Solvent Free Conditions

Graphite brings about a rapid Mannich reaction with a range of activated and unactivated phenolic compounds such as p-cresol and p-nitrophenol. The reactions are carried out with azacrown ether and paraformaldehyde in solvent-free conditions at 100 °C for 20–30 min. The graphite powder can be reused up to three times after simple washing with acetone.Key words: azacrown ether, lariat ether, graphite, solvent-free, Mannich reaction.

scholarly journals Microwave assisted solvent-free mannich bases: synthesis, characterization and effects of these compounds on HCA I and HCA II isozymes

2021 ◽  
Vol 40 (1) ◽  
pp. 43
Author(s):  
Bülent Büyükkıdan ◽  
Nurgün Büyükkıdan ◽  
Metin Bülbül ◽  
Melek Yılmaz ◽  
Evren Derrun Arslanbay ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Esterase Activity ◽  
Inhibitory Concentration ◽  
Mannich Bases ◽  
Solvent Free ◽  
Inhibitory Effects ◽  
Solvent Free Conditions ◽  
Control Compound ◽  
Esterase Activities

Mannich bases (2a–d) of aromatic amines were synthesized by using a conventional microwave technique under solvent-free conditions and characterized by IR and NMR (1H and 13C) and elemental analysis. The inhibitory effects of the synthesized Mannich bases were examined in vitro by using hydratase and esterase assays on carbonic anhydrase I and II isozymes (hCA, EC 4.2.1.1) purified from human erythrocyte cells. Acetazolamide was used as the control compound. The values of IC50, the half-maximum inhibitory concentration, were found for hydratase and esterase activities. Only two compounds (2b and 2d) exhibited poor hCA I and hCA II inhibition effects on esterase activity. In contrast, compounds 2a and 2c could be used as carbonic anhydrase activators as a result of the increased esterase activity of hCA I and hCA II isozymes.

scholarly journals One-Pot Synthesis of Mannich Bases Under Solvent-Free Conditions

2014 ◽  
Vol 44 (9) ◽  
pp. 1279-1285 ◽  
Author(s):  
Onur Demirkol ◽  
Dilek Akbaşlar ◽  
Sultan Giray ◽  
B. Barış Anıl
Keyword(s):  
Mannich Bases ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions

ChemInform Abstract: Direct Mannich Reaction Mediated by Fe(Cp)2PF6under Solvent-Free Conditions.

ChemInform ◽  
2010 ◽  
Vol 41 (16) ◽  
Author(s):  
Rukhsana I. Kureshy ◽  
Santosh Agrawal ◽  
S. Saravanan ◽  
Noor-ul H. Khan ◽  
Arpan K. Shah ◽  
...  
Keyword(s):  
Mannich Reaction ◽  
Solvent Free ◽  
Solvent Free Conditions

A highly efficient, solvent-free and energy-effective method of cellulose acetylation

e-Polymers ◽  
2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdelmajid Memmi ◽  
Robert Granet ◽  
Yves Champavier ◽  
Pierre Krausz
Keyword(s):  
Nmr Spectroscopy ◽  
Acetic Anhydride ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Room Temperature ◽  
Solvent Free ◽  
Highly Efficient ◽  
Solvent Free Conditions ◽  
Cellulose Acetates

AbstractAcetylation of cellulose by acetic anhydride was found to be catalysed quantitatively by iodine under solvent-free conditions at room temperature. Cellulose acetates were characterised by 1H NMR spectroscopy.

ChemInform Abstract: One-Pot Synthesis of Mannich Bases under Solvent-Free Conditions.

ChemInform ◽  
2014 ◽  
Vol 45 (38) ◽  
pp. no-no
Author(s):  
Onur Demirkol ◽  
Dilek Akbaslar ◽  
Sultan Giray ◽  
B. Baris Anil
Keyword(s):  
Mannich Bases ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions
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