scholarly journals Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 23 ◽  
Author(s):  
Tetiana Halenova ◽  
Igor Zlatskiy ◽  
Anton Syroeshkin ◽  
Tatiana Maximova ◽  
Tatiana Pleteneva
Keyword(s):  
Oxidative Stress ◽  
Proinflammatory Cytokines ◽  
High Fat Diet ◽  
Antioxidant Enzyme Activities ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Deuterium Depleted Water ◽  
Anti Inflammatory ◽  
Treatment Of Obesity ◽  
Body Weight Index

In this study, we present the potential application of deuterium-depleted water (DDW) for the prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver. Drinking DDW at a concentration of 10 ppm deuterium/protium (D/H) ad libitum for 3 weeks restored the BWI, glucose (serum), tryptophan (brain), and serotonin (brain) levels and concentration of Zn in the liver in the DIO animals to those of the controls. The levels of proinflammatory cytokines (IL-1β, IL-6, IFNγ) and anti-inflammatory TNFα were decreased in DIO rats, while anti-inflammatory cytokine (IL-4, IL-10) levels remained at the control levels, which is indicative of a pathophysiological syndrome. In contrast, in groups of rats treated with DDW, a significant increase in anti-inflammatory (IL-4, IL-10) and proinflammatory cytokines (IFNγ) was observed. This finding indicates a reduction in systemic inflammation in obese animals treated with DDW. Similarly, the high-fat diet caused an increased level of oxidative stress products, which was accompanied by decreased activity of both superoxide dismutase and catalase, whereas the administration of DDW decreased the level of oxidative stress and enhanced antioxidant enzyme activities.

Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat diet

2016 ◽  
Vol 7 (6) ◽  
pp. 2675-2681 ◽  
Author(s):  
Paula S. Ferreira ◽  
Luis C. Spolidorio ◽  
John A. Manthey ◽  
Thais B. Cesar
Keyword(s):  
Oxidative Stress ◽  
Systemic Inflammation ◽  
High Fat Diet ◽  
High Fat ◽  
Anti Inflammatory

In vivoantioxidant and anti-inflammatory effects of citrus flavanones.

3-Keto-1,5-bisphosphonates Alleviate Serum-Oxidative Stress in the High-fat Diet Induced Obesity in Rats

2015 ◽  
Vol 86 (3) ◽  
pp. 291-301 ◽  
Author(s):  
Karima Lahbib ◽  
Iyadh Aouani ◽  
Jean-François Cavalier ◽  
Soufiane Touil
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1289
Author(s):  
Anna Maria Giudetti ◽  
Daniele Vergara ◽  
Serena Longo ◽  
Marzia Friuli ◽  
Barbara Eramo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Free Access ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Antioxidant Genes ◽  
Diet Induced Obesity ◽  
Hepatic Oxidative Stress

Long-term high-fat diet (HFD) consumption can cause weight gain and obesity, two conditions often associated with hepatic non-alcoholic fatty liver and oxidative stress. Oleoylethanolamide (OEA), a lipid compound produced by the intestine from oleic acid, has been associated with different beneficial effects in diet-induced obesity and hepatic steatosis. However, the role of OEA on hepatic oxidative stress has not been fully elucidated. In this study, we used a model of diet-induced obesity to study the possible antioxidant effect of OEA in the liver. In this model rats with free access to an HFD for 77 days developed obesity, steatosis, and hepatic oxidative stress, as compared to rats consuming a low-fat diet for the same period. Several parameters associated with oxidative stress were then measured after two weeks of OEA administration to diet-induced obese rats. We showed that OEA reduced, compared to HFD-fed rats, obesity, steatosis, and the plasma level of triacylglycerols and transaminases. Moreover, OEA decreased the amount of malondialdehyde and carbonylated proteins and restored the activity of antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, which decreased in the liver of HFD-fed rats. OEA had also an improving effect on parameters linked to endoplasmic reticulum stress, thus demonstrating a role in the homeostatic control of protein folding. Finally, we reported that OEA differently regulated the expression of two transcription factors involved in the control of lipid metabolism and antioxidant genes, namely nuclear factor erythroid-derived 2-related factor 1 (Nrf1) and Nrf2, thus suggesting, for the first time, new targets of the protective effect of OEA in the liver.

scholarly journals Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 733
Author(s):  
Francisco Javier Leyva-Jiménez ◽  
Antonio Jesús Ruiz-Malagón ◽  
José Alberto Molina-Tijeras ◽  
Patricia Diez-Echave ◽  
Teresa Vezza ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
High Fat Diet ◽  
High Fat ◽  
Ionization Time ◽  
Flight Mass Spectrometry ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
Anti Inflammatory ◽  
Tof Ms

Increased levels of reactive oxygen species (ROS) and a low-grade chronic inflammation in multiple organs have been demonstrated in obesity. Morus alba leaves extracts (MAEs) have been used in traditional medicine as anti-inflammatory agents. In this work, the bioactive compounds of different genotypes of M. alba L. (Filipina, Valenciana Temprana, Kokuso, and Italia) were analyzed not only by reverse phase high performance liquid chromatography–electrospray ionization-time of flight-mass spectrometry (RP-HPLC-ESI-TOF-MS) and hydrophilic interaction chromatography–electrospray ionization-time of flight-mass spectrometry (HILIC-ESI-TOF-MS), but also screened for in vitro and in vivo antioxidant activity by means of DPPH• radical scavenging assay and Caenorhabditis elegans model. These MAEs were administered daily in a model of diet-induced obesity in mice. Filipina and Italia genotypes significantly reduced weight gain, the glycemic levels in high fat diet, as well as, levels of LDL-cholesterol and triglycerides. Filipina and Italia MAEs also reduced the expression of proinflammatory mediators such as Tnf-α, Il-1β, Il-6 and increased the levels of adiponectin and AMPK, which exert anti-inflammatory effects. Moreover, Italia genotype ameliorated the intestinal barrier function. In conclusion, Filipina and Italia methanolic extracts show the highest antioxidant and anti-inflammatory effect, due to the presence of compounds such as protocatechuic acid or quercetin-3-glucoside, and they could be developed as a complementary treatment for obesity and metabolic disorders.

Role of anti‐inflammatory interventions in high‐fat‐diet‐induced obesity

2020 ◽  
Vol 34 (3) ◽  
Author(s):  
Rasha Abdelmawla Ghazala ◽  
Azza El Medney ◽  
Anisa Meleis ◽  
Passant Mohie El dien ◽  
Hend Samir
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Anti Inflammatory
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