High-fat-diet–induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches

Nutrition ◽  
2016 ◽  
Vol 32 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Jin Sun ◽  
Yi Qiao ◽  
Ce Qi ◽  
Wei Jiang ◽  
Hang Xiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Lactobacillus Reuteri ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
High Fat ◽  
Diet Induced Obesity

3-Keto-1,5-bisphosphonates Alleviate Serum-Oxidative Stress in the High-fat Diet Induced Obesity in Rats

2015 ◽  
Vol 86 (3) ◽  
pp. 291-301 ◽  
Author(s):  
Karima Lahbib ◽  
Iyadh Aouani ◽  
Jean-François Cavalier ◽  
Soufiane Touil
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1289
Author(s):  
Anna Maria Giudetti ◽  
Daniele Vergara ◽  
Serena Longo ◽  
Marzia Friuli ◽  
Barbara Eramo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Free Access ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Antioxidant Genes ◽  
Diet Induced Obesity ◽  
Hepatic Oxidative Stress

Long-term high-fat diet (HFD) consumption can cause weight gain and obesity, two conditions often associated with hepatic non-alcoholic fatty liver and oxidative stress. Oleoylethanolamide (OEA), a lipid compound produced by the intestine from oleic acid, has been associated with different beneficial effects in diet-induced obesity and hepatic steatosis. However, the role of OEA on hepatic oxidative stress has not been fully elucidated. In this study, we used a model of diet-induced obesity to study the possible antioxidant effect of OEA in the liver. In this model rats with free access to an HFD for 77 days developed obesity, steatosis, and hepatic oxidative stress, as compared to rats consuming a low-fat diet for the same period. Several parameters associated with oxidative stress were then measured after two weeks of OEA administration to diet-induced obese rats. We showed that OEA reduced, compared to HFD-fed rats, obesity, steatosis, and the plasma level of triacylglycerols and transaminases. Moreover, OEA decreased the amount of malondialdehyde and carbonylated proteins and restored the activity of antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, which decreased in the liver of HFD-fed rats. OEA had also an improving effect on parameters linked to endoplasmic reticulum stress, thus demonstrating a role in the homeostatic control of protein folding. Finally, we reported that OEA differently regulated the expression of two transcription factors involved in the control of lipid metabolism and antioxidant genes, namely nuclear factor erythroid-derived 2-related factor 1 (Nrf1) and Nrf2, thus suggesting, for the first time, new targets of the protective effect of OEA in the liver.

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