scholarly journals Constructing Controllable Logic Circuits Based on DNAzyme Activity

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4134 ◽  
Author(s):  
Fengjie Yang ◽  
Yuan Liu ◽  
Bin Wang ◽  
Changjun Zhou ◽  
Qiang Zhang
Keyword(s):  
Simple Structure ◽  
Logic Gates ◽  
Dna Structure ◽  
Logic Circuits ◽  
Logic Circuit ◽  
Cascade Process ◽  
Activity Regulation ◽  
Basic Logic ◽  
Molecular Logic ◽  
Multi Level

Recently, DNA molecules have been widely used to construct advanced logic devices due to their unique properties, such as a simple structure and predictable behavior. In fact, there are still many challenges in the process of building logic circuits. Among them, the scalability of the logic circuit and the elimination of the crosstalk of the cascade circuit have become the focus of research. Inspired by biological allosteric regulation, we developed a controllable molecular logic circuit strategy based on the activity of DNAzyme. The E6 DNAzyme sequence was temporarily blocked by hairpin DNA and activated under appropriate input trigger conditions. Using a substrate with ribonucleobase (rA) modification as the detection strand, a series of binary basic logic gates (YES, AND, and INHIBIT) were implemented on the computational component platform. At the same time, we demonstrate a parallel demultiplexer and two multi-level cascade circuits (YES-YES and YES-Three input AND (YES-TAND)). In addition, the leakage of the cascade process was reduced by exploring factors such as concentration and DNA structure. The proposed DNAzyme activity regulation strategy provides great potential for the expansion of logic circuits in the future.

Target-triggered cascade recycling amplification for label-free detection of microRNA and molecular logic operations

2016 ◽  
Vol 52 (2) ◽  
pp. 402-405 ◽  
Author(s):  
Sai Bi ◽  
Jiayan Ye ◽  
Ying Dong ◽  
Haoting Li ◽  
Wei Cao
Keyword(s):  
Logic Gates ◽  
Logic Circuits ◽  
Label Free ◽  
Chemiluminescence Detection ◽  
Molecular Logic ◽  
Label Free Detection ◽  
Molecular Scale ◽  
Ultrahigh Sensitivity ◽  
Recycling Amplification ◽  
Logic Operations

A cascade recycling amplification (CRA) that implements cascade logic circuits with feedback amplification function is developed for label-free chemiluminescence detection of microRNA-122 with an ultrahigh sensitivity of 0.82 fM and excellent specificity, which is applied to construct a series of molecular-scale two-input logic gates by using microRNAs as inputs and CRA products as outputs.

Memristive Circuit Design of Five-Person Voter Based on Memristor Ratioed Logic

2020 ◽  
Vol 15 (12) ◽  
pp. 1482-1493
Author(s):  
Junwei Sun ◽  
Qinfei Yang ◽  
Yanfeng Wang
Keyword(s):  
Energy Consumption ◽  
Circuit Design ◽  
Simple Structure ◽  
Electronic Device ◽  
Logic Circuits ◽  
Logic Circuit ◽  
Low Power Consumption ◽  
Electronic Components ◽  
Complex Circuits ◽  
Easy Integration

Conventional CMOS-based logic circuits are approaching their limits when it comes to speed and energy consumption, so the development of new electronic components becomes critical. Memristor is a nano-structured special electronic device with the advantages of simple structure, low power consumption and easy integration. This invention supplys a new method for developing complex logic circuits. This article mainly presents the design of a five-person voter circuit. The OR/AND logic can be accomplished by varying the polarity of two parallel memristors. On the basis of the two logic circuits, adder and comparator are constructed. Further, based on the adder and comparator, a five-person voter is implemented. The correctness and rationality of the five-person voter based on MRL are confirmed via logistical analysis and simulation. Compared with the traditional logic circuits, the logic circuit designed in this paper has advantages in area cost. The realization of the five-person voter circuit further proves that the logic circuit based on memristor can be cascaded. The research results are expected to build more complex circuits, which may provide a reference for the design of other practical circuits.

scholarly journals Mathematical logic: construction of logic circuits from logical elements in Maple

2021 ◽  
pp. 155-164
Author(s):  
А.А. Оленев ◽  
К.А. Киричек ◽  
Е.В. Потехина
Keyword(s):  
Mathematical Logic ◽  
Computer Modeling ◽  
Computer Algebra ◽  
Computer Algebra System ◽  
Logic Gates ◽  
Logic Circuits ◽  
Basic Logic ◽  
Logical Circuit

В статье рассматриваются возможности применения библиотеки Logic системы компьютерной алгебры Maple в аспекте компьютерного моделирования логических схем в различных базисах. Смоделированы основные логические элементы в Maple. На конкретном примере детально представлен алгоритм построения логической схемы в различных базисах. The article discusses the possibilities of using the Logic library of the Maple computer algebra system in the aspect of computer modeling of logic circuits in various bases. Basic logic gates are modeled in Maple. On a specific example, an algorithm for constructing a logical circuit in various bases is presented in detail.

A Synthesis Method of Quantum Reversible Logic Circuit Based on Elementary Qutrit Quantum Logic Gates

2015 ◽  
Vol 24 (08) ◽  
pp. 1550121 ◽  
Author(s):  
Fuyou Fan ◽  
Guowu Yang ◽  
Gang Yang ◽  
William N. N. Hung
Keyword(s):  
Quantum Logic ◽  
Synthesis Method ◽  
Logic Gates ◽  
Logic Circuits ◽  
Reversible Logic ◽  
Logic Circuit ◽  
Quantum Gates ◽  
Synthesis Algorithm ◽  
Quantum Logic Gates ◽  
Number Systems

Because ternary computer has more superiority than other d-ary number systems, we focus on the investigation of ternary elementary quantum gates and the synthesis algorithm of ternary quantum logic circuits. Above all, Pauli operators and their matrices on qutrit are introduced. Then eight qutrit operators are selected as elementary operators and eight qutrit quantum logic gates are defined. Permutation groups are introduced to characterize the quantum gates and quantum logic circuits. Some important qutrit quantum logic gates are defined also, such as QNOT, QKCXi, EQKCXi, QSwap, QCNOT and EQCNOT. Based on these elementary gates, we prove two very important theorems: (1) all qutrit quantum reversible logic circuit can be generated by Xi gate and QKCXi gate; (2) all qutrit quantum reversible logic circuits can be generated by Xi gate and QCNOT gate. The two theorems indicate that any complicated qutrit quantum reversible circuit can be constructed by the simplest ternary quantum gate. This will greatly simplify the implementation difficulty of quantum circuit. Subsequently, we propose a synthesis algorithm for qutrit quantum reversible logic circuit, which is verified through simulation experiment by the computer program we have designed.

Research of Molecule Logic Circuit Based on DNA Strand Displacement Reaction

2016 ◽  
Vol 13 (10) ◽  
pp. 7684-7691 ◽  
Author(s):  
Zicheng Wang ◽  
Zijie Cai ◽  
Zhonghua Sun ◽  
Jian Ai ◽  
Yanfeng Wang ◽  
...  
Keyword(s):  
Logic Circuits ◽  
Logic Circuit ◽  
The Other ◽  
Strand Displacement ◽  
Molecular Logic ◽  
Dna Strand Displacement ◽  
Dna Strand ◽  
Gold Nanoprobe ◽  
Decoder Circuit ◽  
Strand Displacement Reaction

Because of its outstanding advantages, DNA strand displacement (DSD) reaction has been widely used for signals processing and molecular logic circuit constructing. Two digital logic circuits are constructed in this paper. One is the encoder circuit with four inputs and two outputs, and the other is the decoder circuit with two inputs and four outputs. Of particular interest to us is the multicolor fluorescent gold nanoprobe detection part, where a gold nanoparticle is modified with multicolor fluorophores which exploits the ultrahigh quenching ability of gold nanoparticles (AuNPs). Finally, the circuits can be programmed and simulated with the software Visual DSD. The simulated results based on DSD show that the molecular circuits constructed in this paper is reliable and effective, which has wide prospects in logical circuits and nano-electronics study.

scholarly journals 8-Bit Adder and Subtractor with Domain Label Based on DNA Strand Displacement

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2989 ◽  
Author(s):  
Weixuan Han ◽  
Changjun Zhou
Keyword(s):  
Dna Computing ◽  
Logic Gates ◽  
Logic Circuits ◽  
Calculation Model ◽  
Strand Displacement ◽  
High Concentration ◽  
Low Concentration ◽  
Molecular Logic ◽  
Dna Strand Displacement ◽  
Dna Strand

DNA strand displacement, which plays a fundamental role in DNA computing, has been widely applied to many biological computing problems, including biological logic circuits. However, there are many biological cascade logic circuits with domain labels based on DNA strand displacement that have not yet been designed. Thus, in this paper, cascade 8-bit adder/subtractor with a domain label is designed based on DNA strand displacement; domain t and domain f represent signal 1 and signal 0, respectively, instead of domain t and domain f are applied to representing signal 1 and signal 0 respectively instead of high concentration and low concentration high concentration and low concentration. Basic logic gates, an amplification gate, a fan-out gate and a reporter gate are correspondingly reconstructed as domain label gates. The simulation results of Visual DSD show the feasibility and accuracy of the logic calculation model of the adder/subtractor designed in this paper. It is a useful exploration that may expand the application of the molecular logic circuit.

Chemically-driven “molecular logic circuit” based on osmium chromophore with a resettable multiple readout

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5217-5220 ◽  
Author(s):  
Anup Kumar ◽  
Megha Chhatwal ◽  
Rinkoo D. Gupta ◽  
Satish Kumar Awasthi
Keyword(s):  
Logic Circuits ◽  
Logic Circuit ◽  
Molecular Logic ◽  
Subsequent Integration

Resettable molecular processing of inputs (Cu2+/H2O and F−/H+) to yield discriminating outputs and subsequent integration of logic circuits.

scholarly journals Multiple advanced logic gates made of DNA-Ag nanocluster and the application for intelligent detection of pathogenic bacterial genes

2018 ◽  
Vol 9 (7) ◽  
pp. 1774-1781 ◽  
Author(s):  
Xiaodong Lin ◽  
Yaqing Liu ◽  
Jiankang Deng ◽  
Yanlong Lyu ◽  
Pengcheng Qian ◽  
...  
Keyword(s):  
Dna Computing ◽  
Logic Gates ◽  
Logic Circuits ◽  
Basic Logic ◽  
Intelligent Detection ◽  
Bacterial Genes

A set of basic logic gates was constructed on a simple and universal DNA-AgNCs platform, and further integrated into advanced logic circuits for DNA computing and biosensing.

Design of Universal Logic Gates Using Homo and Hetero-Junction Double Gate TFETs with Pseudo-Derived Logic

2021 ◽  
Author(s):  
Lokesh B ◽  
Sai Pavan kumar K ◽  
Pown M ◽  
Lakshmi B
Keyword(s):  
Power Consumption ◽  
Logic Gate ◽  
Logic Gates ◽  
Propagation Delay ◽  
Logic Circuits ◽  
Logic Circuit ◽  
Nand Gate ◽  
Double Gate ◽  
Nor Gate ◽  
Nor Logic Gate

Abstract This work explores homo and hetero-junction Tunnel field-effect transistor (TFET) based NAND and NOR logic circuits using 30 nm technology and compares their performance in terms of power consumption and propagation delay. By implementing homo-junction TFET based NAND and NOR logic circuits, it has been observed that NAND consumes less power than NOR gate, since current drawn by PTFET in pull-up network of NOR gate is higher. The delay of homo-junction TFET based NOR logic gate is lesser than that of NAND gate due to its reduced internal capacitances. To meet the enhanced performance of both NAND and NOR logic circuits, shorted and independent double gate hetero-junction (GaSb-InAs) TFETs are designed and implemented. In order to reduce both power consumption and delay further, Pseudo-derived logic is implemented in NAND and NOR logic circuits for the first time. Hetero-junction TFET based NAND with Pseudo-derived logic circuit shows lesser propagation delay of 103 times and reduction in power consumption by 0.75 times compared to hetero-junction NAND logic circuit. Hetero-junction TFET based NOR with Pseudo-derived logic shows that the reduction in power consumption is of 103 times and less propagation delay than that of hetero-junction NOR logic circuit

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