scholarly journals Amphiphilic Block Copolymer PCL-PEG-PCL as Stationary Phase for Capillary Gas Chromatographic Separations

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3158 ◽  
Author(s):  
Tao Sun ◽  
Xiaomin Shuai ◽  
Kaixin Ren ◽  
Xingxing Jiang ◽  
Yujie Chen ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Stationary Phase ◽  
Stationary Phases ◽  
Complex Mixture ◽  
Amphiphilic Block Copolymer ◽  
Separation Performance ◽  
Chromatographic Separations ◽  
Static Coating ◽  
High Column

This work presents the first example of utilization of amphiphilic block copolymer PCL-PEG-PCL as a stationary phase for capillary gas chromatographic (GC) separations. The PCL-PEG-PCL capillary column fabricated by static coating provides a high column efficiency of 3951 plates/m for n-dodecane at 120 °C. McReynolds constants and Abraham system constants were also determined in order to evaluate the polarity and possible molecular interactions of the PCL-PEG-PCL stationary phase. Its selectivity and resolving capability were investigated by using a complex mixture covering analytes of diverse types and positional, structural, and cis-/trans-isomers. Impressively, it exhibits high resolution performance for aliphatic and aromatic isomers with diverse polarity, including those critical isomers such as butanol, dichlorobenzene, dimethylnaphthalene, xylenol, dichlorobenzaldehyde, and toluidine. Moreover, it was applied for the determination of isomer impurities in real samples, suggesting its potential for practical use. The superior separation performance demonstrates the potential of PCL-PEG-PCL and related block copolymers as stationary phases in GC and other separation technologies.

scholarly journals Determination of Nucleotides and Nucleosides in Milks and Pediatric Formulas: A Review

2007 ◽  
Vol 90 (5) ◽  
pp. 1354-1364 ◽  
Author(s):  
Brendon D Gill ◽  
Harvey E Indyk
Keyword(s):  
Complex Mixture ◽  
Analytical Techniques ◽  
Reversed Phase ◽  
Robust Methods ◽  
Structural Units ◽  
Chromatographic Separations ◽  
Analytical Technique ◽  
Minimal Sample ◽  
Nucleotides And Nucleosides

Abstract Nucleotides and nucleosides play important roles as structural units in nucleic acids, as coenzymes in biochemical pathways, and as sources of chemical energy. Milk contains a complex mixture of nucleotides, nucleosides, and nucleobases, and because of the reported differences in their relative levels in bovine and human milks, pediatric formulas are increasingly supplemented with nucleotides. Liquid chromatography is the dominant analytical technique used for the quantitation of nucleospecies and is commonly applied using either ion-exchange, reversed-phase, or ion-pair reversed-phase modes. Robust methods that incorporate minimal sample preparation and rapid chromatographic separations have been developed for routine product compliance analysis. This review summarizes the analytical techniques used to date in the analysis of nucleospecies in bovine and human milks and infant formulas.

scholarly journals Simple and Sensitive Methods for the Determination of 2-(4′-Chloromethyl phenyl) Benzonitrile and 2-(4′-Bromomethyl phenyl) Benzonitrile Contents in Valsartan Drug Substance by Gas Chromatography

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
G. Amarnatha Reddy ◽  
K. Hussain Reddy ◽  
M. Narendra Kumar ◽  
Hemant kumar Sharma
Keyword(s):  
Gas Chromatography ◽  
Stationary Phase ◽  
Particle Diameter ◽  
Internal Standard ◽  
Drug Substance ◽  
Ionization Detector ◽  
Chromatographic Separations ◽  
Flame Ionization ◽  
Dimethyl Polysiloxane

Simple and reliable gas chromatographic methods were developed, optimized, and validated for the determination of 2-(4′-chloromethyl phenyl) benzonitrile (2-CMPB) and 2-(4′-bromomethyl phenyl) benzonitrile (2-BMPB) contents in valsartan drug substance, using benzophenone as internal standard (IS). Efficient chromatographic separations were achieved on DB-1, 30 m length with 0.53 mm i.d., and 3 μm particle diameter column consists of 100% dimethyl polysiloxane as a stationary phase by passing helium as a carrier gas. The analytes were extracted in dichloromethane and monitored by flame ionization detector. The performance of these methods was assessed by evaluating specificity, precision, sensitivity, linearity, and accuracy. The limits of detection (LOD) and limits of quantification (LOQ) established for 2-CMPB are 0.10 μg mL−1 and 0.32 μg mL−1, respectively. For 2-BMPB, LOD is 0.31 μg mL−1 and LOQ is 0.95 μg mL−1. The average recoveries for 2-CMPB are in the range of 96.8% to 106.7% and for 2-BMPB (LOQ level) are 99.3%. The methods can be successfully applied for the routine analysis of valsartan drug substance.

scholarly journals Separation performance of a large π-conjugated truxene-based dendrimer as stationary phase for gas chromatography

RSC Advances ◽  
2017 ◽  
Vol 7 (71) ◽  
pp. 44665-44672 ◽  
Author(s):  
Meng Wang ◽  
Yinhui Yang ◽  
Meiling Qi ◽  
Jinliang Wang
Keyword(s):  
Gas Chromatography ◽  
High Resolution ◽  
Stationary Phase ◽  
Separation Performance ◽  
Chromatographic Separations

High-resolution performance of a π-conjugated truxene-based dendrimer as the stationary phase for gas chromatographic separations.

scholarly journals Determination of molecular masses for petroleum distillates by simualted distillation

2012 ◽  
Vol 4 (5) ◽  
pp. 43-55 ◽  
Author(s):  
Lante Carbognani
Keyword(s):  
Stationary Phases ◽  
Size Exclusion ◽  
Chromatographic Separations ◽  
Calibration Standards ◽  
Hydrocarbon Group ◽  
Simulated Distillation ◽  
Size Exclusion Chromatographic ◽  
Petroleum Distillates ◽  
Molecular Masses

Determination of Molecular Mass (MM) for petroleum distillates is explored for selected samples viaHigh Temperature Simulated Distillation (HTSD). MM is determined as a by-product from routineHTSD carried out using open wall capillary columns coated with apolar stationary phases. No samplepre-separation into hydrocarbon group-types is required. Determined MM values were validated with resultsachieved via correlations based on specific gravity and refractive index. Furthermore, determined MM withthe former methodologies were found to match mass spectrometric determinations carried out for the basicpolar components present within the studied samples. Moreover, HTSD analyzed petroleum distillates areproposed as more representative calibration standards for size exclusion chromatographic separations, thusopening the feasibility of extrapolating MM determination for non volatile petroleum residua.

Gas Chromatographic Determination of Mixtures of Captan, Folpet, and Captafol

1983 ◽  
Vol 66 (6) ◽  
pp. 1365-1370
Author(s):  
Dalia M Gilvydis ◽  
Stephen M Walters
Keyword(s):  
Stationary Phase ◽  
Electron Capture ◽  
Stationary Phases ◽  
Chromatographic Determination ◽  
Electron Capture Detection ◽  
Chromatographic Procedure

Abstract A gas chromatographic procedure, using electron capture detection, has been studied and found to be applicable for determining 3 structurally similar fungicides, captan, folpet, and captafol, which are often found in combination in certain foods. Eight liquid stationary phases (AN-600, OV-25, OV-101, OV-210, OV-225, QF-1, SP-2401, and XE-60) were evaluated. A fluorosilicone stationary phase of moderate polarity, SP-2401, was best suited for column stability, response, resolution of captan and folpet, and freedom from on-column decomposition of the 3 fungicides.

scholarly journals Aggregate of Amphiphilic Block Copolymer as a Pseudo-Stationary Phase in Capillary Electrophoresis.

1999 ◽  
Vol 15 (9) ◽  
pp. 879-883 ◽  
Author(s):  
Tohru NAKAMURA ◽  
Akira OHKI ◽  
Masaki MISHIRO ◽  
Osamu TSUYASHIMA ◽  
Shigeru MAEDA
Keyword(s):  
Capillary Electrophoresis ◽  
Block Copolymer ◽  
Stationary Phase ◽  
Amphiphilic Block Copolymer

Determination of methionine enantiomers by HPLC on the cyclofructan chiral stationary phase

2015 ◽  
Vol 7 (11) ◽  
pp. 4577-4582 ◽  
Author(s):  
Katarína Hroboňová ◽  
Jakub Moravčík ◽  
Jozef Lehotay ◽  
Daniel W. Armstrong
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Stationary Phase ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Enantiomeric Separation

The enantiomeric separation of methionine by high performance liquid chromatography on various cyclofructan type chiral stationary phases in the polar-organic separation mode was studied.

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