scholarly journals Study of Photochemical Cytosine to Uracil Transition via Ultrafast Photo-Cross-Linking Using Vinylcarbazole Derivatives in Duplex DNA

Molecules ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 828 ◽  
Author(s):  
Siddhant Sethi ◽  
Shigetaka Nakamura ◽  
Kenzo Fujimoto
Keyword(s):  
Cross Linking ◽  
Duplex Dna

Rapid Alkene–Alkene Photo-Cross-Linking on the Base-Flipping-Out Field in Duplex DNA

2022 ◽  
Author(s):  
Ahmed Mostafa Abdelhady ◽  
Kazumitsu Onizuka ◽  
Kei Ishida ◽  
Sayaka Yajima ◽  
Eriko Mano ◽  
...  
Keyword(s):  
Cross Linking ◽  
Duplex Dna ◽  
Base Flipping

Specific, high-efficiency, triple-helix-mediated cross-linking to duplex DNA

1991 ◽  
Vol 113 (20) ◽  
pp. 7765-7766 ◽  
Author(s):  
Jeng Pyng Shaw ◽  
John Milligan ◽  
Steven H. Krawczyk ◽  
Mark Matteucci
Keyword(s):  
Triple Helix ◽  
High Efficiency ◽  
Cross Linking ◽  
Duplex Dna

Dynamic Cross-Linking Is Retained in Duplex DNA after Multiple Exchange of Strands

2010 ◽  
Vol 122 (34) ◽  
pp. 6093-6096 ◽  
Author(s):  
Huan Wang ◽  
Steven E. Rokita
Keyword(s):  
Cross Linking ◽  
Duplex Dna ◽  
Multiple Exchange

Covalent Binding and Interstrand Cross-Linking of Duplex DNA by Dirhodium(II,II) Carboxylate Compounds†

Biochemistry ◽  
2005 ◽  
Vol 44 (3) ◽  
pp. 996-1003 ◽  
Author(s):  
Shari U. Dunham ◽  
Helen T. Chifotides ◽  
Szymon Mikulski ◽  
Amity E. Burr ◽  
Kim R. Dunbar
Keyword(s):  
Covalent Binding ◽  
Cross Linking ◽  
Duplex Dna

Sequence-Selective Recognition of Duplex DNA through Covalent Interstrand Cross-Linking:  Kinetic and Molecular Modeling Studies with Pyrrolobenzodiazepine Dimers†

Biochemistry ◽  
2003 ◽  
Vol 42 (27) ◽  
pp. 8232-8239 ◽  
Author(s):  
Melissa Smellie ◽  
Deravander S. Bose ◽  
Andrew S. Thompson ◽  
Terence C. Jenkins ◽  
John A. Hartley ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Selective Recognition ◽  
Cross Linking ◽  
Duplex Dna ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Formation of stable DNA triplexes

2011 ◽  
Vol 39 (2) ◽  
pp. 629-634 ◽  
Author(s):  
Keith R. Fox ◽  
Tom Brown
Keyword(s):  
Triple Helix ◽  
Low Ph ◽  
Cross Linking ◽  
Duplex Dna ◽  
Sequence Specificity ◽  
Modified Oligonucleotides ◽  
Major Groove ◽  
Dna Triplexes ◽  
Helix Formation ◽  
Triple Helix Formation

Triple-helical nucleic acids are formed by binding an oligonucleotide within the major groove of duplex DNA. These complexes offer the possibility of designing oligonucleotides which bind to duplex DNA with considerable sequence specificity. However, triple-helix formation with natural nucleotides is limited by (i) the requirement for low pH, (ii) the requirement for homopurine target sequences, and (iii) their relatively low affinity. We have prepared modified oligonucleotides to overcome these limitations, including the addition of positive charges to the sugar and/or base, the inclusion of cytosine analogues, the development of nucleosides for recognition of pyrimidine interruptions and the attachment of one or more cross-linking groups. By these means we are able to generate triplexes which have high affinities at physiological pH at sequences that contain pyrimidine interruptions.

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