Specific, high-efficiency, triple-helix-mediated cross-linking to duplex DNA

1991 ◽  
Vol 113 (20) ◽  
pp. 7765-7766 ◽  
Author(s):  
Jeng Pyng Shaw ◽  
John Milligan ◽  
Steven H. Krawczyk ◽  
Mark Matteucci
Keyword(s):  
Triple Helix ◽  
High Efficiency ◽  
Cross Linking ◽  
Duplex Dna

High-Efficiency Triple-Helix-Mediated Photo-Cross-Linking at a Targeted Site within a Selectable Mammalian Gene†

Biochemistry ◽  
1996 ◽  
Vol 35 (33) ◽  
pp. 10712-10719 ◽  
Author(s):  
Karen M. Vasquez ◽  
Theodore G. Wensel ◽  
Michael E. Hogan ◽  
John H. Wilson
Keyword(s):  
Triple Helix ◽  
High Efficiency ◽  
Cross Linking ◽  
Mammalian Gene

Formation of stable DNA triplexes

2011 ◽  
Vol 39 (2) ◽  
pp. 629-634 ◽  
Author(s):  
Keith R. Fox ◽  
Tom Brown
Keyword(s):  
Triple Helix ◽  
Low Ph ◽  
Cross Linking ◽  
Duplex Dna ◽  
Sequence Specificity ◽  
Modified Oligonucleotides ◽  
Major Groove ◽  
Dna Triplexes ◽  
Helix Formation ◽  
Triple Helix Formation

Triple-helical nucleic acids are formed by binding an oligonucleotide within the major groove of duplex DNA. These complexes offer the possibility of designing oligonucleotides which bind to duplex DNA with considerable sequence specificity. However, triple-helix formation with natural nucleotides is limited by (i) the requirement for low pH, (ii) the requirement for homopurine target sequences, and (iii) their relatively low affinity. We have prepared modified oligonucleotides to overcome these limitations, including the addition of positive charges to the sugar and/or base, the inclusion of cytosine analogues, the development of nucleosides for recognition of pyrimidine interruptions and the attachment of one or more cross-linking groups. By these means we are able to generate triplexes which have high affinities at physiological pH at sequences that contain pyrimidine interruptions.

Sequence-Specific Targeting of Duplex DNA Using a Camptothecin-Triple Helix Forming Oligonucleotide Conjugate and Topoisomerase I

1997 ◽  
Vol 119 (29) ◽  
pp. 6939-6940 ◽  
Author(s):  
Mark Matteucci ◽  
Kuei-Ying Lin ◽  
Teresa Huang ◽  
Richard Wagner ◽  
Daniel D. Sternbach ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Triple Helix ◽  
Duplex Dna ◽  
Specific Targeting

Rapid Alkene–Alkene Photo-Cross-Linking on the Base-Flipping-Out Field in Duplex DNA

2022 ◽  
Author(s):  
Ahmed Mostafa Abdelhady ◽  
Kazumitsu Onizuka ◽  
Kei Ishida ◽  
Sayaka Yajima ◽  
Eriko Mano ◽  
...  
Keyword(s):  
Cross Linking ◽  
Duplex Dna ◽  
Base Flipping

A universal cross-linking binding polymer composite for ultrahigh-loading Li-ion battery electrodes

2020 ◽  
Vol 8 (19) ◽  
pp. 9693-9700
Author(s):  
Dong Wang ◽  
Qian Zhang ◽  
Jie Liu ◽  
Erying Zhao ◽  
Zhenwei Li ◽  
...  
Keyword(s):  
Polymer Composite ◽  
High Efficiency ◽  
Cross Linking ◽  
Li Ion Battery ◽  
Li Ion

A general, facile-operability, and sustainable strategy to achieve ultrahigh-loading electrodes has been proposed that is simply replacing the traditional PVDF binder with an eco-friendly and robust c-PAA-XG binder with a high-efficiency damper.

Triple-helix molecular-switch-actuated exponential rolling circular amplification for ultrasensitive fluorescence detection of miRNAs

The Analyst ◽  
2019 ◽  
Vol 144 (17) ◽  
pp. 5245-5253 ◽  
Author(s):  
Yihan Zhao ◽  
Yu Wang ◽  
Su Liu ◽  
Chonglin Wang ◽  
Jiaxu Liang ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Triple Helix ◽  
High Efficiency ◽  
Molecular Switch ◽  
Ultrasensitive Detection ◽  
Fluorescent Biosensing

We have developed a rapid and high-efficiency fluorescent biosensing platform based on triple-helix molecular-switch (THMS)-actuated exponential rolling circular amplification (RCA) strategy for the ultrasensitive detection of miR-21.

Importance of Functional Groups in Cross-Linking Methoxysilane Additives for High-Efficiency and Stable Perovskite Solar Cells

2019 ◽  
Vol 4 (9) ◽  
pp. 2192-2200 ◽  
Author(s):  
Lin Xie ◽  
Jiangzhao Chen ◽  
Parth Vashishtha ◽  
Xing Zhao ◽  
Gwang Su Shin ◽  
...  
Keyword(s):  
Solar Cells ◽  
Functional Groups ◽  
High Efficiency ◽  
Perovskite Solar Cells ◽  
Cross Linking

Deoxyoligonucleotides bearing neutral analogs of phosphodiester linkages recognize duplex DNA via triple-helix formation

1991 ◽  
Vol 113 (20) ◽  
pp. 7767-7768 ◽  
Author(s):  
Mark Matteucci ◽  
Kuei Ying Lin ◽  
Samuel Butcher ◽  
Courtney Moulds
Keyword(s):  
Triple Helix ◽  
Duplex Dna ◽  
Helix Formation ◽  
Triple Helix Formation
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