scholarly journals Hochu-ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome

Molecules ◽  
2017 ◽  
Vol 22 (6) ◽  
pp. 978 ◽  
Author(s):  
Eunkuk Park ◽  
Chun Choi ◽  
Soo Kim ◽  
Yong-In Kim ◽  
Samkee Sin ◽  
...  
Keyword(s):  
Rat Model ◽  
Immune Modulation ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Bak Foong pills combined with metformin in the treatment of a polycystic ovarian syndrome rat model

2015 ◽  
Vol 10 (3) ◽  
pp. 1819-1825 ◽  
Author(s):  
WENHUI LIU ◽  
WENPEI LIU ◽  
YULING FU ◽  
YAN WANG ◽  
YUANZHEN ZHANG
Keyword(s):  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Liraglutide Improves Hypertension and Metabolic Perturbation in a Rat Model of Polycystic Ovarian Syndrome

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126119 ◽  
Author(s):  
Vanessa Hoang ◽  
Jiangjiang Bi ◽  
Sheba M. Mohankumar ◽  
Arpita K. Vyas
Keyword(s):  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Metabolic Perturbation ◽  
Ovarian Syndrome

Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota

2020 ◽  
Vol 11 (6) ◽  
pp. 5192-5204 ◽  
Author(s):  
Yufeng He ◽  
Qianqian Wang ◽  
Xiu Li ◽  
Gang Wang ◽  
Jianxin Zhao ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Gut Microbiota ◽  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Sex Hormone ◽  
Ovarian Syndrome

Administration of certain lactic acid bacteria alleviate polycystic ovarian syndrome in a letrozole induced rat model.

scholarly journals Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Reza Salehi ◽  
Hannah L. Mazier ◽  
Anne-Laure Nivet ◽  
Arkadiy A. Reunov ◽  
Patricia Lima ◽  
...  
Keyword(s):  
Cell Fate ◽  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Mitochondrial Dynamics ◽  
Ovarian Syndrome

Neurotransmitter alteration in a testosterone propionate-induced polycystic ovarian syndrome rat model

2016 ◽  
Vol 0 (0) ◽  
Author(s):  
Nirja K. Chaudhari ◽  
Laxmipriya P. Nampoothiri
Keyword(s):  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Testosterone Propionate ◽  
Serum Testosterone ◽  
Ovarian Dysfunction ◽  
Metabolic Complications ◽  
Spectrophotometric Methods ◽  
Gnrh Release ◽  
Major Factors ◽  
Ovarian Syndrome

AbstractBackground:Polycystic ovarian syndrome (PCOS), one of the leading causes of infertility seen in women, is characterized by anovulation and hyperandrogenism, resulting in ovarian dysfunction. In addition, associations of several metabolic complications like insulin resistance, obesity, dyslipidemia and psychological co-morbidities are well known in PCOS. One of the major factors influencing mood and the emotional state of mind is neurotransmitters. Also, these neurotransmitters are very crucial for GnRH release. Hence, the current study investigates the status of neurotransmitters in PCOS.Materials and methods:A PCOS rat model was developed using testosterone. Twenty-one-day-old rats were subcutaneously injected with 10 mg/kg body weight of testosterone propionate (TP) for 35 days. The animals were validated for PCOS characteristics by monitoring estrus cyclicity, serum testosterone and estradiol levels and by histological examination of ovarian sections. Neurotransmitter estimation was carried out using fluorometric and spectrophotometric methods.Results:TP-treated animals demonstrated increased serum testosterone levels with unaltered estradiol content, disturbed estrus cyclicity and many peripheral cysts in the ovary compared to control rats mimicking human PCOS. Norepinephrine (NE), dopamine, serotonin, γ-amino butyric acid (GABA) and epinephrine levels were significantly low in TP-induced PCOS rats compared to control ones, whereas the activity of acetylcholinesterase in the PCOS brain was markedly elevated.Conclusion:Neurotransmitter alteration could be one of the reasons for disturbed gonadotropin-releasing hormone (GnRH) release, consequently directing the ovarian dysfunction in PCOS. Also, decrease in neurotransmitters, mainly NE, serotonin and dopamine (DA) attributes to mood disorders like depression and anxiety in PCOS.

Sign in / Sign up

Export Citation Format

Share Document