Expression of resistin mRNA in adipose tissue of rat model with polycystic ovarian syndrome and its implication

2004 ◽  
Vol 24 (6) ◽  
pp. 621-624 ◽  
Author(s):  
Wang Yuxia ◽  
Sun Yongyu ◽  
Qiu Hongyu
Keyword(s):  
Adipose Tissue ◽  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome ◽  
Resistin Mrna

scholarly journals Bak Foong pills combined with metformin in the treatment of a polycystic ovarian syndrome rat model

2015 ◽  
Vol 10 (3) ◽  
pp. 1819-1825 ◽  
Author(s):  
WENHUI LIU ◽  
WENPEI LIU ◽  
YULING FU ◽  
YAN WANG ◽  
YUANZHEN ZHANG
Keyword(s):  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Liraglutide Improves Hypertension and Metabolic Perturbation in a Rat Model of Polycystic Ovarian Syndrome

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126119 ◽  
Author(s):  
Vanessa Hoang ◽  
Jiangjiang Bi ◽  
Sheba M. Mohankumar ◽  
Arpita K. Vyas
Keyword(s):  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Metabolic Perturbation ◽  
Ovarian Syndrome

Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota

2020 ◽  
Vol 11 (6) ◽  
pp. 5192-5204 ◽  
Author(s):  
Yufeng He ◽  
Qianqian Wang ◽  
Xiu Li ◽  
Gang Wang ◽  
Jianxin Zhao ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Gut Microbiota ◽  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Sex Hormone ◽  
Ovarian Syndrome

Administration of certain lactic acid bacteria alleviate polycystic ovarian syndrome in a letrozole induced rat model.

scholarly journals Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome is not related to insulin or LH

2019 ◽  
Vol 241 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Saad A Amer ◽  
Nadia G Alzanati ◽  
Avril Warren ◽  
Rebecca Tarbox ◽  
Raheela Khan
Keyword(s):  
Adipose Tissue ◽  
Mrna Expression ◽  
Subcutaneous Adipose Tissue ◽  
Polycystic Ovarian Syndrome ◽  
Kinase Inhibitor ◽  
Testosterone Levels ◽  
Androgen Synthesis ◽  
Subcutaneous Adipose ◽  
Ovarian Syndrome

The purpose of this study was to investigate androgen production and the role of insulin and LH in its regulation in subcutaneous adipose tissue (SAT) of women with polycystic ovarian syndrome (PCOS). Protein and mRNA expression of androgen synthesis enzymes (cytochrome P450 17A1 (CYP17A1) and aldo-keto reductase 1C3 (AKR1C3)) were measured in SAT biopsies from women with PCOS, diagnosed according to the Rotterdam criteria (n = 15) and healthy controls (n = 15). Cultured mature adipocytes (differentiated from SAT biopsies) were treated with insulin ± phosphoinositol-3-kinase inhibitor (LY294002) or LH ± insulin. CYP17A1 and AKR1C3 mRNA expression and testosterone concentrations were measured in treated and untreated adipocyte cultures. AKR1C3 mRNA was significantly (P < 0.001) greater in PCOS vs non-PCOS SAT, but CYP17A1 was not significantly different between the two groups. AKR1C3 and CYP17A1 protein expression was not significantly different in PCOS vs non-PCOS SAT. In untreated adipocyte cultures, CYP17A1, AKR1C3 and testosterone levels were significantly higher in the PCOS vs the non-PCOS groups. Addition of insulin increased AKR1C3 mRNA and testosterone levels, but not CYP17A1 mRNA in non-PCOS with no effect on PCOS adipocytes. The stimulatory effects of insulin were not inhibited by LY294002. Addition of LH increased CYP17A1, AKR1C3 and testosterone in non-PCOS adipocytes with no effect in PCOS adipocytes. In conclusion, SAT of women with PCOS produces excess androgen, which may contribute to PCOS-related hyperandrogenaemia. This SAT androgen excess is independent of obesity and is not directly stimulated by inulin or LH.

Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients

2018 ◽  
Vol 233 (8) ◽  
pp. 5885-5894 ◽  
Author(s):  
Genmei Jia ◽  
Hongjiang Tao ◽  
Yunping Xue ◽  
Sujuan Xu ◽  
Kai Xue ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Polycystic Ovarian Syndrome ◽  
Omental Adipose Tissue ◽  
Ovarian Syndrome

scholarly journals Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Reza Salehi ◽  
Hannah L. Mazier ◽  
Anne-Laure Nivet ◽  
Arkadiy A. Reunov ◽  
Patricia Lima ◽  
...  
Keyword(s):  
Cell Fate ◽  
Rat Model ◽  
Polycystic Ovarian Syndrome ◽  
Mitochondrial Dynamics ◽  
Ovarian Syndrome
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