scholarly journals Strengthening Triterpene Saponins Biosynthesis by Over-Expression of Farnesyl Pyrophosphate Synthase Gene and RNA Interference of Cycloartenol Synthase Gene in Panax notoginseng Cells

Molecules ◽  
2017 ◽  
Vol 22 (4) ◽  
pp. 581 ◽  
Author(s):  
Yan Yang ◽  
Feng Ge ◽  
Ying Sun ◽  
Diqiu Liu ◽  
Chaoyin Chen
Keyword(s):  
Rna Interference ◽  
Panax Notoginseng ◽  
Farnesyl Pyrophosphate ◽  
Triterpene Saponins ◽  
Farnesyl Pyrophosphate Synthase ◽  
Over Expression ◽  
Cycloartenol Synthase

scholarly journals Lentiviral-Mediated Silencing of Farnesyl Pyrophosphate Synthase through RNA Interference in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Jian Yang ◽  
Chen-Ze Zhao ◽  
Bin Chen ◽  
Fei Chen ◽  
Jie Han ◽  
...  
Keyword(s):  
Rna Interference ◽  
Mevalonate Pathway ◽  
Transgenic Animals ◽  
Vital Role ◽  
Farnesyl Pyrophosphate ◽  
Perivitelline Space ◽  
Chain Reaction ◽  
Farnesyl Pyrophosphate Synthase ◽  
Polymerase Chain

Farnesyl pyrophosphate synthase (FPPS) plays a vital role in the mevalonate pathway and has been shown to be involved in hypertrophy and cardiovascular diseases. Lentivirus-mediated RNA interference (RNAi) to knock down a gene of interest has become a promising new tool for the establishment of transgenic animals. The interfering fragment, named pLVT202, was chosen from cardiomyocytes tested in vitro and was microinjected into the perivitelline space of zygotes from C57BL/6J mice via a lentivirus vehicle; 20 were identified as carrying copies of the transgene using the polymerase chain reaction (PCR). Real-time PCR and western blotting analysis showed that FPPS was downregulated in multiple tissues in the transgenic mice. The transgenic mouse model provides a novel means of studying the gene function of FPPS.

Cloning and characterization of Farnesyl pyrophosphate synthase gene from Anoectochilus

2019 ◽  
Vol 52 (3) ◽  
Author(s):  
Lin Yang ◽  
Jun Cheng Zhang ◽  
Wan Chen Li ◽  
Jing Tao Qu ◽  
Hao Qiang Yu ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase

Bone ◽  
2011 ◽  
Vol 48 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Verena Stresing ◽  
Pierrick G. Fournier ◽  
Akeila Bellahcène ◽  
Ismahène Benzaïd ◽  
Hannu Mönkkönen ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase

Fragment‐Based Discovery of Non‐bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase

ChemBioChem ◽  
2020 ◽  
Vol 21 (21) ◽  
pp. 3096-3111 ◽  
Author(s):  
Lena Münzker ◽  
Joy Kristin Petrick ◽  
Christian Schleberger ◽  
Damien Clavel ◽  
Irina Cornaciu ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase
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