Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase

Bone ◽  
2011 ◽  
Vol 48 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Verena Stresing ◽  
Pierrick G. Fournier ◽  
Akeila Bellahcène ◽  
Ismahène Benzaïd ◽  
Hannu Mönkkönen ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase

scholarly journals Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051987537
Author(s):  
Jie Han ◽  
Chaoyang Huang ◽  
Jiukun Jiang ◽  
Dongmei Jiang
Keyword(s):  
Molecular Mechanisms ◽  
Cellular Proliferation ◽  
Umbilical Vein ◽  
Mtor Signaling ◽  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase ◽  
Acridine Orange Staining ◽  
Autophagy Induction

Objectives Autophagy is divided into three phases: autophagosome engulfment of intracellular organelles and proteins, autophagosome fusion with lysosomes, and autolysosome degradation. The farnesyl pyrophosphate synthase inhibitor ibandronate (IBAN) has in vivo cardioprotective properties, potentially via anti-oxidant effects. Whether autophagy is involved in the cardioprotective effect of IBAN remains unexplored. Methods Human umbilical vein endothelial cells (HUVECs) were treated in vitro with IBAN to assess autophagy induction. Lysosomal activation and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling were assessed using a LysoTracker assay, acridine orange staining and western blotting. An MTS assay was used to assess cellular proliferation. Autophagy was inhibited using chloroquine or RNA silencing of autophagy-related 7 (Atg7) expression. Results IBAN induced autophagy in HUVECs. Moreover, IBAN activated lysosomal function, which is pivotal to autophagy induction. PI3K/AKT/mTOR activity was inhibited in IBAN-treated HUVECs, indicating the involvement of this pathway in IBAN-induced autophagy. Inhibition of autophagy using either chloroquine or Atg7 siRNA potentiated inhibition of HUVEC growth by IBAN, suggesting the involvement of non-autophagy pathways in the antiproliferative effects of IBAN. Conclusions These findings provide insights into the role of autophagy in the cardioprotective effects of IBAN and the molecular mechanisms underlying autophagy induction by IBAN.

scholarly journals In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii

2002 ◽  
Vol 46 (3) ◽  
pp. 929-931 ◽  
Author(s):  
Vanessa Yardley ◽  
Anis A. Khan ◽  
Michael B. Martin ◽  
Teri R. Slifer ◽  
Fausto G. Araujo ◽  
...  
Keyword(s):  
Body Weight ◽  
Toxoplasma Gondii ◽  
Intravenous Administration ◽  
Leishmania Donovani ◽  
Effective Dosage ◽  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase

ABSTRACT The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii. Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani-infected mice but was less effective against T. gondii-infected mice.

Cloning and characterization of Farnesyl pyrophosphate synthase gene from Anoectochilus

2019 ◽  
Vol 52 (3) ◽  
Author(s):  
Lin Yang ◽  
Jun Cheng Zhang ◽  
Wan Chen Li ◽  
Jing Tao Qu ◽  
Hao Qiang Yu ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase

J-104,871, a Novel Farnesyltransferase Inhibitor, Blocks Ras Farnesylation In Vivo in a Farnesyl Pyrophosphate-Competitive Manner

1998 ◽  
Vol 54 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Mari Yonemoto ◽  
Toshihiko Satoh ◽  
Hiroharu Arakawa ◽  
Ikuko Suzuki-Takahashi ◽  
Yoshiaki Monden ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyltransferase Inhibitor
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