scholarly journals Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 388 ◽  
Author(s):  
Anna Bilska-Wilkosz ◽  
Małgorzata Iciek ◽  
Danuta Kowalczyk-Pachel ◽  
Magdalena Górny ◽  
Maria Sokołowska-Jeżewicz ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Lipoic Acid ◽  
Sulfane Sulfur

Hydrogen Sulfide Increases Endothelial Permeability by Bound Sulfane Sulfur

2014 ◽  
Vol 76 ◽  
pp. S56
Author(s):  
Shuai Yuan ◽  
Arif Yurdagul ◽  
Sibile Pardue ◽  
A. Wayne Orr ◽  
Christopher G. Kevil
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Permeability ◽  
Sulfane Sulfur

scholarly journals Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems

2015 ◽  
Vol 44 (14) ◽  
pp. 4596-4618 ◽  
Author(s):  
Vivian S. Lin ◽  
Wei Chen ◽  
Ming Xian ◽  
Christopher J. Chang
Keyword(s):  
Hydrogen Sulfide ◽  
Molecular Imaging ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Biological Systems ◽  
Molecular Probes ◽  
Chemical Probes ◽  
Sulfur Species ◽  
Sulfane Sulfur ◽  
Reactive Sulfur Species

This review highlights progress in the development of molecular probes for live cell imaging of hydrogen sulfide and other reactive sulfur species, including sulfite, bisulfite, sulfane sulfur species, and S-nitrosothiols.

Effects of aspirin on the levels of hydrogen sulfide and sulfane sulfur in mouse tissues

2010 ◽  
Vol 62 (2) ◽  
pp. 304-310 ◽  
Author(s):  
Anna Bilska ◽  
Małgorzata Iciek ◽  
Inga Kwiecień ◽  
Karol Kaniecki ◽  
Magdalena Paliborek ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfane Sulfur ◽  
Mouse Tissues

scholarly journals Revisit of the Photoirradiation of α-Lipoic Acid—Role of Hydrogen Sulfide Produced in the Reaction

BioChem ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 148-158
Author(s):  
Naoki Wada ◽  
Seiichi Matsugo
Keyword(s):  
Hydrogen Sulfide ◽  
Lipoic Acid ◽  
Photochemical Reaction ◽  
Dimethyl Disulfide ◽  
Polymeric Materials ◽  
Reduced Form ◽  
Product Analysis ◽  
Plausible Mechanism ◽  
Ph Dependent

α-Lipoic acid (LA) has the specific absorption band at 330 nm and is quite vulnerable to UV irradiation, affording a variety of compounds including polymeric materials and hydrogen sulfide. A better understanding of the photochemical reaction of LA has already been carried out focusing mainly on the reaction product analysis derived from LA. We re-investigated the photochemical reaction of LA focusing our attention on the fate of hydrogen sulfide (H2S) produced in the photochemical reaction procedure. The photoirradiation of LA in the presence of oxidized glutathione (GSSG) formed glutathione trisulfide (GSSSG) and a reduced form of glutathione (GSH). Similar results were obtained in the co-presence of cystine and dimethyl disulfide. The concentration of H2S was reaching the maximum concentration, which was gradually decreasing within 10 min after photoirradiation, while the concentration of GSSSG was increasing with the decrease of H2S concentration. The structural confirmation of GSSSG and the plausible mechanism for the formation of GSSSG are proposed based on the time-dependent and pH-dependent profile of the photoirradiation.

scholarly journals Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence in Pseudomonas aeruginosa PAO1

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1498
Author(s):  
Guanhua Xuan ◽  
Chuanjuan Lü ◽  
Huangwei Xu ◽  
Kai Li ◽  
Huaiwei Liu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Hydrogen Sulfide ◽  
Quorum Sensing ◽  
Sulfide Oxidation ◽  
Pseudomonas Aeruginosa Pao1 ◽  
Sulfane Sulfur ◽  
Target Dna ◽  
Production Of Hydrogen

Sulfane sulfur, such as inorganic and organic polysulfide (HSn− and RSn−, n > 2), is a common cellular component, produced either from hydrogen sulfide oxidation or cysteine metabolism. In Pseudomonas aeruginosa PAO1, LasR is a quorum sensing master regulator. After binding its autoinducer, LasR binds to its target DNA to activate the transcription of a suite of genes, including virulence factors. Herein, we report that the production of hydrogen sulfide and sulfane sulfur were positively correlated in P. aeruginosa PAO1, and sulfane sulfur was able to modify LasR, which generated Cys188 persulfide and trisulfide and produced a pentasulfur link between Cys201 and Cys203. The modifications did not affect LasR binding to its target DNA site, but made it several-fold more effective than unmodified LasR in activating transcription in both in vitro and in vivo assays. On the contrary, H2O2 inactivates LasR via producing a disulfide bond between Cys201 and Cys203. P. aeruginosa PAO1 had a high cellular sulfane sulfur and high LasR activity in the mid log phase and early stationary phase, but a low sulfane sulfur and low LasR activity in the declination phase. Thus, sulfane sulfur is a new signaling factor in the bacterium, adding another level of control over LasR-mediated quorum sensing and turning down the activity in old cells.

scholarly journals Cytoprotective effects of hydrogen sulfide-releasing N-methyl-d-aspartate receptor antagonists mediated by intracellular sulfane sulfur

MedChemComm ◽  
2014 ◽  
Vol 5 (10) ◽  
pp. 1577-1583 ◽  
Author(s):  
Eizo Marutani ◽  
Masahiro Sakaguchi ◽  
Wei Chen ◽  
Kiyoshi Sasakura ◽  
Jifeng Liu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Biological Effects ◽  
Receptor Antagonists ◽  
Sulfane Sulfur ◽  
Aspartate Receptor

Hydrogen sulfide (H2S) exerts a host of biological effects ranging from cytotoxicity to cytoprotection.

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

2009 ◽  
Vol 11 (4) ◽  
pp. 703-714 ◽  
Author(s):  
Norihiro Shibuya ◽  
Makiko Tanaka ◽  
Mikiharu Yoshida ◽  
Yuki Ogasawara ◽  
Tadayasu Togawa ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfane Sulfur ◽  
Mercaptopyruvate Sulfurtransferase ◽  
The Brain

3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide that is stored as bound sulfane sulfur in the brain

2009 ◽  
Vol 65 ◽  
pp. S57 ◽  
Author(s):  
Norihiro Shibuya ◽  
Makiko Tanaka ◽  
Mikiharu Yoshida ◽  
Yuki Ogasawara ◽  
Tadayasu Togawa ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Sulfane Sulfur ◽  
Mercaptopyruvate Sulfurtransferase ◽  
The Brain
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