scholarly journals A Novel Polysaccharide Conjugate from Bullacta exarata Induces G1-Phase Arrest and Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 384 ◽  
Author(s):  
Ningbo Liao ◽  
Liang Sun ◽  
Jiang Chen ◽  
Jianjun Zhong ◽  
Yanjun Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepg2 Cells ◽  
Human Hepatocellular Carcinoma ◽  
G1 Phase ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Bullacta Exarata

scholarly journals Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yang Yang ◽  
Qi Mei
Keyword(s):  
Hepatocellular Carcinoma ◽  
Small Rna ◽  
Human Hepatocellular Carcinoma ◽  
Cell Behaviors ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Different Types ◽  
Cell Cycle Inhibition ◽  
Xenograft Mice

AGO2 (Argonaute RISC Catalytic Component 2) plays an important role in small RNA-guided gene silencing processes. It has been implied in tumorigenesis of different types of tumors. In this study, we found that AGO2 expression was remarkably increased in human hepatocellular carcinoma (HCC) tissues when compared with adjacent noncancerous tissues. High expression of AGO2 was associated with poor prognosis in HCC patients. The CRISPR/Cas9-mediated knockout of AGO2 in SMMC-7721 cells inhibited cell proliferation and induced significant G1 phase arrest of cell cycle. Inhibition of cell migration was also observed in SMMC-7721 AGO2-/- cells. In vivo experiments showed that tumors grew slower in nude mice transplanted with AGO2-/- cells than in SMMC-7721 cell-derived xenograft mice. Microarray analysis and western blot analysis revealed that AGO2 depletion decreased expression of Survivin, Vimentin, and Snail. Overexpression of AGO2 in SMMC-7721 and Huh-7 cells could reverse the knockout-induced inhibition effects on either cell behaviors or expression of Survivin, Vimentin, and Snail Therefore, our data demonstrated that AGO2 might facilitate HCC tumorigenesis and metastasis through modulating expression of Survivin, Vimentin, and Snail.

scholarly journals Astragaloside IV Induces Apoptosis, G1-Phase Arrest and Inhibits Anti-apoptotic Signaling in Hepatocellular Carcinoma

In Vivo ◽  
2020 ◽  
Vol 34 (2) ◽  
pp. 631-638
Author(s):  
CHUN-MIN SU ◽  
HSIAO-CHIA WANG ◽  
FEI-TING HSU ◽  
CHUN-HUI LU ◽  
CHIEN-KAI LAI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
G1 Phase ◽  
Astragaloside Iv ◽  
Apoptotic Signaling ◽  
Phase Arrest ◽  
G1 Phase Arrest

6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

2012 ◽  
Vol 695 (1-3) ◽  
pp. 27-33 ◽  
Author(s):  
Xiao-Guang Yang ◽  
Yong-Li Bao ◽  
Yan-Xin Huang ◽  
Lu-Guo Sun ◽  
Yu-Wei Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepg2 Cells ◽  
Human Hepatocellular Carcinoma ◽  
Phase Arrest ◽  
M Phase

scholarly journals Quercetin reduces cyclin D1 activity and induces G1 phase arrest in HepG2 cells

2016 ◽  
Vol 12 (1) ◽  
pp. 516-522 ◽  
Author(s):  
JIN ZHOU ◽  
LU LI ◽  
LI FANG ◽  
HUA XIE ◽  
WENXIU YAO ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Hepg2 Cells ◽  
G1 Phase ◽  
Phase Arrest ◽  
G1 Phase Arrest

scholarly journals Knockdown of CENPW Inhibits Hepatocellular Carcinoma Progression by Inactivating E2F Signaling

2021 ◽  
Vol 20 ◽  
pp. 153303382110072
Author(s):  
Yajing Zhou ◽  
Hua Chai ◽  
Lei Guo ◽  
Zhongqiu Dai ◽  
Jianming Lai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
G1 Phase ◽  
Migration And Invasion ◽  
Cell Cycle Distribution ◽  
Colony Formation Assay ◽  
Transwell Assay ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Hcc Cells

Aim: This study aimed to evaluate the effects of centromere protein W (CENPW, also known as CUG2) in hepatocellular carcinoma (HCC). Methods: CENPW expression in HCC tissues and cells was detected by RT-qPCR assay. CCK-8 and colony formation assay were used to assess cell proliferation. Wound healing and Transwell assay was used to detect cell migration and invasion, respectively. The flow cytometry was used to analyze the cell cycle distribution and apoptosis. Results: CENPW expression was upregulated in HCC tissues and cells. Knockdown of CENPW inhibited cell proliferation, migration, and invasion and induced the G0/G1 phase arrest and cell apoptosis in HCC cells, which might involve the E2F signaling regulation. Conclusion: CENPW acted as an oncogenic role in HCC progression via activation E2F signaling. Our findings may provide new insights into the studying mechanisms of HCC.

Ellipticine induces apoptosis through p53-dependent pathway in human hepatocellular carcinoma HepG2 cells

Life Sciences ◽  
2006 ◽  
Vol 78 (22) ◽  
pp. 2550-2557 ◽  
Author(s):  
Yu-Chun Kuo ◽  
Po-Lin Kuo ◽  
Ya-Ling Hsu ◽  
Chien-Yu Cho ◽  
Chun-Ching Lin
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepg2 Cells ◽  
Human Hepatocellular Carcinoma ◽  
Dependent Pathway
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