scholarly journals Ethyl acetate extraction from a Chinese herbal formula, Jiedu Xiaozheng Yin, inhibits the proliferation of hepatocellular carcinoma cells via induction of G0/G1 phase arrest in vivo and in vitro

2012 ◽  
Vol 42 (1) ◽  
pp. 202-210 ◽  
Author(s):  
ZHIYUN CAO ◽  
WEI LIN ◽  
ZHENGRONG HUANG ◽  
XUZHENG CHEN ◽  
JINYAN ZHAO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
G1 Phase ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Phase Arrest ◽  
G1 Phase Arrest

scholarly journals Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro

2016 ◽  
Vol 37 (7) ◽  
pp. 950-962 ◽  
Author(s):  
Jing-bo Yang ◽  
Muhammad Khan ◽  
Yang-yang He ◽  
Min Yao ◽  
Yong-ming Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Carcinoma ◽  
Carcinoma Cells ◽  
Human Prostate ◽  
G1 Phase ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Human Prostate Carcinoma

scholarly journals Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo

2020 ◽  
Vol 72 (7) ◽  
pp. 979-989
Author(s):  
Sheng‐Quan Fang ◽  
Jian Huang ◽  
Feng Zhang ◽  
Hong‐Mei Ni ◽  
Qi‐Long Chen ◽  
...  
Keyword(s):  
Pharmacokinetic Interaction ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Oral Liquid

scholarly journals San Wu Huangqin Decoction, a Chinese Herbal Formula, Inhibits Influenza a/PR/8/34 (H1N1) Virus Infection In Vitro and In Vivo

Viruses ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 117 ◽  
Author(s):  
Qinhai Ma ◽  
Qingtian Yu ◽  
Xuefeng Xing ◽  
Sinian Liu ◽  
Chunyu Shi ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A ◽  
H1n1 Virus ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
H1n1 Virus Infection

Jiawei-Yupingfeng-Tang, a Chinese herbal formula, inhibits respiratory viral infections in vitro and in vivo

2013 ◽  
Vol 150 (2) ◽  
pp. 521-528 ◽  
Author(s):  
Qiang Liu ◽  
Li Lu ◽  
Moli Hua ◽  
Yu Xu ◽  
Hairong Xiong ◽  
...  
Keyword(s):  
Viral Infections ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Respiratory Viral Infections

scholarly journals BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis

2020 ◽  
Vol 11 ◽  
pp. 204062072093268
Author(s):  
Guang Li ◽  
Yan-Hua Zheng ◽  
Li Xu ◽  
Juan Feng ◽  
Hai-Long Tang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Proliferation ◽  
Cell Apoptosis ◽  
Tumor Model ◽  
G1 Phase ◽  
Bortezomib Treatment ◽  
Phase Arrest ◽  
G1 Phase Arrest

Background: Multiple myeloma (MM) is the second most common hematological neoplasm. Wide administration of bortezomib significantly improves the survival of MM patients compared with conventional chemotherapy. Bromodomain-containing protein 4 (BRD4) inhibitors also have been demonstrated to retard cell proliferation and induce cellular apoptosis in various cancers. However, it is unclear whether the BRD4 inhibitor nitroxoline plus bortezomib has a synergistic anti-tumor effect on MM. Methods: Cell viability was determined via 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle and cell apoptosis were assessed via flow cytometry. Protein expression levels were determined via western blotting. The expression of apoptosis-related proteins in xenograft tissue were detected by means of immunohistochemistry. Results: Treatment with nitroxoline or bortezomib suppressed cell proliferation, and caused G0/G1 phase arrest and apoptosis in H929 and RPMI8226 cells. Furthermore, nitroxoline intensified the retardation of cell proliferation, as well as further enhanced the G0/G1 phase arrest and apoptosis induced by bortezomib in H929 and RPMI8226 cells. The western blot analysis revealed that nitroxoline or bortezomib treatment markedly diminished the levels of Bcl-2 and cyclin D1, and increased the levels of p21, Bax, cleaved PARP and cleaved caspase-3. Combination of these two agents was observed to result in further marked changes on these levels compared with nitroxoline or bortezomib treatment alone. What is more, in the xenograft tumor model, combinative treatment markedly inhibited tumor growth compared with the single drug treatment. Conclusion: Combination of bortezomib with nitroxoline has a synergistic anti-tumor activity in MM cells and may be a novel treatment method for MM.

Lycorine Induces Apoptosis and G1 Phase Arrest Through ROS/p38 MAPK Signaling Pathway in Human Osteosarcoma Cells In Vitro and In Vivo

Spine ◽  
2020 ◽  
Vol 45 (3) ◽  
pp. E126-E139 ◽  
Author(s):  
Lei Ning ◽  
Shuanglin Wan ◽  
Zhiwei Jie ◽  
Ziang Xie ◽  
Xiang Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mapk Signaling ◽  
G1 Phase ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Phase Arrest ◽  
Human Osteosarcoma Cells ◽  
G1 Phase Arrest

scholarly journals Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vivo and In Vitro

2011 ◽  
Vol 140 (5) ◽  
pp. S-515
Author(s):  
Zhonghan Yang ◽  
Viktoriya Grinchuk ◽  
Terez Shea-Donohue ◽  
Chun-Tao Che ◽  
Lixing Lao ◽  
...  
Keyword(s):  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Anti Inflammatory
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