scholarly journals Antiproliferative Effects of New Dimeric Ellagitannin from Cornus alba in Prostate Cancer Cells Including Apoptosis-Related S-Phase Arrest

Molecules ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 137 ◽  
Author(s):  
Kwan Park ◽  
Jun Yin ◽  
Ki Yoon ◽  
Yoon Hwang ◽  
Min Lee
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells ◽  
Antiproliferative Effects ◽  
Cornus Alba ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Retracted: Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells

2006 ◽  
Vol 119 (9) ◽  
pp. 2071-2077 ◽  
Author(s):  
Yuxiang Zhang ◽  
Zhiwei Wang ◽  
Fakhara Ahmed ◽  
Sanjeev Banerjee ◽  
Yiwei Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
S Phase ◽  
Cell Growth Inhibition ◽  
Prostate Cancer Cells ◽  
Down Regulation ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G1 to S Phase

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56692 ◽  
Author(s):  
Shalini Murthy ◽  
Min Wu ◽  
V. Uma Bai ◽  
Zizheng Hou ◽  
Mani Menon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells

Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells

2018 ◽  
Vol 47 (33) ◽  
pp. 11397-11410 ◽  
Author(s):  
Ceyda Icsel ◽  
Veysel T. Yilmaz ◽  
Muhittin Aygun ◽  
Buse Cevatemre ◽  
Pinar Alper ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
S Phase ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
Cell Arrest ◽  
Human Colon Cancer Cells

Highly cytotoxic Pd(ii)/Pt(ii) complexes of saccharin with diphosphines cause cell arrest at the S phase and the production of excessive ROS, damaging mitochondria and DNA.

scholarly journals Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Yuanshen Mao ◽  
Wenfeng Li ◽  
Bao Hua ◽  
Xin Gu ◽  
Weixin Pan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Prostate Cancer Cells ◽  
Migration Inhibition ◽  
Akt Inhibitor ◽  
Phase Arrest ◽  
M Phase ◽  
And Migration

ELK3, an ETS domain-containing transcription factor, participates in various physiological and pathological processes including cell proliferation, migration, angiogenesis, and malignant progression. However, the role of ELK3 in prostate cancer cells and its mechanism are not fully understood. The contribution of ELK3 to prostate cancer progression was investigated in the present study. We showed that silencing of ELK3 by siRNA in prostate cancer cell DU145 induced S-M phase arrest, promoted apoptosis, inhibited cell proliferation and migration in vitro, and suppressed xenograft growth in mice in vivo. In accordance with its ability to arrest cells in S-M phase, the expression of cyclin A and cyclin B was downregulated. In addition, the expression of p53 was upregulated following ELK3 knockdown, while that of antiapoptotic Bcl-2 was decreased. The migration inhibition may partly due to upregulation of SERPINE1 (a serine protease inhibitor) followed ELK3 knockdown. Consistently, downregulation of SERPINE1 resulted in a modest elimination of migration inhibition resulted from ELK3 knockdown. Furthermore, we found that the AKT signaling was activated in ELK3 knockdown cells, and treatment these cells with AKT inhibitor attenuated SERPINE1 expression induced by ELK3 silencing, suggesting that activation of AKT pathway may be one of the reasons for upregulation of SERPINE1 after ELK3 knockdown. In conclusion, modulation of ELK3 expression may control the progression of prostate cancer partly by regulating cell growth, apoptosis, and migration.

Sign in / Sign up

Export Citation Format

Share Document