A LOW MOLECULAR WEIGHT FACTOR IN FETAL CALF SERUM INHIBITS THE PROGRESSION OF PROSTATE CANCER CELLS THROUGH S PHASE

2000 ◽  
Vol 28 (5) ◽  
pp. A369-A369
Author(s):  
P. V. G. Reddy ◽  
M. Menon ◽  
E. R. Barrack
Keyword(s):  
Prostate Cancer ◽  
Molecular Weight ◽  
Cancer Cells ◽  
Fetal Calf Serum ◽  
Calf Serum ◽  
S Phase ◽  
Low Molecular Weight ◽  
Weight Factor ◽  
Prostate Cancer Cells

scholarly journals Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G1 to S Phase

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56692 ◽  
Author(s):  
Shalini Murthy ◽  
Min Wu ◽  
V. Uma Bai ◽  
Zizheng Hou ◽  
Mani Menon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells

S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11–induced apoptosis of prostate cancer cells

2007 ◽  
Vol 6 (4) ◽  
pp. 1368-1378 ◽  
Author(s):  
Subrata Ray ◽  
Sunitha Shyam ◽  
Gail C. Fraizer ◽  
Alexandru Almasan
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis

Abstract 3918: A structural role of androgen receptor in progression of prostate cancer cells from G1to S phase

2012 ◽  
Author(s):  
Shalini Murthy ◽  
Kannagi Chinnakannu ◽  
Min Wu ◽  
Sahn-Ho Kim ◽  
Evelyn R. Barrack ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
S Phase ◽  
Prostate Cancer Cells ◽  
Structural Role

scholarly journals Inhibition of Prostate Cancer Cells by 4,5-Dicaffeoylquinic Acid through Cell Cycle Arrest

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Olivia Lodise ◽  
Ketki Patil ◽  
Igor Karshenboym ◽  
Scott Prombo ◽  
Chidinma Chukwueke ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Mapk Signaling ◽  
S Phase ◽  
Prostate Cancer Cells ◽  
Cycle Arrest ◽  
Dicaffeoylquinic Acid

Prostate cancer is a major cause of cancer-related mortality in men. Even though current therapeutic management has contributed to reducing mortality, additional intervention strategies are warranted to further improve the outcomes. To this end, we have investigated the efficacy of dicaffeoylquinic acids, ingredients in Yerba Mate (Ilex paraguariensis), an evergreen cultivated in South America, the leaves of which are used to prepare a tea/coffee-like drink. Of the various analogs tested, 4,5-dicaffeoylquinic acid (4,5-diCQA) was the most active molecule against DU-145 prostate cancer cells with a 50% inhibitory concentration (IC50) of 5 μM. 4,5-diCQA was active both under normoxic and hypoxic conditions. The effect of 72-hour treatment on DU-145 cells persisted for an extended time period as assessed by clonogenic assay. Mechanistic studies revealed that the toxic effect was not due to induction of programmed cell death but through cell cycle arrest at S phase. Additionally, 4,5-diCQA did not impact PI3K/MAPK signaling pathway nor did it affect the depolarization of the mitochondrial membrane. 4,5-diCQA-induced accumulation of cells in the S-phase also seems to negatively impact Bcl-2 expression. 4,5-diCQA also exhibited inhibitory activity on LNCaP and PC-3 prostate cancer cells suggesting that it has therapeutic potential on a broad range of prostate cancers. Taken together, the novel inhibitory activity and mechanism of action of 4,5-diCQA opens up potential therapeutic options for using this molecule as monotherapy as well as in combinatorial therapies for the clinical management of prostate cancer.

scholarly journals Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition

2015 ◽  
Vol 12 (6) ◽  
pp. 7907-7914 ◽  
Author(s):  
JIEBING TANG ◽  
YUANYUAN CHEN ◽  
RONGJUN CUI ◽  
DONG LI ◽  
LIJIE XIAO ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Phase Transition ◽  
Cancer Cells ◽  
Proliferative Response ◽  
S Phase ◽  
Prostate Cancer Cells

scholarly journals Retracted: Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells

2006 ◽  
Vol 119 (9) ◽  
pp. 2071-2077 ◽  
Author(s):  
Yuxiang Zhang ◽  
Zhiwei Wang ◽  
Fakhara Ahmed ◽  
Sanjeev Banerjee ◽  
Yiwei Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
S Phase ◽  
Cell Growth Inhibition ◽  
Prostate Cancer Cells ◽  
Down Regulation ◽  
Phase Arrest ◽  
S Phase Arrest
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