scholarly journals Oxidized Fatty Acids as Inter-Kingdom Signaling Molecules

Molecules ◽  
2014 ◽  
Vol 19 (1) ◽  
pp. 1273-1285 ◽  
Author(s):  
Carolina Pohl ◽  
Johan Kock
Keyword(s):  
Fatty Acids ◽  
Signaling Molecules ◽  
Oxidized Fatty Acids

Sa1937 Mass Spectrometric Profiling of Oxidized Fatty Acids (OxFAS) in Esophageal Adenocarcinoma (EAC) - A Pilot Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-360-S-361
Author(s):  
Amit Bhatt ◽  
Arthi Kumaravel ◽  
Scott L. Gabbard ◽  
Murthy C. Sudish ◽  
Sunguk Jang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pilot Study ◽  
Esophageal Adenocarcinoma ◽  
Mass Spectrometric ◽  
Oxidized Fatty Acids

Nitro-fatty acids: electrophilic signaling molecules in plant physiology

Planta ◽  
2021 ◽  
Vol 254 (6) ◽  
Author(s):  
Luciano Di Fino ◽  
Andrés Arruebarrena Di Palma ◽  
Enzo A. Perk ◽  
Carlos García-Mata ◽  
Francisco J. Schopfer ◽  
...  
Keyword(s):  
Plant Physiology ◽  
Fatty Acids ◽  
Signaling Molecules

Nitrated Fatty Acids as Signaling Molecules

2006 ◽  
Vol 2006 (363) ◽  
pp. tw401-tw401
Author(s):  
L. B. Ray
Keyword(s):  
Fatty Acids ◽  
Signaling Molecules

scholarly journals The insectivorous bat Pipistrellus nathusii uses a mixed-fuel strategy to power autumn migration

2012 ◽  
Vol 279 (1743) ◽  
pp. 3772-3778 ◽  
Author(s):  
Christian C. Voigt ◽  
Karin Sörgel ◽  
Jurģis Šuba ◽  
Oskars Keišs ◽  
Gunārs Pētersons
Keyword(s):  
Fatty Acids ◽  
Stable Carbon Isotope ◽  
Carbon Isotope Ratio ◽  
Dietary Fatty Acids ◽  
Autumn Migration ◽  
Dietary Proteins ◽  
Mixed Fuel ◽  
Feeding Experiments ◽  
Body Reserves ◽  
Oxidized Fatty Acids

In contrast to birds, bats are possibly limited in their capacity to use body fat as an energy source for long migrations. Here, we studied the fuel choice of migratory Pipistrellus nathusii (approximate weight: 8 g) by analysing the stable carbon isotope ratio ( δ 13 C V-PDB ) of breath and potential energy sources. Breath δ 13 C V-PDB was intermediate between δ 13 C V-PDB of insect prey and adipocyte triacylglycerols, suggesting a mixed-fuel use of P. nathusii during autumn migration. To clarify the origin of oxidized fatty acids, we performed feeding experiments with captive P. nathusii . After an insect diet, bat breath was enriched in 13 C relative to the bulk and fat portion of insects, but not deviating from the non-fat portion of insects, suggesting that bats oxidized exogenous proteins and carbohydrates, but not exogenous fatty acids. A feeding experiment with 13 C-labelled substrates confirmed these findings. In conclusion, migratory P. nathusii oxidized dietary proteins directly from insects captured en route in combination with endogenous fatty acids from adipocytes, and replenished their body reserves by routing dietary fatty acids to their body reserves.

Breaking the cycle: the role of omega-3 polyunsaturated fatty acids in inflammation-driven cancers

2014 ◽  
Vol 92 (5) ◽  
pp. 321-328 ◽  
Author(s):  
William L. Patterson ◽  
Philippe T. Georgel
Keyword(s):  
Fatty Acids ◽  
Transcription Factors ◽  
Polyunsaturated Fatty Acids ◽  
Chronic Inflammation ◽  
Cancer Progression ◽  
Immune Cells ◽  
Signaling Molecules ◽  
Inflammatory Signaling ◽  
Vast Number ◽  
Anti Inflammatory

Chronic inflammation is a cyclical, self-stimulating process. Immune cells called to sites of inflammation release pro-inflammatory signaling molecules that stimulate activation of inducible enzymes and transcription factors. These enzymes and transcription factors then stimulate production of signaling molecules that attract more immune cells and induce more enzymatic and transcriptional activity, creating a perpetual loop of inflammation. This self-renewing pool of inflammatory stimuli makes for an ideal tumor microenvironment, and chronic inflammation has been linked to oncogenesis, tumor growth, tumor cell survival, and metastasis. Three protein pathways in particular, nuclear factor kappa B (NF-kB), cyclooxygenase (COX), and lipoxygenase (LOX), provide excellent examples of the cyclical, self-renewing nature of chronic inflammation-driven cancers. NF-kB is an inducible transcription factor responsible for the expression of a vast number of inflammation and cancer related genes. COX and LOX convert omega-6 (n-6) and omga-3 (n-3) polyunsaturated fatty acids (PUFA) into pro- and anti-inflammatory signaling molecules. These signaling molecules stimulate or repress activity of all three of these pathways. In this review, we will discuss the pro- and anti-inflammatory functions of these fatty acids and their role in chronic inflammation and cancer progression.

scholarly journals Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils

2017 ◽  
Vol 65 (9) ◽  
pp. 1941-1951 ◽  
Author(s):  
Christine E. Richardson ◽  
Marie Hennebelle ◽  
Yurika Otoki ◽  
Daisy Zamora ◽  
Jun Yang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipidomic Analysis ◽  
Oxidized Fatty Acids

Carcinogens and Oxidized Fatty Acids in the Skin

Nature ◽  
1953 ◽  
Vol 172 (4372) ◽  
pp. 306-307 ◽  
Author(s):  
MARY L. C. BERNHEIM ◽  
FREDERICK BERNHEIM ◽  
KARL M. WILBUR
Keyword(s):  
Fatty Acids ◽  
Oxidized Fatty Acids

scholarly journals Structural basis for the activation of PPARγ by oxidized fatty acids

2008 ◽  
Vol 15 (9) ◽  
pp. 924-931 ◽  
Author(s):  
Toshimasa Itoh ◽  
Louise Fairall ◽  
Kush Amin ◽  
Yuka Inaba ◽  
Attila Szanto ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Structural Basis ◽  
Oxidized Fatty Acids
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