scholarly journals Structural basis for the activation of PPARγ by oxidized fatty acids

2008 ◽  
Vol 15 (9) ◽  
pp. 924-931 ◽  
Author(s):  
Toshimasa Itoh ◽  
Louise Fairall ◽  
Kush Amin ◽  
Yuka Inaba ◽  
Attila Szanto ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Structural Basis ◽  
Oxidized Fatty Acids

Sa1937 Mass Spectrometric Profiling of Oxidized Fatty Acids (OxFAS) in Esophageal Adenocarcinoma (EAC) - A Pilot Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-360-S-361
Author(s):  
Amit Bhatt ◽  
Arthi Kumaravel ◽  
Scott L. Gabbard ◽  
Murthy C. Sudish ◽  
Sunguk Jang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pilot Study ◽  
Esophageal Adenocarcinoma ◽  
Mass Spectrometric ◽  
Oxidized Fatty Acids

Design of the oxygen and substrate pathways. V. Structural basis of vascular substrate supply to muscle cells.

1996 ◽  
Vol 199 (8) ◽  
pp. 1675-1688 ◽  
Author(s):  
R Vock ◽  
E R Weibel ◽  
H Hoppeler ◽  
G Ordway ◽  
J M Weber ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Surface Area ◽  
Oxygen Demand ◽  
Intercellular Junctions ◽  
Muscle Cells ◽  
Structural Basis ◽  
Physiological Data ◽  
Capillary Surface ◽  
Substrate Supply ◽  
Structural Capacity

This paper quantifies the structural capacity of the transport steps for oxygen, glucose and fatty acids from the blood in capillaries to the cytosol of muscle cells and compares it with maximal rates of oxygen and substrate transport measured in the same animals and reported in the preceding papers of this series. Dogs have relatively more muscle per unit body mass than goats (37 versus 26%), but the maximal rate of oxidation per gram of muscle is still larger in the dog by a factor of 1.55. The maximal rates of substrate supply from the circulation are similar in both species. We predict that these differences in physiological parameters should be matched by proportional differences in structural capacity. We find that capillary volume and surface area are matched to maximal oxygen demand. The rate of vascular substrate supply is proportional neither to the capillary surface area nor to the length of intercellular junctions. The sarcolemmal surface area per gram of muscle is the same in both species. Using the physiological data presented in the companion papers of this series, we have calculated the maximal flux densities of circulatory glucose and fatty acids across the capillary wall and the sarcolemma. We find, for both substrates, that the flux densities across the sarcolemma reach a maximum at nearly the same level and at low exercise intensities in both species. In contrast, the flux densities across the capillary surface and the endothelial junctions are higher in goats than in dogs. We conclude that the capillaries are designed for O2 supply up to maximal rates of oxidation but not for the supply of the substrates (glucose and fatty acids) at the rates required at high exercise intensities. These are limited by the transport capacities of the sarcolemma.

scholarly journals The insectivorous bat Pipistrellus nathusii uses a mixed-fuel strategy to power autumn migration

2012 ◽  
Vol 279 (1743) ◽  
pp. 3772-3778 ◽  
Author(s):  
Christian C. Voigt ◽  
Karin Sörgel ◽  
Jurģis Šuba ◽  
Oskars Keišs ◽  
Gunārs Pētersons
Keyword(s):  
Fatty Acids ◽  
Stable Carbon Isotope ◽  
Carbon Isotope Ratio ◽  
Dietary Fatty Acids ◽  
Autumn Migration ◽  
Dietary Proteins ◽  
Mixed Fuel ◽  
Feeding Experiments ◽  
Body Reserves ◽  
Oxidized Fatty Acids

In contrast to birds, bats are possibly limited in their capacity to use body fat as an energy source for long migrations. Here, we studied the fuel choice of migratory Pipistrellus nathusii (approximate weight: 8 g) by analysing the stable carbon isotope ratio ( δ 13 C V-PDB ) of breath and potential energy sources. Breath δ 13 C V-PDB was intermediate between δ 13 C V-PDB of insect prey and adipocyte triacylglycerols, suggesting a mixed-fuel use of P. nathusii during autumn migration. To clarify the origin of oxidized fatty acids, we performed feeding experiments with captive P. nathusii . After an insect diet, bat breath was enriched in 13 C relative to the bulk and fat portion of insects, but not deviating from the non-fat portion of insects, suggesting that bats oxidized exogenous proteins and carbohydrates, but not exogenous fatty acids. A feeding experiment with 13 C-labelled substrates confirmed these findings. In conclusion, migratory P. nathusii oxidized dietary proteins directly from insects captured en route in combination with endogenous fatty acids from adipocytes, and replenished their body reserves by routing dietary fatty acids to their body reserves.

scholarly journals Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils

2017 ◽  
Vol 65 (9) ◽  
pp. 1941-1951 ◽  
Author(s):  
Christine E. Richardson ◽  
Marie Hennebelle ◽  
Yurika Otoki ◽  
Daisy Zamora ◽  
Jun Yang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipidomic Analysis ◽  
Oxidized Fatty Acids
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