scholarly journals Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils

2017 ◽  
Vol 65 (9) ◽  
pp. 1941-1951 ◽  
Author(s):  
Christine E. Richardson ◽  
Marie Hennebelle ◽  
Yurika Otoki ◽  
Daisy Zamora ◽  
Jun Yang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipidomic Analysis ◽  
Oxidized Fatty Acids

Sa1937 Mass Spectrometric Profiling of Oxidized Fatty Acids (OxFAS) in Esophageal Adenocarcinoma (EAC) - A Pilot Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-360-S-361
Author(s):  
Amit Bhatt ◽  
Arthi Kumaravel ◽  
Scott L. Gabbard ◽  
Murthy C. Sudish ◽  
Sunguk Jang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pilot Study ◽  
Esophageal Adenocarcinoma ◽  
Mass Spectrometric ◽  
Oxidized Fatty Acids

scholarly journals Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acids

2019 ◽  
Vol 17 (2) ◽  
pp. 347-355 ◽  
Author(s):  
Jianzhong Chen ◽  
Kelly K. Nichols ◽  
Landon Wilson ◽  
Stephen Barnes ◽  
Jason J. Nichols
Keyword(s):  
Fatty Acids ◽  
Hydroxy Fatty Acids ◽  
New Approach ◽  
Lipidomic Analysis

scholarly journals CBMT-43. INTEGRATED LIPIDOMIC AND MOLECULAR ANALYSIS REVEALS A SUBSET OF GLIOBLASTOMA VULNERABLE TO FERROPTOSIS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi42-vi42
Author(s):  
Danielle Morrow ◽  
Nicholas Bayley ◽  
Kevin Williams ◽  
Hayato Muranaka ◽  
Robert Prins ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Metabolic Phenotype ◽  
Molecular Signatures ◽  
Critical Feature ◽  
Molecular Alterations ◽  
Lipidomic Analysis ◽  
Regulated Cell Death ◽  
Novel Association ◽  
Therapeutic Opportunity

Abstract Cancers, including the universally lethal glioblastoma (GBM), have reprogrammed lipid metabolism to fuel tumor growth. However, the molecular alterations responsible for aberrant lipid metabolism, and the potential for identifying new therapeutic opportunities are not fully understood. To systematically investigate the GBM lipidome, we performed integrated transcriptomic, genomic and shotgun lipidomic analysis of a library of molecularly diverse patient-derived GBM cells (n=30). Using this comprehensive approach, we discovered two GBM sub-groups defined by their combined molecular and lipidomic profile. Polyunsaturated fatty acids (PUFAs) were among the most significant lipids that distinguished these two groups of GBM tumors. Intriguingly, this lipid metabolic phenotype was associated with heightened sensitivity to ferroptosis – a newly discovered form of regulated cell death. As PUFA oxidation is a critical feature of ferroptosis, our findings suggest a novel association between specific molecular signatures of GBM, lipid metabolism and ferroptosis. This relationship may present a new therapeutic opportunity to target ferroptosis in a molecularly-defined subset of GBMs.

scholarly journals Altered Levels of Desaturation and ω-6 Fatty Acids in Breast Cancer Patients’ Red Blood Cell Membranes

Metabolites ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 469
Author(s):  
Javier Amézaga ◽  
Gurutze Ugartemendia ◽  
Aitziber Larraioz ◽  
Nerea Bretaña ◽  
Aizpea Iruretagoyena ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Blood Cell ◽  
Cancer Patients ◽  
Red Blood Cell ◽  
Breast Cancer Patients ◽  
Disease Evolution ◽  
Lipidomic Analysis ◽  
Rbc Membrane

Red blood cell (RBC) membrane can reflect fatty acid (FA) contribution from diet and biosynthesis. In cancer, membrane FAs are involved in tumorigenesis and invasiveness, and are indicated as biomarkers to monitor the disease evolution as well as potential targets for therapies and nutritional strategies. The present study provides RBC membrane FA profiles in recently diagnosed breast cancer patients before starting chemotherapy treatment. Patients and controls were recruited, and their dietary habits were collected. FA lipidomic analysis of mature erythrocyte membrane phospholipids in blood samples was performed. Data were adjusted to correct for the effects of diet, body mass index (BMI), and age, revealing that patients showed lower levels of saturated fatty acids (SFA) and higher levels of monounsaturated fatty acid, cis-vaccenic (25%) than controls, with consequent differences in desaturase enzymatic index (∆9 desaturase, –13.1%). In the case of polyunsaturated fatty acids (PUFA), patients had higher values of ω-6 FA (C18:2 (+11.1%); C20:4 (+7.4%)). RBC membrane lipidomic analysis in breast cancer revealed that ω-6 pathways are favored. These results suggest new potential targets for treatments and better nutritional guidelines.

scholarly journals The insectivorous bat Pipistrellus nathusii uses a mixed-fuel strategy to power autumn migration

2012 ◽  
Vol 279 (1743) ◽  
pp. 3772-3778 ◽  
Author(s):  
Christian C. Voigt ◽  
Karin Sörgel ◽  
Jurģis Šuba ◽  
Oskars Keišs ◽  
Gunārs Pētersons
Keyword(s):  
Fatty Acids ◽  
Stable Carbon Isotope ◽  
Carbon Isotope Ratio ◽  
Dietary Fatty Acids ◽  
Autumn Migration ◽  
Dietary Proteins ◽  
Mixed Fuel ◽  
Feeding Experiments ◽  
Body Reserves ◽  
Oxidized Fatty Acids

In contrast to birds, bats are possibly limited in their capacity to use body fat as an energy source for long migrations. Here, we studied the fuel choice of migratory Pipistrellus nathusii (approximate weight: 8 g) by analysing the stable carbon isotope ratio ( δ 13 C V-PDB ) of breath and potential energy sources. Breath δ 13 C V-PDB was intermediate between δ 13 C V-PDB of insect prey and adipocyte triacylglycerols, suggesting a mixed-fuel use of P. nathusii during autumn migration. To clarify the origin of oxidized fatty acids, we performed feeding experiments with captive P. nathusii . After an insect diet, bat breath was enriched in 13 C relative to the bulk and fat portion of insects, but not deviating from the non-fat portion of insects, suggesting that bats oxidized exogenous proteins and carbohydrates, but not exogenous fatty acids. A feeding experiment with 13 C-labelled substrates confirmed these findings. In conclusion, migratory P. nathusii oxidized dietary proteins directly from insects captured en route in combination with endogenous fatty acids from adipocytes, and replenished their body reserves by routing dietary fatty acids to their body reserves.

Carcinogens and Oxidized Fatty Acids in the Skin

Nature ◽  
1953 ◽  
Vol 172 (4372) ◽  
pp. 306-307 ◽  
Author(s):  
MARY L. C. BERNHEIM ◽  
FREDERICK BERNHEIM ◽  
KARL M. WILBUR
Keyword(s):  
Fatty Acids ◽  
Oxidized Fatty Acids

scholarly journals Structural basis for the activation of PPARγ by oxidized fatty acids

2008 ◽  
Vol 15 (9) ◽  
pp. 924-931 ◽  
Author(s):  
Toshimasa Itoh ◽  
Louise Fairall ◽  
Kush Amin ◽  
Yuka Inaba ◽  
Attila Szanto ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Structural Basis ◽  
Oxidized Fatty Acids

scholarly journals Renal Oxidized Fatty Acids are Reduced in LDL Receptor Deficient Mice following treatment with Anti Inflammatory Peptide F

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kaveh Daniel Navab ◽  
Omeed Elboudwarej ◽  
Massood Memarzadeh ◽  
Ladan Vakili ◽  
Maryam Shabihkhani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ldl Receptor ◽  
Anti Inflammatory ◽  
Oxidized Fatty Acids ◽  
Deficient Mice
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