scholarly journals Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish

Molecules ◽  
2012 ◽  
Vol 17 (7) ◽  
pp. 8617-8632 ◽  
Author(s):  
Yingjie Wei ◽  
Ping Li ◽  
Changmei Wang ◽  
Yunru Peng ◽  
Luan Shu ◽  
...  
Keyword(s):  
Salvia Miltiorrhiza ◽  
Tanshinone Iia ◽  
Tanshinone I ◽  
Radix Salvia Miltiorrhiza

Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza

2012 ◽  
Vol 35 (8) ◽  
pp. 1457-1464 ◽  
Author(s):  
Hang Yu ◽  
Robhash Kusam Subedi ◽  
Pushp R. Nepal ◽  
Yoon G. Kim ◽  
Hoo-Kyun Choi
Keyword(s):  
Dissolution Rate ◽  
Salvia Miltiorrhiza ◽  
Tanshinone Iia ◽  
Tanshinone I

scholarly journals Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2043
Author(s):  
Yuanyuan Li ◽  
Zhuoni Hou ◽  
Feng Su ◽  
Jipeng Chen ◽  
Xiaodan Zhang ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Salvia Miltiorrhiza ◽  
Tanshinone Iia ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Salvia Miltiorrhiza Bunge ◽  
Simple Method ◽  
Tanshinone I

Salvia mltiorrhiza Bunge (SMB) is native to China, whose dried root has been used as medicine. A few chromatographic- or spectrometric-based methods have already been used to analyze the lipid-soluble components in SMB. However, the methodology of qNMR on the extracts of fresh SMB root has not been verified so far. The purpose of this study was to establish a fast and simple method to quantify the tanshinone I, tanshinone IIA, dihydrotanshinone, and cryptotanshinone in fresh Salvia Miltiorrhiza Bunge root without any pre-purification steps using 1H-NMR spectroscopy. The process is as follows: first, 70% methanol aqueous extracts of fresh Salvia Miltiorrhiza Bunge roots were quantitatively analyzed for tanshinone I, tanshinone IIA, dihydrotanshinone, and cryptotanshinone using 1H-NMR spectroscopy. Different internal standards were tested and the validated method was compared with HPLC. 3,4,5-trichloropyridine was chosen as the internal standard. Twelve samples of Salvia Miltiorrhiza Bunge were quantitatively analyzed by qNMR and HPLC respectively. Then, the results were analyzed by chemometric approaches. This NMR method offers a fast, stable, and accurate analysis of four ketones: tanshinone I, tanshinone IIA, dihydrotanshinone, and cryptotanshinone in fresh roots of Salvia Miltiorrhiza Bunge.

Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza

Phytomedicine ◽  
2012 ◽  
Vol 19 (3-4) ◽  
pp. 330-333 ◽  
Author(s):  
Qianliang Ming ◽  
Ting Han ◽  
Wenchao Li ◽  
Qiaoyan Zhang ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Salvia Miltiorrhiza ◽  
Tanshinone Iia ◽  
Trichoderma Atroviride ◽  
Tanshinone I

Ultrafine Grinding of Radix Salvia Miltiorrhiza Particles and the Physicochemical Properties by High Speed Centrifugal Sheering

2007 ◽  
Vol 330-332 ◽  
pp. 215-218 ◽  
Author(s):  
Y.L. Su ◽  
Zheng Yi Fu ◽  
Wei Min Wang ◽  
Hang Wang ◽  
Yu Cheng Wang ◽  
...  
Keyword(s):  
High Speed ◽  
High Performance ◽  
Laser Light ◽  
Salvia Miltiorrhiza ◽  
Tanshinone Iia ◽  
Nano Particles ◽  
Active Ingredients ◽  
Ultrafine Grinding ◽  
Radix Salvia Miltiorrhiza ◽  
Nanoparticles Suspension

Radix salvia miltiorrhiza is a commonly used herbal medicine in China, and tanshinone IIA is one of the major active ingredients. Nano Radix salvia miltiorrhiza particles were successfully prepared by high speed centrifugal sheering (HSCS) technology, and the prepared nanoparticles suspension was subsequently spray-dried. The different properties of nano particles and raw powder were systematically studied by laser light scattering granulometric analyzer, TEM, SEM and FTIR. The extractive quantity of tanshinone IIA was determined by high-performance liquid chromatography (HPLC). The results illustrate that raw Radix salvia miltiorrhiza powder can be ultrafinely ground to nanosize within 50min, and the molecular structure of active ingredients doesn’t change after being ground. Furthermore, the active ingredients can dissolve out directly and fully, and the extractive ratio of tanshinone IIA increases 28.6% by HSCS processing. It is valuable to combine nanotechnology and TCM to improve the bioavailability and rapid releasing.

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